Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice

Yaoxue Xuebao

Volumn 45, Issue 10, 2010, Pages 1239-1246

  Hu, Qing Hua ^a   Zhang, Xian ^a   Wang, Yu ^a   Kong, Ling Dong ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Hyperuricemia; Mangiferin; Renal transporter; Uromodulin

Indexed keywords

ALLOPURINOL; CARNITINE TRANSPORTER; CARRIER PROTEIN; GLUCOSE TRANSPORTER 9; MANGIFERIN; MESSENGER RNA; ORGANIC ANION TRANSPORTER; PROTEIN; TAMM HORSFALL GLYCOPROTEIN; UNCLASSIFIED DRUG; URATE TRANSPORTER 1; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERURICEMIA; KIDNEY FUNCTION; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL; URIC ACID URINE LEVEL; WESTERN BLOTTING;

ANIMALS; BLOOD UREA NITROGEN; CARRIER PROTEINS; CREATININE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HYPERURICEMIA; KIDNEY; MALE; MEMBRANE PROTEINS; MICE; OCTAMER TRANSCRIPTION FACTOR-1; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS; ORGANIC CATION TRANSPORT PROTEINS; OXONIC ACID; PROTECTIVE AGENTS; RANDOM ALLOCATION; RNA, MESSENGER; URIC ACID; UROMODULIN; XANTHONES;

EID: 78650184510     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Choi HK, Mount DB, Reginato AM. Pathogenesis of gout [J]. Ann Intern Med, 2005, 143: 499-516.
2. Kojima R, Sekine T, Kawachi M, et al. Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3 in rat kidney [J]. J Am Soc Nephrol, 2002, 13: 848-857. (Pubitemid 34274080)
3. Enomoto A, Kimura H, Chairoungdua A, et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels [J]. Nature, 2002, 417: 447-452.
4. Vitart V, Rudan I, Hayward C, et al. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout [J]. Nat Genet, 2008, 40: 437-442.
5. Karbach U, Kricke J, Meyer-Wentrup F, et al. Localization of organic cation transporters OCT1 and OCT2 in rat kidney [J]. Am J Physiol Renal Physiol, 2000, 279: 679-687.
6. Wang FC, Guo RC. Advances in the study of regulation of novel organic cation transporter-2 [J]. Acta Pharm Sin, 2009, 44: 1061-1065.
7. Calado J, Gaspar FJ, Clement C, et al. A novel heterozygous missense mutation in the UMOD gene responsible for familial juvenile hyperuricemic nephropathy [J]. BMC Med Genet, 2005, 6: 5-9.
8. Yasushi H, Ikuko Y, Ayako T, et al. Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2 [J]. Biochem Pharmacol, 2003, 66: 1107-1114.
9. Hu QH, Wang C, Li JM, et al. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement [J]. Am J Physiol Renal Physiol, 2009, 297: 1080-1091.
10. Hu QH, Jiao RQ, Wang X, et al. Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice [J]. J Ethnopharmacol, 2010, 128: 685-692.
11. Sanchez GM, Re L, Giuliani A, et al. Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice [J]. Pharmacol Res, 2000, 42: 565-573.
12. Garciaa D, Delgadob R, Ubeira FM. Modulation of rat macrophage function by the Mangifera indica L. extracts vimang and mangiferin [J]. Int Immunopharmacol, 2002, 2: 797-806.
13. Muruganandan S, Gupta S, Kataria M, et al. Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats [J]. Toxicology, 2002, 176: 165-173. (Pubitemid 34692590)
14. Mo SF. Effects of Flavonoids on Serum and Hepatic Uric Acid Levels in Mice and Xanthine Dehydrogenase and Xanthine Oxidase Activities in Mouse Liver [D]. Nanjing: Nanjing University, 2006.
15. Prabhu S, Jainua M, Sabithaa KE, et al. Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats [J]. J Ethnopharmacol, 2006, 107: 126-133. (Pubitemid 44038820)
16. Li X, Cui XB, Sun XY, et al. Mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats [J]. Phytother Res, 2010, 24: 893-899.