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Volumn 23, Issue 46, 2017, Pages 8140-8151

MiR-192-5p regulates lipid synthesis in non-Alcoholic fatty liver disease through SCD-1

Author keywords

High fat diet; Lipid synthesis; MiR 192 5p; Non Alcoholic fatty liver disease; Stearoyl coa desaturase 1

Indexed keywords

LIPID; LIRAGLUTIDE; MICRORNA 192; MICRORNA 192 5P; OXYGENASE; PALMITIC ACID; SMALL INTERFERING RNA; STEAROYL COENZYME A DESATURASE 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ACYL COENZYME A DESATURASE; MICRORNA; STEAROYL-COA DESATURASE SCD-1, RAT;

EID: 85038440795     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v23.i46.8140     Document Type: Article
Times cited : (68)

References (43)
  • 1
    • 85026462124 scopus 로고    scopus 로고
    • New trends on obesity and NAFLD in Asia
    • PMID: 28642059
    • Fan JG, Kim SU, Wong VW. New trends on obesity and NAFLD in Asia. J Hepatol 2017; 67: 862-873 [PMID: 28642059 DOI:10.1016/j.jhep.2017.06.003].
    • (2017) J Hepatol , vol.67 , pp. 862-873
    • Fan, J.G.1    Kim, S.U.2    Wong, V.W.3
  • 2
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • PMID: 16447287
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43: S99-S112 [PMID: 16447287 DOI:10.1002/hep.20973].
    • (2006) Hepatology , vol.43 , pp. S99-S112
    • Farrell, G.C.1    Larter, C.Z.2
  • 3
    • 77953971188 scopus 로고    scopus 로고
    • Disease progression of nonalcoholic fatty liver disease: A prospective study with paired liver biopsies at 3 years
    • PMID: 20581244
    • Wong VW, Wong GL, Choi PC, Chan AW, Li MK, Chan HY, Chim AM, Yu J, Sung JJ, Chan HL. Disease progression of nonalcoholic fatty liver disease: A prospective study with paired liver biopsies at 3 years. Gut 2010; 59: 969-974 [PMID: 20581244 DOI:10.1136/gut.2009.205088].
    • (2010) Gut , vol.59 , pp. 969-974
    • Wong, V.W.1    Wong, G.L.2    Choi, P.C.3    Chan, A.W.4    Li, M.K.5    Chan, H.Y.6    Chim, A.M.7    Yu, J.8    Sung, J.J.9    Chan, H.L.10
  • 4
    • 84957812743 scopus 로고    scopus 로고
    • The multiple-hit pathogenesis of non-Alcoholic fatty liver disease (NAFLD)
    • PMID: 26823198
    • Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-Alcoholic fatty liver disease (NAFLD). Metabolism 2016; 65: 1038-1048 [PMID: 26823198 DOI:10.1016/j.metabol.2015.12.012].
    • (2016) Metabolism , vol.65 , pp. 1038-1048
    • Buzzetti, E.1    Pinzani, M.2    Tsochatzis, E.A.3
  • 5
    • 78649568544 scopus 로고    scopus 로고
    • Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-Activated receptor γ coactivator 1α promoter
    • PMID: 20890895
    • Sookoian S, Rosselli MS, Gemma C, Burgueño AL, Fernández Gianotti T, Castaño GO, Pirola CJ. Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-Activated receptor γ coactivator 1α promoter. Hepatology 2010; 52: 1992-2000 [PMID: 20890895 DOI:10.1002/hep.23927].
    • (2010) Hepatology , vol.52 , pp. 1992-2000
    • Sookoian, S.1    Rosselli, M.S.2    Gemma, C.3    Burgueño, A.L.4    Fernández, G.T.5    Castaño, G.O.6    Pirola, C.J.7
  • 6
    • 85009274723 scopus 로고    scopus 로고
    • MicroRNAs as biomarkers and regulators of nonalcoholic fatty liver disease
    • PMID: 27628945
    • Liu XL, Cao HX, Fan JG. MicroRNAs as biomarkers and regulators of nonalcoholic fatty liver disease. J Dig Dis 2016; 17: 708-715 [PMID: 27628945 DOI:10.1111/1751-2980.12408].
    • (2016) J Dig Dis , vol.17 , pp. 708-715
    • Liu, X.L.1    Cao, H.X.2    Fan, J.G.3
  • 7
    • 84925851270 scopus 로고    scopus 로고
    • Potential epigenetic mechanism in nonalcoholic Fatty liver disease
