Knockout of microRNA-155 ameliorates the Th1/Th17 immune response and tissue injury in chronic rejection

Journal of Heart and Lung Transplantation

Volumn 36, Issue 2, 2017, Pages 175-184

  Zhang, Anchen ^a,b   Wang, Ke ^a   Zhou, Cheng ^a   Gan, Zheng ^a   Ma, Dongxia ^a   Ye, Ping ^b   Sun, Yuan ^a   Wu, Jie ^a   Huang, Xiaofan ^a   Ren, Lingyun ^a   Deng, Peng ^a   Wu, Chuangyan ^a   Yue, Zhang ^a   Ding, Xiangchao ^a   Chen, Jiuling ^a   Xia, Jiahong ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CENTRAL HOSPITAL OF WUHAN   (China)

Author keywords

CAV; heart transplantation; miR 155; rejection; Th17

Indexed keywords

CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 9; MESSENGER RNA; MICRORNA; MICRORNA 142 3P; MICRORNA 142 5P; MICRORNA 146A 5P; MICRORNA 146B 5P; MICRORNA 150 5P; MICRORNA 155; MICRORNA 155 5P; MICRORNA 196A; MICRORNA 196A 5P; MICRORNA 196B 5P; MICRORNA 223 3P; MICRORNA 342 3P; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATE BUFFERED SALINE; SMAD2 PROTEIN; STAT6 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR C MAF; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC ALLOGRAFT VASCULOPATHY; CD4+ T LYMPHOCYTE; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOPATHOLOGY; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATION; LYMPHOCYTE CULTURE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTIC INFILTRATION; MALE; MICROARRAY ANALYSIS; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN CELL; TH1 CELL; TH17 CELL; TISSUE INJURY; UPREGULATION; ALLOGRAFT; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL DIFFERENTIATION; CHRONIC DISEASE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; GRAFT REJECTION; HISTOCOMPATIBILITY; IMMUNOLOGY; KNOCKOUT MOUSE; PROCEDURES; RANDOMIZATION; WESTERN BLOTTING;

ALLOGRAFTS; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRAFT REJECTION; HEART TRANSPLANTATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; RANDOM ALLOCATION; REAL-TIME POLYMERASE CHAIN REACTION; TH1 CELLS; TH17 CELLS; TRANSPLANTATION IMMUNOLOGY; UP-REGULATION;

EID: 85006930149     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2016.04.018     Document Type: Article

References (22)

1. 1 Rodriguez, A., Vigorito, E., Clare, S., et al. Requirement of bic/microRNA-155 for normal immune function. Science 316 (2007), 608–611.
2. 2 Lu, L.F., Thai, T.H., Calado, D.P., et al. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 30 (2009), 80–91.
3. 3 Kohlhaas, S., Garden, O.A., Scudamore, C., et al. Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol 182 (2009), 2578–2582.
4. 4 O'Connell, R.M., Kahn, D., Gibson, W.S., et al. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 33 (2010), 607–619.
5. 5 Yuan, X., Paez-Cortez, J., Schmitt-Knosalla, I., et al. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 205 (2008), 3133–3144.
6. 6 Gorbacheva, V., Fan, R., Li, X., et al. Interleukin-17 promotes early allograft inflammation. Am J Pathol 177 (2010), 1265–1273.
7. 7 Deteix, C., Attuil-Audenis, V., Duthey, A., et al. Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection. J Immunol 184 (2010), 5344–5351.
8. 8 Billingham, M.E., Cary, N.R., Hammond, M.E., et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection. J Heart Transplant 9 (1990), 587–593.
9. 9 Furukawa, Y., Libby, P., Stinn, J.L., et al. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hosts. Am J Pathol 160 (2002), 1077–1087.
10. 10 Quah, B.J., Warren, H.S., Parish, C.R., monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester. Nat Protoc 2 (2007), 2049–2056.
11. 11 Sun, Y., Ye, P., Wu, J., et al. Inhibition of intimal hyperplasia in murine aortic allografts by the oral administration of the transforming growth factor-beta receptor I kinase inhibitor SD-208. J Heart Lung Transplant 33 (2014), 654–661.
12. 12 Feng, Z., Xia, Y., Zhang, M., et al. MicroRNA-155 regulates T cell proliferation through targeting GSK3beta in cardiac allograft rejection in a murine transplantation model. Cellular Immunology 281 (2013), 141–149.
13. 13 Li, J., Gong, J., Li, P., et al. Knockdown of microRNA-155 in Kupffer cells results in immunosuppressive effects and prolongs survival of mouse liver allografts. Transplantation 97 (2014), 626–635.
14. 14 Gao, Y., Liu, F., Zhou, Q., et al. mir-155 regulates cardiac allograft rejection by targeting the expression of suppressor of cytokine signaling-1 (DOCS1) in dendritic cells. Int. J Clin Exp Med 7 (2014), 4572–4583.
15. 15 Banerjee, A., Schambach, F., DeJong, C.S., et al. Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur J Immunol 40 (2010), 225–231.
16. 16 Chadha, R., Heidt, S., Jones, N.D., et al. Th17: contributors to allograft rejection and a barrier to the induction of transplantation tolerance?. Transplantation 91 (2011), 939–945.
17. 17 Escobar, T.M., Kanellopoulou, C., Kugler, D.G., et al. miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity 40 (2014), 865–879.
18. + cells home to the graft early after human heart transplantation. J Heart Lung Transplant 34 (2014), 933–940.
19. 19 Flowers, L.O., Subramaniam, P.S., Johnson, H.M., A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells. Oncogene 24 (2005), 2114–2120.
20. 20 Yu, C.R., Mahdi, R.R., Oh, H.M., et al. Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation. Invest Ophthalmol Vis Sci 52 (2011), 6978–6986.
21. 21 Adamson, A.S., Collins, K., Laurence, A., et al. The current STATus of lymphocyte signaling: new roles for old players. Curr Opin Immunol 21 (2009), 161–166.
22. 22 Sato, K., Miyoshi, F., Yokota, K., et al. Marked induction of c-Maf protein during Th17 cell differentiation and its implication in memory Th cell development. J Biol Chem, 286, 2011, 14963.