Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

Molecular Cell

Volumn 63, Issue 1, 2016, Pages 135-145

  Wang, Guanbo ^a,b   de Jong, Rob N ^c   van den Bremer, Ewald T J ^c   Beurskens, Frank J ^c   Labrijn, Aran F ^c   Ugurlar, Deniz ^d   Gros, Piet ^d   Schuurman, Janine ^c   Parren, Paul W H I ^c,e   Heck, Albert J R ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^c GENMAB   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; COMPLEMENT; COMPLEMENT COMPONENT C1; COMPLEMENT COMPONENT C1Q; FC RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; PROTEIN BINDING;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT INHIBITION; CONTROLLED STUDY; DEGLYCOSYLATION; GENE DELETION; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS SPECTROMETRY; MEDIATOR; MOLECULAR DYNAMICS; OLIGOMERIZATION; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; SIZE EXCLUSION CHROMATOGRAPHY; ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY REACTION; CHEMISTRY; GENETICS; GLYCOSYLATION; IMMUNOLOGY; METABOLISM; MUTATION; PROTEIN STABILITY; TANDEM MASS SPECTROMETRY; TUMOR CELL LINE;

ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; BINDING SITES, ANTIBODY; CELL LINE, TUMOR; CHROMATOGRAPHY, GEL; COMPLEMENT ACTIVATION; COMPLEMENT C1Q; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MUTATION; PROTEIN BINDING; PROTEIN STABILITY; TANDEM MASS SPECTROMETRY;

EID: 84992313071     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.05.016     Document Type: Article

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