Tissue distribution and relative gene expression of udp- glucuronosyltransferases (2B7, 2B15, 2B17) in the human fetus

Drug Metabolism and Disposition

Volumn 41, Issue 2, 2013, Pages 291-295

  Ekström, Lena ^a   Johansson, Maria ^a   Rane, Anders ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B17; GLUCURONOSYLTRANSFERASE 2B7; MESSENGER RNA; UNCLASSIFIED DRUG;

ADRENAL GLAND; ADULT; ALLELE; ARTICLE; CORRELATION ANALYSIS; FEMALE; FETUS; GENE DELETION; GENE DOSAGE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN TISSUE; KIDNEY PARENCHYMA; LIVER PARENCHYMA; LUNG PARENCHYMA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; UGT2B15 GENE; UGT2B17 GENE; UGT2B7 GENE;

ADRENAL GLANDS; ADULT; AGED; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GESTATIONAL AGE; GLUCURONOSYLTRANSFERASE; HUMANS; KIDNEY; LIVER; LUNG; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 84872717480     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.049197     Document Type: Article

References (31)

1. Bélanger A, Pelletier G, Labrie F, Barbier O, and Chouinard S (2003) Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans. Trends Endocrinol Metab 14:473-479. (Pubitemid 37517349)
2. Bowalgaha K, Elliot DJ, Mackenzie PI, Knights KM, Swedmark S, and Miners JO (2005) SNaproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol 60:423-433. (Pubitemid 41428474)
3. Burchell B, Coughtrie M, Jackson M, Harding D, Fournel-Gigleux S, Leakey J, and Hume R (1989) Development of human liver UDP-glucuronosyltransferases. Dev Pharmacol Ther 13: 70-77.
4. Cappiello M, Giuliani L, Rane A, and Pacifici GM (2000) Uridine 59-diphosphoglucuronic acid (UDPGLcUA) in the human fetal liver, kidney and placenta. Eur J Drug Metab Pharmacokinet 25:161-163. (Pubitemid 32531236)
5. Chouinard S, Pelletier G, Bélanger A, and Barbier O (2006) Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation. Endocrinology 147:5431-5442. (Pubitemid 44790598)
6. Coffman BL, Rios GR, King CD, and Tephly TR (1997) Human UGT2B7 catalyzes morphine glucuronidation. Drug Metab Dispos 25:1-4. (Pubitemid 27045126)
7. Court MH, Zhang X, Ding X, Yee KK, Hesse LM, and Finel M (2012) Quantitative distribution of mRNAs encoding the 19 human UDP- glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues. Xenobiotica 42:266-277.
8. Ekström L, Gök, E, Johansson M, Garle M, Rane A, Schulze J (2012) Doping and genetic testing: sex difference in UGTB15 epxression, testosterone glucuronidation activity and urianry testosterone/epitestosterone glucuronide ratio. Curr Pharmacogenomics Person Med 10:125-131.
9. Fleischmann R, Remmer H, and Stärz U (1986) Induction of cytochrome P-448 iso-enzymes and related glucuronyltransferases in the human liver by cigarette smoking. Eur J Clin Pharmacol 30:475-480. (Pubitemid 16088209)
10. Gallagher CJ, Balliet RM, Sun D, Chen G, and Lazarus P (2010) Sex differences in UDPglucuronosyltransferase 2B17 expression and activity. Drug Metab Dispos 38:2204-2209.
11. Izukawa T, Nakajima M, Fujiwara R, Yamanaka H, Fukami T, Takamiya M, Aoki Y, Ikushiro S, Sakaki T, and Yokoi T (2009) Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers. Drug Metab Dispos 37:1759-1768.
12. Jakobsson J, Ekström L, Inotsume N, Garle M, Lorentzon M, Ohlsson C, Roh HK, Carlström K, and Rane A (2006) Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism. J Clin Endocrinol Metab 91:687-693. (Pubitemid 43236944)
