The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection

Journal of Immunology Research

Volumn 2017, Issue , 2017, Pages

  Hamdorf, Matthias ^a   Kawakita, Satoru ^a   Everly, Matthew ^a  

^a TERASAKI FOUNDATION LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MICRORNA;

B LYMPHOCYTE; CHRONIC GRAFT REJECTION; DIAGNOSTIC VALUE; GENE EXPRESSION; GRAFT REJECTION; HEART; HUMAN; LUNG; MACROPHAGE; MOLECULAR PATHOLOGY; REVIEW; RNA ANALYSIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSPLANTATION; ALLOTRANSPLANTATION; BIOPSY; BLOOD; CELL DIFFERENTIATION; GENETICS; IMMUNOLOGY; PATHOPHYSIOLOGY;

BIOMARKERS; BIOPSY; CELL DIFFERENTIATION; GRAFT REJECTION; HUMANS; MICRORNAS; SIGNAL TRANSDUCTION; TRANSPLANTATION, HOMOLOGOUS;

EID: 85011602119     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2017/4072364     Document Type: Review

References (73)

1. M. Chekulaeva and W. Filipowicz, "Mechanisms of miRNAmediated post-Transcriptional regulation in animal cells, " Current Opinion in Cell Biology, vol. 21, no. 3, pp. 452-460, 2009.
2. D. P. Bartel, "MicroRNAs: genomics, biogenesis, mechanism, and function, " Cell, vol. 116, no. 2, pp. 281-297, 2004.
3. R. C. Friedman, K. K.-H. Farh, C. B. Burge, and D. P. Bartel, "Most mammalian mRNAs are conserved targets of microRNAs, " Genome Research, vol. 19, no. 1, pp. 92-105, 2009.
4. P. Sood, A. Krek, M. Zavolan, G. Macino, and N. Rajewsky, "Cell-Type-specific signatures of microRNAs on target mRNA expression, " Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 8, pp. 2746-2751, 2006.
5. D. P. Bartel, "MicroRNAs: Target recognition and regulatory functions, " Cell, vol. 136, no. 2, pp. 215-233, 2009.
6. D. G. Zisoulis, M. T. Lovci, M. L. Wilbert et al., "Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans, " Nature Structural & Molecular Biology, vol. 17, no. 2, pp. 173-179, 2010.
7. G. B. Loeb, A. A. Khan, D. Canner et al., "Transcriptomewide miR-155 binding map reveals widespread noncanonical microRNA targeting, " Molecular Cell, vol. 48, no. 5, pp. 760-770, 2012.
8. D. Sayed and M. Abdellatif, "Micrornas in development and disease, " Physiological Reviews, vol. 91, no. 3, pp. 827-887, 2011.
9. B. D. Adams, A. L. Kasinski, and F. J. Slack, "Aberrant regulation and function of microRNAs in cancer, " Current Biology, vol. 24, no. 16, pp. R762-R776, 2014.
10. C. Guay and R. Regazzi, "Circulating microRNAs as novel biomarkers for diabetes mellitus, " Nature Reviews Endocrinology, vol. 9, no. 9, pp. 513-521, 2013.
11. J. Zhang, S. Li, L. Li et al., "Exosome and exosomal microRNA: Trafficking, sorting, and function, " Genomics, Proteomics & Bioinformatics, vol. 13, no. 1, pp. 17-24, 2015.
12. A. A. Aravin, R. Sachidanandam, A. Girard, K. Fejes-Toth, and G. J. Hannon, "Developmentally regulated piRNA clusters implicate MILI in transposon control, " Science, vol. 316, no. 5825, pp. 744-747, 2007.
13. M. Halic and D. Moazed, "Transposon silencing by piRNAs, " Cell, vol. 138, no. 6, pp. 1058-1060, 2009.
14. J. E. Wilusz, H. Sunwoo, and D. L. Spector, "Long noncoding RNAs: functional surprises from the RNA world, " Genes & Development, vol. 23, no. 13, pp. 1494-1504, 2009.
15. V. J. Peschansky and C. Wahlestedt, "Non-coding RNAs as direct and indirect modulators of epigenetic regulation, " Epigenetics, vol. 9, no. 1, pp. 3-12, 2014.
16. W. R. R. Farid, Q. Pan, A. J. P. Van DerMeer et al., "Hepatocytederived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation, " Liver Transplantation, vol. 18, no. 3, pp. 290-297, 2012.
17. T. Asaoka, D. Hernandez, P. Tryphonopoulos et al., "Clinical significance of intragraft miR-122 and-155 expression after liver transplantation, " Hepatology Research, vol. 45, no. 8, pp. 898-905, 2015.
