The microbiology and treatment of human mastitis

Medical Microbiology and Immunology

Volumn 207, Issue 2, 2018, Pages 83-94

  Angelopoulou, Angeliki ^a,b   Field, Des ^a,b   Ryan, C Anthony ^a,c   Stanton, Catherine ^a,d   Hill, Colin ^a,b   Ross, R Paul ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c Irish Centre for Fetal and Neonatal Translational Research   (Ireland)

^d TEAGASC FOOD RESEARCH CENTRE   (Ireland)

Author keywords

Antibiotics; Bacteriocins; Human mastitis; Microbiota; Probiotics

Indexed keywords

ANTIBIOTIC AGENT; BACTERIOCIN; PROBIOTIC AGENT; ANTIINFECTIVE AGENT;

ACUTE MASTITIS; ANTIBIOTIC RESISTANCE; CELL CULTURE TECHNIQUE; CORYNEBACTERIUM; DYSBIOSIS; GENE SEQUENCE; GRANULOMATOUS MASTITIS; HUMAN; INCIDENCE; MASTITIS; METAGENOMICS; MICROBIAL DIVERSITY; MICROBIOLOGY; MICROBIOME; MILK PRODUCTION; NONHUMAN; NUTRITIONAL STATUS; ORGANOLEPTIC PROPERTY; PRIORITY JOURNAL; REVIEW; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; SUBACUTE MASTITIS; ACTINOMYCETALES; ACTINOMYCETALES INFECTION; BIOLOGICAL THERAPY; FEMALE; ISOLATION AND PURIFICATION; PROCEDURES; STAPHYLOCOCCUS INFECTION;

ACTINOMYCETALES; ACTINOMYCETALES INFECTIONS; ANTI-BACTERIAL AGENTS; BIOLOGICAL THERAPY; DRUG RESISTANCE, BACTERIAL; FEMALE; HUMANS; MASTITIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 85040689037     PISSN: 03008584     EISSN: 14321831     Source Type: Journal    
DOI: 10.1007/s00430-017-0532-z     Document Type: Review

References (98)

