Inhibitor of the human telomerase reverse trancriptase (hTERT) gene promoter induces cell apoptosis via a mitochondrial-dependent pathway

European Journal of Medicinal Chemistry

Volumn 145, Issue , 2018, Pages 370-378

  Li, Yuyin ^a   Pan, Guojun ^a   Chen, Yue ^a   Yang, Qian ^a   Hao, Tiantian ^a   Zhao, Lianbo ^a   Zhao, Long ^a   Cong, Yusheng ^b   Diao, Aipo ^a   Yu, Peng ^a  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HANGZHOU NORMAL UNIVERSITY   (China)

Author keywords

Apoptosis; hTERT; Inhibitor; Synthesis

Indexed keywords

1 (4 CHLOROBENZYL) 3 (HYDROXYIMINO) 4 (4 METHOXYPHENYL) INDOLIN 2 ONE; 1 (4 CHLOROBENZYL) 3 (HYDROXYIMINO) 4 (4- TRIFLUOROMETHYL)PHENYL)INDOLIN 2 ONE; 1 (4 CHLOROBENZYL) 3 (HYDROXYIMINO) 4 IODOINDOLIN 2 ONE; 4 BROMO 1 (4 CHLOROBENZYL) 3 (HYDROXYIMINO)INDOLIN 2 ONE; 4 BROMO 1 (4 CHLOROBENZYL) 3 (METHOXYIMINO)INDOLIN 2 ONE; 4 CHLORO 1 (4 CHLOROBENZYL) 3 (HYDROXYIMINO)INDOLIN 2 ONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; SHORT HAIRPIN RNA; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; RNA DIRECTED DNA POLYMERASE INHIBITOR; TELOMERASE; TERT PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CHROMATIN CONDENSATION; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EC50; ENZYME ACTIVATION; GENE EXPRESSION; GENE KNOCKDOWN; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MITOCHONDRION; MTT ASSAY; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SUZUKI REACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HELA CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; MITOCHONDRIA; MOLECULAR STRUCTURE; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE;

EID: 85040325681     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2017.12.077     Document Type: Article

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