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Volumn 127, Issue 4, 2017, Pages 1375-1391

Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CD3 ANTIBODY; FXYD2 PROTEIN; GLUCAGON; GLUCOSE; HLA ANTIBODY; INSULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; MICRORNA; MICRORNA 122 5P; MICRORNA 1281; MICRORNA 16-5P; MICRORNA 191 5P; MICRORNA 23 3P; MICRORNA 24 3P; MICRORNA 3613 3P; MICRORNA 3613 5P; MICRORNA 375; MICRORNA 4508; MICRORNA 4668 5P; MICRORNA 486 5P; MICRORNA 5787; MICRORNA 6732 5P; MICRORNA 7704; MICRORNA 8075; PROTEIN; RIBOSOME RNA; SOMATOSTATIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; PROTEOME;

EID: 85018697833     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI87993     Document Type: Article
Times cited : (132)

References (59)
  • 1
    • 84943260823 scopus 로고    scopus 로고
    • The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Lung and Heart-Lung Transplantation Report-2015; Focus Theme: Early Graft Failure
    • Yusen RD, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Lung and Heart-Lung Transplantation Report-2015; Focus Theme: Early Graft Failure. J Heart Lung Transplant. 2015;34(10):1264-1277.
    • (2015) J Heart Lung Transplant , vol.34 , Issue.10 , pp. 1264-1277
    • Yusen, R.D.1
  • 2
    • 84943268792 scopus 로고    scopus 로고
    • The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Heart Transplantation Report-2015; Focus Theme: Early Graft Failure
    • Lund LH, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Heart Transplantation Report-2015; Focus Theme: Early Graft Failure. J Heart Lung Transplant. 2015;34(10):1244-1254.
    • (2015) J Heart Lung Transplant , vol.34 , Issue.10 , pp. 1244-1254
    • Lund, L.H.1
  • 3
    • 84943268959 scopus 로고    scopus 로고
    • The Registry of the International Society for Heart and Lung Transplantation: Eighteenth Official Pediatric Lung and Heart-Lung Transplantation Report-2015; Focus Theme: Early Graft Failure
    • Goldfarb SB, et al. The Registry of the International Society for Heart and Lung Transplantation: Eighteenth Official Pediatric Lung and Heart-Lung Transplantation Report-2015; Focus Theme: Early Graft Failure. J Heart Lung Transplant. 2015;34(10):1255-1263.
    • (2015) J Heart Lung Transplant , vol.34 , Issue.10 , pp. 1255-1263
    • Goldfarb, S.B.1
  • 4
    • 84943262846 scopus 로고    scopus 로고
    • The Registry of the International Society for Heart and Lung Transplantation: Eighteenth Official Pediatric Heart Transplantation Report-2015; Focus Theme: Early Graft Failure
    • Dipchand AI, et al. The Registry of the International Society for Heart and Lung Transplantation: Eighteenth Official Pediatric Heart Transplantation Report-2015; Focus Theme: Early Graft Failure. J Heart Lung Transplant. 2015;34(10):1233-1243.
    • (2015) J Heart Lung Transplant , vol.34 , Issue.10 , pp. 1233-1243
    • Dipchand, A.I.1
  • 5
    • 79960302391 scopus 로고    scopus 로고
    • Monitoring and managing graft health in the kidney transplant recipient
    • Josephson MA. Monitoring and managing graft health in the kidney transplant recipient. Clin J Am Soc Nephrol. 2011;6(7):1774-1780.
    • (2011) Clin J Am Soc Nephrol , vol.6 , Issue.7 , pp. 1774-1780
    • Josephson, M.A.1
  • 6
    • 84857622379 scopus 로고    scopus 로고
    • Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation
    • Farid WR, et al. Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation. Liver Transpl. 2012;18(3):290-297.
    • (2012) Liver Transpl , vol.18 , Issue.3 , pp. 290-297
    • Farid, W.R.1
  • 7
    • 84856468503 scopus 로고    scopus 로고
    • Microvesicles as novel biomarkers and therapeutic targets in transplantation medicine
    • Fleissner F, Goerzig Y, Haverich A, Thum T. Microvesicles as novel biomarkers and therapeutic targets in transplantation medicine. Am J Transplant. 2012;12(2):289-297.