    • PMID: 25751727
    • Sun C, Fan JG, Qiao L. Potential epigenetic mechanism in nonalcoholic Fatty liver disease. Int J Mol Sci 2015; 16: 5161-5179 [PMID: 25751727 DOI:10.3390/ijms16035161].
    • (2015) Int J Mol Sci , vol.16 , pp. 5161-5179
    • Sun, C.1    Fan, J.G.2    Qiao, L.3
  • 8
    • 84881546730 scopus 로고    scopus 로고
    • Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease
    • PMID: 22879518
    • Pirola CJ, Gianotti TF, Burgueño AL, Rey-Funes M, Loidl CF, Mallardi P, Martino JS, Castaño GO, Sookoian S. Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease. Gut 2013; 62: 1356-1363 [PMID: 22879518 DOI:10.1136/gutjnl-2012-302962].
    • (2013) Gut , vol.62 , pp. 1356-1363
    • Pirola, C.J.1    Gianotti, T.F.2    Burgueño, A.L.3    Rey-Funes, M.4    Loidl, C.F.5    Mallardi, P.6    Martino, J.S.7    Castaño, G.O.8    Sookoian, S.9
  • 9
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • PMID: 14744438
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297 [PMID: 14744438 DOI:10.1016/S0092-8674(04)00045-5].
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 10
    • 84858776574 scopus 로고    scopus 로고
    • MicroRNAs in metabolism and metabolic disorders
    • PMID: 22436747
    • Rottiers V, Näär AM. MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol 2012; 13: 239-250 [PMID: 22436747 DOI:10.1038/nrm3313].
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 239-250
    • Rottiers, V.1    Näär, A.M.2
  • 11
    • 84928885523 scopus 로고    scopus 로고
    • Circulating microRNA signature in non-Alcoholic fatty liver disease: From serum noncoding RNAs to liver histology and disease pathogenesis
    • PMID: 24973316
    • Pirola CJ, Fernández Gianotti T, Castaño GO, Mallardi P, San Martino J, Mora Gonzalez Lopez Ledesma M, Flichman D, Mirshahi F, Sanyal AJ, Sookoian S. Circulating microRNA signature in non-Alcoholic fatty liver disease: from serum noncoding RNAs to liver histology and disease pathogenesis. Gut 2015; 64: 800-812 [PMID: 24973316 DOI:10.1136/gutjnl-2014-306996].
    • (2015) Gut , vol.64 , pp. 800-812
    • Pirola, C.J.1    Fernández, G.T.2    Castaño, G.O.3    Mallardi, P.4    San, M.J.5    Mora, G.L.L.M.6    Flichman, D.7    Mirshahi, F.8    Sanyal, A.J.9    Sookoian, S.10
  • 12
    • 84997285897 scopus 로고    scopus 로고
    • Disease-specific miR-34a as diagnostic marker of non-Alcoholic steatohepatitis in a Chinese population
    • PMID: 27956809
    • Liu XL, Pan Q, Zhang RN, Shen F, Yan SY, Sun C, Xu ZJ, Chen YW, Fan JG. Disease-specific miR-34a as diagnostic marker of non-Alcoholic steatohepatitis in a Chinese population. World J Gastroenterol 2016; 22: 9844-9852 [PMID: 27956809 DOI:10.3748/wjg.v22.i44.9844].
    • (2016) World J Gastroenterol , vol.22 , pp. 9844-9852
    • Liu, X.L.1    Pan, Q.2    Zhang, R.N.3    Shen, F.4    Yan, S.Y.5    Sun, C.6    Xu, Z.J.7    Chen, Y.W.8    Fan, J.G.9
  • 14
    • 84962259452 scopus 로고    scopus 로고
    • MiR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma
    • PMID: 26684241
    • Lian J, Jing Y, Dong Q, Huan L, Chen D, Bao C, Wang Q, Zhao F, Li J, Yao M, Qin L, Liang L, He X. miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma. Oncotarget 2016; 7: 2672-2683 [PMID: 26684241 DOI:10.18632/oncotarget.6603].
    • (2016) Oncotarget , vol.7 , pp. 2672-2683
    • Lian, J.1    Jing, Y.2    Dong, Q.3    Huan, L.4    Chen, D.5    Bao, C.6    Wang, Q.7    Zhao, F.8    Li, J.9    Yao, M.10    Qin, L.11    Liang, L.12    He, X.13
  • 15
    • 84894327806 scopus 로고    scopus 로고
    • Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease
    • PMID: 24316260
    • Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology 2014; 146: 726-735 [PMID: 24316260 DOI:10.1053/j.gastro.2013.11.049].
    • (2014) Gastroenterology , vol.146 , pp. 726-735
    • Lambert, J.E.1    Ramos-Roman, M.A.2    Browning, J.D.3    Parks, E.J.4
  • 16
    • 84947268804 scopus 로고    scopus 로고
    • The subtle balance between lipolysis and lipogenesis: A critical point in metabolic homeostasis
    • PMID: 26580649
    • Saponaro C, Gaggini M, Carli F, Gastaldelli A. The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis. Nutrients 2015; 7: 9453-9474 [PMID: 26580649 DOI:10.3390/nu7115475].
    • (2015) Nutrients , vol.7 , pp. 9453-9474
    • Saponaro, C.1    Gaggini, M.2    Carli, F.3    Gastaldelli, A.4
  • 17
    • 2942588527 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1cdependent and -independent mechanisms
    • PMID: 15066988
    • Miyazaki M, Dobrzyn A, Man WC, Chu K, Sampath H, Kim HJ, Ntambi JM. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1cdependent and -independent mechanisms. J Biol Chem 2004; 279: 25164-25171 [PMID: 15066988 DOI:10.1074/jbc.M402781200].
    • (2004) J Biol Chem , vol.279 , pp. 25164-25171
    • Miyazaki, M.1    Dobrzyn, A.2    Man, W.C.3    Chu, K.4    Sampath, H.5    Kim, H.J.6    Ntambi, J.M.7
  • 22
    • 84956550206 scopus 로고    scopus 로고
    • Performance of serum microRNAs -122, -192 and -21 as biomarkers in patients with non-Alcoholic steatohepatitis
    • PMID: 26565986
    • Becker PP, Rau M, Schmitt J, Malsch C, Hammer C, Bantel H, Müllhaupt B, Geier A. Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis. PLoS One 2015; 10: E0142661 [PMID: 26565986 DOI:10.1371/journal.pone.0142661].
    • (2015) PLoS One , vol.10 , pp. e0142661
    • Becker, P.P.1    Rau, M.2    Schmitt, J.3    Malsch, C.4    Hammer, C.5    Bantel, H.6    Müllhaupt, B.7    Geier, A.8
  • 25
    • 84940849475 scopus 로고    scopus 로고
    • Effect of miR- 34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease
    • PMID: 26330104
    • Ding J, Li M, Wan X, Jin X, Chen S, Yu C, Li Y. Effect of miR- 34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease. Sci Rep 2015; 5: 13729 [PMID: 26330104 DOI:10.1038/srep13729].
    • (2015) Sci Rep , vol.5 , pp. 13729
    • Ding, J.1    Li, M.2    Wan, X.3    Jin, X.4    Chen, S.5    Yu, C.6    Li, Y.7
  • 26
    • 84935009342 scopus 로고    scopus 로고
    • A metabolic stressinducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism
    • PMID: 26100857
    • Xu Y, Zalzala M, Xu J, Li Y, Yin L, Zhang Y. A metabolic stressinducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism. Nat Commun 2015; 6: 7466 [PMID: 26100857 DOI:10.1038/ncomms8466].
    • (2015) Nat Commun , vol.6 , pp. 7466
    • Xu, Y.1    Zalzala, M.2    Xu, J.3    Li, Y.4    Yin, L.5    Zhang, Y.6
  • 28
  • 29
    • 85013015686 scopus 로고    scopus 로고
    • Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha
    • PMID: 28217257
    • Lu H, Lei X, Liu J, Klaassen C. Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha. World J Hepatol 2017; 9: 191-208 [PMID: 28217257 DOI:10.4254/wjh.v9.i4.191].
    • (2017) World J Hepatol , vol.9 , pp. 191-208
    • Lu, H.1    Lei, X.2    Liu, J.3    Klaassen, C.4
  • 30
    • 84859462370 scopus 로고    scopus 로고
    • Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding
    • PMID: 22264233
    • Jenkins RH, Martin J, Phillips AO, Bowen T, Fraser DJ. Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding. Biochem J 2012; 443: 407-416 [PMID: 22264233 DOI:10.1042/BJ20111861].
