메뉴 건너뛰기




Volumn 25, Issue 13, 2017, Pages 1549-1566

Update on cardiovascular effects of older and newer anti-diabetic medications

Author keywords

Cardiovascular events; Dipeptidyl peptidase 4 inhibitors; Glucagon like peptide 1 receptor agonists; Insulin; Metformin; Pioglitazone; Sodium glucose co transporters 2 inhibitors; Sulfonylureas

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HEMOGLOBIN A1C; INSULIN; MEGLITINIDE; METFORMIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SULFONYLUREA DERIVATIVE; BENZHYDRYL DERIVATIVE; EMPAGLIFLOZIN; GLUCAGON LIKE PEPTIDE; GLUCOSIDE; LIRAGLUTIDE; PIOGLITAZONE; SEMAGLUTIDE; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 85039999004     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867324666170530075533     Document Type: Review
Times cited : (16)

References (90)
  • 5
    • 0037092995 scopus 로고    scopus 로고
    • Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management
    • Beckman J.A.; Creager M.A.; Libby P. Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management. JAMA, 2002, 287, 2570-2581.
    • (2002) JAMA , vol.287 , pp. 2570-2581
    • Beckman, J.A.1    Creager, M.A.2    Libby, P.3
  • 6
    • 0031817898 scopus 로고    scopus 로고
    • Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971-1993
    • Gu K.; Cowie C.C.; Harris M.I. Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971-1993. Diabetes Care, 1998, 21, 1138-1145.
    • (1998) Diabetes Care , vol.21 , pp. 1138-1145
    • Gu, K.1    Cowie, C.C.2    Harris, M.I.3
  • 7
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet, 1998, 352, 837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 10
  • 11
    • 77955492704 scopus 로고    scopus 로고
    • The case for hypoglycaemia as a proarrhythmic event: Basic and clinical evidence
    • Nordin C. The case for hypoglycaemia as a proarrhythmic event: Basic and clinical evidence. Diabetologia, 2010, 53, 1552-1561.
    • (2010) Diabetologia , vol.53 , pp. 1552-1561
    • Nordin, C.1
  • 12
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen S.E.; Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med., 2007, 356, 2457-2471.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 14
    • 79955690629 scopus 로고    scopus 로고
    • June 21, (Accessed July 21, 2016)
    • European Medicines Agency. Guideline on the Investigation of Drug Interactions; June 21, 2012. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/07/WC500129606.pdf(Accessed July 21, 2016).
    • (2012) Guideline on the Investigation of Drug Interactions
  • 15
    • 84960189946 scopus 로고    scopus 로고
    • Approaches to Glycemic Treatment
    • American Diabetes Association. Approaches to Glycemic Treatment. Diabetes Care, 2016, 39 Suppl 1, S52-59.
    • (2016) Diabetes Care , vol.39 , pp. S52-S59
  • 17
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet, 1998, 352, 854-865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 18
    • 78851470539 scopus 로고    scopus 로고
    • Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials
    • Lamanna C.; Monami M.; Marchionni N.; Mannucci E. Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials. Diabetes Obes. Metab., 2011, 13, 221-228.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 221-228
    • Lamanna, C.1    Monami, M.2    Marchionni, N.3    Mannucci, E.4
  • 20
    • 84968809053 scopus 로고    scopus 로고
    • Association between Insulin Monotherapy versus Insulin plus Metformin and the Risk of All-Cause Mortality and Other Serious Outcomes: A Retrospective Cohort Study
    • Holden S.E.; Jenkins-Jones S.; Currie C.J. Association between Insulin Monotherapy versus Insulin plus Metformin and the Risk of All-Cause Mortality and Other Serious Outcomes: A Retrospective Cohort Study. PLoS One, 2016, 11, e0153594.
    • (2016) Plos One , vol.11
    • Holden, S.E.1    Jenkins-Jones, S.2    Currie, C.J.3
  • 21
    • 13444272949 scopus 로고    scopus 로고
    • Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: An observational study
    • Masoudi F.A.; Inzucchi S.E.; Wang Y.; Havranek E.P.; Foody J.M.; Krumholz H.M. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: An observational study. Circulation, 2005, 111, 583-590.
