Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Nature Genetics

Volumn 49, Issue 6, 2017, Pages 834-841

  Day, Felix R ^a   Thompson, Deborah J ^b   Helgason, Hannes ^c,d   Chasman, Daniel I ^e,f   Finucane, Hilary ^g,h   Sulem, Patrick ^c   Ruth, Katherine S ⁱ   Whalen, Sean ^j   Sarkar, Abhishek K ^k,l   Albrecht, Eva ^m   Altmaier, Elisabeth ^m   Amini, Marzyeh ⁿ   Barbieri, Caterina M ^o   Boutin, Thibaud ^p   Campbell, Archie ^q   Demerath, Ellen ^r   Giri, Ayush ^s,t   He, Chunyan ^u,v   Hottenga, Jouke J ^w   Karlsson, Robert ^x   Kolcic, Ivana ^y   Loh, Po Ru ^g,l   Lunetta, Kathryn L ^z,aa   Mangino, Massimo ^ab,ac   Marco, Brumat ^ad   McMahon, George ^ae   Medland, Sarah E ^af   Nolte, Ilja M ⁿ   Noordam, Raymond ^ag   Nutile, Teresa ^ah   Paternoster, Lavinia ^ae   Perjakova, Natalia ^ai   Porcu, Eleonora ^aj   Rose, Lynda M ^e   Schraut, Katharina E ^ak,al   Segrè, Ayellet V ^l   Smith, Albert V ^d,am   Stolk, Lisette ^an   Teumer, Alexander ^ao   Andrulis, Irene L ^ap,aq   Bandinelli, Stefania ^ar   Beckmann, Matthias W ^as   Benitez, Javier ^at,au   Bergmann, Sven ^av,aw   Bochud, Murielle ^ax   Boerwinkle, Eric ^ay   Bojesen, Stig E ^az,ba   Bolla, Manjeet K ^b   Brand, Judith S ^x   Brauch, Hiltrud ^bb,bc,bd   Brenner, Hermann ^bd   Broer, Linda ^an   Brüning, Thomas ^be   Buring, Julie E ^e,f   Campbell, Harry ^al   Catamo, Eulalia ^bf   Chanock, Stephen ^bg   Chenevix Trench, Georgia ^af   Corre, Tanguy ^av,aw,ax   Couch, Fergus J ^bh   Cousminer, Diana L ^bi,bj   Cox, Angela ^bk   Crisponi, Laura ^aj   Czene, Kamila ^x   Davey Smith, George ^ae   De Geus, Eco J C N ^w   De Mutsert, Renée ^ag   De Vivo, Immaculata ^f,g   Dennis, Joe ^b   Devilee, Peter ^ag   Dos Santos Silva, Isabel ^bl   Dunning, Alison M ^b   Eriksson, Johan G ^bm   Fasching, Peter A ^as,bn   Fernández Rhodes, Lindsay ^bo   Ferrucci, Luigi ^bp   Flesch Janys, Dieter ^bq   Franke, Lude ⁿ   Gabrielson, Marike ^x   Gandin, Ilaria ^ad   Giles, Graham G ^br,bs   Grallert, Harald ^m,bt   Gudbjartsson, Daniel F ^c,d   Guénel, Pascal ^bu   Hall, Per ^x   Hallberg, Emily ^bh   Hamann, Ute ^bd   Harris, Tamara B ^bp   Hartman, Catharina A ⁿ   Heiss, Gerardo ^bo   Hooning, Maartje J ^an   Hopper, John L ^bs   Hu, Frank ^f,g   Hunter, David J ^f,g   Ikram, M Arfan ^an   Im, Hae Kyung ^bv   Järvelin, Marjo Riitta ^bw,bx,by,bz   Joshi, Peter K ^al   Karasik, David ^f,ca   Kellis, Manolis ^k,l   Kutalik, Zoltan ^av,ax   Lachance, Genevieve ^ab   Lambrechts, Diether ^cb,cc   Langenberg, Claudia ^a   Launer, Lenore J ^bp   Laven, Joop S E ^an   Lenarduzzi, Stefania ^bf   Li, Jingmei ^x   Lind, Penelope A ^af   Lindstrom, Sara ^cd   Liu, Yongmei ^ce   Luan, Jian'An ^a   Mägi, Reedik ^ai   Mannermaa, Arto ^cf,cg   Mbarek, Hamdi ^w   McCarthy, Mark I ^ch,ci,cj   Meisinger, Christa ^m,ck   Meitinger, Thomas ^m   Menni, Cristina ^ab   Metspalu, Andres ^ai   Michailidou, Kyriaki ^b,cl   Milani, Lili ^ai   Milne, Roger L ^br,bs   Montgomery, Grant W ^cm   Mulligan, Anna M ^aq,cn   Nalls, Mike A ^bp   Navarro, Pau ^p   Nevanlinna, Heli ^co   Nyholt, Dale R ^cp   Oldehinkel, Albertine J ⁿ   O'Mara, Tracy A ^af   Padmanabhan, Sandosh ^cq   Palotie, Aarno ^l,bm,cr,cs   Pedersen, Nancy ^x   Peters, Annette ^m,bt   Peto, Julian ^bl   Pharoah, Paul D P ^b   Pouta, Anneli ^by   Radice, Paolo ^ct   Rahman, Iffat ^x   Ring, Susan M ^ae   Robino, Antonietta ^bf   Rosendaal, Frits R ^ag   Rudan, Igor ^al   Rueedi, Rico ^av,aw   Ruggiero, Daniela ^ah   Sala, Cinzia F ^o   Schmidt, Marjanka K ^cu   Scott, Robert A ^a   Shah, Mitul ^b   Sorice, Rossella ^ah   Southey, Melissa C ^cv   Sovio, Ulla ^b,bw   Stampfer, Meir ^f,g   Steri, Maristella ^aj   Strauch, Konstantin ^m,cw   Tanaka, Toshiko ^bp   Tikkanen, Emmi ^bm   Timpson, Nicholas J ^ae   Traglia, Michela ^o   Truong, Thérèse ^bu   Tyrer, Jonathan P ^b   Uitterlinden, André G ^an   Edwards, Digna R Velez ^t,cx   Vitart, Veronique ^p   Völker, Uwe ^ao   Vollenweider, Peter ^cy   Wang, Qin ^b   Widen, Elisabeth ^bm   Van Dijk, Ko Willems ^ag   Willemsen, Gonneke ^w   Winqvist, Robert ^bx,cz   Wolffenbuttel, Bruce H R ⁿ   Zhao, Jing Hua ^a   Zoledziewska, Magdalena ^aj   Zygmunt, Marek ^ao   Alizadeh, Behrooz Z ⁿ   Boomsma, Dorret I ^w   Ciullo, Marina ^ah   Cucca, Francesco ^aj,da   Esko, Tõnu ^l,ai   Franceschini, Nora ^bo   Gieger, Christian ^m,bt   Gudnason, Vilmundur ^d,am   Hayward, Caroline ^p   Kraft, Peter ^g   Lawlor, Debbie A ^ae   Magnusson, Patrik K E ^x   Martin, Nicholas G ^af   Mook Kanamori, Dennis O ^ag   Nohr, Ellen A ^db   Polasek, Ozren ^y   Porteous, David ^q   Price, Alkes L ^g,h,l   Ridker, Paul M ^e,f   Snieder, Harold ⁿ   Spector, Tim D ^ab   Stöckl, Doris ^m,dc   Toniolo, Daniela ^o   Ulivi, Sheila ^bf   Visser, Jenny A ^an   Völzke, Henry ^ao   Wareham, Nicholas J ^a   Wilson, James F ^p,al   Spurdle, Amanda B ^af   Thorsteindottir, Unnur ^c,d   Pollard, Katherine S ^j,dd   Easton, Douglas F ^b   Tung, Joyce Y ^de   Chang Claude, Jenny ^bd,bq   Hinds, David ^de   Murray, Anna ⁱ   Murabito, Joanne M ^aa,df   Stefansson, Kari ^c,d   Ong, Ken K ^a,b   Perry, John R B ^a   more..

