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Volumn 8, Issue 1, 2018, Pages

Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE RECEPTOR; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4;

EID: 85040767033     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-19062-7     Document Type: Article
Times cited : (9)

References (59)
  • 1
    • 84871630781 scopus 로고    scopus 로고
    • Intestinal Microbes inInflammatory Bowel Diseases
    • Sartor, R. B. &Mazmanian, S. K. Intestinal Microbes inInflammatory Bowel Diseases. Am J Gastroenterol Suppl 1, 15-21 (2012).
    • (2012) Am J Gastroenterol Suppl , vol.1 , pp. 15-21
    • Sartor, R.B.1    Mazmanian, S.K.2
  • 3
    • 79957749035 scopus 로고    scopus 로고
    • The intestinal epithelial barrier in the control of homeostasis and immunity
    • Rescigno, M. The intestinal epithelial barrier in the control of homeostasis and immunity. Trends in immunology 32, 256-264, https://doi.org/10.1016/j.it.2011.04.003 (2011).
    • (2011) Trends in Immunology , vol.32 , pp. 256-264
    • Rescigno, M.1
  • 5
    • 84866167497 scopus 로고    scopus 로고
    • Reciprocal interactions of the intestinal microbiota and immune system
    • Maynard, C. L., Elson, C. O., Hatton, R. D. &Weaver, C. T. Reciprocal interactions of the intestinal microbiota and immune system. Nature 489, 231-241, https://doi.org/10.1038/nature11551 (2012).
    • (2012) Nature , vol.489 , pp. 231-241
    • Maynard, C.L.1    Elson, C.O.2    Hatton, R.D.3    Weaver, C.T.4
  • 6
    • 84896851032 scopus 로고    scopus 로고
    • Intestinal epithelial cells: Regulators of barrier function and immune homeostasis
    • Peterson, L. W. &Artis, D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nature reviews. Immunology 14, 141-153, https://doi.org/10.1038/nri3608 (2014).
    • (2014) Nature Reviews. Immunology , vol.14 , pp. 141-153
    • Peterson, L.W.1    Artis, D.2
  • 8
    • 84873716991 scopus 로고    scopus 로고
    • Regulation of intestinal epithelial permeability by tight junctions
    • Suzuki, T. Regulation of intestinal epithelial permeability by tight junctions. Cellular and molecular life sciences: CMLS 70, 631-659, https://doi.org/10.1007/s00018-012-1070-x (2013).
    • (2013) Cellular and Molecular Life Sciences: CMLS , vol.70 , pp. 631-659
    • Suzuki, T.1
  • 9
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. &Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241, https://doi.org/10.1016/j.cell.2004.07.002 (2004).
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 10
    • 84876348441 scopus 로고    scopus 로고
    • The role of pattern recognition receptors in intestinal inflammation
    • Fukata, M. &Arditi, M. The role of pattern recognition receptors in intestinal inflammation. Mucosal immunology 6, 451-463, https://doi.org/10.1038/mi.2013.13 (2013).
    • (2013) Mucosal Immunology , vol.6 , pp. 451-463
    • Fukata, M.1    Arditi, M.2
  • 11
    • 77249150015 scopus 로고    scopus 로고
    • The role of tlrs, nlrs, and rlrs in mucosal innate immunity and homeostasis
    • Lavelle, E. C., Murphy, C., O'Neill, L. A. &Creagh, E. M. The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal immunology 3, 17-28, https://doi.org/10.1038/mi.2009.124 (2010).
    • (2010) Mucosal Immunology , vol.3 , pp. 17-28
    • Lavelle, E.C.1    Murphy, C.2    O'Neill, L.A.3    Creagh, E.M.4
  • 12
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • Maloy, K. J. &Powrie, F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474, 298-306, https://doi. org/10.1038/nature10208 (2011).