1. Martin CR, Ling PR, Blackburn GL (2016) Review of infant feeding: key features of breast milk and infant formula. Nutrients 8(5):279. https://doi.org/10.3390/nu8050279
2. Victora CG, Bahl R, Barros AJD, França GVA, Horton S, Krasevec J et al (2016) Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet 387(10017):475–490. https://doi.org/10.1016/S0140-6736(15)01024-7
3. WHO (2000) Mastitis: causes and management. World Health Organization, Geneva, pp 1–45
4. Abou-Dakn M, Richardt A, Schaefer-Graf U, Wockel A (2010) Inflammatory breast diseases during lactation: milk stasis, puerperal mastitis, abscesses of the breast and malignant tumors–current and evidence-based strategies for diagnosis and therapy. Breast Care 5(1):33–37. https://doi.org/10.1159/000272223
5. Amir LH, Cullinane M, Garland SM, Tabrizi SN, Donath SM, Bennett CM et al (2011) The role of micro-organisms (Staphylococcus aureus and Candida albicans) in the pathogenesis of breast pain and infection in lactating women: study protocol. BMC Pregnancy Childbirth 11:54. https://doi.org/10.1186/1471-2393-11-54
6. Li R, Fein SB, Chen J, Grummer-Strawn LM (2008) Why mothers stop breastfeeding: mothers’ self-reported reasons for stopping during the first year. Pediatrics 122(Suppl 2):S69–S76. https://doi.org/10.1542/peds.2008-1315i
7. Osterman KL, Rahm VA (2000) Lactation mastitis: bacterial cultivation of breast milk, symptoms, treatment, and outcome. J Hum Lact 16(4):297–302. https://doi.org/10.1177/089033440001600405
8. Betzold CM (2007) An update on the recognition and management of lactational breast inflammation. J Midwifery Womens Health 52(6):595–605. https://doi.org/10.1016/j.jmwh.2007.08.002
9. Cullinane M, Amir LH, Donath SM, Garland SM, Tabrizi SN, Payne MS et al (2015) Determinants of mastitis in women in the CASTLE study: a cohort study. BMC Fam Pract 16(1):181. https://doi.org/10.1186/s12875-015-0396-5
10. Fernández L, Arroyo R, Espinosa I, Marín M, Jiménez E, Rodríguez JM (2014) Probiotics for human lactational mastitis. Benef Microb 5(2):169–183. https://doi.org/10.3920/bm2013.0036
11. Jiménez E, Fernández L, Maldonado A, Martín R, Olivares M, Xaus J et al (2008) Oral administration of Lactobacillus strains isolated from breast milk as an alternative for the treatment of infectious mastitis during lactation. Appl Environ Microbiol 74(15):4650–4655. https://doi.org/10.1128/aem.02599-07
12. Civardi E, Garofoli F, Tzialla C, Paolillo P, Bollani L, Stronati M (2013) Microorganisms in human milk: lights and shadows. J Matern Fetal Neonatal Med 26(Suppl 2):30–34. https://doi.org/10.3109/14767058.2013.829693
13. Foxman B, D’Arcy H, Gillespie B, Bobo JK, Schwartz K (2002) Lactation mastitis: occurrence and medical management among 946 breastfeeding women in the United States. Am J Epidemiol 155(2):103–114. https://doi.org/10.1093/aje/155.2.103
14. Kinlay JR, O’Connell DL, Kinlay S (2001) Risk factors for mastitis in breastfeeding women: results of a prospective cohort study. Aust N Z J Public Health 25(2):115–120. https://doi.org/10.1111/j.1753-6405.2001.tb01831.x
15. Scott JA, Robertson M, Fitzpatrick J, Knight C, Mulholland S (2008) Occurrence of lactational mastitis and medical management: a prospective cohort study in Glasgow. Int Breastfeed J 3(1):21. https://doi.org/10.1186/1746-4358-3-21
16. Mediano P, Fernández L, Rodríguez JM, Marín M (2014) Case-control study of risk factors for infectious mastitis in Spanish breastfeeding women. BMC Pregnancy Childbirth 14:195. https://doi.org/10.1186/1471-2393-14-195
17. Jonsson S, Pulkkinen MO (1994) Mastitis today: incidence, prevention and treatment. Ann Chir Gynaecol Suppl 208:84–87
18. Amir LH, Forster DA, Lumley J, McLachlan H (2007) A descriptive study of mastitis in Australian breastfeeding women: incidence and determinants. BMC Public Health 7(1):62. https://doi.org/10.1186/1471-2458-7-62
19. Spencer JP (2008) Management of mastitis in breastfeeding women. Am Fam Phys 78(6):727–731
20. Patel SH, Vaidya YH, Patel RJ, Pandit RJ, Joshi CG, Kunjadiya AP (2017) Culture independent assessment of human milk microboal community in lactational mastitis. Sci Rep 7:7804. https://doi.org/10.1038/s41598-017-08451-728
