Micro-RNAs in transplant tolerance

Current Opinion in Organ Transplantation

Volumn 23, Issue 1, 2018, Pages 66-72

  Harden, James T ^a   Krams, Sheri M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

biomarker; graft rejection; micro RNAs; therapy; tolerance

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA;

B LYMPHOCYTE; CYTOKINE RELEASE; DENDRITIC CELL; EXOSOME; GRAFT SURVIVAL; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; ORGAN TRANSPLANTATION; REVIEW; T LYMPHOCYTE; TRANSPLANTATION TOLERANCE; ANIMAL; CELLULAR IMMUNITY; GENETICS; GRAFT REJECTION; IMMUNOLOGY;

ANIMALS; GRAFT REJECTION; HUMANS; IMMUNITY, CELLULAR; MICRORNAS; ORGAN TRANSPLANTATION; TRANSPLANTATION TOLERANCE;

EID: 85041467161     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0000000000000479     Document Type: Review

References (52)

1. Kaul V, Krams S. MicroRNAs as master regulators of immune responses in transplant recipients. Curr Opin Organ Transplant 2015; 20:29-36.
2. Ladak SS, Ward C, Ali S. The potential role of microRNAs in lung allograft rejection. J Heart Lung Transplant 2016; 35:550-559.
3. Zhou M, Hara H, Dai Y, et al. Circulating organ-specific microRNAs serve as biomarkers in organ-specific diseases: implications for organ Allo-and Xenotransplantation. Int J Mol Sci 2016; 17:1232.
4. Hamdorf M, Kawakita S, Everly M. The Potential of microRNAs as novel biomarkers for transplant rejection. J Immunol Res 2017; 2017:4072364.
5. Anglicheau D, Sharma VK, Ding R, et al. MicroRNA expression profiles predictive of human renal allograft status. Proc Natl Acad Sci U S A 2009; 106:5330-5335.
6. Sun Y, Jin X, Liu X, et al. MicroRNA let-7i regulates dendritic cells maturation targeting interleukin-10 via the Janus kinase 1-signal transducer and activator of transcription 3 signal pathway subsequently induces prolonged cardiac allograft survival in rats. J Heart Lung Transplant 2016; 35:378-388.
7. SongJ,SuW,Chen X, et al. MicroRNA-98 suppresses interleukin-10 inperipheral B cells in patient postcardio transplantation. Oncotarget 2017; 8:28237.
8. Wei L, Kaul V, Qu X, et al. Absence of miR-182 augments cardiac allograft survival. Transplantation 2017; 101:524-530.
9. Zhang A, Wang K, Zhou C, et al. Knockout of microRNA-155 ameliorates the Th1/Th17 immune response and tissue injury in chronic rejection. J Heart Lung Transplant 2017; 36:175-184.
10. Revilla-Nuin B, de Bejar A, Martínez-Alarcón L, et al. Differential profile of activated regulatory T cell subsets and microRNAs in tolerant liver transplant recipients. Liver Transpl 2017; 23:933-945.
11. Vitalone MJ, Wei L, Fujiki M, et al. Liver microRNA profile of induced allograft tolerance. Transplantation 2016; 100:781-790.
12. Vallabhajosyula P, Korutla L, Habertheuer A, et al. Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue. J Clin Invest 2017; 127:1375-1391.
13. Wang T, Li F, Geng W, et al. MicroRNA-122 ameliorates corneal allograft rejection through the downregulation of its target CPEB1. Cell Death Discov 2017; 3:17021.
14. Schauerte C, Hübner A, Rong S, et al. Antagonism of profibrotic microRNA-21 improves outcome of murine chronic renal allograft dysfunction. Kidney Int 2017; 92:646-656.
15. Harris A, Krams SM, Martinez OM. MicroRNAs as immune regulators: implications for transplantation. Am J Transplant 2010; 10:713-719.
16. Turner ML, Schnorfeil FM, Brocker T. MicroRNAs regulate dendritic cell differentiation and function. J Immunol 2011; 187:3911-3917.
17. Baumjohann D, Ansel KM. MicroRNA regulation of T helper cell differentiation and plasticity. Nat Rev Immunol 2013; 13:666.
18. Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007; 7:610.
19. Durand J, Chiffoleau E. B cells with regulatory properties in transplantation tolerance. World J Transplant 2015; 5:196.
20. Chesneau M, Michel L, Degauque N, Brouard S. Regulatory B cells and tolerance in transplantation: from animal models to human. Front Immunol 2013; 4:497.
21. Redfield RR, Rodriguez E, Parsons R, et al. Essential role for B cells in transplantation tolerance. Curr Opin Immunol 2011; 23:685-691.
22. Xu Z, Nayak D, Yang W, et al. Dysregulated MicroRNA expression and chronic lung allograft rejection in recipients with antibodies to donor HLA. Am J Transplant 2015; 15:1933-1947.