13. Kang SP, Ramirez J, House L, Zhang W, Mirkov S, Liu W, Haverfield E, and Ratain MJ (2010) A pharmacogenetic study of vorinostat glucuronidation. Pharmacogenet Genomics 20:638-641.
14. Karypidis AH, Olsson M, Andersson SO, Rane A, and Ekstrom L (2008) Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate. Pharmacogenomics J 8:147-151. (Pubitemid 351411551)
15. Leakey JE, Hume R, and Burchell B (1987) Development of multiple activities of UDPglucuronyltransferase in human liver. Biochem J 243:859-861. (Pubitemid 17073727)
16. Livak KJ and Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408. (Pubitemid 34164012)
17. Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, and Nebert DW (2005) Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics 15:677-685. (Pubitemid 41345319)
18. Mano Y, Usui T, and Kamimura H (2007) Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur J Clin Pharmacol 63: 289-296. (Pubitemid 46233157)
19. Nakamura A, Nakajima M, Yamanaka H, Fujiwara R, and Yokoi T (2008) Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. Drug Metab Dispos 36: 1461-1464.
20. Ohno S and Nakajin S (2009) Determination of mRNA expression of human UDPglucuronosyltransferases and application for localization in various human tissues by realtime reverse transcriptase-polymerase chain reaction. Drug Metab Dispos 37:32-40.
21. Pacifici GM, Säwe J, Kager L, and Rane A (1982) Morphine glucuronidation in human fetal and adult liver. Eur J Clin Pharmacol 22:553-558. (Pubitemid 12059202)
22. Pacifici GM, Franchi M, Giuliani L, and Rane A (1989) Development of the glucuronyltransferase and sulphotransferase towards 2-naphthol in human fetus. Dev Pharmacol Ther 14:108-114.
23. Ramírez J, Mirkov S, Zhang W, Chen P, Das S, Liu W, Ratain MJ, and Innocenti F (2008) Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver. Pharmacogenomics J 8:152-161. (Pubitemid 351411552)
24. Rollins DE, von Bahr C, Glaumann H, Moldéus P, and Rane A (1979) Acetaminophen: potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells. Science 205:1414-1416. (Pubitemid 10226659)
25. Sadeque AJ, Usmani KA, Palamar S, Cerny MA, and Chen WG (2012) Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin. Drug Metab Dispos 40:772-778.
26. Schulze JJ, Lorentzon M, Ohlsson C, Lundmark J, Roh HK, Rane A, and Ekström L (2008) Genetic aspects of epitestosterone formation and androgen disposition: influence of polymorphisms in CYP17 and UGT2B enzymes. Pharmacogenet Genomics 18:477-485. (Pubitemid 351769915)
27. Tukey RH and Strassburg CP (2000) Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581-616. (Pubitemid 30340694)
28. Wang YH, Trucksis M, McElwee JJ, Wong PH, Maciolek C, Thompson CD, Prueksaritanont T, Garrett GC, Declercq R, and Vets E, et al. (2012) UGT2B17 genetic polymorphisms dramatically affect the pharmacokinetics of MK-7246 in healthy subjects in a first-in-human study. Clin Pharmacol Ther 92:96-102.
29. Wilson W, 3rd, Pardo-Manuel de Villena F, Lyn-Cook BD, Chatterjee PK, Bell TA, Detwiler DA, Gilmore RC, Valladeras IC, Wright CC, and Threadgill DW, et al. (2004) Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15. Genomics 84: 707-714. (Pubitemid 39310948)
30. von Bahr C, Groth CG, Jansson H, Lundgren G, Lind M, and Glaumann H (1980) Drug metabolism in human liver in vitro: establishment of a human liver bank. Clin Pharmacol Ther 27:711-725. (Pubitemid 10072956)
31. Wong NS, Seah EZh, Wang LZ, Yeo WL, Yap HL, Chuah B, Lim YW, Ang PC, Tai BC, and Lim R, et al. (2011) Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer. Pharmacogenet Genomics 21:760-768.