21. West PA, Hewitt JH, Murphy OM (1979) The influence of methods of collection and storage on the bacteriology of human milk. J Appl Microbiol 46(2):269–277. https://doi.org/10.1111/j.1365-2672.1979.tb00820.x
22. Heikkila MP, Saris PE (2003) Inhibition of Staphylococcus aureus by the commensal bacteria of human milk. J Appl Microbiol 95(3):471–478. https://doi.org/10.1046/j.1365-2672.2003.02002.x
23. Perez PF, Doré J, Leclerc M, Levenez F, Benyacoub J, Serrant P et al (2007) Bacterial imprinting of the neonatal immune system: lessons from maternal cells? Pediatrics 119(3):e724. https://doi.org/10.1542/peds.2006-1649
24. Collado MC, Delgado S, Maldonado A, Rodríguez JM (2009) Assessment of the bacterial diversity of breast milk of healthy women by quantitative real-time PCR. Lett Appl Microbiol 48(5):523–528. https://doi.org/10.1111/j.1472-765X.2009.02567.x
25. Hunt KM, Foster JA, Forney LJ, Schütte UME, Beck DL, Abdo Z et al (2011) Characterization of the diversity and temporal stability of bacterial communities in human milk. PLOS One 6(6):e21313. https://doi.org/10.1371/journal.pone.0021313
26. Jiménez E, de Andrés J, Manrique M, Pareja-Tobes P, Tobes R, Martínez-Blanch JF et al (2015) Metagenomic analysis of milk of healthy and mastitis-suffering women. J Jum Lact 31(3):406–415. https://doi.org/10.1177/0890334415585078
27. Mediano P, Fernández L, Jiménez E, Arroyo R, Espinosa-Martos I, Rodríguez JM et al (2017) Microbial diversity in milk of women with mastitis: potential role of coagulase-negative staphylococci, viridans group streptococci, and corynebacteria. J Jum Lact 33(2):309–318. https://doi.org/10.1177/0890334417692968
28. Murphy K, Curley D, O’Callaghan TF, O’Shea C-A, Dempsey EM, O’Toole PW et al (2017) The Composition of human milk and infant faecal microbiota over the first three months of life: a pilot study. Sci Rep 7:40597. https://doi.org/10.1038/srep40597
29. Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, Bonasio R et al (2001) Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2(4):361–367. https://doi.org/10.1038/86373
30. Macpherson AJ, Uhr T (2004) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303(5664):1662–1665. https://doi.org/10.1126/science.1091334
31. Kort R, Caspers M, van de Graaf A, van Egmond W, Keijser B, Roeselers G (2014) Shaping the oral microbiota through intimate kissing. Microbiome 2(1):41. https://doi.org/10.1186/2049-2618-2-41
32. Ross AA, Doxey AC, Neufeld JD (2017) The skin microbiome of cohabiting couples. mSystems 2 (4)
33. Wyatt RG, Mata LJ (1969) Bacteria in colostrum and milk of Guatemalan Indian women. J Trop Pediatr 15(4):159–162
34. Eidelman AI, Szilagyi G (1979) Patterns of bacterial colonization of human milk. Obstet Gynecol 53:550–552
35. Serafini ÁB, André MCDPB., Rodrigues MAV, Kipnis A, Carvalho CO, Campos MRH et al (2003) Qualidade microbiológica de leite humano obtido em banco de leite. Rev Saúde Pública 37:775–779
36. Martín R, Jiménez E, Heilig H, Fernández L, Marín ML, Zoetendal EG et al (2009) Isolation of bifidobacteria from breast milk and assessment of the bifidobacterial population by PCR-denaturing gradient gel electrophoresis and quantitative real-time PCR. Appl Environ Microbiol 75:965–969. https://doi.org/10.1128/AEM.02063-08
37. Martín V, Maldonado-Barragán A, Moles L, Rodriguez-Banõs M, del Campo R, Fernández L et al (2012) Sharing of bacterial strains between breast milk and infant feces. J Hum Lact 28:36–44. https://doi.org/10.1177/0890334411424729
38. Jost T, Lacroix C, Braegger CP, Rochat F, Chassard C (2014) Vertical mother-neonate transfer of maternal gut bacteria via breastfeeding. Environ Microbiol 16(9):2891–2904. https://doi.org/10.1111/1462-2920.12238
39. Rodríguez JM, Fernández L (2017) Infectious mastitis during lactation: a mammary dysbiosis model in McGuire M. In: McGuire M, Bode L (eds) Prebiotics and probiotics in human milk, 2nd edn. Academic Press, San Diego, pp 401–428
40. Salter SJ, Cox MJ, Turek EM, Calus ST, Cookson WO, Moffatt MF et al (2014) Reagent and laboratory contamination can critically impact sequence-based microbiome analyses. BMC Biol 12:87. https://doi.org/10.1186/s12915-014-0087-z
