Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

American Journal of Human Genetics

Volumn 102, Issue 1, 2018, Pages 88-102

  Medina Gomez, Carolina ^a   Kemp, John P ^b,c   Trajanoska, Katerina ^a   Luan, Jian'an ^d   Chesi, Alessandra ^e   Ahluwalia, Tarunveer S ^f,g   Mook Kanamori, Dennis O ^h   Ham, Annelies ^a   Hartwig, Fernando P ⁱ   Evans, Daniel S ^j   Joro, Raimo ^k   Nedeljkovic, Ivana ^a   Zheng, Hou Feng ^l,m,n,o   Zhu, Kun ^p,q   Atalay, Mustafa ^k   Liu, Ching Ti ^r   Nethander, Maria ^s   Broer, Linda ^a   Porleifsson, Gudmar ^t   Mullin, Benjamin H ^p,q   Handelman, Samuel K ^u   Nalls, Mike A ^v,w   Jessen, Leon E ^f   Heppe, Denise H M ^a   Richards, J Brent ^l,m   Wang, Carol ^x   Chawes, Bo ^f   Schraut, Katharina E ^y,z   Amin, Najaf ^a   Wareham, Nick ^d   Karasik, David ^aa,ab   Van der Velde, Nathalie ^a,ac   Ikram, M Arfan ^a   Zemel, Babette S ^e   Zhou, Yanhua ^r   Carlsson, Christian J ^f   Liu, Yongmei ^ad   McGuigan, Fiona E ^ae   Boer, Cindy G ^a   Bønnelykke, Klaus ^f   Ralston, Stuart H ^af   Robbins, John A ^ag   Walsh, John P ^p,q   Zillikens, M Carola ^a   Langenberg, Claudia ^d   Li Gao, Ruifang ^h   Williams, Frances M K ^ah   Harris, Tamara B ^v   Akesson, Kristina ^ae,ai   Jackson, Rebecca D ^aj   Sigurdsson, Gunnar ^ak,al   den Heijer, Martin ^h,am   van der Eerden, Bram C J ^a   van de Peppel, Jeroen ^a   Spector, Timothy D ^ah   Pennell, Craig ^x   Horta, Bernardo L ⁱ   Felix, Janine F ^a   Zhao, Jing Hua ^d   Wilson, Scott G ^p,q,ah   de Mutsert, Renée ^h   Bisgaard, Hans ^f   Styrkársdóttir, Unnur ^t   Jaddoe, Vincent W ^a   Orwoll, Eric ^an   Lakka, Timo A ^k,ao   Scott, Robert ^d   Grant, Struan F A ^e,ap   Lorentzon, Mattias ^aq   van Duijn, Cornelia M ^a   Wilson, James F ^y,ar   Stefansson, Kari ^t,ak   Psaty, Bruce M ^as,at   Kiel, Douglas P ^aa,au,av   Ohlsson, Claes ^s   Ntzani, Evangelia ^aw   van Wijnen, Andre J ^ax   Forgetta, Vincenzo ^l,m   Ghanbari, Mohsen ^a,ay   Logan, John G ^az   Williams, Graham R ^az   Bassett, J H Duncan ^az   Croucher, Peter I ^ba   Evangelou, Evangelos ^aw,az   Uitterlinden, Andre G ^a   Ackert Bicknell, Cheryl L ^bb   Tobias, Jonathan H ^c   Evans, David M ^b,c   Rivadeneira, Fernando ^a   more..

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g STENO DIABETES CENTER   (Denmark)

^h LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁱ FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

^j CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^k UNIVERSITY OF EASTERN FINLAND   (Finland)

^l MCGILL UNIVERSITY   (Canada)

^m MCGILL UNIVERSITY   (Canada)

ⁿ WESTLAKE UNIVERSITY   (China)

^o HANGZHOU NORMAL UNIVERSITY   (China)

^p SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^q UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^r BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^s UNIVERSITY OF GOTHENBURG   (Sweden)

^t DECODE GENETICS   (Iceland)

^u WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^v NATIONAL INSTITUTE ON AGING   (United States)

^w Data Tecnica International LLC   (United States)

^x UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^y UNIVERSITY OF EDINBURGH   (United Kingdom)

^z UNIVERSITY OF EDINBURGH   (United Kingdom)

^aa Hebrew Senior Life   (United States)

^ab BAR ILAN UNIVERSITY   (Israel)

^ac ACADEMIC MEDICAL CENTER   (Netherlands)

^ad WAKE FOREST SCHOOL OF MEDICINE   (United States)

^ae LUND UNIVERSITY   (Sweden)

^af UNIVERSITY OF EDINBURGH   (United Kingdom)

^ag UNIVERSITY OF CALIFORNIA   (United States)

^ah KING'S COLLEGE LONDON   (United Kingdom)

^ai LUND UNIVERSITY HOSPITAL   (Sweden)

^aj OHIO STATE UNIVERSITY   (United States)

^ak LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^al UNIVERSITY OF ICELAND   (Iceland)

^am VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^an OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^ao KUOPIO UNIVERSITY HOSPITAL   (Finland)

^ap UNIVERSITY OF PENNSYLVANIA   (United States)

^aq UNIVERSITY OF GOTHENBURG   (Sweden)

^ar UNIVERSITY OF EDINBURGH   (United Kingdom)

^as UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^at KAISER PERMANENTE   (United States)

^au HARVARD MEDICAL SCHOOL   (United States)

^av BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^aw UNIVERSITY OF IOANNINA   (Greece)

^ax MAYO CLINIC   (United States)

^ay MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^az IMPERIAL COLLEGE LONDON   (United Kingdom)

^ba GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^bb UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

more..

Author keywords

age dependent effects; BMD; bone mineral density; CREB3L1; ESR1; fracture; genetic correlation; genome wide association studies; GWASs; meta regression; RANKL; total body DXA

Indexed keywords

ESTROGEN RECEPTOR ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; SMAD PROTEIN;

AGE; ARTICLE; BONE DENSITY; CELL GROWTH; DUAL ENERGY X RAY ABSORPTIOMETRY; ENHANCER REGION; FRACTURE; GENE CLUSTER; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE OVEREXPRESSION; GENETIC TRAIT; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HERITABILITY; HUMAN; MUSCULOSKELETAL SYSTEM; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW; ADOLESCENT; ANIMAL; CHILD; GENETICS; INFANT; KNOCKOUT MOUSE; META ANALYSIS; NEWBORN; PRESCHOOL CHILD; QUANTITATIVE TRAIT; REGRESSION ANALYSIS;

ADOLESCENT; AGE FACTORS; ANIMALS; BONE DENSITY; CHILD; CHILD, PRESCHOOL; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INFANT; INFANT, NEWBORN; MICE, KNOCKOUT; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; REGRESSION ANALYSIS;

EID: 85039787162     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2017.12.005     Document Type: Article

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