Assessment of circulating sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 1, 2010, Pages 82-92

  Courant, Frédérique ^a   Aksglaede, Lise ^b   Antignac, Jean Philippe ^a   Monteau, Fabrice ^a   Sorensen, Kaspar ^b   Andersson, Anna Maria ^b   Skakkebaek, Niels E ^b   Juul, Anders ^b   Bizec, Bruno Le ^a  

^a Waters Corporation   (France)

^b Mental Health Services CPH   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

17BETA TESTOSTERONE; 5BETA ANDROSTANOLONE; ANDROSTANOLONE; ANDROSTERONE; EPITESTOSTERONE; ESTRADIOL; ESTROGEN; ESTRONE; ETIOCHOLANOLONE; SEX HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; HAIR GROWTH; HORMONE BLOOD LEVEL; HUMAN; MALE; PREPUBERTY; PRESCHOOL CHILD; PRIORITY JOURNAL; PUBERTY; SCHOOL CHILD; SEX DIFFERENCE; TANDEM MASS SPECTROMETRY;

EID: 75149182254     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1140     Document Type: Article

References (40)

1. Ross JL, Long LM, Skerda M, Cassorla F, Kurtz D, Loriaux DL, Cutler Jr GB 1986 Effect of low doses of estradiol on 6-month growth rates and predicted height in patients with Turner syndrome. J Pediatr 109:950-953
2. Klein KO, Baron J, Colli MJ, McDonnell DP, Cutler Jr GB 1994 Estrogen levels in childhood determined by ultrasensitive recombinant cell bioassay. J Clin Invest 94:2475-2480
3. Henley DV, Lipson N, Korach KS, Bloch CA 2007 Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med 356: 479-485
4. Zimmerman PA, Francis GL, Poth M 1995 Hormone-containing cosmetics may cause signs of early sexual development. Mil Med 160:628-630
5. Felner EI, White PC 2000 Prepubertal gynecomastia: indirect exposure to estrogen cream. Pediatrics 105:E55
6. Karpe B, Fredricsson B, Svensson J, Ritzén EM 1982 Testosterone concentration within the tunica vaginalis of boys and adult men. International Journal of Andrology 5:549-556
7. Bay K, Andersson AM, Skakkebaek NE 2004 Estradiol levels in prepubertal boys and girls-analytical challenges. Int J Androl 27: 266-273
8. Ikegami S, Moriwaki T, Tanaka H 2001 An ultrasensitive assay revealed age-related changes in serum oestradiol at low concentrations in both sexes from infancy to puberty. Clin Endocrinol (Oxf) 55:789-795
9. Norjavaara E, Ankarberg C, Albertsson-Wikland K 1996 Diurnal rhythm of 17β-estradiol secretion throughout pubertal development in healthy girls: evaluation by a sensitive radioimmunoassay. J Clin Endocrinol Metab 81:4095-4102
10. Kushnir MM, Rockwood AL, Bergquist J, Varshavsky M, Roberts WL, Yue B, Bunker AM, Meikle AW 2008 High-sensitivity tandem mass spectrometry assay for serum estrone and estradiol. American Journal of Clinical Pathology 129:530-539
11. Potischman N, Falk RT, Laiming VA, Siiteri PK, Hoover RN 1994 Reproducibility of laboratory assays for steroid hormones and sex hormone-binding globulin. Cancer Res 54:5363-5367
12. Carlström K 1996 Low endogenous estrogen levels: analytical problems and tissue sensitivity. Acta Obstet Gynecol Scand Suppl 163: 11-15
13. Biancotto G, Angeletti R, Traldi P, Silvestri M, Saccon M, Guidugli F 2002 Determination of 17β-estradiol in bovine plasma: development of a highly sensitive technique by ion trap gas chromatography-tandem mass-spectrometry using negative chemical ionization. J Mass Spectrom 37:1266-1271
14. Nelson RE, Grebe SK, OKane DJ, Singh RJ 2004 Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasma. Clin Chem 50:373-384
15. Courant F, Antignac JP, Maume D, Monteau F, Andersson AM, Skakkebaek N, Andre F, Le Bizec B 2007 Exposure assessment of prepubertal children to steroid endocrine disrupters 1. Analytical strategy for estrogens measurement in plasma at ultra-trace level. Anal Chim Acta 586:105-114
16. Aksglaede L, Sørensen K, Petersen JH, Skakkebaek NE, Juul A 2009 Recent decline in age at breast development. The Copenhagen Puberty Study. Pediatrics 123:e932-e939
17. Sørensen K, Aksglaede L, Munch-Andersen T, Aachmann-Andersen NJ, Petersen JH, Hilsted L, Helge JW, Juul A 2009 Sex hormone-binding globulin levels predict insulin sensitivity, disposition index and cardiovascular risk during puberty. Diabetes Care 32:909-914
18. Juul A, Sørensen K, Aksglaede L, Garn I, Rajpert-De Meyts E, Hullstein I, Hemmersbach P, Ottesen AM 2009 A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys. J Clin Endocrinol Metab 94:1005-1011