41. Glassing A, Dowd SE, Galandiuk S, Davis B, Chiodini RJ (2016) Inherent bacterial DNA contamination of extraction and sequencing reagents may affect interpretation of microbiota in low bacterial biomass samples. Gut Pathog 8:24. https://doi.org/10.1186/s13099-016-0103-7
42. Patel SH, Vaidya YH, Joshi CG, Kunjadia AP (2016) Culture-dependent assessment of bacterial diversity from human milk with lactational mastitis. Comp Clin Path 25:437–443. https://doi.org/10.1007/s00580-015-2205-x
43. Marín M, Arroyo R, Espinosa-Martos I, Fernández L, Rodríguez JM (2017) Identification of emerging human mastitis pathogens by MALDI-TOF and assessment of their antibiotic resistance patterns. Front Microbiol 8:1258. https://doi.org/10.3389/fmicb.2017.01258
44. Delgado S, Arroyo R, Martín R, Rodríguez JM (2008) PCR-DGGE assessment of the bacterial diversity of breast milk in women with lactational infectious mastitis. BMC Infect Dis 8:51. https://doi.org/10.1186/1471-2334-8-51
45. Delgado S, Arroyo R, Jiménez E, Marín ML, del Campo R, Fernández L et al (2009) Staphylococcus epidermidis strains isolated from breast milk of women suffering infectious mastitis: potential virulence traits and resistance to antibiotics. BMC Microbiol 9::82. https://doi.org/10.1186/1471-2180-9-82
46. Alexandraki V, Kazou M, Angelopoulou A, Arena MP, Capozzi V, Russo P et al (2016) The microbiota of non-cow milk and products. In: Tsakalidou E, Papadimitriou K (eds) Non-bovine Milk and Milk Products, 1st edn. Academic Press, San Diego, pp 117–159
47. Martín R, Langa S, Reviriego C, Jimínez E, Marín ML, Xaus J et al (2003). Human milk is a source of lactic acid bacteria for the infant gut. J Pediatr 143(6):754–758. https://doi.org/10.1016/j.jpeds.2003.09.028
48. Albesharat R, Ehrmann MA, Korakli M, Yazaji S, Vogel RF (2011) Phenotypic and genotypic analyses of lactic acid bacteria in local fermented food, breast milk and faeces of mothers and their babies. Syst Appl Microbiol 34:148–155. https://doi.org/10.1016/j.syapm.2010.12.001
49. Martín R, Heilig HGHJ., Zoetendal EG, Jiménez E, Fernández L, Smidt H et al (2007) Cultivation-independent assessment of the bacterial diversity of breast milk among healthy women. Res Microbiol 158:31–37. https://doi.org/10.1016/j.resmic.2006.11.004
50. Riffon R, Sayasith K, Khalil H, Dubreuil P, Drolet M, Lagace J (2001) Development of a rapid and sensitive test for identification of major pathogens in bovine mastitis by PCR. J Clin Microbiol 39:2584–2589. https://doi.org/10.1128/jcm.39.7.2584-2589.2001
51. Gavin A, Ostovar K (1977) Microbiological characterization of human milk. J Food Prot 40:614–616. https://doi.org/10.4315/0362-028X-40.9.614
52. Martín R, Jiménez E, Olivares M, Marin ML, Fernández L, Xaus J et al (2006) Lactobacillus salivarius CECT 5713, a potential probiotic strain isolated from infant feces and breast milk of a mother–child pair. Int J Food Microbiol 112:35–43. https://doi.org/10.1016/j.ijfoodmicro.2006.06.011
53. Gonzalez R, Mandomando I, Fumado V, Sacoor C, Macete E, Alonso PL et al (2013) Breast milk and gut microbiota in African mothers and infants from an area of high HIV prevalence. PloS One 8:e80299. https://doi.org/10.1371/journal.pone.0080299
54. Thompson N, Pickler RH, Munro C, Shotwell J (1997). Contamination in expressed breast milk following breast cleansing. J Hum Lact 13:127–130. https://doi.org/10.1177/089033449701300213
55. Cabrera-Rubio R, Mira-Pascual L, Mira À, Collado MC (2016) Impact of mode of delivery on the milk microbiota composition of healthy women. J Dev Orig Health Dis 7:54–60. https://doi.org/10.1017/S2040174415001397
56. Delgado S, Garcia P, Fernández L, Jiménez E, Rodriguez-Banõs M, del Campo R et al (2011) Characterization of Staphylococcus aureus strains involved in human and bovine mastitis. FEMS Immunol Med Microbiol 62:225–235. https://doi.org/10.1111/j.1574-695X.2011.00806.x
57. Delgado S, Collado C, Fernández L, Rodríguez JM (2009) Bacterial analysis of breast milk: a tool to differentiate Raynaud’s phenomenon from infectious mastitis during lactation. Curr Microbiol 59:59–64. https://doi.org/10.1007/s00284-009-9393-z
58. Martín R, Langa S, Reviriego C, Jiménez E, Marín ML, Olivares M et al (2004) The commensal microflora of human milk: new perspectives for food bacteriotherapy and probiotics. Trends Food Sci Technol 15 (3):121–127. https://doi.org/10.1016/j.tifs.2003.09.010