    • (2012) Am J Transplant , vol.12 , Issue.2 , pp. 289-297
    • Fleissner, F.1    Goerzig, Y.2    Haverich, A.3    Thum, T.4
  • 8
    • 35148829338 scopus 로고    scopus 로고
    • Biomarker discovery: Tissues versus fluids versus both
    • Johann DJ Jr. Blonder J. Biomarker discovery: tissues versus fluids versus both. Expert Rev Mol Diagn. 2007;7(5):473-475.
    • (2007) Expert Rev Mol Diagn , vol.7 , Issue.5 , pp. 473-475
    • Johann, D.J.1    Blonder, J.2
  • 9
    • 84919394606 scopus 로고    scopus 로고
    • Extracellular vesicle profiling and their use as potential disease specific biomarker
    • Julich H, Willms A, Lukacs-Kornek V, Kornek M. Extracellular vesicle profiling and their use as potential disease specific biomarker. Front Immunol. 2014;5:413.
    • (2014) Front Immunol , vol.5 , pp. 413
    • Julich, H.1    Willms, A.2    Lukacs-Kornek, V.3    Kornek, M.4
  • 10
    • 42749092828 scopus 로고    scopus 로고
    • Itinerant exosomes: Emerging roles in cell and tissue polarity
    • Lakkaraju A, Rodriguez-Boulan E. Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol. 2008;18(5):199-209.
    • (2008) Trends Cell Biol , vol.18 , Issue.5 , pp. 199-209
    • Lakkaraju, A.1    Rodriguez-Boulan, E.2
  • 11
    • 84897108187 scopus 로고    scopus 로고
    • Biomarkers for kidney transplant rejection
    • Lo DJ, Kaplan B, Kirk AD. Biomarkers for kidney transplant rejection. Nat Rev Nephrol. 2014;10(4):215-225.
    • (2014) Nat Rev Nephrol , vol.10 , Issue.4 , pp. 215-225
    • Lo, D.J.1    Kaplan, B.2    Kirk, A.D.3
  • 12
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: Extracellular organelles important in intercellular communication
    • Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010;73(10):1907-1920.
    • (2010) J Proteomics , vol.73 , Issue.10 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 13
    • 84880770209 scopus 로고    scopus 로고
    • Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction
    • Matsumoto S, et al. Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction. Circ Res. 2013;113(3):322-326.
    • (2013) Circ Res , vol.113 , Issue.3 , pp. 322-326
    • Matsumoto, S.1
  • 14
    • 79960630579 scopus 로고    scopus 로고
    • Biomarkers in solid organ transplantation: Establishing personalized transplantation medicine
    • Roedder S, Vitalone M, Khatri P, Sarwal MM. Biomarkers in solid organ transplantation: establishing personalized transplantation medicine. Genome Med. 2011;3(6):37.
    • (2011) Genome Med , vol.3 , Issue.6 , pp. 37
    • Roedder, S.1    Vitalone, M.2    Khatri, P.3    Sarwal, M.M.4
  • 15
    • 79955536976 scopus 로고    scopus 로고
    • MicroRNAs: Potential biomarker in organ transplantation
    • Shan J, et al. MicroRNAs: potential biomarker in organ transplantation. Transpl Immunol. 2011;24(4):210-215.
    • (2011) Transpl Immunol , vol.24 , Issue.4 , pp. 210-215
    • Shan, J.1
  • 17
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654-659.
    • (2007) Nat Cell Biol , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 18
    • 85016448020 scopus 로고    scopus 로고
    • Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles
    • Lötvall J, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles. 2014;3:26913.
    • (2014) J Extracell Vesicles , vol.3 , pp. 26913
    • Lötvall, J.1
  • 19
    • 84874918933 scopus 로고    scopus 로고
    • Hyperplasia of pancreatic beta cells and improved glucose tolerance in mice deficient in the FXYD2 subunit of Na,KATPase
    • Arystarkhova E, et al. Hyperplasia of pancreatic beta cells and improved glucose tolerance in mice deficient in the FXYD2 subunit of Na,KATPase. J Biol Chem. 2013;288(10):7077-7085.
    • (2013) J Biol Chem , vol.288 , Issue.10 , pp. 7077-7085
    • Arystarkhova, E.1
  • 20
    • 77955629622 scopus 로고    scopus 로고
    • A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker
    • Flamez D, et al. A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker. Diabetologia. 2010;53(7):1372-1383.
