HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects: Prospective data from the Verona Diabetes Complications Study

Diabetes Care

Volumn 25, Issue 7, 2002, Pages 1135-1141

  Bonora, Enzo ^a,b   Formentini, Gianni ^a   Calcaterra, Francesco ^a   Lombardi, Simonetta ^a   Marini, Franco ^a   Zenari, Luciano ^a   Saggiani, Francesca ^a   Poli, Maurizio ^a   Perbellini, Sandro ^a   Raffaelli, Andrea ^a   Cacciatori, Vittorio ^a   Santi, Lorenza ^a   Targher, Giovanni ^a   Bonadonna, Riccardo ^a   Muggeo, Michele ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; CHOLESTEROL; LIPID; LIPOPROTEIN; TRIACYLGLYCEROL;

ANAMNESIS; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ARTERY; CEREBROVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONFIDENCE INTERVAL; CORONARY ARTERY DISEASE; DEATH CERTIFICATE; DOPPLER ECHOGRAPHY; ECG ABNORMALITY; ELECTROCARDIOGRAPHY; FATALITY; FOLLOW UP; HUMAN; HYPERTENSION; INSULIN RESISTANCE; LEG ARTERY; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MEDICAL RECORD; METABOLIC REGULATION; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL VASCULAR DISEASE; PHYSICAL EXAMINATION; PREDICTION; SMOKING; STATISTICAL ANALYSIS; VASCULAR LESION; BLOOD; BODY MASS; CLINICAL TRIAL; DIABETIC ANGIOPATHY; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; MALE; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; ONSET AGE; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; RISK FACTOR;

AGE OF ONSET; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FEMALE; HOMEOSTASIS; HUMANS; HYPERTENSION; INSULIN RESISTANCE; LIPIDS; LIPOPROTEINS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RISK FACTORS; SMOKING; TRIGLYCERIDES;

EID: 0036633043     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.25.7.1135     Document Type: Article

References (50)