    • (2005) Circulation , vol.111 , pp. 583-590
    • Masoudi, F.A.1    Inzucchi, S.E.2    Wang, Y.3    Havranek, E.P.4    Foody, J.M.5    Krumholz, H.M.6
  • 23
    • 79952260043 scopus 로고    scopus 로고
    • Metformin use and mortality in ambulatory patients with diabetes and heart failure
    • Aguilar D.; Chan W.; Bozkurt B.; Ramasubbu K.; Deswal A. Metformin use and mortality in ambulatory patients with diabetes and heart failure. Circ. Heart Fail., 2011, 4, 53-58.
    • (2011) Circ. Heart Fail. , vol.4 , pp. 53-58
    • Aguilar, D.1    Chan, W.2    Bozkurt, B.3    Ramasubbu, K.4    Deswal, A.5
  • 24
    • 5644291823 scopus 로고    scopus 로고
    • The UGDP controversy: Thirty-four years of contentious ambiguity laid to rest
    • Schwartz T.B.; Meinert C.L. The UGDP controversy: Thirty-four years of contentious ambiguity laid to rest. Perspect. Biol. Med., 2004, 47, 564-574.
    • (2004) Perspect. Biol. Med. , vol.47 , pp. 564-574
    • Schwartz, T.B.1    Meinert, C.L.2
  • 25
    • 0017040411 scopus 로고
    • A study of the effects of hypoglycemia agents on vascular complications in patients with adult-onset diabetes. VI. Supplementary report on nonfatal events in patients treated with tolbutamide
    • A study of the effects of hypoglycemia agents on vascular complications in patients with adult-onset diabetes. VI. Supplementary report on nonfatal events in patients treated with tolbutamide. Diabetes, 1976, 25, 1129-1153.
    • (1976) Diabetes , vol.25 , pp. 1129-1153
  • 26
    • 79958197888 scopus 로고    scopus 로고
    • Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: A nationwide study
    • Schramm T.K.; Gislason G.H.; Vaag A.; Rasmussen J.N.; Folke F.; Hansen M.L.; Fosbol E.L.; Kober L.; Norgaard M.L.; Madsen M.; Hansen P.R.; Torp-Pedersen C. Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: A nationwide study. Eur. Heart J., 2011, 32, 1900-1908.
    • (2011) Eur. Heart J. , vol.32 , pp. 1900-1908
    • Schramm, T.K.1    Gislason, G.H.2    Vaag, A.3    Rasmussen, J.N.4    Folke, F.5    Hansen, M.L.6    Fosbol, E.L.7    Kober, L.8    Norgaard, M.L.9    Madsen, M.10    Hansen, P.R.11    Torp-Pedersen, C.12
  • 29
    • 84888091849 scopus 로고    scopus 로고
    • The role of nateglinide and repaglinide, derivatives of meglitinide, in the treatment of type 2 diabetes mellitus
    • Guardado-Mendoza R.; Prioletta A.; Jimenez-Ceja L.M.; Sosale A.; Folli F. The role of nateglinide and repaglinide, derivatives of meglitinide, in the treatment of type 2 diabetes mellitus. Arch. Med. Sci., 2013, 9, 936-943.
    • (2013) Arch. Med. Sci. , vol.9 , pp. 936-943
    • Guardado-Mendoza, R.1    Prioletta, A.2    Jimenez-Ceja, L.M.3    Sosale, A.4    Folli, F.5
  • 31
    • 84945456985 scopus 로고    scopus 로고
    • Cardiovascular risks associated with secondline oral antidiabetic agents added to metformin in patients with Type 2 diabetes: A nationwide cohort study
    • Chang Y.C.; Chuang L.M.; Lin J.W.; Chen S.T.; Lai M.S.; Chang C.H. Cardiovascular risks associated with secondline oral antidiabetic agents added to metformin in patients with Type 2 diabetes: A nationwide cohort study. Diabet. Med., 2015, 32, 1460-1469.
    • (2015) Diabet. Med. , vol.32 , pp. 1460-1469
    • Chang, Y.C.1    Chuang, L.M.2    Lin, J.W.3    Chen, S.T.4    Lai, M.S.5    Chang, C.H.6
  • 32
    • 0036255529 scopus 로고    scopus 로고
    • The mode of action of thiazolidinediones
    • Hauner H. The mode of action of thiazolidinediones. Diabetes Metab. Res. Rev., 2002, 18 Suppl 2, S10-15.
