-
1
-
-
84868488604
-
New developments in osteoimmunology
-
Takayanagi H,. New developments in osteoimmunology. Nat Rev Rheumatol 2012; 8: 684-9.
-
(2012)
Nat Rev Rheumatol
, vol.8
, pp. 684-689
-
-
Takayanagi, H.1
-
2
-
-
0031894140
-
Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis
-
Gravallese EM, Harada Y, Wang JT, Gorn AH, Thornhill TS, Goldring SR,. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol 1998; 152: 943-51.
-
(1998)
Am J Pathol
, vol.152
, pp. 943-951
-
-
Gravallese, E.M.1
Harada, Y.2
Wang, J.T.3
Gorn, A.H.4
Thornhill, T.S.5
Goldring, S.R.6
-
3
-
-
75049085147
-
Osteoimmunology and the effects of the immune system on bone
-
Takayanagi H,. Osteoimmunology and the effects of the immune system on bone. Nat Rev Rheumatol 2009; 5: 667-76.
-
(2009)
Nat Rev Rheumatol
, vol.5
, pp. 667-676
-
-
Takayanagi, H.1
-
4
-
-
7344243723
-
Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-γ receptor
-
Kageyama Y, Koide Y, Yoshida A, Uchijima M, Arai T, Miyamoto S, et al., Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-γ receptor. J Immunol 1998; 161: 1542-8.
-
(1998)
J Immunol
, vol.161
, pp. 1542-1548
-
-
Kageyama, Y.1
Koide, Y.2
Yoshida, A.3
Uchijima, M.4
Arai, T.5
Miyamoto, S.6
-
5
-
-
13444256307
-
The role of T-cell interleukin-17 in conducting destructive arthritis: Lessons from animal models
-
Lubberts E, Koenders MI, van den Berg WB,. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 2005; 7: 29-37.
-
(2005)
Arthritis Res Ther
, vol.7
, pp. 29-37
-
-
Lubberts, E.1
Koenders, M.I.2
Van Den Berg, W.B.3
-
6
-
-
52949151882
-
New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation
-
Wei L, Laurence A, O'Shea JJ,. New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation. Semin Cell Dev Biol 2008; 19: 394-400.
-
(2008)
Semin Cell Dev Biol
, vol.19
, pp. 394-400
-
-
Wei, L.1
Laurence, A.2
O'Shea, J.J.3
-
7
-
-
33947583822
-
Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems
-
Takayanagi H,. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 2007; 7: 292-304.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 292-304
-
-
Takayanagi, H.1
-
9
-
-
3543140687
-
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
-
Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, et al., Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J Exp Med 2004; 200: 277-85.
-
(2004)
J Exp Med
, vol.200
, pp. 277-285
-
-
Ehrenstein, M.R.1
Evans, J.G.2
Singh, A.3
Moore, S.4
Warnes, G.5
Isenberg, D.A.6
-
10
-
-
17644384896
-
+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
-
+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 2005; 140: 360-7.
-
(2005)
Clin Exp Immunol
, vol.140
, pp. 360-367
-
-
Mottonen, M.1
Heikkinen, J.2
Mustonen, L.3
Isomaki, P.4
Luukkainen, R.5
Lassila, O.6
-
11
-
-
0033758633
-
Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis
-
Schett G, Tohidast-Akrad M, Smolen JS, Schmid BJ, Steiner CW, Bitzan P, et al., Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. Arthritis Rheum 2000; 43: 2501-12.
-
(2000)
Arthritis Rheum
, vol.43
, pp. 2501-2512
-
-
Schett, G.1
Tohidast-Akrad, M.2
Smolen, J.S.3
Schmid, B.J.4
Steiner, C.W.5
Bitzan, P.6
-
12
-
-
43049101029
-
Dual-specificity MAP kinase phosphatases (MKPs) and cancer
-
Keyse SM,. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev 2008; 27: 253-61.
-
(2008)
Cancer Metastasis Rev
, vol.27
, pp. 253-261
-
-
Keyse, S.M.1
-
13
-
-
77956963274
-
DUSP5 and DUSP6 modulate corneal epithelial cell proliferation
-
Wang Z, Reinach PS, Zhang F, Vellonen KS, Urtti A, Turner H, et al., DUSP5 and DUSP6 modulate corneal epithelial cell proliferation. Mol Vis 2010; 16: 1696-704.