    • (2011) Nature , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 13
    • 84863872794 scopus 로고    scopus 로고
    • Host-microbiota interactions in inflammatory bowel disease
    • Elson, C. O. &Cong, Y. Host-microbiota interactions in inflammatory bowel disease. Gut microbes 3, 332-344, https://doi. org/10.4161/gmic.20228 (2012).
    • (2012) Gut Microbes , vol.3 , pp. 332-344
    • Elson, C.O.1    Cong, Y.2
  • 14
    • 84885658881 scopus 로고    scopus 로고
    • Recent advances in inflammatory bowel disease: Mucosal immune cells in intestinal inflammation
    • Cader, M. Z. &Kaser, A. Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut 62, 1653-1664, https://doi.org/10.1136/gutjnl-2012-303955 (2013).
    • (2013) Gut , vol.62 , pp. 1653-1664
    • Cader, M.Z.1    Kaser, A.2
  • 15
    • 84879962392 scopus 로고    scopus 로고
    • Inflammatory bowel disease epidemiology
    • Burisch, J. &Munkholm, P. Inflammatory bowel disease epidemiology. Current opinion in gastroenterology 29, 357-362, https://doi. org/10.1097/MOG.0b013e32836229fb (2013).
    • (2013) Current Opinion in Gastroenterology , vol.29 , pp. 357-362
    • Burisch, J.1    Munkholm, P.2
  • 16
    • 0036886298 scopus 로고    scopus 로고
    • The current future understanding of inflammatory bowel disease Best practice &research
    • Podolsky, D. K. The current future understanding of inflammatory bowel disease. Best practice &research. Clinical gastroenterology 16, 933-943 (2002).
    • (2002) Clinical Gastroenterology , vol.16 , pp. 933-943
    • Podolsky, D.K.1
  • 17
    • 0023687039 scopus 로고
    • The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage
    • Haziot, A. et al. The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. Journal of immunology 141, 547-552 (1988).
    • (1988) Journal of Immunology , vol.141 , pp. 547-552
    • Haziot, A.1
  • 18
    • 72549110487 scopus 로고    scopus 로고
    • Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice
    • de Buhr, M. F. et al. Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice. Inflammatory bowel diseases 15, 1824-1836, https://doi.org/10.1002/ibd.21030 (2009).
    • (2009) Inflammatory Bowel Diseases , vol.15 , pp. 1824-1836
    • De Buhr, M.F.1
  • 19
    • 0037018107 scopus 로고    scopus 로고
    • Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells
    • Hornef, M. W., Frisan, T., Vandewalle, A., Normark, S. &Richter-Dahlfors, A. Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. The Journal of experimental medicine 195, 559-570 (2002).
    • (2002) The Journal of Experimental Medicine , vol.195 , pp. 559-570
    • Hornef, M.W.1    Frisan, T.2    Vandewalle, A.3    Normark, S.4    Richter-Dahlfors, A.5
  • 20
    • 0035001419 scopus 로고    scopus 로고
    • CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: Lipopolysaccharide activation of epithelial cells revisited
    • Funda, D. P. et al. CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited. Infection and immunity 69, 3772-3781, https://doi.org/10.1128/IAI.69.6.3772-3781.2001 (2001).
    • (2001) Infection and Immunity , vol.69 , pp. 3772-3781
    • Funda, D.P.1
  • 21
    • 33646792189 scopus 로고    scopus 로고
    • Cd14, Gbp1, and Pla2g2a: Three major candidate genes for experimental IBD identified by combining QTL and microarray analyses
    • de Buhr, M. F. et al. Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses. Physiological genomics 25, 426-434, https://doi.org/10.1152/physiolgenomics.00022.2005 (2006).
    • (2006) Physiological Genomics , vol.25 , pp. 426-434
    • De Buhr, M.F.1
  • 22
    • 85017436669 scopus 로고    scopus 로고
    • CD14 plays a protective role in experimental inflammatory bowel disease by enhancing intestinal barrier function
    • Buchheister, S. et al. CD14 Plays a Protective Role in Experimental Inflammatory Bowel Disease by Enhancing Intestinal Barrier Function. The American journal of pathology 187, 1106-1120, https://doi.org/10.1016/j.ajpath.2017.01.012 (2017).