59. Jost T, Lacroix C, Braegger C, Chassard C (2013) Assessment of bacterial diversity in breast milk using culture-dependent and culture-independent approaches. Br J Nutr 110(7):1253–1262. https://doi.org/10.1017/s0007114513000597
60. Ward TL, Hosid S, Ioshikhes I, Altosaar I (2013) Human milk metagenome: a functional capacity analysis. BMC Microbiol 13:116. https://doi.org/10.1186/1471-2180-13-116
61. Gueimonde M, Laitinen K, Salminen S, Isolauri E (2007) Breast milk: a source of bifidobacteria for infant gut development and maturation? Neonatology 92:64–66. https://doi.org/10.1159/000100088
62. Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC et al (2009) Topographical and temporal diversity of the human skin microbiome. Science 324(5931):1190–1192. https://doi.org/10.1126/science.1171700
63. Otto M (2014) Staphylococcus epidermidis pathogenesis. Methods Mol Biol 1106:17–31. https://doi.org/10.1007/978-1-62703-736-5_2
64. Sabel MS (2009) Infectious and inflammatory diseases of the breast in essentials of breast surgery. Mosby, Philadelphia, pp 83–90
65. Dobinson HC, Anderson TP, Chambers ST, Doogue MP, Seaward L, Werno AM (2015) Antimicrobial treatment options for granulomatous mastitis caused by Corynebacterium species. J Clin Microbiol 53:2895–2899. https://doi.org/10.1128/jcm.00760-15
66. Korkut E, Akcay MN, Karadeniz E, Subasi ID, Gursan N (2015) Granulomatous mastitis: a ten-year experience at a university hospital. Eurasian J Med 47(3):165–173. https://doi.org/10.5152/eurasianjmed.2015.118
67. Kiyak G, Dumlu EG, Kilinc I, Tokaç M, Akbaba S, Gurer A et al (2014) Management of idiopathic granulomatous mastitis: dilemmas in diagnosis and treatment. BMC Surg 14(1):66. https://doi.org/10.1186/1471-2482-14-66
68. Taylor GB, Paviour SD, Musaad S, Jones WO, Holland DJ (2003) A clinicopathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. Pathology 35:109–119
69. Say B, Dizdar EA, Degirmencioglu H, Uras N, Sari FN, Oguz S et al (2016) The effect of lactational mastitis on the macronutrient content of breast milk. Early Hum Dev 98:7–9. https://doi.org/10.1016/j.earlhumdev.2016.03.009
70. Prentice A, Prentice AM, Lamb WH (1985) Mastitis in rural Gambian mothers and the protection of the breast by milk antimicrobial factors. Trans R Soc Trop Med Hyg 79:90–95
71. Nommsen LA, Lovelady CA, Heinig MJ, Lonnerdal B, Dewey KG (1991) Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 months of lactation: the DARLING study. Am J Clin Nutr 53:457–465
72. Le Roux Y, Laurent F, Moussaoui F (2003) Polymorphonuclear proteolytic activity and milk composition change. Vet Res 34:629–645. https://doi.org/10.1051/vetres:2003021
73. Perez M, Ladero V, Redruello B, Del Rio B, Fernández L, Rodríguez JM et al (2016) Mastitis modifies the biogenic amines profile in human milk, with significant changes in the presence of histamine, putrescine and spermine. PLoS One 11:e0162426. https://doi.org/10.1371/journal.pone.0162426
74. Thomas T, Thomas TJ (2001) Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Molec Life Sci 58(2):244–258. https://doi.org/10.1007/pl00000852
75. Chanphai P, Thomas TJ, Tajmir-Riahi HA (2016) Conjugation of biogenic and synthetic polyamines with serum proteins: a comprehensive review. Int J Biol Macromo. 92:515–522. https://doi.org/10.1016/j.ijbiomac.2016.07.049
76. Jahanfar S, Ng CJ, Teng CL (2013) Antibiotics for mastitis in breastfeeding women. Cochrane Database Syst Rev 2:CD005458. https://doi.org/10.1002/14651858.CD005458.pub3
77. Arroyo R, Martín V, Maldonado A, Jiménez E, Fernández L, Rodríguez JM (2010) Treatment of infectious mastitis during lactation: antibiotics versus oral administration of lactobacilli isolated from breast milk. Clin Infect Dis 50:1551–1558. https://doi.org/10.1086/652763
78. Fernández L, Cardenas N, Arroyo R, Manzano S, Jiménez E, Martín V et al (2016) Prevention of infectious mastitis by oral administration of Lactobacillus salivarius PS2 during late pregnancy. Clin Infect Dis 62:568–573. https://doi.org/10.1093/cid/civ974