    • (2002) Diabetes Metab. Res. Rev. , vol.18 , pp. S10-S15
    • Hauner, H.1
  • 33
    • 0344304678 scopus 로고    scopus 로고
    • Thiazolidinedione use, fluid retention, and congestive heart failure: A consensus statement from the American Heart Association and American Diabetes Association
    • October 7, 2003
    • Nesto R.W.; Bell D.; Bonow R.O.; Fonseca V.; Grundy S.M.; Horton E.S.; Le Winter M.; Porte D.; Semenkovich C.F.; Smith S.; Young L.H.; Kahn R. Thiazolidinedione use, fluid retention, and congestive heart failure: A consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003. Circulation, 2003, 108, 2941-2948.
    • (2003) Circulation , vol.108 , pp. 2941-2948
    • Nesto, R.W.1    Bell, D.2    Bonow, R.O.3    Fonseca, V.4    Grundy, S.M.5    Horton, E.S.6    Le Winter, M.7    Porte, D.8    Semenkovich, C.F.9    Smith, S.10    Young, L.H.11    Kahn, R.12
  • 35
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials
    • Lincoff A.M.; Wolski K.; Nicholls S.J.; Nissen S.E. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials. JAMA, 2007, 298, 1180-1188.
    • (2007) JAMA , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 37
    • 67149146438 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): A multicentre, randomised, open-label trial
    • Home P.D.; Pocock S.J.; Beck-Nielsen H.; Curtis P.S.; Gomis R.; Hanefeld M.; Jones N.P.; Komajda M.; McMurray J.J. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): A multicentre, randomised, open-label trial. Lancet, 2009, 373, 2125-2135.
    • (2009) Lancet , vol.373 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3    Curtis, P.S.4    Gomis, R.5    Hanefeld, M.6    Jones, N.P.7    Komajda, M.8    McMurray, J.J.9
  • 38
    • 77955285732 scopus 로고    scopus 로고
    • Rosiglitazone revisited: An updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
    • Nissen S.E.; Wolski K. Rosiglitazone revisited: An updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch. Intern. Med., 2010, 170, 1191-1201.
    • (2010) Arch. Intern. Med. , vol.170 , pp. 1191-1201
    • Nissen, S.E.1    Wolski, K.2
  • 39
    • 84872311972 scopus 로고    scopus 로고
    • Critical evaluation of the role of acarbose in the treatment of diabetes: Patient considerations
    • Rosak C.; Mertes G. Critical evaluation of the role of acarbose in the treatment of diabetes: Patient considerations. Diabetes Metab. Syndr. Obes., 2012, 5, 357-367.
    • (2012) Diabetes Metab. Syndr. Obes. , vol.5 , pp. 357-367
    • Rosak, C.1    Mertes, G.2
  • 40
    • 0038455703 scopus 로고    scopus 로고
    • Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: The STOP-NIDDM trial
    • Chiasson J.L.; Josse R.G.; Gomis R.; Hanefeld M.; Karasik A.; Laakso M. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: The STOP-NIDDM trial. JAMA, 2003, 290, 486-494.
    • (2003) JAMA , vol.290 , pp. 486-494
    • Chiasson, J.L.1    Josse, R.G.2    Gomis, R.3    Hanefeld, M.4    Karasik, A.5    Laakso, M.6
  • 41
    • 0346727578 scopus 로고    scopus 로고
    • Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: Meta-analysis of seven long-term studies
    • Hanefeld M.; Cagatay M.; Petrowitsch T.; Neuser D.; Petzinna D.; Rupp M. Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: Meta-analysis of seven long-term studies. Eur. Heart J., 2004, 25, 10-16.
    • (2004) Eur. Heart J. , vol.25 , pp. 10-16
    • Hanefeld, M.1    Cagatay, M.2    Petrowitsch, T.3    Neuser, D.4    Petzinna, D.5    Rupp, M.6
  • 42
    • 13444283628 scopus 로고    scopus 로고
    • Insulin treatment and cardiovascular disease; friend or foe? A point of view
    • Muis M.J.; Bots M.L.; Grobbee D.E.; Stolk R.P. Insulin treatment and cardiovascular disease; friend or foe? A point of view. Diabet. Med., 2005, 22, 118-126.
