Portulaca oleracea L. Alleviates liver injury in streptozotocin-induced diabetic mice

Drug Design, Development and Therapy

Volumn 12, Issue , 2018, Pages 47-55

  Zheng, Guoyin ^a   Mo, Fengfeng ^b   Ling, Chen ^c   Peng, Hao ^a   Gu, Wei ^a   Li, Min ^b   Chen, Zhe ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Diabetes; Liver injury; Portulaca oleracea L; Rho NF B

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CELL PROTEIN; CHOLESTEROL; GLUCOSE; I KAPPA B KINASE ALPHA; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; METFORMIN; PORTULACA OLERACEA EXTRACT; RHO FACTOR; ROCK1 PROTEIN; ROCK2 PROTEIN; STREPTOZOCIN; TRANSCRIPTION FACTOR RELA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; AUTACOID; BIOLOGICAL MARKER; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID; PLANT EXTRACT; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; FOOD INTAKE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIVER INJURY; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BLOOD; CELL PROTECTION; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; EXPERIMENTAL DIABETES MELLITUS; ISOLATION AND PURIFICATION; LIVER; MEDICINAL PLANT; METABOLISM; PATHOLOGY; PHYTOTHERAPY; PORTULACA; TIME FACTOR; TOXIC HEPATITIS;

ANIMALS; BIOMARKERS; BLOOD GLUCOSE; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYTOKINES; CYTOPROTECTION; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOGLYCEMIC AGENTS; INFLAMMATION MEDIATORS; INSULIN; LIPIDS; LIVER; MALE; MICE; NF-KAPPA B; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PORTULACA; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; STREPTOZOCIN; TIME FACTORS;

EID: 85039797797     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S121084     Document Type: Article

References (28)

1. Ercisli S, Coruh I, Gormez A, Sengul M. Antioxidant and antibacterial activities of Portulaca oleracea L. grown wild in Turkey. Ital J Food Sci. 2008;20:533–542.
2. Bruix J, Reig M, Sherman M. Evidence-based diagnosis, staging, and treatment of patients with hepatocellular carcinoma. Gastroenterology. 2016;150:835–853.
3. Xin H, Hou Y, Xu Y, et al. Portulacerebroside A: new cerebroside from Portulaca oleracea L. Chin J Nat Med. 2008;6(6):401–403.
4. Xin H, Xu Y, Hou Y, et al. Two novel triterpenoids from Portulaca oleracea L. Helvetica Chimica Acta. 2008;91:2075–2080.
5. Kim JY, Oh HM, Kwak SC, et al. Purslane suppresses osteoclast differentiation and bone resorbing activity via inhibition of Akt/GSK3β-c-Fos-NFATc1 signaling in vitro and prevents lipopolysaccharide-induced bone loss in vivo. Biol Pharm Bull. 2015;38:66–74.
6. Barakat LA, Mahmoud RH. The antiatherogenic, renal protective and immunomodulatory effects of purslane, pumpkin and flax seeds on hypercholesterolemic rats. N Am J Med Sci. 2011;3:411–417.
7. Panth N, Paudel KR, Karki R. Phytochemical profile and biological activity of Juglans regia. J Integr Med. 2016;14(5):359–373.
8. Eidi A, Mortazavi P, Moghadam JZ, Mardani PM. Hepatoprotective effects of Portulaca oleracea extract against CCl4-induced damage in rats. Pharm Biol. 2014;53:1–10.
9. Liu XF, Zheng CG, Shi HG, et al. Ethanol extract from Portulaca oleracea L. attenuated acetaminophen-induced mice liver injury. Am J Transl Res. 2015;7:309–318.
10. Campbell IW. Type 2 diabetes mellitus: ‘the silent killer’. Pract Diabetes Int. 2001;18:187–191.
11. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33(Suppl 1):S62–S69.
12. Aguiree F, Brown A, Cho NH, et al. IDF Diabetes Atlas. 6th ed. Brussels: International Diabetes Federation; 2013.
13. Wu MC. [Traditional Chinese medicine in prevention and treatment of liver cancer: function, status and existed problems]. J Chin Integr Med. 2003;1(3):163–164. Chinese.
14. Chehade JM, Gladysz M, Mooradian AD. Dyslipidemia in type 2 diabetes: prevalence, pathophysiology, and management. Drugs. 2013;73:327–339.
15. Chen T, Gao J, Xiang P, et al. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. Int Immunopharmacol. 2015;26:338–348.
16. Chen T, Guo Q, Wang H, et al. Effects of esculetin on lipopolysaccharide (LPS)-induced acute lung injury via regulation of RhoA/Rho kinase/NF-κB pathways in vivo and in vitro. Free Radic Res. 2015;49:1459–1468.
17. Wong CC, Wong CM, Tung EK, Man K, Ng IO. Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion. Hepatology. 2009;49:1583–1594.
18. Zhu L, Chen T, Chang X, et al. Salidroside ameliorates arthritis-induced brain cognition deficits by regulating Rho/ROCK/NF-κB pathway. Neuropharmacology. 2016;103:134–142.
19. Jain SK, Rains JL, Croad JL. Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-α, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats. Free Radic Biol Med. 2007;43:1124–1131.
20. Guo X, Yoshitomi H, Gao M, et al. Guava leaf extracts promote glucose metabolism in SHRSP.Z-Leprfa/Izm rats by improving insulin resistance in skeletal muscle. BMC Complement Altern Med. 2013;13:52.
21. Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care. 1989;12:553–564.
22. Li A, Liu YG, Wang LY, Zhang SY, Xu LT, Wang SM. Ergosterol alleviates kidney injury in streptozotocin-induced diabetic mice. Evid Based Complement Alternat Med. 2015;2015:691594.
23. Saravanan G, Ponmurugan P. Ameliorative potential of S-allylcysteine: effect on lipid profile and changes in tissue fatty acid composition in experimental diabetes. Exp Toxicol Pathol. 2012;64:639–644.
24. Yang Y, Zhang DM, Liu JH, et al. Wuling san protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice. J Ethnopharmacol. 2015;169:49–59.
25. Hu QH, Zhang X, Wang Y, Kong LD. [Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice]. Yao Xue Xue Bao. 2010;45:1239–1246. Chinese.
26. Ma CH, Kang LL, Ren HM, Zhang DM, Kong LD. Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-κB/NLRP3 inflammasome activation in high fructose-fed rats. J Ethnopharmacol. 2015;172:108–117.
27. Lee DH, Shi J, Jeoung NH, et al. Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem. 2009;284:11776–11780.
28. Chen T, Wang R, Jiang W, et al. Protective effect of astragaloside IV against paraquat-induced lung injury in mice by suppressing Rho signaling. Inflammation. 2016;39:483–492.