    • (2010) Diabetologia , vol.53 , Issue.7 , pp. 1372-1383
    • Flamez, D.1
  • 21
    • 84856744460 scopus 로고    scopus 로고
    • Pancreatic islet and progenitor cell surface markers with cell sorting potential
    • Hald J, et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012;55(1):154-165.
    • (2012) Diabetologia , vol.55 , Issue.1 , pp. 154-165
    • Hald, J.1
  • 22
    • 84924499346 scopus 로고    scopus 로고
    • FXYD2, a ? subunit of Na+, K+-ATPase, maintains persistent mechanical allodynia induced by inflammation
    • Wang F, et al. FXYD2, a ? subunit of Na+, K+-ATPase, maintains persistent mechanical allodynia induced by inflammation. Cell Res. 2015;25(3):318-334.
    • (2015) Cell Res , vol.25 , Issue.3 , pp. 318-334
    • Wang, F.1
  • 23
    • 9144270691 scopus 로고    scopus 로고
    • A pancreatic islet-specific microRNA regulates insulin secretion
    • Poy MN, et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 2004;432(7014):226-230.
    • (2004) Nature , vol.432 , Issue.7014 , pp. 226-230
    • Poy, M.N.1
  • 24
    • 65249093130 scopus 로고    scopus 로고
    • MiR-375 maintains normal pancreatic alpha-and beta-cell mass
    • Poy MN, et al. miR-375 maintains normal pancreatic alpha-and beta-cell mass. Proc Natl Acad Sci U S A. 2009;106(14):5813-5818.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.14 , pp. 5813-5818
    • Poy, M.N.1
  • 25
    • 84864761391 scopus 로고    scopus 로고
    • Essential metabolic, antiinflammatory, and anti-tumorigenic functions of miR-122 in liver
    • Hsu SH, et al. Essential metabolic, antiinflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest. 2012;122(8):2871-2883.
    • (2012) J Clin Invest , vol.122 , Issue.8 , pp. 2871-2883
    • Hsu, S.H.1
  • 26
    • 84858195484 scopus 로고    scopus 로고
    • Liver-specific microRNA-122: Biogenesis and function
    • Jopling C. Liver-specific microRNA-122: Biogenesis and function. RNA Biol. 2012;9(2):137-142.
    • (2012) RNA Biol , vol.9 , Issue.2 , pp. 137-142
    • Jopling, C.1
  • 27
    • 78649752499 scopus 로고    scopus 로고
    • Regulation and biological function of the liver-specific miR-122
    • Lewis AP, Jopling CL. Regulation and biological function of the liver-specific miR-122. Biochem Soc Trans. 2010;38(6):1553-1557.
    • (2010) Biochem Soc Trans , vol.38 , Issue.6 , pp. 1553-1557
    • Lewis, A.P.1    Jopling, C.L.2
  • 28
    • 84965088312 scopus 로고    scopus 로고
    • MiR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir
    • Thakral S, Ghoshal K. miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir. Curr Gene Ther. 2015;15(2):142-150.
    • (2015) Curr Gene Ther , vol.15 , Issue.2 , pp. 142-150
    • Thakral, S.1    Ghoshal, K.2
  • 29
    • 84864773072 scopus 로고    scopus 로고
    • MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
    • Tsai WC, et al. MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest. 2012;122(8):2884-2897.
    • (2012) J Clin Invest , vol.122 , Issue.8 , pp. 2884-2897
    • Tsai, W.C.1
  • 30
    • 63149121152 scopus 로고    scopus 로고
    • Circulating microRNAs, potential biomarkers for drug-induced liver injury
    • Wang K, et al. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A. 2009;106(11):4402-4407.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.11 , pp. 4402-4407
    • Wang, K.1
  • 31
    • 34447115728 scopus 로고    scopus 로고
    • Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity
    • Rickels MR, Kamoun M, Kearns J, Markmann JF, Naji A. Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity. J Clin Endocrinol Metab. 2007;92(7):2410-2414.
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.7 , pp. 2410-2414
    • Rickels, M.R.1    Kamoun, M.2    Kearns, J.3    Markmann, J.F.4    Naji, A.5
  • 32
    • 40849097609 scopus 로고    scopus 로고
    • Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft function
    • Aquino-Dias EC, et al. Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft function. Kidney Int. 2008;73(7):877-884.