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c DECODE GENETICS   (Iceland)

^d UNIVERSITY OF ICELAND   (Iceland)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^h MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

ⁱ UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^j GLADSTONE INSTITUTES   (United States)

^k MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^l BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^m INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁿ UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^o VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^p UNIVERSITY OF EDINBURGH   (United Kingdom)

^q UNIVERSITY OF EDINBURGH   (United Kingdom)

^r UNIVERSITY OF MINNESOTA   (United States)

^s VANDERBILT UNIVERSITY   (United States)

^t VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^u INDIANA UNIVERSITY   (United States)

^v INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^w VU UNIVERSITY AMSTERDAM   (Netherlands)

^x KAROLINSKA INSTITUTE   (Sweden)

^y UNIVERSITY OF SPLIT   (Croatia)

^z BOSTON UNIVERSITY   (United States)

^aa FRAMINGHAM HEART STUDY   (United States)

^ab KING'S COLLEGE LONDON   (United Kingdom)

^ac GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^ad UNIVERSITY OF TRIESTE   (Italy)

^ae UNIVERSITY OF BRISTOL   (United Kingdom)

^af QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^ag LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^ah INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^ai UNIVERSITY OF TARTU   (Estonia)

^aj Milan Unit   (Italy)

^ak UNIVERSITY OF EDINBURGH   (United Kingdom)

^al UNIVERSITY OF EDINBURGH   (United Kingdom)

^am ICELANDIC HEART ASSOCIATION   (Iceland)

^an ERASMUS MEDICAL CENTER   (Netherlands)

^ao UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^ap MOUNT SINAI HOSPITAL   (Canada)

^aq UNIVERSITY OF TORONTO   (Canada)

^ar SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^as UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^at Centro Nacional de Investigaciones Oncológicas   (Spain)

^au CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^av SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^aw UNIVERSITY OF LAUSANNE   (Switzerland)