23. Danger R, Pallier A, Giral M, et al. Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant. J Am Soc Nephrol 2012; 23:597-606.
24. Li J, Gong J, Li P, et al. Knockdown of microRNA-155 in Kupffer cells results in immunosuppressive effects and prolongs survival of mouse liver allografts. Transplantation 2014; 97:626-635.
25. Gao Y, Liu F, Zhou Q, et al. Mir-155 regulates cardiac allograft rejection by targing the expression of suppressor of cytokine signaling-1 (DOCS1) in dendritic cells. Int J Clin Exp Med 2014; 7:4572.
26. Rodriguez A, Vigorito E, Clare S, et al. Requirement of bic/microRNA-155 for normal immune function. Science 2007; 316:608-611.
27. O'connell RM, Kahn D, Gibson WS, et al. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 2010; 33:607-619.
28. Lu LF, Thai TH, Calado DP, et al. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 2009; 30:80-91.
29. Danger R, Paul C, Giral M, et al. Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibodymediated rejection. PloS One 2013; 8:e60702.
30. Lozano JJ, Pallier A, Martinez-Llordella M, et al. Comparison of transcriptional and blood cell-phenotypic markers between operationally tolerant liver and kidney recipients. Am J Transplant 2011; 11:1916-1926.
31. Londonõ MC, Danger R, Giral M, et al. A need for biomarkers of operational tolerance in liver and kidney transplantation. Am J Transplant 2012; 12:1370-1377.
32. Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303:83-86.
33. Ebert PJ, Jiang S, Xie J, et al. An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol 2009; 10:1162-1169.
34. Schietinger A, Delrow JJ, Basom RS, et al. Rescued tolerant CD8 T cells are preprogrammed to reestablish the tolerant state. Science 2012; 335: 723-727.
35. Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, et al. Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation. Sci Immunol 2016; 1:aaf8759.
36. Song J, Huang J, Chen X, et al. Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart. Sci Rep 2016; 7:7 46389.
37. Gallo A, Tandon M, Alevizos I, Illei GG. The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PloS One 2012; 7:e30679.
38. Rabinowits G, Gerçel-Taylor C, Day JM, et al. Exosomal microRNA: a diagnostic marker for lung cancer. Clin Lung Cancer 2009; 10:42-46.
39. Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 2008; 110:13-21.
40. Bala S, Petrasek J, Mundkur S, et al. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology 2012; 56:1946-1957.
41. Sugimachi K, Matsumura T, Hirata H, et al. Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. Br J Cancer 2015; 112:532.
42. Weichhart T, Hengstschläger M, Linke M. Regulation of innate immune cell function by mTOR. Nat Rev Immunol 2015; 15:599.
43. Sang W, Sun C, Zhang C, et al. MicroRNA-150 negatively regulates the function of CD4(+) T cells through AKT3/Bim signaling pathway. Cell Immunol 2016; 306:35-40.
44. Williams A, Henao-Mejia J, Harman CC, Flavell RA. miR-181 and metabolic regulation in the immune system. Cold Spring Harbor symposia on quantitative biology. Vol 78. Harbor: Cold Spring Harbor Laboratory Press; 2013; 223-230
45. Lau A, Schaffert S, Qu X, Krams S. miRNA-181a is critical for the tolerogenic properties of plasmacytoid dendritic cells (TRAN3P. 886). J Immunol 2014; 192(1 Supplement):202.25.
46. Ekshyyan O, Anandharaj A, Nathan CA. Dual PI3K/mTOR inhibitors: does p53 modulate response? Clin Cancer Res 2013; 19:3719-3721.
47. Alpdogan O, van den Brink MR. Immune tolerance and transplantation. Semin Oncol 2012; 39:629-642.
48. Kasinski AL, Slack FJ. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer 2011; 11:849-864.
49. Van Rooij E, Olson EN. MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat Rev Drug Discov 2012; 11:860.
50. Vahed SZ, Zonouzi AP, Ghanbarian H, et al. Differential expression of circulating miR-21, miR-142-3p and miR-155 in renal transplant recipients with impaired graft function. Int Urol Nephrol 2017; 1-9.
51. Ben-Dov IZ, Muthukumar T, Morozov P, et al. MicroRNA sequence profiles of human kidney allografts with or without tubulointerstitial fibrosis. Transplantation 2012; 94:1086-1094.
52. Mas VR, Portilla D, Maluf DG. Biomarkers of transplant tolerance: a provisional analysis for an unmet need. Transplantation 2016; 100:705-706.