    • (2008) Kidney Int , vol.73 , Issue.7 , pp. 877-884
    • Aquino-Dias, E.C.1
  • 33
    • 3042614142 scopus 로고    scopus 로고
    • Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection
    • Kotsch K, et al. Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection. Transplantation. 2004;77(12):1866-1875.
    • (2004) Transplantation , vol.77 , Issue.12 , pp. 1866-1875
    • Kotsch, K.1
  • 34
    • 0035967217 scopus 로고    scopus 로고
    • Noninvasive diagnosis of renalallograft rejection by measurement of messenger RNA for perforin and granzyme B in urine
    • Li B, et al. Noninvasive diagnosis of renalallograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med. 2001;344(13):947-954.
    • (2001) N Engl J Med , vol.344 , Issue.13 , pp. 947-954
    • Li, B.1
  • 35
    • 84879776271 scopus 로고    scopus 로고
    • Urinary-cell mRNA profile and acute cellular rejection in kidney allografts
    • Suthanthiran M, et al. Urinary-cell mRNA profile and acute cellular rejection in kidney allografts. N Engl J Med. 2013;369(1):20-31.
    • (2013) N Engl J Med , vol.369 , Issue.1 , pp. 20-31
    • Suthanthiran, M.1
  • 36
    • 2442652560 scopus 로고    scopus 로고
    • Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine
    • Tatapudi RR, et al. Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int. 2004;65(6):2390-2397.
    • (2004) Kidney Int , vol.65 , Issue.6 , pp. 2390-2397
    • Tatapudi, R.R.1
  • 37
    • 34548438601 scopus 로고    scopus 로고
    • Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis
    • Su D, et al. Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis. Diabetes. 2007;56(9):2274-2283.
    • (2007) Diabetes , vol.56 , Issue.9 , pp. 2274-2283
    • Su, D.1
  • 38
    • 0036284207 scopus 로고    scopus 로고
    • Local synthesis of complement component C3 regulates acute renal transplant rejection
    • Pratt JR, Basheer SA, Sacks SH. Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med. 2002;8(6):582-587.
    • (2002) Nat Med , vol.8 , Issue.6 , pp. 582-587
    • Pratt, J.R.1    Basheer, S.A.2    Sacks, S.H.3
  • 39
    • 84902537686 scopus 로고    scopus 로고
    • Expression of hemopexin in acute rejection of rat liver allograft identified by serum proteomic analysis
    • Xu M, et al. Expression of hemopexin in acute rejection of rat liver allograft identified by serum proteomic analysis. Shock. 2014;42(1):65-74.
    • (2014) Shock , vol.42 , Issue.1 , pp. 65-74
    • Xu, M.1
  • 40
    • 77954473208 scopus 로고    scopus 로고
    • High plasma hemopexin activity is an independent risk factor for late graft failure in renal transplant recipients
    • Krikken JA, et al. High plasma hemopexin activity is an independent risk factor for late graft failure in renal transplant recipients. Transpl Int. 2010;23(8):805-812.
    • (2010) Transpl Int , vol.23 , Issue.8 , pp. 805-812
    • Krikken, J.A.1
  • 41
    • 33644610514 scopus 로고    scopus 로고
    • Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling
    • Deng MC, et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant. 2006;6(1):150-160.
    • (2006) Am J Transplant , vol.6 , Issue.1 , pp. 150-160
    • Deng, M.C.1
  • 42
    • 84941933577 scopus 로고    scopus 로고
    • Cell-free DNA: An upcoming biomarker in transplantation
    • Gielis EM, et al. Cell-free DNA: An upcoming biomarker in transplantation. Am J Transplant. 2015;15(10):2541-2551.
    • (2015) Am J Transplant , vol.15 , Issue.10 , pp. 2541-2551
    • Gielis, E.M.1
  • 43
    • 84951933250 scopus 로고    scopus 로고
    • Altered exosomal RNA profiles in bronchoalveolar lavage from lung transplants with acute rejection
    • Gregson AL, et al. Altered exosomal RNA profiles in bronchoalveolar lavage from lung transplants with acute rejection. Am J Respir Crit Care Med. 2015;192(12):1490-1503.