    • (2005) Diabet. Med. , vol.22 , pp. 118-126
    • Muis, M.J.1    Bots, M.L.2    Grobbee, D.E.3    Stolk, R.P.4
  • 43
    • 10544234410 scopus 로고
    • Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VII. Mortality and selected nonfatal events with insulin treatment
    • Knatterud G.L.; Klimt C.R.; Levin M.E.; Jacobson M.E.; Goldner M.G. Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VII. Mortality and selected nonfatal events with insulin treatment. JAMA, 1978, 240, 37-42.
    • (1978) JAMA , vol.240 , pp. 37-42
    • Knatterud, G.L.1    Klimt, C.R.2    Levin, M.E.3    Jacobson, M.E.4    Goldner, M.G.5
  • 44
    • 0030974812 scopus 로고    scopus 로고
    • Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus
    • DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group
    • Malmberg K. Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. BMJ, 1997, 314, 1512-1515.
    • (1997) BMJ , vol.314 , pp. 1512-1515
    • Malmberg, K.1
  • 46
    • 84873656406 scopus 로고    scopus 로고
    • Mortality and other important diabetes-related outcomes with insulin vs other antihyperglycemic therapies in type 2 diabetes
    • Currie C.J.; Poole C.D.; Evans M.; Peters J.R.; Morgan C.L. Mortality and other important diabetes-related outcomes with insulin vs other antihyperglycemic therapies in type 2 diabetes. J. Clin. Endocrinol. Metab., 2013, 98, 668-677.
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 668-677
    • Currie, C.J.1    Poole, C.D.2    Evans, M.3    Peters, J.R.4    Morgan, C.L.5
  • 47
    • 84902216056 scopus 로고    scopus 로고
    • Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes
    • Roumie C.L.; Greevy R.A.; Grijalva C.G.; Hung A.M.; Liu X.; Murff H.J.; Elasy T.A.; Griffin M.R. Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes. JAMA, 2014, 311, 2288-2296.
    • (2014) JAMA , vol.311 , pp. 2288-2296
    • Roumie, C.L.1    Greevy, R.A.2    Grijalva, C.G.3    Hung, A.M.4    Liu, X.5    Murff, H.J.6    Elasy, T.A.7    Griffin, M.R.8
  • 48
    • 84987762184 scopus 로고    scopus 로고
    • Cardiovascular Safety of Glucose-Lowering Agents as Add-on Medication to Metformin Treatment in Type 2 Diabetes:Report from the Swedish National Diabetes Register (NDR)
    • Ekstrom N.; Svensson A.M.; Miftaraj M.; Franzen S.; Zethelius B.; Eliasson B.; Gudbjornsdottir S. Cardiovascular Safety of Glucose-Lowering Agents as Add-on Medication to Metformin Treatment in Type 2 Diabetes:Report from the Swedish National Diabetes Register (NDR). Diabetes Obes. Metab., 2016, 18, 990-998.
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 990-998
    • Ekstrom, N.1    Svensson, A.M.2    Miftaraj, M.3    Franzen, S.4    Zethelius, B.5    Eliasson, B.6    Gudbjornsdottir, S.7
  • 50
    • 84924733192 scopus 로고    scopus 로고
    • Glucose-lowering with exogenous insulin monotherapy in type 2 diabetes: Dose association with allcause mortality, cardiovascular events and cancer
    • Holden S.E.; Jenkins-Jones S.; Morgan C.L.; Schernthaner G.; Currie C.J. Glucose-lowering with exogenous insulin monotherapy in type 2 diabetes: Dose association with allcause mortality, cardiovascular events and cancer. Diabetes Obes. Metab., 2015, 17, 350-362.
    • (2015) Diabetes Obes. Metab. , vol.17 , pp. 350-362
    • Holden, S.E.1    Jenkins-Jones, S.2    Morgan, C.L.3    Schernthaner, G.4    Currie, C.J.5
  • 53
    • 79959773411 scopus 로고    scopus 로고
    • DPP-4 inhibitors: Impact on glycemic control and cardiovascular risk factors
    • Dicker D. DPP-4 inhibitors: Impact on glycemic control and cardiovascular risk factors. Diabetes Care, 2011, 34 Suppl 2, S276-278.
    • (2011) Diabetes Care , vol.34 , pp. S276-S278
    • Dicker, D.1
  • 55
    • 84893116807 scopus 로고    scopus 로고
    • Saxagliptin, alogliptin, and cardiovascular outcomes
    • Scirica B.M.; Braunwald E.; Bhatt D.L. Saxagliptin, alogliptin, and cardiovascular outcomes. N. Engl. J. Med,. 2014, 370, 483-484.