    • (2017) The American Journal of Pathology , vol.187 , pp. 1106-1120
    • Buchheister, S.1
  • 23
    • 18244370045 scopus 로고    scopus 로고
    • A polymorphism in the CD14 gene is associated with Crohn disease
    • Klein, W. et al. A polymorphism in the CD14 gene is associated with Crohn disease. Scandinavian journal of gastroenterology 37, 189-191 (2002).
    • (2002) Scandinavian Journal of Gastroenterology , vol.37 , pp. 189-191
    • Klein, W.1
  • 24
    • 40449140459 scopus 로고    scopus 로고
    • The c.1-260C T promoter variant of CD14 but not the c.896A G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease
    • Baumgart, D. C. et al. The c.1-260C T promoter variant of CD14 but not the c.896A G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease. Digestion 76, 196-202, https://doi.org/10.1159/000112646 (2007).
    • (2007) Digestion , vol.76 , pp. 196-202
    • Baumgart, D.C.1
  • 25
    • 84970021301 scopus 로고    scopus 로고
    • Transcription factor sp2 enhanced the expression of cd14 in colitis-susceptible c3h/hejbir
    • Zschemisch, N. H., Brusch, I., Hambusch, A. S. &Bleich, A. Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir. PloS one 11, e0155821, https://doi.org/10.1371/journal.pone.0155821 (2016).
    • (2016) PloS One , vol.11 , pp. e0155821
    • Zschemisch, N.H.1    Brusch, I.2    Hambusch, A.S.3    Bleich, A.4
  • 27
    • 0037972478 scopus 로고    scopus 로고
    • Recombinant soluble CD14 reduces severity of intramammary infection by Escherichia coli
    • Lee, J. W., Paape, M. J., Elsasser, T. H. &Zhao, X. Recombinant soluble CD14 reduces severity of intramammary infection by Escherichia coli. Infection and immunity 71, 4034-4039 (2003).
    • (2003) Infection and Immunity , vol.71 , pp. 4034-4039
    • Lee, J.W.1    Paape, M.J.2    Elsasser, T.H.3    Zhao, X.4
  • 28
    • 84983070515 scopus 로고    scopus 로고
    • Soluble cd14 enhances the response of periodontal ligament stem cells to p gingivalis lipopolysaccharide
    • Andrukhov, O. et al. Soluble CD14 Enhances the Response of Periodontal Ligament Stem Cells to P. gingivalis Lipopolysaccharide. PloS one 11, e0160848, https://doi.org/10.1371/journal.pone.0160848 (2016).
    • (2016) PloS One , vol.11 , pp. e0160848
    • Andrukhov, O.1
  • 29
    • 0002763605 scopus 로고
    • Die antagonistische Behandlung chronischer Darmstörungen mit Colibakterien
    • Nissle, A. Die antagonistische Behandlung chronischer Darmstörungen mit Colibakterien. Medizinische Klinik 2, 29-33 (1918).
    • (1918) Medizinische Klinik , vol.2 , pp. 29-33
    • Nissle, A.1
  • 30
    • 2442715243 scopus 로고    scopus 로고
    • Effects of feeding a probiotic preparation (SIM) containing inulin on the severity of colitis and on the composition of the intestinal microflora in HLA-B27 transgenic rats
    • Schultz, M. et al. Effects of feeding a probiotic preparation (SIM) containing inulin on the severity of colitis and on the composition of the intestinal microflora in HLA-B27 transgenic rats. Clinical and diagnostic laboratory immunology 11, 581-587, https://doi. org/10.1128/CDLI.11.3.581-587.2004 (2004).