-
(2010)
Mol Vis
, vol.16
, pp. 1696-1704
-
-
Wang, Z.1
Reinach, P.S.2
Zhang, F.3
Vellonen, K.S.4
Urtti, A.5
Turner, H.6
-
14
-
-
76249124674
-
ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis
-
Singh K, Deshpande P, Pryshchep S, Colmegna I, Liarski V, Weyand CM, et al., ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis. J Immunol 2009; 183: 8258-67.
-
(2009)
J Immunol
, vol.183
, pp. 8258-8267
-
-
Singh, K.1
Deshpande, P.2
Pryshchep, S.3
Colmegna, I.4
Liarski, V.5
Weyand, C.M.6
-
15
-
-
11844262129
-
Delivery of siRNA and siRNA expression constructs to adult mammals by hydrodynamic intravascular injection
-
Lewis DL, Wolff JA,. Delivery of siRNA and siRNA expression constructs to adult mammals by hydrodynamic intravascular injection. Methods Enzymol 2005; 392: 336-50.
-
(2005)
Methods Enzymol
, vol.392
, pp. 336-350
-
-
Lewis, D.L.1
Wolff, J.A.2
-
16
-
-
0034269179
-
High-level protein secretion into blood circulation after electric pulse-mediated gene transfer into skeletal muscle
-
Bettan M, Emmanuel F, Darteil R, Caillaud JM, Soubrier F, Delaere P, et al., High-level protein secretion into blood circulation after electric pulse-mediated gene transfer into skeletal muscle. Mol Ther 2000; 2: 204-10.
-
(2000)
Mol Ther
, vol.2
, pp. 204-210
-
-
Bettan, M.1
Emmanuel, F.2
Darteil, R.3
Caillaud, J.M.4
Soubrier, F.5
Delaere, P.6
-
19
-
-
84863861008
-
Understanding the dynamics: Pathways involved in the pathogenesis of rheumatoid arthritis
-
Choy E,. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 2012; 51 Suppl 5: v3-11.
-
(2012)
Rheumatology (Oxford)
, vol.51
, pp. v3-v11
-
-
Choy, E.1
-
20
-
-
80051669017
-
Angiogenesis in rheumatoid arthritis: A disease specific process or a common response to chronic inflammation?
-
Marrelli A, Cipriani P, Liakouli V, Carubbi F, Perricone C, Perricone R, et al., Angiogenesis in rheumatoid arthritis: a disease specific process or a common response to chronic inflammation? Autoimmun Rev 2011; 10: 595-8.
-
(2011)
Autoimmun Rev
, vol.10
, pp. 595-598
-
-
Marrelli, A.1
Cipriani, P.2
Liakouli, V.3
Carubbi, F.4
Perricone, C.5
Perricone, R.6
-
21
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N, Gerber HP, LeCouter J,. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-76.
-
(2003)
Nat Med
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
22
-
-
0035463151
-
Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis
-
Fraser A, Fearon U, Reece R, Emery P, Veale DJ,. Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis. Arthritis Rheum 2001; 44: 2024-8.
-
(2001)
Arthritis Rheum
, vol.44
, pp. 2024-2028
-
-
Fraser, A.1
Fearon, U.2
Reece, R.3
Emery, P.4
Veale, D.J.5
-
23
-
-
36849036211
-
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
-
Wei L, Laurence A, Elias KM, O'Shea JJ,. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem 2007; 282: 34605-10.