1. Bonora E, Kiechl S, Oberhollenzer F, Egger G, Bonadonna RC, Muggeo M: Impaired glucose tolerance, type 2 diabetes mellitus and carotid artherosclerosis: prospective results from the Bruneck Study. Diabetologia 43:156-164, 2000
2. Kannel WB, McGee DL: Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham Study. Diabetes Care 2:120-126, 1979
3. De Marco R, Locatelli F, Zoppini G, Verlato G, Bonora E, Muggeo M: Cause-specific mortality in type 2 diabetes. Diabetes Care 22:756-761, 1999
4. Taskinen MR: Hyperlipidaemia in diabetes. Clin Endocrinol Metab 4:743-775, 1990
5. Fuller JH: Epidemiology of hypertension associated with diabetes mellitus. Hypertension 7 (Suppl. II):3-7, 1985
6. Jokl R, Colwell JA: Arterial thrombosis and atherosclerosis in diabetes. Diabetes Rev 5:316-330, 1997
7. Bierman EL: Atherogenesis in diabetes. Arterioscler Thromb 12:647-656, 1992
8. Muggeo M, Verlato G, Bonora E, Zoppini G, Corbellini M, De Marco R: Long-term instability of fasting plasma glucose: a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: the Verona Diabetes Study. Circulation 96:1750-1754, 1997
9. Laakso M: Hyperglycemia and cardiovascular disease in type 2 diabetes. Diabetes 48:937-942, 1999
10. Barrett-Connor E: Does hyperglycemia really cause coronary heart disease? Diabetes Care 20:1620-1623, 1997
11. Haffner SM, Howard G, Mayer E, Bergman RN, Savage PJ, Rewers M, Mykkanen L, Karter AJ, Hamman R, Saad MF: Insulin sensitivity and acute insulin response in African-Americans, Non-Hispanic Whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. Diabetes 46:63-69, 1997
12. Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Targher G, Alberiche M, Bonadonna R, Muggeo M: Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes 47:1643-1649, 1998
13. Laakso M, Sarlund H, Salonen R, Suhonen M, Pyorala K, Salonen JT, Karhapaa P: Asymptomatic atherosclerosis and insulin resistance. Arterioscl Thromb Vasc Biol 11:1068-1076, 1991
14. Bressler P, Bailey SR, Matsuda M, DeFronzo RA: Insulin resistance and coronary heart disease. Diabetologia 39:1345-1350, 1996
15. Howard G, O'Leary DH, Zaccaro D, Haffner S, Rewers M, Hamman R, Selby JV, Saad MF, Savage P, Bergman R, the IRAS Investigators: Insulin sensitivity and atherosclerosis. Circulation 93:1809-1817, 1996
16. Inchiostro S, Bertoli G, Zanette G, Donadon V: Evidence of higher insulin resistance in NIDDM patients with ischaemic heart disease. Diabetologia 37:597-603, 1994
17. Bonora E, Tessari R, Micciolo R, Zenere M, Targher G, Padovani R, Falezza G, Muggeo M: Intimal-medial thickness of the carotid artery in nondiabetic and non-insulin-dependent diabetic subjects: relationship with insulin resistance. Diabetes Care 20:627-631, 1997
18. Yip J, Facchini F, Reaven GM: Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab 88:2773-2776, 1998
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419, 1985
20. Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clin Chem 18:499-502, 1972
21. Bonora E, Targger G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T, Muggeo M: Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degree of glucose tolerance and insulin sensitivity. Diabetes Care 23:57-63, 2000
22. Epstein FH, Ostrander LD, Johnson BC, Payne MW, Hayner NS, Keller JB, Francis T: Epidemiological studies of cardiovascular diseases in a total community-Tecumseh, Michigan. Ann Intern Med 62:1170-1187, 1965
23. DeFronzo RA: The triumvirate: B-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 37:667-687, 1988
24. Lillioja S, Mott DM, Howard BV, Bennett PH, Yki-Jarvinen H, Freymond D, Nyomba BL, Zurlo F, Swinburn B, Bogardus C: Impaired glucose tolerance as a disorder of insulin action: longitudinal and cross-sectional studies in Pima Indians. N Engl J Med 318:1217-1225, 1988
25. Bonora E, Targher G, Alberiche M, Bonadonna RC, Zenere MB, Saggiani F, Muggeo M: Intracellular partition of plasma glucose disposal in hypertensive and normotensive subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 86:2073-2079, 2001
26. Juhan-Vague I, Thompson SG, Jespersen J: Involvement of the hemostatic system in the insulin resistance syndrome: a study of 1500 patients with angina pectoris: the ECAT Angina Pectoris Study Group. Arterioscl Thromb 13:1865-1873, 1993
27. Targher G, Alberiche M, Zenere MB, Bonadonna RC Muggeo M, Bonora E: Cigarette smoking and insulin resistance in patients with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 82:3619-3624, 1997
28. Hu FB, Stampfer MJ, Solomon C, Liu S, Colditz GA, Speizer FE, Willet W, Manson JE: Physical activity and risk of cardiovascular events in diabetic women. Ann Intern Med 134:96-105, 2001
29. Davidson MB, Peters AL: An overview of metformin in the treatment of type 2 diabetes mellitus. Am J Med 102:99-110, 1997
30. UK Prospective Diabetes Study (UKPDS) Group: Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352:854-865, 1998
31. Minamikawa J, Tanaka S, Yamauchi M, Inoue D, Koshiyama H: Potent inhibitory effect of troglitazone on carotid arterial thickness in type 2 diabetes. J Clin Endocrinol Metab 83:1818-1820, 1998
32. DeFronzo RA, Tobin JD, Andres R: The glucose clamp technique: a method for the quantification of beta cell sensitivity to glucose and of tissue sensitivity to insulin. Am J Physiol 237:E214-E223, 1979
33. Emoto M, Nishizawa Y, Maekawa K, Hiura Y, Kanda H, Kawagishi T, Shoji T, Okuno Y, Morii H: Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulphonylureas. Diabetes Care 22:818-822, 1999
34. Pyorala K: Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 2:131-141, 1979
35. Welborn TA, Wearne K: Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentration. Diabetes Care 2:154-160, 1979
36. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ: Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 334:952-957, 1996
37. Welin L, Eriksson H, Larsson B, Ohlson LO, Svardsudd K, Tibblin G: Hyperinsulinemia is not a major coronary risk factor in elderly men. Diabetologia 35:766-770, 1992
38. Hargreaves AD, Logan RL, Elton RA, Buchanan KD, Oliver MF, Riemersma RA: Glucose tolerance, plasma insulin, HDL cholesterol and obesity: 12-yr follow-up and development of coronary heart disease in Edinburgh men. Atherosclerosis 94:61-69, 1992
39. Bonora E, Willeit J, Kiechl S, Oberhollenzer F, Egger G, Bonadonna R, Muggeo M: Relationship between insulin and carotid atherosclerosis in the general population: the Bruneck Study. Stroke 28:1147-1152, 1997
40. Trovati M, Anfossi G, Cavalot F, Massucco P, Mularoni E, Emanuelli G: Insulin directly reduces platelet sensitivity to aggregating agents: studies in vitro and in vivo. Diabetes 37:780-786, 1988
41. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD: Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent: a novel action of insulin to increase nitric oxide release. J Clin Invest 94:1172-1179, 1994
42. Kahn AM, Allen JC, Seidel CL, Zhang S: Insulin inhibits migration of vascular smooth muscle cells with inducible nitric oxide synthase. Hypertension 35:303-306, 2000
43. De Feo PP, Gaisano MG, Haymond MW: Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans. J Clin Invest 88:833-840, 1991
44. Trovati M, Mularoni EM, Burzacca S, Ponziani MC, Massucco P, Mattiello L, Piretto V, Cavalot F, Anfossi G: Impaired insulin-induced platelet anti-aggregating effect in obesity and obese NIDDM patients. Diabetes 44:1318-1322, 1995
45. Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G, Baron A: Obesity/insulin resistance is associated with endothelial dysfunction: implications for the syndrome of insulin resistance. J Clin Invest 97:2601-2610, 1996
46. Quinones-Galvan A, Sironi AM, Baldi S, Galetta F, Garbin U, Fratta-Pasini A, Cominacini L, Ferrannini E: Evidence that acute insulin administration enhances LDL cholesterol susceptibility to oxidation in healthy humans. Arterioscl Thromb Vasc Biol 19:2929-2932, 1999
47. Carmassi F, Morale M, Ferrini L, Dell'Omo G, Ferdeghini M, Pedrinelli R, De Negri F: Local insulin infusion stimulates expression of plasminogen activator Inhibitor-1 and tissue-type plasminogen activator in normal subjects. Am J Med 107:344-350, 1999
48. Piatti PM, Monti L, Conti M, Baruffaldi L, Galli L, Phan CV, Guazzini B, Pontiroli AE, Pozza G: Hypertriglyceridemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans. Diabetes 45:316-321, 1996
49. Stout RW: Insulin and atheroma: 20-yr perspective. Diabetes Care 13:631-654, 1990
50. UKPDS Group: UK Prospective Diabetes Study 6: complications in newly diagnosed type 2 diabetic patients and their association with different clinical and biochemical risk factors. Diabetes Res 13:1-11, 1990