Structure and activation of C1, the complex initiating the classical pathway of the complement cascade

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 5, 2017, Pages 986-991

  Mortensen, Simon A ^a   Sander, Bjoern ^a   Jensen, Rasmus K ^a   Pedersen, Jan Skov ^a   Golas, Monika M ^a   Jensenius, Jens C ^a   Hansen, Annette G ^a   Thiel, Steffen ^a   Andersen, Gregers R ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Complement; Innate immunity; Proteolytic cascade; Structural biology

Indexed keywords

COMPLEMENT COMPONENT C1; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; SERINE PROTEINASE; TETRAMER; RECOMBINANT PROTEIN; SYNTHETIC DNA;

AB INITIO CALCULATION; ANTIGEN ANTIBODY COMPLEX; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT FIXATION; CONTROLLED STUDY; HEK293 CELL LINE; HUMAN; HUMAN CELL; INNATE IMMUNITY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; REACTION ANALYSIS; CHEMISTRY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; GENETICS; METABOLISM; PHYSIOLOGY; SMALL ANGLE SCATTERING; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

COMPLEMENT C1R; COMPLEMENT C1S; COMPLEMENT PATHWAY, CLASSICAL; ENZYME ACTIVATION; GENES, SYNTHETIC; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; STRUCTURE-ACTIVITY RELATIONSHIP; X-RAY DIFFRACTION;

EID: 85011003042     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1616998114     Document Type: Article

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