19. Tanner JM, Whitehouse RH 1976 Clinical longitudinal Standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 51:170-179
20. Courant F, Antignac J, Maume D, Monteau F, Andre F, Le Bizec B 2007 Determination of naturally occurring estrogens and androgens in retail samples of milk and eggs. Food Addit Contam 24:1358-1366
21. Courant F, Antignac J, Laille J, Monteau F, Andre F, Le Bizec B 2008 Exposure assessment of prepubertal children to steroid endocrine disrupters. 2. Determination of steroid hormones in milk, egg, and meat samples. J Agric Food Chem 56:3176-3184
22. Horwitz W 1984 Effects of scientific advances on the decision-making process: analytical chemistry. Fundam Appl Toxicol 4(3 Pt 2): S309-S317
23. Thijssen JH 2004 Local biosynthesis and metabolism of estrogens in the human breast. Maturitas 49:25-33
24. Gässler N, Peuschel T, Pankau R 2000 Pediatric reference values of estradiol, testosterone, lutropin, follitropin and prolactin. Clin Lab 46:553-560
25. Mitamura R, Yano K, Suzuki N, Ito Y, Makita Y, Okuno A 1999 Diurnal rhythms of luteinizing hormone, follicle-stimulating hormone, and testosterone secretion before the onset of male puberty. J Clin Endocrinol Metab 84:29-37
26. Mitamura R, Yano K, Suzuki N, Ito Y, Makita Y, Okuno A 2000 Diurnal rhythms of luteinizing hormone follicle-stimulating hormone testosterone and estradiol secretion before the onset of female puberty in short children. J Clin Endocrinol Metab 85:1074-1080
27. Gupta D, Attanasio A, Raaf S 1975 Plasma estrogen and androgen concentrations in children during adolescence. J Clin Endocrinol Metab 40:636-643
28. Paris F, Servant N, Térouanne B, Sultan C 2002 Evaluation of androgenic bioactivity in human serum by recombinant cell line: preliminary results. Mol Cell Endocrinol 198:123-129
29. Vanluchene E, Eechaute W, Vandekerckhove D 1982 Conversion of free 3β-hydroxy-5-ene-steroids by incubation with Helix pomatia. J Steroid Biochem 16:701-703
30. Messeri G, Cugnetto G, Moneti G, Serio M 1984 Helix pomatia induced conversion of some 3β-hydroxysteroids. J Steroid Biochem 20:793-796
31. Juul A, Teilmann G, Scheike T, Hertel NT, Holm K, Laursen EM, Main KM, Skakkebaek NE 2006 Pubertal development in Danish children: comparison of recent European and US data. Int J Androl 29:247-255; discussion 286-290
32. Nakamura Y, Gang HX, Suzuki T, Sasano H, Rainey WE 2009 Adrenal changes associated with adrenarche. Rev Endocr Metab Disord 10:19-26
33. Remer T, Boye K, Hartmann M, Wudy S 2005 Urinary markers of adrenarche: reference values in healthy subjects, aged 3-18 years. J Clin Endocrinal Metab 90:2015-2021
34. Turan S, Bereket A, Guran T, Akcay T, Papari-Zareei M, Auchus RJ 2009 Puberty in a case with novel 17-hydroxylase mutation and the putative role of estrogens in development of pubic hair. Eur J Endocrinol 160:325-330
35. Albertsson-Wikland K, Rosberg S, Lannering B, Dunkel L, Selstam G, Norjavaara E 1997 Twenty-four-hour profiles of luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol levels: a semilongitudinal study throughout puberty in healthy boys. J Clin Endocrinol Metab 82:541-549
36. Ankarberg-Lindgren C, Norjavaara E 2008 A purification step prior to commercial sensitive immunoassay is necessary to achieve clinical usefulness when quantifying serum 17β-estradiol in prepubertal children. Eur J Endocrinol 158:117-124
37. Janfaza M, Sherman TI, Larmore KA, Brown-Dawson J, Klein KO 2006 Estradiol levels and secretory dynamics in normal girls and boys as determined by an ultrasensitive bioassay: a 10 year experience. J Pediatr Endocrinol Metab 19:901-909
38. Paris F, Servant N, Térouanne B, Balaguer P, Nicolas JC, Sultan C 2002 A new recombinant cell bioassay for ultrasensitive determination of serum estrogenic bioactivity in children. J Clin Endocrinol Metab 87:791-797
39. Ankarberg-Lindgren C, Norjavaara E 2008 Twenty-four hours secretion pattern of serum estradiol in healthy prepubertal and pubertal boys as determined by a validated ultra-sensitive extraction RIA. BMC Endocr Disord 8:10
40. Ankarberg C, Norjavaara E 1999 Diurnal rhythm of testosterone secretion before and throughout puberty in healthy girls: correlation with 17β-estradiol and dehydroepiandrosterone sulfate. J Clin Endocrinol Metab 84:975-984