    • (2015) Am J Respir Crit Care Med , vol.192 , Issue.12 , pp. 1490-1503
    • Gregson, A.L.1
  • 44
  • 46
    • 84916910217 scopus 로고    scopus 로고
    • Monitoring of transplanted liver health by quantification of organ-specific genomic marker in circulating DNA from receptor
    • Macher HC, et al. Monitoring of transplanted liver health by quantification of organ-specific genomic marker in circulating DNA from receptor. PLoS One. 2014;9(12):e113987.
    • (2014) PLoS One , vol.9 , Issue.12 , pp. e113987
    • Macher, H.C.1
  • 47
    • 84879840452 scopus 로고    scopus 로고
    • A rapid noninvasive assay for the detection of renal transplant injury
    • Sigdel TK, et al. A rapid noninvasive assay for the detection of renal transplant injury. Transplantation. 2013;96(1):97-101.
    • (2013) Transplantation , vol.96 , Issue.1 , pp. 97-101
    • Sigdel, T.K.1
  • 48
    • 0032855152 scopus 로고    scopus 로고
    • Presence of donor-and recipient-derived DNA in cell-free urine samples of renal transplantation recipients: Urinary DNA chimerism
    • Zhang J, et al. Presence of donor-and recipient-derived DNA in cell-free urine samples of renal transplantation recipients: urinary DNA chimerism. Clin Chem. 1999;45(10):1741-1746.
    • (1999) Clin Chem , vol.45 , Issue.10 , pp. 1741-1746
    • Zhang, J.1
  • 49
    • 84889839628 scopus 로고    scopus 로고
    • Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury
    • Beck J, et al. Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury. Clin Chem. 2013;59(12):1732-1741.
    • (2013) Clin Chem , vol.59 , Issue.12 , pp. 1732-1741
    • Beck, J.1
  • 50
    • 0033870263 scopus 로고    scopus 로고
    • Genetic analysis of DNA excreted in urine: A new approach for detecting specific genomic DNA sequences from cells dying in an organism
    • Botezatu I, et al. Genetic analysis of DNA excreted in urine: a new approach for detecting specific genomic DNA sequences from cells dying in an organism. Clin Chem. 2000;46(8 Pt 1):1078-1084.
    • (2000) Clin Chem , vol.46 , Issue.8 , pp. 1078-1084
    • Botezatu, I.1
  • 51
    • 84903776814 scopus 로고    scopus 로고
    • Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection
    • De Vlaminck I, et al. Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection. Sci Transl Med. 2014;6(241):241ra77.
    • (2014) Sci Transl Med , vol.6 , Issue.241 , pp. 241ra77
    • De Vlaminck, I.1
  • 52
    • 84901842265 scopus 로고    scopus 로고
    • Double-stranded DNA in exosomes: A novel biomarker in cancer detection
    • Thakur BK, et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 2014;24(6):766-769.
    • (2014) Cell Res , vol.24 , Issue.6 , pp. 766-769
    • Thakur, B.K.1
  • 53
    • 84946559154 scopus 로고    scopus 로고
    • Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
    • Zhang L, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015;527(7576):100-104.
    • (2015) Nature , vol.527 , Issue.7576 , pp. 100-104
    • Zhang, L.1
  • 55
    • 4444226979 scopus 로고    scopus 로고
    • Identification and proteomic profiling of exosomes in human urine
    • Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A. 2004;101(36):13368-13373.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.36 , pp. 13368-13373
    • Pisitkun, T.1    Shen, R.F.2    Knepper, M.A.3
  • 56
    • 77957557995 scopus 로고    scopus 로고
    • Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome
    • Rood IM, et al. Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome. Kidney Int. 2010;78(8):810-816.
    • (2010) Kidney Int , vol.78 , Issue.8 , pp. 810-816
    • Rood, I.M.1
  • 57
    • 80055118968 scopus 로고    scopus 로고
    • Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
    • Dragovic RA, et al. Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis. Nanomedicine. 2011;7(6):780-788.
    • (2011) Nanomedicine , vol.7 , Issue.6 , pp. 780-788
    • Dragovic, R.A.1
  • 59
    • 0023710206 scopus 로고
    • Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach
    • DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44(3):837-845.
    • (1988) Biometrics , vol.44 , Issue.3 , pp. 837-845
    • DeLong, E.R.1    DeLong, D.M.2    Clarke-Pearson, D.L.3


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