Design, synthesis and docking study of novel tetracyclic oxindole derivatives as α-glucosidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 7, 2015, Pages 1471-1475

  Han, Kailin ^a   Li, Yashan ^a   Zhang, Yazhou ^a   Teng, Yuou ^a   Ma, Ying ^b   Wang, Meiyan ^b   Wang, Runling ^b   Xu, Weiren ^c   Yao, Qingwei ^d   Zhang, Yongmin ^a   Qin, Haijuan ^a   Sun, Hua ^a   Yu, Peng ^a  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

^d Sphinx Scientific Laboratory Corporation   (United States)

Author keywords

Docking study; Phenanthridine derivatives; SAR study; Tetracyclic isatins; Glucosidase inhibitors

Indexed keywords

ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; PALLADIUM; TETRACYCLIC OXINDOLE DERIVATIVE; UNCLASSIFIED DRUG; ALPHA GLUCOSIDASE; GLYCOSIDASE INHIBITOR; INDOLE ALKALOID;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; IC50; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICHAEL ADDITION; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; SUZUKI REACTION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALPHA-GLUCOSIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GLYCOSIDE HYDROLASE INHIBITORS; INDOLE ALKALOIDS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925521960     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.02.031     Document Type: Article

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