79. Espinosa-Martos I, Jiménez E, de Andrés J, Rodríguez-Alcalá LM, Tavárez S, Manzano S et al (2016) Milk and blood biomarkers associated to the clinical efficacy of a probiotic for the treatment of infectious mastitis. Benef Microbes 7(3):305–318. https://doi.org/10.3920/bm2015.0134
80. Fernández L, Delgado S, Herrero H, Maldonado A, Rodríguez JM (2008) The bacteriocin nisin, an effective agent for the treatment of staphylococcal mastitis during lactation. J Hum Lact 24:311–316. https://doi.org/10.1177/0890334408317435
81. Devereux WP (1969) Acute puerperal mastitis. Am J Obstet Gynecol 108:78–81. https://doi.org/10.1016/0002-9378(70)90208-5
82. Wall RJ, Powell AM, Paape MJ, Kerr DE, Bannerman DD, Pursel VG et al (2005) Genetically enhanced cows resist intramammary Staphylococcus aureus infection. Nat Biotechnol 23:445–451. https://doi.org/10.1038/nbt1078
83. Schoenfeld EM, McKay MP (2010) Mastitis and methicillin-resistant Staphylococcus aureus (MRSA): the calm before the storm? J Emerg Med 38:e31–34. https://doi.org/10.1016/j.jemermed.2008.11.021
84. Reddy P, Qi C, Zembower T, Noskin GA, Bolon M (2007) Postpartum mastitis and community-acquired methicillin-resistant Staphylococcus aureus. Emerg Infect Dis 13::298–301. https://doi.org/10.3201/eid1302.060989
85. Joffe TH, Simpson NA (2009) Cesarean section and risk of asthma. The role of intrapartum antibiotics: a missing piece? J Pediatr 154:154. https://doi.org/10.1016/j.jpeds.2008.08.039
86. Willing BP, Vacharaksa A, Croxen M, Thanachayanont T, Finlay BB (2011) Altering host resistance to infections through microbial transplantation. PLOS One 6:e26988. https://doi.org/10.1371/journal.pone.0026988
87. Mueller NT, Bakacs E, Combellick J, Grigoryan Z, Dominguez-Bello MG (2015) The infant microbiome development: mom matters. Trends Mol Med 21:109–117. https://doi.org/10.1016/j.molmed.2014.12.002
88. Arvola T, Ruuska T, Keränen J, Hyöty H, Salminen S, Isolauri E (2006) Rectal bleeding in infancy: clinical, allergological, and microbiological examination. Pediatrics 117:e760. https://doi.org/10.1542/peds.2005-1069
89. de Weerth C, Fuentes S, Puylaert P, de Vos WM (2013) Intestinal microbiota of infants with colic: development and specific signatures. Pediatrics 131:e550–e558. https://doi.org/10.1542/peds.2012-1449
90. Kummeling I, Stelma FF, Dagnelie PC, Snijders BEP, Penders J, Huber M et al (2007) Early life exposure to antibiotics and the subsequent development of eczema, wheeze and allergic sensitization in the first 2 years of life: the KOALA birth cohort study. Pediatrics 119:e225. https://doi.org/10.1542/peds.2006-0896
91. FAO/WHO (2001); Report of joint FAO/WHO expert consultation on the health and nutritional properties of powder milk with live lactic acid bacteria. http://www.fao.org/3/a-a0512e.pdf
92. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B et al (2014) Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11:506–514. https://doi.org/10.1038/nrgastro.2014.66
93. Pacheco AR, Barile D, Underwood MA, Mills DA (2015) The impact of the milk glycobiome on the neonate gut microbiota. Annu Rev Anim Biosci 3:419–445. https://doi.org/10.1146/annurev-animal-022114-111112
94. Fernández L, Langa S, Martín V, Maldonado A, Jiménez E, Martín R et al (2013) The human milk microbiota: origin and potential roles in health and disease. Pharmacol Res 69:1–10. https://doi.org/10.1016/j.phrs.2012.09.001
95. Cotter PD, Hill C, Ross RP (2005) Bacteriocins: developing innate immunity for food. Nat Rev Microbiol 3:777–788. https://doi.org/10.1038/nrmicro1273
96. Beasley SS, Saris PE (2004) Nisin-producing Lactococcus lactis strains isolated from human milk. Appl Environ Microbiol 70:5051–5053. https://doi.org/10.1128/aem.70.8.5051-5053.2004
97. Crispie F, Twomey D, Flynn J, Hill C, Ross P, Meaney W (2005) The lantibiotic lacticin 3147 produced in a milk-based medium improves the efficacy of a bismuth-based teat seal in cattle deliberately infected with Staphylococcus aureus. J Dairy Res 72:159–167. https://doi.org/10.1017/S0022029905000816
98. Klostermann K, Crispie F, Flynn J, Meaney WJ, Ross PR, Hill C (2010) Efficacy of a teat dip containing the bacteriocin lacticin 3147 to eliminate Gram-positive pathogens associated with bovine mastitis. J Dairy Res 77:231–238. https://doi.org/10.1017/s0022029909990239