    • (2004) Clinical and Diagnostic Laboratory Immunology , vol.11 , pp. 581-587
    • Schultz, M.1
  • 31
    • 33745599630 scopus 로고    scopus 로고
    • Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2-and toll-like receptor 4-dependent pathways
    • Grabig, A. et al. Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2-and toll-like receptor 4-dependent pathways. Infection and immunity 74, 4075-4082, https://doi.org/10.1128/IAI.01449-05 (2006).
    • (2006) Infection and Immunity , vol.74 , pp. 4075-4082
    • Grabig, A.1
  • 32
    • 4644239296 scopus 로고    scopus 로고
    • Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
    • Kruis, W. et al. Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53, 1617-1623, https://doi.org/10.1136/gut.2003.037747 (2004).
    • (2004) Gut , vol.53 , pp. 1617-1623
    • Kruis, W.1
  • 33
    • 38049107790 scopus 로고    scopus 로고
    • Sensitivity to Escherichia coli nissle 1917 in mice is dependent on environment and genetic background
    • Bleich, A. et al. Sensitivity to Escherichia coli Nissle 1917 in mice is dependent on environment and genetic background. International journal of experimental pathology 89, 45-54, https://doi.org/10.1111/j.1365-2613.2007.00560.x (2008).
    • (2008) International Journal of Experimental Pathology , vol.89 , pp. 45-54
    • Bleich, A.1
  • 35
    • 80155211998 scopus 로고    scopus 로고
    • Polymeric immunoglobulin receptor
    • Asano, M. &Komiyama, K. Polymeric immunoglobulin receptor. Journal of oral science 53, 147-156 (2011).
    • (2011) Journal of Oral Science , vol.53 , pp. 147-156
    • Asano, M.1    Komiyama, K.2
  • 36
    • 0035895279 scopus 로고    scopus 로고
    • Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation
    • Filipp, D. et al. Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation. Proceedings of the National Academy of Sciences of the United States of America 98, 603-608, https://doi.org/10.1073/pnas.98.2.603 (2001).
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , pp. 603-608
    • Filipp, D.1
  • 37
    • 0034653532 scopus 로고    scopus 로고
    • Blockade of CD14 increases Shigella-mediated invasion and tissue destruction
    • Wenneras, C. et al. Blockade of CD14 increases Shigella-mediated invasion and tissue destruction. Journal of immunology 164, 3214-3221 (2000).
    • (2000) Journal of Immunology , vol.164 , pp. 3214-3221
    • Wenneras, C.1
  • 38
    • 44949153787 scopus 로고    scopus 로고
    • Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
    • Ukena, S. N. et al. Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PloS one 2, e1308, https:// doi.org/10.1371/journal.pone.0001308 (2007).
    • (2007) PloS One , vol.2 , pp. e1308
    • Ukena, S.N.1
  • 39
    • 33846894974 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair
    • Zyrek, A. A. et al. Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair. Cellular microbiology 9, 804-816, https://doi. org/10.1111/j.1462-5822.2006.00836.x (2007).
    • (2007) Cellular Microbiology , vol.9 , pp. 804-816
    • Zyrek, A.A.1
  • 40
    • 85008881120 scopus 로고    scopus 로고
    • Outer membrane vesicles and soluble factors released by probiotic Escherichia coli nissle 1917 and commensal ecor63 enhance barrier function by regulating expression of tight junction proteins in intestinal epithelial cells
    • Alvarez, C. S., Badia, J., Bosch, M., Gimenez, R. &Baldoma, L. Outer Membrane Vesicles and Soluble Factors Released by Probiotic Escherichia coli Nissle 1917 and Commensal ECOR63 Enhance Barrier Function by Regulating Expression of Tight Junction Proteins in Intestinal Epithelial Cells. Frontiers in microbiology 7, 1981, https://doi.org/10.3389/fmicb.2016.01981 (2016).
