메뉴 건너뛰기




Volumn 11, Issue 5, 2016, Pages

Association between insulin monotherapy versus insulin plus metformin and the risk of all-cause mortality and other serious outcomes: A retrospective cohort study

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; METFORMIN; ANTIDIABETIC AGENT;

EID: 84968809053     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0153594     Document Type: Article
Times cited : (29)

References (31)
  • 2
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • PMID: 22517736
    • Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012; 35: 1364-79. doi: 10.2337/dc12-0413 PMID: 22517736
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6
  • 3
    • 16644372491 scopus 로고    scopus 로고
    • Insulin monotherapy versus combinations of insulin with oral hypoglycaemic agents in patients with type 2 diabetes mellitus
    • PMID: 15495054
    • Goudswaard AN, Furlong NJ, Valk GD, Stolk RP, Rutten GEHM. Insulin monotherapy versus combinations of insulin with oral hypoglycaemic agents in patients with type 2 diabetes mellitus. Cochrane Database Syst Rev. 2004: CD003418. PMID: 15495054
    • (2004) Cochrane Database Syst Rev
    • Goudswaard, A.N.1    Furlong, N.J.2    Valk, G.D.3    Stolk, R.P.4    Rutten, G.E.H.M.5
  • 5
    • 0032939905 scopus 로고    scopus 로고
    • Methylglyoxal Metformin reduces systemic methylglyoxal levels in type 2 diabetes
    • Beisswenger PJ, Howell SK, Touchette AD, Lal S, Szwergold BS. Methylglyoxal Metformin reduces systemic methylglyoxal levels in type 2 diabetes. Diabetes. 1999; 4: 198-202.
    • (1999) Diabetes , vol.4 , pp. 198-202
    • Beisswenger, P.J.1    Howell, S.K.2    Touchette, A.D.3    Lal, S.4    Szwergold, B.S.5
  • 6
    • 63849328978 scopus 로고    scopus 로고
    • Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus
    • PMID: 19307526
    • Kooy A, de Jager J, Lehert P, Bets D, Wulffele MG, Donker AJM, et al. Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus. Arch Intern Med. 2009; 169: 616-25. doi: 10.1001/archinternmed.2009.20 PMID: 19307526
    • (2009) Arch Intern Med , vol.169 , pp. 616-625
    • Kooy, A.1    De Jager, J.2    Lehert, P.3    Bets, D.4    Wulffele, M.G.5    Donker, A.J.M.6
  • 7
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • PMID: 19572116
    • Currie CJ, Poole CD, Gale EAM. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia. 2009; 52: 1766-77. doi: 10.1007/s00125-009-1440-6 PMID: 19572116
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.M.3
  • 8
    • 77957241580 scopus 로고    scopus 로고
    • The proliferating role of insulin and insulin-like growth factors in cancer
    • PMID: 20663687
    • Gallagher EJ, LeRoith D. The proliferating role of insulin and insulin-like growth factors in cancer. Trends Endocrinol Metab. 2010; 21: 610-8. doi: 10.1016/j.tem.2010.06.007 PMID: 20663687
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 610-618
    • Gallagher, E.J.1    LeRoith, D.2
  • 9
    • 84881567755 scopus 로고    scopus 로고
    • Mortality among veterans with type 2 diabetes initiating metformin, sulfonylurea or rosiglitazone monotherapy
    • PMID: 23797633
    • Wheeler S, Moore K, Forsberg CW, Riley K, Floyd JS, Smith NL, et al. Mortality among veterans with type 2 diabetes initiating metformin, sulfonylurea or rosiglitazone monotherapy. Diabetologia. 2013; 56: 1934-43. doi: 10.1007/s00125-013-2958-1 PMID: 23797633
    • (2013) Diabetologia , vol.56 , pp. 1934-1943
    • Wheeler, S.1    Moore, K.2    Forsberg, C.W.3    Riley, K.4    Floyd, J.S.5    Smith, N.L.6
  • 10
  • 11
    • 84862848716 scopus 로고    scopus 로고
    • Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: A meta-analysis
    • PMID: 22643536
    • Soranna D, Scotti L, Zambon A, Bosetti C, Grassi G, Catapano A, et al. Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis. Oncologist. 2012; 17: 813-22. doi: 10.1634/theoncologist.2011-0462 PMID: 22643536
    • (2012) Oncologist , vol.17 , pp. 813-822
    • Soranna, D.1    Scotti, L.2    Zambon, A.3    Bosetti, C.4    Grassi, G.5    Catapano, A.6
  • 12
    • 84879552899 scopus 로고    scopus 로고
    • Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: A meta-analysis using primary data of published studies
    • PMID: 23419783
    • Thakkar B, Aronis KN, Vamvini MT, Shields K, Mantzoros CS. Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies. Metabolism. 2013; 62: 922-34. doi: 10.1016/j.metabol.2013.01.014 PMID: 23419783
    • (2013) Metabolism , vol.62 , pp. 922-934