-
(2007)
J Biol Chem
, vol.282
, pp. 34605-34610
-
-
Wei, L.1
Laurence, A.2
Elias, K.M.3
O'Shea, J.J.4
-
26
-
-
0032872521
-
Jun N-terminal kinase in rheumatoid arthritis
-
Han Z, Boyle DL, Aupperle KR, Bennett B, Manning AM, Firestein GS,. Jun N-terminal kinase in rheumatoid arthritis. J Pharmacol Exp Ther 1999; 291: 124-30.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 124-130
-
-
Han, Z.1
Boyle, D.L.2
Aupperle, K.R.3
Bennett, B.4
Manning, A.M.5
Firestein, G.S.6
-
27
-
-
33749370145
-
Differential tissue expression and activation of p38 MAPK α, β, γ, and δ isoforms in rheumatoid arthritis
-
Korb A, Tohidast-Akrad M, Cetin E, Axmann R, Smolen J, Schett G,. Differential tissue expression and activation of p38 MAPK α, β, γ, and δ isoforms in rheumatoid arthritis. Arthritis Rheum 2006; 54: 2745-56.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2745-2756
-
-
Korb, A.1
Tohidast-Akrad, M.2
Cetin, E.3
Axmann, R.4
Smolen, J.5
Schett, G.6
-
28
-
-
59649114148
-
Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis
-
Cohen SB, Cheng TT, Chindalore V, Damjanov N, Burgos-Vargas R, DeLora P, et al., Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis. Arthritis Rheum 2009; 60: 335-44.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 335-344
-
-
Cohen, S.B.1
Cheng, T.T.2
Chindalore, V.3
Damjanov, N.4
Burgos-Vargas, R.5
DeLora, P.6
-
29
-
-
66049086274
-
Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies
-
Damjanov N, Kauffman RS, Spencer-Green GT,. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum 2009; 60: 1232-41.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1232-1241
-
-
Damjanov, N.1
Kauffman, R.S.2
Spencer-Green, G.T.3
-
30
-
-
79955563297
-
A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis
-
Genovese MC, Cohen SB, Wofsy D, Weinblatt ME, Firestein GS, Brahn E, et al., A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis. J Rheumatol 2011; 38: 846-54.
-
(2011)
J Rheumatol
, vol.38
, pp. 846-854
-
-
Genovese, M.C.1
Cohen, S.B.2
Wofsy, D.3
Weinblatt, M.E.4
Firestein, G.S.5
Brahn, E.6
-
31
-
-
24944521495
-
Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: Discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent
-
Miwatashi S, Arikawa Y, Kotani E, Miyamoto M, Naruo K, Kimura H, et al., Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J Med Chem 2005; 48: 5966-79.
-
(2005)
J Med Chem
, vol.48
, pp. 5966-5979
-
-
Miwatashi, S.1
Arikawa, Y.2
Kotani, E.3
Miyamoto, M.4
Naruo, K.5
Kimura, H.6
-
32
-
-
0242473165
-
Feedback control of the protein kinase TAK1 by SAPK2a/p38α
-
Cheung PC, Campbell DG, Nebreda AR, Cohen P,. Feedback control of the protein kinase TAK1 by SAPK2a/p38α. EMBO J 2003; 22: 5793-805.
-
(2003)
EMBO J
, vol.22
, pp. 5793-5805
-
-
Cheung, P.C.1
Campbell, D.G.2
Nebreda, A.R.3
Cohen, P.4
-
33
-
-
14044251529
-
Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5
-
Mandl M, Slack DN, Keyse SM,. Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5. Mol Cell Biol 2005; 25: 1830-45.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 1830-1845
-
-
Mandl, M.1
Slack, D.N.2
Keyse, S.M.3
-
34
-
-
15444371183
-
Signal transduction by IL-2 and its receptors as target in treatment of rheumatoid arthritis
-
Kozanidou VI, Theocharis AD, Georgiadis A, Voulgari PV, Drosos AA, Karamanos NK,. Signal transduction by IL-2 and its receptors as target in treatment of rheumatoid arthritis. Curr Drug Targets Immune Endocr Metabol Disord 2005; 5: 41-50.
-
(2005)
Curr Drug Targets Immune Endocr Metabol Disord
, vol.5
, pp. 41-50
-
-
Kozanidou, V.I.1
Theocharis, A.D.2
Georgiadis, A.3
Voulgari, P.V.4
Drosos, A.A.5
Karamanos, N.K.6
-
35
-
-
0038813748
-
c-family cytokine target genes: Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling
-
c-family cytokine target genes: identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling. J Biol Chem 2003; 278: 5205-13.
-
(2003)
J Biol Chem
, vol.278
, pp. 5205-5213
-
-
Kovanen, P.E.1
Rosenwald, A.2
Fu, J.3
Hurt, E.M.4
Lam, L.T.5
Giltnane, J.M.6
|