Synthesis, α-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 20, 2015, Pages 4567-4571

  Sun, Hua ^a   Li, Yashan ^a   Zhang, Xiaoting ^a   Lei, Yanan ^a   Ding, Weina ^a   Zhao, Xue ^a   Wang, Haomeng ^a   Song, Xiaotong ^a   Yao, Qingwei ^d   Zhang, Yongmin ^a,c   Ma, Ying ^b   Wang, Runling ^b   Zhu, Tao ^a   Yu, Peng ^a  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c SORBONNE UNIVERSITÉ   (France)

^d UMR CNRS 8232 ^*  (United States)

Author keywords

Docking study; Flavonoid; Geranyl; Prenyl; Glucosidase inhibitors

Indexed keywords

3',5' DIGERANYLATED CHALCONE; ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; CHALCONE DERIVATIVE; FLAVONE DERIVATIVE; ISOFLAVONE DERIVATIVE; UNCLASSIFIED DRUG; ALPHA GLUCOSIDASE; GLYCOSIDASE INHIBITOR;

ARTICLE; CHEMICAL MODIFICATION; COMPETITIVE INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GERANYLATION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR INTERACTION; PRENYLATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALPHA-GLUCOSIDASES; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONES; GLYCOSIDE HYDROLASE INHIBITORS; HUMANS; ISOFLAVONES; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84942819691     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.08.059     Document Type: Article

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