    • Thakkar, B.1    Aronis, K.N.2    Vamvini, M.T.3    Shields, K.4    Mantzoros, C.S.5
  • 13
    • 84880974660 scopus 로고    scopus 로고
    • Metformin therapy and risk of cancer in patients with type 2 diabetes: Systematic review
    • PMID: 23936520
    • Franciosi M, Lucisano G, Lapice E, Strippoli GF, Pellegrini F, Nicolucci A. Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review. PLoS One. 2013; 8: e71583. doi: 10.1371/journal.pone.0071583 PMID: 23936520
    • (2013) PLoS One , vol.8
    • Franciosi, M.1    Lucisano, G.2    Lapice, E.3    Strippoli, G.F.4    Pellegrini, F.5    Nicolucci, A.6
  • 14
    • 84866138849 scopus 로고    scopus 로고
    • Cancer outcomes and all-cause mortality in adults allocated to metformin: Systematic review and collaborative meta-analysis of randomised clinical trials
    • PMID: 22875195
    • Stevens RJ, Ali R, Bankhead CR, Bethel MA, Cairns BJ, Camisasca RP, et al. Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials. Diabetologia. 2012; 55: 2593-603. doi: 10.1007/s00125-012-2653-7 PMID: 22875195
    • (2012) Diabetologia , vol.55 , pp. 2593-2603
    • Stevens, R.J.1    Ali, R.2    Bankhead, C.R.3    Bethel, M.A.4    Cairns, B.J.5    Camisasca, R.P.6
  • 15
    • 84924733192 scopus 로고    scopus 로고
    • Glucose-lowering with exogenous insulin monotherapy in type 2 diabetes: Dose-response association with all-cause mortality, cardiovascular events and incident cancer
    • PMID: 25399739
    • Holden SE, Jenkins-Jones S, Morgan CL, Schernthaner G, Currie CJ. Glucose-lowering with exogenous insulin monotherapy in type 2 diabetes: dose-response association with all-cause mortality, cardiovascular events and incident cancer. Diabetes Obes Metab. 2015; 17: 350-62. doi: 10.1111/dom.12412 PMID: 25399739
    • (2015) Diabetes Obes Metab , vol.17 , pp. 350-362
    • Holden, S.E.1    Jenkins-Jones, S.2    Morgan, C.L.3    Schernthaner, G.4    Currie, C.J.5
  • 16
    • 73349095732 scopus 로고    scopus 로고
    • Insulin use and increased risk of mortality in type 2 diabetes: A cohort study
    • PMID: 19788429
    • Gamble J-M, Simpson SH, Eurich DT, Majumdar SR, Johnson JA. Insulin use and increased risk of mortality in type 2 diabetes: a cohort study. Diabetes Obes Metab. 2010; 12:.47-53. doi: 10.1111/j. 1463-1326.2009.01125.x PMID: 19788429
    • (2010) Diabetes Obes Metab , vol.12 , pp. 47-53
    • Gamble, J.-M.1    Simpson, S.H.2    Eurich, D.T.3    Majumdar, S.R.4    Johnson, J.A.5
  • 17
    • 84902216056 scopus 로고    scopus 로고
    • Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes
    • PMID: 24915260
    • Roumie CL, Greevy RA, Grijalva CG, Hung AM, Liu X, Murff HJ, et al. Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes. JAMA. 2014; 311: 2288-96. doi: 10.1001/jama.2014.4312 PMID: 24915260
    • (2014) JAMA , vol.311 , pp. 2288-2296
    • Roumie, C.L.1    Greevy, R.A.2    Grijalva, C.G.3    Hung, A.M.4    Liu, X.5    Murff, H.J.6
  • 18
    • 84873656406 scopus 로고    scopus 로고
    • Mortality and other important diabetes-related outcomes with insulin vs other antihyperglycemic therapies in type 2 diabetes
    • PMID: 23372169
    • Currie CJ, Poole CD, Evans M, Peters JR, Morgan CLl. Mortality and other important diabetes-related outcomes with insulin vs other antihyperglycemic therapies in type 2 diabetes. J Clin Endocrinol Metab. 2013; 98: 668-77. doi: 10.1210/jc.2012-3042 PMID: 23372169
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 668-677
    • Currie, C.J.1    Poole, C.D.2    Evans, M.3    Peters, J.R.4    Morgan, C.L.L.5
  • 19
    • 84965015003 scopus 로고    scopus 로고
    • Clinical Practice Research Datalink (CPRD). Clinical Practice Research Datalink. 2016. Available: http://www.cprd.com/intro.asp
    • (2016) Clinical Practice Research Datalink
  • 20
    • 0023092594 scopus 로고
    • A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
    • PMID: 3558716
    • Charlson M, Pompei P, Ales K, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40: 373-83. PMID: 3558716
    • (1987) J Chronic Dis , vol.40 , pp. 373-383
    • Charlson, M.1    Pompei, P.2    Ales, K.3    MacKenzie, C.R.4
  • 21
    • 78649315767 scopus 로고    scopus 로고
    • Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: A retrospective nationwide cohort study
    • PMID: 20838985
    • Andersson C, Olesen JB, Hansen PR, Weeke P, Norgaard ML, Jørgensen CH, et al. Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study. Diabetologia. 2010; 53: 2546-53. doi: 10.1007/s00125-010-1906-6 PMID: 20838985
    • (2010) Diabetologia , vol.53 , pp. 2546-2553