18. D. Joshi, S. Salehi, H. Brereton et al., "Distinct microRNA profiles are associated with the severity of hepatitis C virus recurrence and acute cellular rejection after liver transplantation, " Liver Transplantation, vol. 19, no. 4, pp. 383-394, 2013.
19. Y. Chen, L. Li, Z. Zhou, N. Wang, C.-Y. Zhang, and K. Zen, "A pilot study of serummicroRNA signatures as a novel biomarker for occult hepatitis B virus infection, " MedicalMicrobiology and Immunology, vol. 201, no. 3, pp. 389-395, 2012.
20. Z. Xu, S. Ramachandran, M. Gunasekaran et al., "MicroRNA-144 dysregulates the transforming growth factor-signaling cascade and contributes to the development of bronchiolitis obliterans syndrome after human lung transplantation, " The Journal of Heart and Lung Transplantation, vol. 34, no. 9, pp. 1154-1162, 2015.
21. Z. Xu, D. Nayak, W. Yang et al., "Dysregulated MicroRNA expression and chronic lung allograft rejection in recipients with antibodies to donor HLA, " American Journal of Transplantation, vol. 15, no. 7, pp. 1933-1947, 2015.
22. W. Zhang, T. Zhou, S. F. Ma, R. F. Machado, S. M. Bhorade, and J. G. Garcia, "MicroRNAs implicated in dysregulation of gene expression following human lung transplantation, " Translational Respiratory Medicine, vol. 1, no. 1, article 12, 2013.
23. Z. Xu, D. K. Nayak, N. Benshoff, R. Hachem, A. E. Gelman, and T. Mohanakumar, "De novo-developed antibodies to donor MHC antigens lead to dysregulation of microRNAs and induction of MHC class II, " The Journal of Immunology, vol. 194, no. 12, pp. 6133-6143, 2015.
24. W. Sui, H. Lin, W. Peng et al., "Molecular dysfunctions in acute rejection after renal transplantation revealed by integrated analysis of transcription factor, microRNA and long noncoding RNA, " Genomics, vol. 102, no. 4, pp. 310-322, 2013.
25. S. Oghumu, A. Bracewell, U. Nori et al., "Acute pyelonephritis in renal allografts-A new role for microRNAs?" Transplantation, vol. 97, no. 5, pp. 559-568, 2014.
26. M. K. Misra, S. K. Pandey, R. Kapoor, R. K. Sharma, and S. Agrawal, "Genetic variants of MicroRNA-related genes in susceptibility and prognosis of end-stage renal disease and renal allograft outcome among north Indians, " Pharmacogenetics and Genomics, vol. 24, no. 9, pp. 442-450, 2014.
27. D. Anglicheau, V. K. Sharma, R. Ding et al., "MicroRNA expression profiles predictive of human renal allograft status, " Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 13, pp. 5330-5335, 2009.
28. X. Liu, C. Dong, Z. Jiang et al., "MicroRNA-10b downregulation mediates acute rejection of renal allografts by derepressing BCL2L11, " Experimental Cell Research, vol. 333, no. 1, pp. 155-163, 2015.
29. J. Tao, X. Yang, Z. Han et al., "Serum MicroRNA-99a helps detect acute rejection in renal transplantation, " Transplantation Proceedings, vol. 47, no. 6, pp. 1683-1687, 2015.
30. W. Sui, Y. Dai, Y. Huang, H. Lan, Q. Yan, and H. Huang, "Microarray analysis of MicroRNA expression in acute rejection after renal transplantation, " Transplant Immunology, vol. 19, no. 1, pp. 81-85, 2008.
31. J. Wilflingseder, J. Sunzenauer, E. Toronyi et al., "Molecular pathogenesis of post-Transplant acute kidney injury: Assessment of whole-genome mRNA and miRNA profiles, " PLoS ONE, vol. 9, no. 8, Article ID e104164, 2014.
32. R. Danger, A. Pallier, M. Giral et al., "Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant, " Journal of the American Society of Nephrology, vol. 23, no. 4, pp. 597-606, 2012.
33. J. M. Lorenzen, I. Volkmann, J. Fiedler et al., "Urinary miR-210 as amediator of acuteT-cell mediated rejection in renal allograft recipients, " American Journal of Transplantation, vol. 11, no. 10, pp. 2221-2227, 2011.