^ax UNIVERSITY OF LAUSANNE   (Switzerland)

^ay UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^az GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^ba UNIVERSITY OF COPENHAGEN   (Denmark)

^bb DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^bc UNIVERSITY OF TÜBINGEN   (Germany)

^bd GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^be RUHR UNIVERSITY BOCHUM   (Germany)

^bf INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^bg NATIONAL CANCER INSTITUTE   (United States)

^bh MAYO CLINIC   (United States)

^bi CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^bj UNIVERSITY OF PENNSYLVANIA   (United States)

^bk UNIVERSITY OF SHEFFIELD   (United Kingdom)

^bl LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^bm UNIVERSITY OF HELSINKI   (Finland)

^bn UNIVERSITY OF CALIFORNIA   (United States)

^bo IL   (United States)

^bp NATIONAL INSTITUTE ON AGING   (United States)

^bq UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^br CANCER EPIDEMIOLOGY CENTRE   (Australia)

^bs UNIVERSITY OF MELBOURNE   (Australia)

^bt GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^bu CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^bv UNIVERSITY OF CHICAGO   (United States)

^bw IMPERIAL COLLEGE LONDON   (United Kingdom)

^bx UNIVERSITY OF OULU   (Finland)

^by NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^bz OULU UNIVERSITY HOSPITAL   (Finland)

^ca Hebrew SeniorLife Institute for Aging Research   (United States)

^cb UNIVERSITY OF LEUVEN   (Belgium)

^cc DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^cd UNIVERSITY OF WASHINGTON   (United States)

^ce WAKE FOREST SCHOOL OF MEDICINE   (United States)

^cf UNIVERSITY OF EASTERN FINLAND   (Finland)

^cg KUOPIO UNIVERSITY HOSPITAL   (Finland)

^ch CHURCHILL HOSPITAL   (United Kingdom)

^ci UNIVERSITY OF OXFORD   (United Kingdom)

^cj UNIVERSITY OF OXFORD   (United Kingdom)

^ck KLINIKUM AUGSBURG   (Germany)

^cl CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS   (Cyprus)

^cm UNIVERSITY OF QUEENSLAND   (Australia)

^cn UNIVERSITY HEALTH NETWORK   (Canada)

^co HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^cp QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^cq UNIVERSITY OF GLASGOW   (United Kingdom)

^cr MASSACHUSETTS GENERAL HOSPITAL   (United States)

^cs WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^ct NATIONAL CANCER INSTITUTE   (Italy)

^cu ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^cv UNIVERSITY OF MELBOURNE   (Australia)

^cw UNIVERSITY OF MUNICH   (Germany)

^cx VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cy LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^cz Northern Finland Laboratory Centre NordLab Oulu   (Finland)

^da UNIVERSITY OF SASSARI   (Italy)

^db UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^dc LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^dd UNIVERSITY OF CALIFORNIA   (United States)

^de Ludwig Maximilians University ^*  (United States)

^df BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AROMATASE; BRAIN DERIVED NEUROTROPHIC FACTOR; DLK1 PROTEIN; FUCOSYLTRANSFERASE; GONADORELIN; HYDROXYSTEROID 17 BETA DEHYDROGENASE; INHBA PROTEIN; JMJD1C PROTEIN; KDM4B PROTEIN; KISSPEPTIN; LIN28B PROTEIN; MKRN3 PROTEIN; NUCLEAR RECEPTOR COACTIVATOR 6; PHF2 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PITUITARY HOMEOBOX 1; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E SYNTHASE 2; PROTEIN; PTGES2 PROTEIN; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR BETA; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR BETA; RETINOID X RECEPTOR GAMMA; SEX HORMONE; TACR3 PROTEIN; THRB PROTEIN; UNCLASSIFIED DRUG; DLK1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MKRN3 PROTEIN, HUMAN; RIBONUCLEOPROTEIN; SIGNAL PEPTIDE;

AGE AT MENARCHE; ARTICLE; BODY MASS; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC REGULATION; GENETIC RISK; GENETIC VARIATION; GENOME ANALYSIS; HERITABILITY; HUMAN; MALE; MENARCHE; MENDELIAN RANDOMIZATION ANALYSIS; META ANALYSIS (TOPIC); NERVOUS TISSUE; ONSET AGE; PATERNAL INHERITANCE; POPULATION; PRIORITY JOURNAL; PROSTATE CANCER; PUBERTY; RISK ASSESSMENT; RISK FACTOR; ADOLESCENT; AGE; GENETIC DATABASE; GENETIC PREDISPOSITION; GENETICS; GENOME IMPRINTING; GENOME-WIDE ASSOCIATION STUDY; NEOPLASM; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; AGE FACTORS; BODY MASS INDEX; DATABASES, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOMIC IMPRINTING; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MENARCHE; NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; PUBERTY; QUANTITATIVE TRAIT LOCI; RIBONUCLEOPROTEINS; RISK FACTORS;

EID: 85018441896     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3841     Document Type: Article

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