    • Andersson, C.1    Olesen, J.B.2    Hansen, P.R.3    Weeke, P.4    Norgaard, M.L.5    Jørgensen, C.H.6
  • 22
    • 84859977229 scopus 로고    scopus 로고
    • Comparison of metformin and insulin versus insulin alone for type 2 diabetes: Systematic review of randomised clinical trials with meta-analyses and trial sequential analyses
    • PMID: 22517929
    • Hemmingsen B, Lundby L, Wetterslev J. Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses. BMJ. 2012; 344: e1771. doi: 10.1136/bmj.e1771 PMID: 22517929
    • (2012) BMJ , vol.344 , pp. e1771
    • Hemmingsen, B.1    Lundby, L.2    Wetterslev, J.3
  • 23
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • PMID: 9742977
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998; 352: 854-65. PMID: 9742977
    • (1998) Lancet , vol.352 , pp. 854-865
  • 24
    • 78649664499 scopus 로고    scopus 로고
    • Metformin use and mortality among patients with diabetes and atherothrombosis
    • PMID: 21098347
    • Roussel R, Travert F, Pasquet B, Wilson PW, Smith SC Jr, Goto S, et al; Reduction of Atherothrombosis for Continued Health (REACH) Registry Investigators. Metformin use and mortality among patients with diabetes and atherothrombosis. Arch Intern Med. 2010; 170: 1892-9. doi: 10.1001/archinternmed.2010.409 PMID: 21098347
    • (2010) Arch Intern Med , vol.170 , pp. 1892-1899
    • Roussel, R.1    Travert, F.2    Pasquet, B.3    Wilson, P.W.4    Smith, S.C.5    Goto, S.6
  • 25
    • 84870753442 scopus 로고    scopus 로고
    • What next after metformin? A retrospective evaluation of the outcome of second-line, glucose- lowering therapies in people with type 2 diabetes
    • Morgan CL, Poole CD, Evans M, Barnett AH, Jenkins-Jones S, Currie CJ. What next after metformin? A retrospective evaluation of the outcome of second-line, glucose- lowering therapies in people with type 2 diabetes. J Clin Endocrin Metab. 2012; 97: 1-8.
    • (2012) J Clin Endocrin Metab , vol.97 , pp. 1-8
    • Morgan, C.L.1    Poole, C.D.2    Evans, M.3    Barnett, A.H.4    Jenkins-Jones, S.5    Currie, C.J.6
  • 26
    • 84856698481 scopus 로고    scopus 로고
    • Glucose-lowering agents and the patterns of risk for cancer: A study with the General Practice Research Database and secondary care data
    • PMID: 22127412
    • van Staa TP, Patel D, Gallagher AM, de Bruin ML. Glucose-lowering agents and the patterns of risk for cancer: a study with the General Practice Research Database and secondary care data. Diabetologia. 2012; 55: 654-65. doi: 10.1007/s00125-011-2390-3 PMID: 22127412
    • (2012) Diabetologia , vol.55 , pp. 654-665
    • Van Staa, T.P.1    Patel, D.2    Gallagher, A.M.3    De Bruin, M.L.4
  • 27
    • 84864270406 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes in dysglycemia
    • PMID: 22686416
    • ORIGIN Trial Investigators, Gerstein HC, Bosch J, Dagenais GR, Díaz R, Jung H, Maggioni AP, et al. Basal insulin and cardiovascular and other outcomes in dysglycemia. New Engl J Med. 2012; 367: 319-28. doi: 10.1056/NEJMoa1203858 PMID: 22686416
    • (2012) New Engl J Med , vol.367 , pp. 319-328
    • Gerstein, H.C.1    Bosch, J.2    Dagenais, G.R.3    Díaz, R.4    Jung, H.5    Maggioni, A.P.6
  • 28
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • PMID: 16443869
    • Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care. 2006; 29: 254-8. PMID: 16443869
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 29
    • 77950370275 scopus 로고    scopus 로고
    • Validity of diagnostic coding within the General Practice Research Database: A systematic review
    • Khan NF, Harrison SE, Rose PW. Validity of diagnostic coding within the General Practice Research Database: a systematic review. Brit J Gen Pr. 2010; 60: e128-36.
    • (2010) Brit J Gen Pr , vol.60 , pp. e128-e136
    • Khan, N.F.1    Harrison, S.E.2    Rose, P.W.3
  • 30
    • 84884536106 scopus 로고    scopus 로고
    • BMJ Group and Pharmaceutical Press
    • Joint Formulary Committee. British National Formulary (online). BMJ Group and Pharmaceutical Press. Available: http://www.medicinescomplete.com.
    • British National Formulary (Online)
  • 31
    • 0030069896 scopus 로고    scopus 로고
    • Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors
    • PMID: 8668867
    • Harrell F, Lee K, Mark D. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996; 15: 361-87. PMID: 8668867
    • (1996) Stat Med , vol.15 , pp. 361-387
    • Harrell, F.1    Lee, K.2    Mark, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.