34. M. J. Vitalone, T. K. Sigdel, N. Salomonis, R. D. Sarwal, S.-C. Hsieh, and M. M. Sarwal, "Transcriptional perturbations in graft rejection, " Transplantation, vol. 99, no. 9, pp. 1882-1893, 2015.
35. J.-P. D. Van Huyen, M. Tible, A. Gay et al., "MicroRNAs as noninvasive biomarkers of heart transplant rejection, " European Heart Journal, vol. 35, no. 45, pp. 3194-3202, 2014.
36. I. Sukma Dewi, K. Torngren, O. Gidlöf, B. Kornhall, and J. Ohman, "Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance, " Journal ofHeart and Lung Transplantation, vol. 32, no. 4, pp. 463-466, 2013.
37. L. De Luca, S. Trino, I. Laurenzana et al., "MiRNAs and piRNAs frombone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: A new insight in transplantation, " Oncotarget, vol. 7, no. 6, pp. 6676-6692, 2015.
38. J. Scheller, A. Chalaris, D. Schmidt-Arras, and S. Rose-John, "The pro-And anti-inflammatory properties of the cytokine interleukin-6, " Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1813, no. 5, pp. 878-888, 2011.
39. X. Meng, D. J. Nikolic-Paterson, and H. Y. Lan, "TGF-: The master regulator of fibrosis, " Nature Reviews Nephrology, vol. 12, no. 6, pp. 325-338, 2016.
40. S. Piera-Velazquez, Z. Li, and S. A. Jimenez, "Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders, " American Journal of Pathology, vol. 179, no. 3, pp. 1074-1080, 2011.
41. M. T. Pinto, D. T. Covas, S. Kashima, and C. O. Rodrigues, "Endothelial mesenchymal transition: comparative analysis of different induction methods, " Biological Procedures Online, vol. 18, article 10, 2016.
42. J. Wilflingseder, R. Reindl-Schwaighofer, J. Sunzenauer et al., "MicroRNAs in kidney transplantation, " Nephrology Dialysis Transplantation, vol. 30, no. 6, pp. 910-917, 2015.
43. A. Mehta andD. Baltimore, "MicroRNAs as regulatory elements in immune system logic, " Nature Reviews Immunology, vol. 16, no. 5, pp. 279-294, 2016.
44. S. K. Gupta, R. Itagaki, X. Zheng et al., "miR-21 promotes fibrosis in an acute cardiac allograft transplantation model, " Cardiovascular Research, vol. 110, no. 2, pp. 215-226, 2016.
45. W. Ouyang, W. Liao, C. T. Luo et al., "Novel Foxo1-dependent transcriptional programs control Treg cell function, " Nature, vol. 491, no. 7425, pp. 554-559, 2012.
46. L. Wei, M. Wang, X. Qu et al., "Differential expression of microRNAs during allograft rejection, " American Journal of Transplantation, vol. 12, no. 5, pp. 1113-1123, 2012.
47. S. Banerjee, N. Xie, H. Cui et al., "MicroRNA let-7c regulates macrophage polarization, " Journal of Immunology, vol. 190, no. 12, pp. 6542-6549, 2013.
48. W. Zhang, H. Liu, W. Liu, Y. Liu, and J. Xu, "Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-B pathway, " Cell Death and Differentiation, vol. 22, no. 2, pp. 287-297, 2015.
49. A. Coppola, A. Romito, C. Borel et al., "Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications, " Stem Cell Research, vol. 12, no. 2, pp. 323-337, 2014.
50. D. A. Chistiakov, A. N. Orekhov, and Y. V. Bobryshev, "Cardiacspecific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction), " Journal of Molecular and Cellular Cardiology, vol. 94, pp. 107-121, 2016.
51. L. Barile, T. Moccetti, E. Marbán, and G. Vassalli, "Roles of exosomes in cardioprotection, " European Heart Journal, Article ID ehw304, 2016.
52. X. Liu, Z. Zhan, L. Xu et al., "MicroRNA-148/152 impair innate response and antigen presentation of TLR-Triggered dendritic cells by targeting CaMKII, " Journal of Immunology, vol. 185, no. 12, pp. 7244-7251, 2010.
53. M. Morita, J. Chen, M. Fujino et al., "Identification of microRNAs involved in acute rejection and spontaneous tolerance in murine hepatic allografts, " Scientific Reports, vol. 4, article no. 6649, pp. 1-11, 2014.