    • (2014) N. Engl. J. Med , vol.370 , pp. 483-484
    • Scirica, B.M.1    Braunwald, E.2    Bhatt, D.L.3
  • 57
    • 84928699536 scopus 로고    scopus 로고
    • Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: A meta-analysis of randomised controlled trials
    • Udell J.A.; Cavender M.A.; Bhatt D.L.; Chatterjee S.; Farkouh M.E.; Scirica B.M. Glucose-lowering drugs or strategies and cardiovascular outcomes in patients with or at risk for type 2 diabetes: A meta-analysis of randomised controlled trials. Lancet Diabetes Endocrinol., 2015, 3, 356-366.
    • (2015) Lancet Diabetes Endocrinol. , vol.3 , pp. 356-366
    • Udell, J.A.1    Cavender, M.A.2    Bhatt, D.L.3    Chatterjee, S.4    Farkouh, M.E.5    Scirica, B.M.6
  • 63
    • 84964739559 scopus 로고    scopus 로고
    • Association Between Hospitalization for Heart Failure and Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes: An Observational Study
    • Fu A.Z.; Johnston S.S.; Ghannam A.; Tsai K.; Cappell K.; Fowler R.; Riehle E.; Cole A.L.; Kalsekar I.; Sheehan J. Association Between Hospitalization for Heart Failure and Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes: An Observational Study. Diabetes Care, 2016, 39, 726-734.
    • (2016) Diabetes Care , vol.39 , pp. 726-734
    • Fu, A.Z.1    Johnston, S.S.2    Ghannam, A.3    Tsai, K.4    Cappell, K.5    Fowler, R.6    Riehle, E.7    Cole, A.L.8    Kalsekar, I.9    Sheehan, J.10
  • 64
    • 84941228070 scopus 로고    scopus 로고
    • Risk of hospitalization for heart failure in patients with type 2 diabetes newly treated with DPP-4 inhibitors or other oral glucose-lowering medications: A retrospective registry study on 127,555 patients from the Nationwide OsMed Health-DB Database
    • Fadini G.P.; Avogaro A.; Degli Esposti L.; Russo P.; Saragoni S.; Buda S.; Rosano G.; Pecorelli S.; Pani L.; OsMed Health D.B.N. Risk of hospitalization for heart failure in patients with type 2 diabetes newly treated with DPP-4 inhibitors or other oral glucose-lowering medications: A retrospective registry study on 127,555 patients from the Nationwide OsMed Health-DB Database. Eur. Heart J., 2015, 36, 2454-2462.
    • (2015) Eur. Heart J. , vol.36 , pp. 2454-2462
    • Fadini, G.P.1    Avogaro, A.2    Degli Esposti, L.3    Russo, P.4    Saragoni, S.5    Buda, S.6    Rosano, G.7    Pecorelli, S.8    Pani, L.9    Osmed Health, D.B.N.10
  • 65
    • 84855481995 scopus 로고    scopus 로고
    • Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: A pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme
    • Johansen O.E.; Neubacher D.; von Eynatten M.; Patel S.; Woerle H.J. Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: A pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme. Cardiovasc. Diabetol., 2012, 11, 3.
    • (2012) Cardiovasc. Diabetol. , vol.11
    • Johansen, O.E.1    Neubacher, D.2    Von Eynatten, M.3    Patel, S.4    Woerle, H.J.5
  • 67
    • 77953182696 scopus 로고    scopus 로고
    • Assessing the cardiocerebrovascular safety of vildagliptin: Meta-analysis of adjudicated events from a large Phase III type 2 diabetes population
    • Schweizer A.; Dejager S.; Foley J.E.; Couturier A.; Ligueros- Saylan M.; Kothny W. Assessing the cardiocerebrovascular safety of vildagliptin: Meta-analysis of adjudicated events from a large Phase III type 2 diabetes population. Diabetes Obes. Metab., 2010, 12, 485-494.
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 485-494
    • Schweizer, A.1    Dejager, S.2    Foley, J.E.3    Couturier, A.4    Ligueros-Saylan, M.5    Kothny, W.6
  • 70
    • 79959778328 scopus 로고    scopus 로고
    • Long-acting glucagon-like peptide 1 receptor agonists: A review of their efficacy and tolerability
    • Garber A.J. Long-acting glucagon-like peptide 1 receptor agonists: A review of their efficacy and tolerability. Diabetes Care, 2011, 34 Suppl 2, S279-284.