    • (2016) Frontiers in Microbiology , vol.7 , pp. 1981
    • Alvarez, C.S.1    Badia, J.2    Bosch, M.3    Gimenez, R.4    Baldoma, L.5
  • 41
    • 34247235029 scopus 로고    scopus 로고
    • Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    • Cario, E., Gerken, G. &Podolsky, D. K. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 132, 1359-1374, https://doi.org/10.1053/j.gastro.2007.02.056 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1359-1374
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 42
    • 54349106465 scopus 로고    scopus 로고
    • Barrier-protective function of intestinal epithelial Toll-like receptor
    • Cario, E. Barrier-protective function of intestinal epithelial Toll-like receptor Mucosal immunology 1(Suppl 1), S62-66, https://doi. org/10.1038/mi.2008.47 (2008).
    • (2008) Mucosal Immunology , vol.1 , pp. S62-66
    • Cario, E.1
  • 43
    • 38049174332 scopus 로고    scopus 로고
    • Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis
    • Gibson, D. L. et al. Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis. Cellular microbiology 10, 388-403, https://doi.org/10.1111/j.1462-5822.2007.01052.x (2008).
    • (2008) Cellular Microbiology , vol.10 , pp. 388-403
    • Gibson, D.L.1
  • 44
    • 84875979474 scopus 로고    scopus 로고
    • Human lipopolysaccharide-binding protein (LBP) and cd14 independently deliver triacylated lipoproteins to toll-like receptor 1 (tlr1) and tlr2 and enhance formation of the ternary signaling complex
    • Ranoa, D. R., Kelley, S. L. &Tapping, R. I. Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to Toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex. The Journal of biological chemistry 288, 9729-9741, https://doi.org/10.1074/jbc.M113.453266 (2013).
    • (2013) The Journal of Biological Chemistry , vol.288 , pp. 9729-9741
    • Ranoa, D.R.1    Kelley, S.L.2    Tapping, R.I.3
  • 45
    • 26844536104 scopus 로고    scopus 로고
    • Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury
    • Zhang, X. et al. Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. Journal of immunology 175, 4834-4838 (2005).
    • (2005) Journal of Immunology , vol.175 , pp. 4834-4838
    • Zhang, X.1
  • 47
    • 0028258577 scopus 로고
    • Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
    • Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H. &Ley, T. J. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76, 977-987 (1994).
    • (1994) Cell , vol.76 , pp. 977-987
    • Heusel, J.W.1    Wesselschmidt, R.L.2    Shresta, S.3    Russell, J.H.4    Ley, T.J.5
  • 48
    • 77953957401 scopus 로고    scopus 로고
    • Safety of probiotic Escherichia coli strain Nissle 1917 depends on intestinal microbiota and adaptive immunity of the host
    • Gronbach, K. et al. Safety of probiotic Escherichia coli strain Nissle 1917 depends on intestinal microbiota and adaptive immunity of the host. Infection and immunity 78, 3036-3046, https://doi.org/10.1128/IAI.00218-10 (2010).
    • (2010) Infection and Immunity , vol.78 , pp. 3036-3046
    • Gronbach, K.1
  • 49
    • 80054963764 scopus 로고    scopus 로고
    • Regulation of the polymeric immunoglobulin receptor and IgA transport: New advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity
    • Johansen, F. E. &Kaetzel, C. S. Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity. Mucosal immunology 4, 598-602, https:// doi.org/10.1038/mi.2011.37 (2011).
    • (2011) Mucosal Immunology , vol.4 , pp. 598-602
    • Johansen, F.E.1    Kaetzel, C.S.2
  • 50
    • 77952158547 scopus 로고    scopus 로고
    • Regulation of the polymeric immunoglobulin receptor in intestinal epithelial cells by Enterobacteriaceae: Implications for mucosal homeostasis
    • Bruno, M. E. et al. Regulation of the polymeric immunoglobulin receptor in intestinal epithelial cells by Enterobacteriaceae: implications for mucosal homeostasis. Immunological investigations 39, 356-382, https://doi.org/10.3109/08820131003622809 (2010).