54. H.-X. Fan and H. Tang, "Complex interactions between micro-RNAs and hepatitis B/C viruses, " World Journal of Gastroenterology, vol. 20, no. 37, pp. 13477-13492, 2014.
55. Y. Chen, J. Chen, H. Wang et al., "HCV-induced miR-21 contributes to evasion of host immune systemby targetingMyD88 and IRAK1, " PLoS Pathogens, vol. 9, no. 4, Article IDe1003248, 2013.
56. C. H. Lee, J. H. Kim, and S.-W. Lee, "The role of microRNAs in hepatitis C virus replication and related liver diseases, " Journal of Microbiology, vol. 52, no. 6, pp. 445-451, 2014.
57. S. Shrivastava, R. Steele, R. Ray, and R. B. Ray, "MicroRNAs: role in hepatitis C virus pathogenesis, " Genes & Diseases, vol. 2, no. 1, pp. 35-45, 2015.
58. S. Bala, J. Petrasek, S. Mundkur et al., "Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases, " Hepatology, vol. 56, no. 5, pp. 1946-1957, 2012.
59. Z. Guo, M. Maki, R. Ding, Y. Yang, B. Zhang, and L. Xiong, "Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues, " Scientific Reports, vol. 4, article 5150, 2014.
60. J. Agudo, A. Ruzo, N. Tung et al., "The miR-126-VEGFR2 axis controls the innate response to pathogen-Associated nucleic acids, " Nature Immunology, vol. 15, no. 1, pp. 54-62, 2014.
61. H. M. Sheppard, D. Verdon, A. E. Brooks et al., "MicroRNA regulation in human CD8+ T cell subsets-cytokine exposure alone drives miR-146a expression, " Journal of Translational Medicine, vol. 12, article no. 292, 2014.
62. L.-F. Lu, M. P. Boldin, A. Chaudhry et al., "Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses, " Cell, vol. 142, no. 6, pp. 914-929, 2010.
63. Y. Fang, C. Shi, E. Manduchi, M. Civelek, and P. F. Davies, "MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro, " Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 30, pp. 13450-13455, 2010.
64. L. A. Smyth, D. A. Boardman, S. L. Tung, R. Lechler, and G. Lombardi, "MicroRNAs affect dendritic cell function and phenotype, " Immunology, vol. 144, no. 2, pp. 197-205, 2015.
65. M. Ceppi, P. M. Pereira, I. Dunand-Sauthier et al., "MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells, " Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 8, pp. 2735-2740, 2009.
66. Z. Feng, Y. Xia, M. Zhang, and J. Zheng, "MicroRNA-155 regulates T cell proliferation through targeting GSK3 in cardiac allograft rejection in a murine transplantation model, " Cellular Immunology, vol. 281, no. 2, pp. 141-149, 2013.
67. M. W. Feinberg and K. J. Moore, "MicroRNA regulation of atherosclerosis, " Circulation Research, vol. 118, no. 4, pp. 703-720, 2016.
68. M. Zhou, H. Hara, Y. Dai et al., "Circulating organ-specific MicroRNAs serve as biomarkers in organ-specific diseases: implications for organ Allo-And Xeno-Transplantation, " International Journal ofMolecular Sciences, vol. 17, no. 8, p. 1232, 2016.
69. J. Song, J. Huang, X. Chen et al., "Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart, " Scientific Reports, vol. 7, article no. 20077, 2016.
70. V. Cantaluppi, S. Gatti, D. Medica et al., "Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells, " Kidney International, vol. 82, no. 4, pp. 412-427, 2012.
71. M. Monguío-Tortajada, R. Lauzurica-Valdemoros, and F. E. Borras, "Tolerance in organ transplantation: from conventional immunosuppression to extracellular vesicles, " Frontiers in Immunology, vol. 5, article 416, 2014.
72. A. F. Christopher, R. P. Kaur, G. Kaur, A. Kaur, V. Gupta, and P. Bansal, "MicroRNA therapeutics: discovering novel targets and developing specific therapy, " Perspectives in Clinical Research, vol. 7, no. 2, pp. 68-74, 2016.
73. A. Bader and P. Lammers, "The therapeutic potential of microRNAs, " Innovations in Pharmaceutical Technology, pp. 52-55, 2011.