    • (2011) Diabetes Care , vol.34 , pp. S279-S284
    • Garber, A.J.1
  • 77
    • 84964773926 scopus 로고    scopus 로고
    • SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME Study
    • Abdul-Ghani M.; Del Prato S.; Chilton R.; DeFronzo R.A. SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME Study. Diabetes Care, 2016, 39, 717-725.
    • (2016) Diabetes Care , vol.39 , pp. 717-725
    • Abdul-Ghani, M.1    Del Prato, S.2    Chilton, R.D.3
  • 80
    • 84964507777 scopus 로고    scopus 로고
    • Erratum to: SGLT2 Inhibition and cardiovascular events: Why did EMPA-REG Outcomes surprise and what were the likely mechanisms?
    • Sattar N.; McLaren J.; Kristensen S.L.; Preiss D.; McMurray J.J. Erratum to: SGLT2 Inhibition and cardiovascular events: Why did EMPA-REG Outcomes surprise and what were the likely mechanisms? Diabetologia, 2016, 59, 1333-1339.
    • (2016) Diabetologia , vol.59 , pp. 1333-1339
    • Sattar, N.1    McLaren, J.2    Kristensen, S.L.3    Preiss, D.4    McMurray, J.J.5
  • 81
    • 0344373794 scopus 로고    scopus 로고
    • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA, 2002, 288, 2981-2997.
    • (2002) JAMA , vol.288 , pp. 2981-2997
  • 82
    • 84948432337 scopus 로고    scopus 로고
    • Cardiovascular Risk and Sodium-Glucose Cotransporter 2 Inhibition in Type 2 Diabetes
    • Ingelfinger J.R.; Rosen C.J. Cardiovascular Risk and Sodium-Glucose Cotransporter 2 Inhibition in Type 2 Diabetes. N. Engl. J. Med., 2015, 373, 2178-2179.
    • (2015) N. Engl. J. Med. , vol.373 , pp. 2178-2179
    • Ingelfinger, J.R.1    Rosen, C.J.2
  • 83
    • 84975853831 scopus 로고    scopus 로고
    • CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis
    • Ferrannini E.; Mark M.; Mayoux E. CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis. Diabetes Care, 2016, 39, 1108-1114.
    • (2016) Diabetes Care , vol.39 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 84
    • 84975840750 scopus 로고    scopus 로고
    • Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis
    • Mudaliar S.; Alloju S.; Henry R.R. Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis. Diabetes Care, 2016, 39, 1115-1122.
    • (2016) Diabetes Care , vol.39 , pp. 1115-1122
    • Mudaliar, S.1    Alloju, S.2    Henry, R.R.3
  • 88
    • 85002833256 scopus 로고    scopus 로고
    • Pharmacologic Management of Type 2 Diabetes: 2016 Interim Update
    • Canadian Diabetes Association. Pharmacologic Management of Type 2 Diabetes: 2016 Interim Update. Can. J. Diabetes, 2016, 40, 484-486.
    • (2016) Can. J. Diabetes , vol.40 , pp. 484-486
  • 89
    • 85009168575 scopus 로고    scopus 로고
    • American Diabetes A. 8. Pharmacologic Approaches to Glycemic Treatment
    • American Diabetes A. 8. Pharmacologic Approaches to Glycemic Treatment. Diabetes Care, 2017, 40, S64-S74.
    • (2017) Diabetes Care , vol.40 , pp. S64-S74
  • 90
    • 85019608363 scopus 로고    scopus 로고
    • Editorial: Do Some Glucagon-Like-Peptide-1 Receptor Agonists (GLP-1 RA) Reduce Macrovascular Complications of Type 2 Diabetes Mellitus A Commentary on the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) Trial
    • Athyros V.G.; Katsiki N.; Tentolouris N. Editorial: Do Some Glucagon-Like-Peptide-1 Receptor Agonists (GLP-1 RA) Reduce Macrovascular Complications of Type 2 Diabetes Mellitus A Commentary on the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) Trial. Curr. Vasc. Pharmacol., 2016, 14, 469-473.
    • (2016) Curr. Vasc. Pharmacol. , vol.14 , pp. 469-473
    • Athyros, V.G.1    Katsiki, N.2    Tentolouris, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.