Targeted deletion of Btg1 and Btg2 results in homeotic transformation of the axial skeleton

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Tijchon, Esther ^a   Van Ingen Schenau, Dorette ^a   Van Opzeeland, Fred ^a   Tirone, Felice ^b   Hoogerbrugge, Peter M ^c   Van Leeuwen, Frank N ^a   Scheijen, Blanca ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CNR   (Italy)

^c University Medical Center Utrecht Princess Máxima Center for Pediatric Oncology   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXIAL SKELETON; B CELL TRANSLOCATION GENE 1; B CELL TRANSLOCATION GENE 2; BTG1 GENE; BTG2 GENE; CERVICAL SPINE; CONTROLLED STUDY; DEVELOPMENT; EMBRYO; GENE; GENE DELETION; GENE LOSS; HOMEOTIC TRANSFORMATION; IN VIVO STUDY; INHERITANCE; KNOCKOUT MOUSE; LITTER SIZE; LUMBAR VERTEBRA; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; SKELETON; VERTEBRA; ANIMAL; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; SPINE;

BTG1 PROTEIN, MOUSE; BTG2 PROTEIN, MOUSE; IMMEDIATE EARLY PROTEIN; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMALS; IMMEDIATE-EARLY PROTEINS; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; PHENOTYPE; SPINE; TUMOR SUPPRESSOR PROTEINS;

EID: 84941710697     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0131481     Document Type: Article

References (41)

