Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts

Archives of Toxicology

Volumn 92, Issue 4, 2018, Pages 1453-1469

  Mahemuti, Laziyan ^a,c   Chen, Qixuan ^b   Coughlan, Melanie C ^a   Qiao, Cunye ^b   Chepelev, Nikolai L ^c,e   Florian, Maria ^a,c   Dong, Dillon ^a   Woodworth, Robert G ^a   Yan, Jin ^a   Cao, Xu liang ^d   Scoggan, Kylie A ^b,e   Jin, Xiaolei ^a   Willmore, William G ^c  

^a TOXICOLOGY RESEARCH DIVISION   (Canada)

^b Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

^c CARLETON UNIVERSITY   (Canada)

^d FOOD RESEARCH DIVISION   (Canada)

^e Environmental Health Center   (Canada)

Author keywords

ATM signaling; Autophagy; Bisphenol A; Cell cycle arrest; CYP1B1; DNA double strand breaks; Estradiol release; G1 S transition; HSD17B14; Human fetal lung fibroblasts; Nrf2; p53; ROS; Senescence; Steroid synthesis and metabolism; H2AX

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ATM PROTEIN; BETA GALACTOSIDASE; CYTOCHROME P450 1B1; G PROTEIN COUPLED RECEPTOR 30; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GROWTH DIFFERENTIATION FACTOR 15; HEME OXYGENASE 1; HISTONE H2A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; BENZHYDRYL DERIVATIVE; CYP1B1 PROTEIN, HUMAN; ESTRADIOL; HSD17B14 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE; NFE2L2 PROTEIN, HUMAN; PHENOL DERIVATIVE;

ARTICLE; AUTOPHAGY; CELL CYCLE ARREST; CELL MATURATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DNA DAMAGE RESPONSE; DOUBLE STRANDED DNA BREAK; ESTROGEN RELEASE; FETUS LUNG; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; NORMAL HUMAN; OXIDATIVE STRESS; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEOMICS; REGULATORY MECHANISM; RESPIRATORY TRACT DISEASE; SENESCENCE; SIGNAL TRANSDUCTION; STEROIDOGENESIS; UPREGULATION; AIR POLLUTANT; CELL AGING; CELL CYCLE CHECKPOINT; DRUG EFFECT; FIBROBLAST; GENETICS; LUNG; METABOLISM; TOXICITY;

17-HYDROXYSTEROID DEHYDROGENASES; AIR POLLUTANTS, OCCUPATIONAL; AUTOPHAGY; BENZHYDRYL COMPOUNDS; CELL CYCLE CHECKPOINTS; CELLULAR SENESCENCE; CYTOCHROME P-450 CYP1B1; ESTRADIOL; FIBROBLASTS; HUMANS; LUNG; NF-E2-RELATED FACTOR 2; PHENOLS; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 85038859783     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-017-2150-3     Document Type: Article

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