GWAS of epigenetic aging rates in blood reveals a critical role for TERT

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Lu, Ake T ^a   Xue, Luting ^b   Salfati, Elias L ^c   Chen, Brian H ^d,e   Ferrucci, Luigi ^d   Levy, Daniel ^e   Joehanes, Roby ^e   Murabito, Joanne M ^f   Kiel, Douglas P ^g   Tsai, Pei Chien ^h   Yet, Idil ^h   Bell, Jordana T ^h   Mangino, Massimo ^h   Tanaka, Toshiko ^d   McRae, Allan F ⁱ   Marioni, Riccardo E ^i,j   Visscher, Peter M ⁱ   Wray, Naomi R ⁱ   Deary, Ian J ^j   Levine, Morgan E ^a   Quach, Austin ^a   Assimes, Themistocles ^c   Tsao, Philip S ^c,k   Absher, Devin ^l   Stewart, James D ^m   Li, Yun ^m,n   Reiner, Alex P ^o   Hou, Lifang ^p   Baccarelli, Andrea A ^q   Whitsel, Eric A ^m,n   Aviv, Abraham ^r   Cardona, Alexia ^s   Day, Felix R ^s   Wareham, Nicholas J ^s   Perry, John R B ^s   Ong, Ken K ^s   Raj, Kenneth ^t   Lunetta, Kathryn L ^b   Horvath, Steve ^a,u   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

^h KING'S COLLEGE LONDON   (United Kingdom)

ⁱ UNIVERSITY OF QUEENSLAND   (Australia)

^j UNIVERSITY OF EDINBURGH   (United Kingdom)

^k VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^l HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

^m The University of North Carolina at Chapel Hill   (United States)

ⁿ UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^o Fred Hutchinson Cancer Research Center   (United States)

^p NORTHWESTERN UNIVERSITY   (United States)

^q Mailman School of Public Health   (United States)

^r University of Medicine and Dentistry of New Jersey Medical School   (United States)

^s UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^t PUBLIC HEALTH ENGLAND   (United Kingdom)

^u UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; LIPOPROTEIN; MESSENGER RNA; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE; TERT PROTEIN, HUMAN;

AGE; BIOCHRONOLOGY; BIOMARKER; CELL; CHROMOSOME; GENE; GENE EXPRESSION; GENETICS; GENOME; METHYLATION; MODELING; MOLECULAR ANALYSIS; PROTEIN;

AGING; ARTICLE; BLOOD; CELL DIVISION; DNA METHYLATION; EPIGENETICS; FIBROBLAST; GENE; GENE EXPRESSION; GENE MAPPING; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; LEUKOCYTE; MENARCHE; MENOPAUSE; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; TELOMERE LENGTH; TELOMERE SHORTENING; TERT GENE; TRANSCRIPTOMICS; ADOLESCENT; ADULT; AGED; CELL CULTURE; CHILD; CPG ISLAND; FEMALE; GENETIC EPIGENESIS; GENETICS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; METABOLISM; MIDDLE AGED; TELOMERE; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; CELLS, CULTURED; CHILD; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FIBROBLASTS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LEUKOCYTES; MALE; MENARCHE; MENDELIAN RANDOMIZATION ANALYSIS; MENOPAUSE; MIDDLE AGED; TELOMERASE; TELOMERE; YOUNG ADULT;

EID: 85041131712     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-02697-5     Document Type: Article

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