    • (2010) Immunological Investigations , vol.39 , pp. 356-382
    • Bruno, M.E.1
  • 51
    • 21244462251 scopus 로고    scopus 로고
    • Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: Linking innate and adaptive immune responses
    • Schneeman, T. A. et al. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. Journal of immunology 175, 376-384 (2005).
    • (2005) Journal of Immunology , vol.175 , pp. 376-384
    • Schneeman, T.A.1
  • 52
    • 83655210632 scopus 로고    scopus 로고
    • Homeostatic impact of indigenous microbiota and secretory immunity
    • Brandtzaeg, P. Homeostatic impact of indigenous microbiota and secretory immunity. Beneficial microbes 1, 211-227, https://doi. org/10.3920/BM2010.0009 (2010).
    • (2010) Beneficial Microbes , vol.1 , pp. 211-227
    • Brandtzaeg, P.1
  • 53
    • 4344680649 scopus 로고    scopus 로고
    • Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens
    • Hopken, U. E., Achtman, A. H., Kruger, K. &Lipp, M. Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens. Journal of leukocyte biology 76, 709-718, https://doi.org/10.1189/jlb.1203643 (2004).
    • (2004) Journal of Leukocyte Biology , vol.76 , pp. 709-718
    • Hopken, U.E.1    Achtman, A.H.2    Kruger, K.3    Lipp, M.4
  • 54
    • 84858796247 scopus 로고    scopus 로고
    • Integration of B cell responses through Toll-like receptors and antigen receptors
    • Rawlings, D. J., Schwartz, M. A., Jackson, S. W. &Meyer-Bahlburg, A. Integration of B cell responses through Toll-like receptors and antigen receptors. Nature reviews. Immunology 12, 282-294, https://doi.org/10.1038/nri3190 (2012).
    • (2012) Nature Reviews. Immunology , vol.12 , pp. 282-294
    • Rawlings, D.J.1    Schwartz, M.A.2    Jackson, S.W.3    Meyer-Bahlburg, A.4
  • 55
    • 84881634130 scopus 로고    scopus 로고
    • How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth
    • Baumgarth, N. How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth. Immunological reviews 255, 82-94, https://doi.org/10.1111/imr.12094 (2013).
    • (2013) Immunological Reviews , vol.255 , pp. 82-94
    • Baumgarth, N.1
  • 56
    • 0034679710 scopus 로고    scopus 로고
    • B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection
    • Baumgarth, N. et al. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. The Journal of experimental medicine 192, 271-280 (2000).
    • (2000) The Journal of Experimental Medicine , vol.192 , pp. 271-280
    • Baumgarth, N.1
  • 57
    • 0032445137 scopus 로고    scopus 로고
    • A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection
    • Boes, M., Prodeus, A. P., Schmidt, T., Carroll, M. C. &Chen, J. A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection. The Journal of experimental medicine 188, 2381-2386 (1998).
    • (1998) The Journal of Experimental Medicine , vol.188 , pp. 2381-2386
    • Boes, M.1    Prodeus, A.P.2    Schmidt, T.3    Carroll, M.C.4    Chen, J.5
  • 58
    • 0034695878 scopus 로고    scopus 로고
    • B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites
    • Paciorkowski, N., Porte, P., Shultz, L. D. &Rajan, T. V. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. The Journal of experimental medicine 191, 731-736 (2000).
    • (2000) The Journal of Experimental Medicine , vol.191 , pp. 731-736
    • Paciorkowski, N.1    Porte, P.2    Shultz, L.D.3    Rajan, T.V.4
  • 59
    • 84897144989 scopus 로고    scopus 로고
    • Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice
    • Basic, M. et al. Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice. Inflammatory bowel diseases 20, 431-443, https://doi.org/10.1097/01.MIB.0000441346.86827.ed (2014).
    • (2014) Inflammatory Bowel Diseases , vol.20 , pp. 431-443
    • Basic, M.1


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