1. Dubrulle J, Pourquie O. Coupling segmentation to axis formation. Development. 2004; 131(23):5783-93. Epub 2004/11/13. PMID: 15539483
2. Hirsinger E, Jouve C, Dubrulle J, Pourquie O. Somite formation and patterning. International review of cytology. 2000; 198:1-65. Epub 2000/05/11. PMID: 10804460
3. Krumlauf R. Hox genes in vertebrate development. Cell. 1994; 78(2):191-201. Epub 1994/07/29. PMID: 7913880
4. Duboule D. The rise and fall of Hox gene clusters. Development. 2007; 134(14):2549-60. Epub 2007/06/08. PMID: 17553908
5. Duboule D, Dolle P. The structural and functional organization of the murine HOX gene family resembles that of Drosophilahomeotic genes. The EMBO journal. 1989; 8(5):1497-505. Epub 1989/05/01. PMID: 2569969
6. Graham A, Papalopulu N, Krumlauf R. The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell. 1989; 57(3):367-78. Epub 1989/05/05. PMID: 2566383
7. Alexander T, Nolte C, Krumlauf R. Hox genes and segmentation of the hindbrain and axial skeleton. Annual review of cell and developmental biology. 2009;25:431-56. Epub 2009/07/07. doi: 10.1146/annurev.cellbio.042308.113423 PMID: 19575673
8. Mallo M, Wellik DM, Deschamps J. Hox genes and regional patterning of the vertebrate body plan. Developmental biology. 2010; 344(1):7-15. Epub 2010/05/04. doi: 10.1016/j.ydbio.2010.04.024 PMID: 20435029
9. Tschopp P, Duboule D. A genetic approach to the transcriptional regulation of Hox gene clusters. Annual review of genetics. 2011; 45:145-66. Epub 2011/11/09. doi: 10.1146/annurev-genet-102209-163429 PMID: 22060042
10. Cernilogar FM, Orlando V. Epigenome programming by Polycomb and Trithorax proteins. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2005; 83(3):322-31. Epub 2005/06/17. PMID: 15959558
11. Grimaud C, Negre N, Cavalli G. From genetics to epigenetics: the tale of Polycomb group and trithorax group genes. Chromosome research: an international journal on the molecular, supramolecularand evolutionary aspects of chromosome biology. 2006; 14(4):363-75. Epub 2006/07/06.
12. Mallo M, Vinagre T, Carapuco M. The road to the vertebral formula. The International journal of developmental biology. 2009; 53(8-10):1469-81. Epub 2009/02/28. doi: 10.1387/ijdb.072276mm PMID: 19247958
13. Benazeraf B, Pourquie O. Formation and segmentation of the vertebrate body axis. Annual review of cell and developmental biology. 2013; 29:1-26. Epub 2013/07/03. doi: 10.1146/annurev-cellbio-101011-155703 PMID: 23808844
14. Rouault JP, Falette N, Guehenneux F, Guillot C, Rimokh R, Wang Q, et al. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nature genetics. 1996; 14(4):482-6. Epub 1996/12/01. PMID: 8944033
15. Winkler GS. The mammalian anti-proliferative BTG/Tob protein family. Journal of cellular physiology. 2010; 222(1):66-72. Epub 2009/09/12. doi: 10.1002/jcp.21919 PMID: 19746446
16. Sun Q, Hang M, Guo X, Shao W, Zeng G. Expression and significance of miRNA-21 and BTG2in lung cancer. Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine. 2013; 34(6):4017-26. Epub 2013/07/17.
17. Zhao Y, Gou WF, Chen S, Takano Y, Xiu YL, Zheng HC. BTG1 expression correlates with the pathogenesis and progression of ovarian carcinomas. International journal of molecular sciences. 2013; 14 (10):19670-80. Epub 2013/10/03. doi: 10.3390/ijms141019670 PMID: 24084718
18. Kuiper RP, Schoenmakers EF, van Reijmersdal SV, Hehir-Kwa JY, van Kessel AG, van Leeuwen FN, et al. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia. 2007; 21 (6):1258-66. Epub 2007/04/20. PMID: 17443227
19. Sheng SH, Zhao CM, Sun GG. BTG1 expression correlates with the pathogenesis and progression of breast carcinomas. Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014; 35(4):3317-26. Epub 2013/11/26.
20. Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007; 446(7137):758-64. Epub 2007/03/09. PMID: 17344859
21. Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(10):3879-84. Epub 2012/02/22. doi: 10.1073/pnas.1121343109 PMID: 22343534
22. Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011; 476(7360):298-303. Epub 2011/07/29. doi: 10.1038/nature10351 PMID: 21796119
23. Park S, Lee YJ, Lee HJ, Seki T, Hong KH, Park J, et al. B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Molecular and cellular biology. 2004; 24(23):10256-62. Epub 2004/11/16. PMID: 15542835
24. Prevot D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, et al. The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation. The Journal of biological chemistry. 2000; 275(1):147-53. Epub 2000/01/05. PMID: 10617598
25. Alharbi RA, Pettengell R, Pandha HS, Morgan R. The role of HOX genes in normal hematopoiesis and acute leukemia. Leukemia. 2013; 27(5):1000-8. Epub 2012/12/06. doi: 10.1038/leu.2012.356 PMID: 23212154
26. Radulovic V, de Haan G, Klauke K. Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms. Leukemia. 2013; 27(3):523-33. Epub 2012/12/22. doi: 10.1038/leu.2012. 368 PMID: 23257781
27. Casaca A, Santos AC, Mallo M. Controlling Hox gene expression and activity to build the vertebrate axial skeleton. Developmental dynamics: an official publication of the American Association of Anatomists. 2014; 243(1):24-36. Epub 2013/07/03.
28. Farioli-Vecchioli S, Micheli L, Saraulli D, Ceccarelli M, Cannas S, Scardigli R, et al. Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and SubventricularZone. Frontiers in neuroscience. 2012; 6:124. Epub 2012/09/13. doi: 10.3389/fnins.2012.00124 PMID: 22969701
29. Horan GS, Wu K, Wolgemuth DJ, Behringer RR. Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 1994; 91(26):12644-8. Epub 1994/12/20. PMID: 7809093
30. Ding M, Lu Y, Abbassi S, Li F, Li X, Song Y, et al. Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development. Journal of cellular physiology. 2012; 227(10):3446-56. Epub 2012/01/10. doi: 10.1002/jcp.24045 PMID: 22223437
31. Soungdo Y, Talebian L, Matheny CJ, Guzzo R, Speck ME, Lieberman JR, et al. Runx1 dose-depen-dently regulates endochondral ossification during skeletal development and fracture healing. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research. 2012; 27(7):1585-97. Epub 2012/03/21.
32. van der Lugt NM, Domen J, Linders K, van Roon M, Robanus-Maandag E, te Riele H, et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes & development. 1994; 8(7):757-69. Epub 1994/04/01.
33. Core N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A, et al. Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development. 1997; 124(3):721-9. Epub 1997/02/01. PMID: 9043087
34. Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M, et al. Mice doubly deficient for the Polycomb Group genes Mel18andBmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development. 2001; 128(9):1587-97. Epub 2001/04/06. PMID: 11290297
35. Bel S, Core N, Djabali M, Kieboom K, Van der Lugt N, Alkema MJ, et al. Genetic interactions and dosage effects of Polycomb group genes in mice. Development. 1998; 125(18):3543-51. Epub 1998/08/26. PMID: 9716520
36. Storre J, Elsasser HP, Fuchs M, Ullmann D, Livingston DM, Gaubatz S. Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6. EMBO reports. 2002; 3(7):695-700. Epub 2002/07/09. PMID: 12101104
37. Attwooll C, Lazzerini Denchi E, Helin K. The E2F family: specific functions and overlapping interests. The EMBO journal. 2004; 23(24):4709-16. Epub 2004/11/13. PMID: 15538380
38. Trimarchi JM, Fairchild B, Wen J, Lees JA. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(4):1519-24. Epub 2001/02/15. PMID: 11171983
39. Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H. Mammalian polycomb-medi-ated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes & development. 2005; 19(5):536-41. Epub 2005/03/03.
40. Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y. A complex with chromatin modifiers that occupies E2F-and Myc-responsive genes in G0 cells. Science. 2002; 296(5570):1132-6. Epub 2002/05/11. PMID: 12004135
41. Courel M, Friesenhahn L, Lees JA. E2f6 and Bmi1 cooperate in axial skeletal development. Developmental dynamics: an official publication of the American Association of Anatomists. 2008; 237 (5):1232-42. Epub 2008/03/28.