    • (2012) Biochem J , vol.443 , pp. 407-416
    • Jenkins, R.H.1    Martin, J.2    Phillips, A.O.3    Bowen, T.4    Fraser, D.J.5
  • 32
    • 85020194449 scopus 로고    scopus 로고
    • Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-Triggered non-Alcoholic fatty liver disease
    • PMID: 28483554
    • Lin Y, Ding D, Huang Q, Liu Q, Lu H, Lu Y, Chi Y, Sun X, Ye G, Zhu H, Wei J, Dong S. Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-Triggered non-Alcoholic fatty liver disease. Biochim Biophys Acta 2017; 1862: 869-882 [PMID: 28483554 DOI:10.1016/j.bbalip.2017.05.001].
    • (2017) Biochim Biophys Acta , vol.1862 , pp. 869-882
    • Lin, Y.1    Ding, D.2    Huang, Q.3    Liu, Q.4    Lu, H.5    Lu, Y.6    Chi, Y.7    Sun, X.8    Ye, G.9    Zhu, H.10    Wei, J.11    Dong, S.12
  • 33
    • 84978245141 scopus 로고    scopus 로고
    • Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice
    • PMID: 26663351
    • Marchesini G, Petta S, Dalle Grave R. Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice. Hepatology 2016; 63: 2032-2043 [PMID: 26663351 DOI:10.1002/hep.28392].
    • (2016) Hepatology , vol.63 , pp. 2032-2043
    • Marchesini, G.1    Petta, S.2    Dalle, G.R.3
  • 34
    • 84988462353 scopus 로고    scopus 로고
    • Current and upcoming pharmacotherapy for non-Alcoholic fatty liver disease
    • PMID: 27646933
    • Rotman Y, Sanyal AJ. Current and upcoming pharmacotherapy for non-Alcoholic fatty liver disease. Gut 2017; 66: 180-190 [PMID: 27646933 DOI:10.1136/gutjnl-2016-312431].
    • (2017) Gut , vol.66 , pp. 180-190
    • Rotman, Y.1    Sanyal, A.J.2
  • 35
    • 84858701950 scopus 로고    scopus 로고
    • The interaction of hepatic lipid and glucose metabolism in liver diseases
    • PMID: 22173168
    • Bechmann LP, Hannivoort RA, Gerken G, Hotamisligil GS, Trauner M, Canbay A. The interaction of hepatic lipid and glucose metabolism in liver diseases. J Hepatol 2012; 56: 952-964 [PMID: 22173168 DOI:10.1016/j.jhep.2011.08.025].
    • (2012) J Hepatol , vol.56 , pp. 952-964
    • Bechmann, L.P.1    Hannivoort, R.A.2    Gerken, G.3    Hotamisligil, G.S.4    Trauner, M.5    Canbay, A.6
  • 36
    • 84991508506 scopus 로고    scopus 로고
    • Long-Term fructose consumption prolongs hepatic stearoyl-CoA desaturase 1 activity independent of upstream regulation in rats
    • PMID: 27697525
    • Liu L, Wang S, Yao L, Li JX, Ma P, Jiang LR, Ke DZ, Pan YQ, Wang JW. Long-Term fructose consumption prolongs hepatic stearoyl-CoA desaturase 1 activity independent of upstream regulation in rats. Biochem Biophys Res Commun 2016; 479: 643-648 [PMID: 27697525 DOI:10.1016/j.bbrc.2016.09.160].
    • (2016) Biochem Biophys Res Commun , vol.479 , pp. 643-648
    • Liu, L.1    Wang, S.2    Yao, L.3    Li, J.X.4    Ma, P.5    Jiang, L.R.6    Ke, D.Z.7    Pan, Y.Q.8    Wang, J.W.9
  • 37
    • 67650088283 scopus 로고    scopus 로고
    • Biochemical and physiological function of stearoyl-CoA desaturase
    • PMID: 19066317
    • Paton CM, Ntambi JM. Biochemical and physiological function of stearoyl-CoA desaturase. Am J Physiol Endocrinol Metab 2009; 297: E28-E37 [PMID: 19066317 DOI:10.1152/ajpendo.90897.2008].
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. E28-E37
    • Paton, C.M.1    Ntambi, J.M.2
  • 38
    • 43249127067 scopus 로고    scopus 로고
    • Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
    • PMID: 18460915
    • Flowers MT, Ntambi JM. Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Curr Opin Lipidol 2008; 19: 248-256 [PMID: 18460915 DOI:10.1097/MOL.0b013e3282f9b54d].
    • (2008) Curr Opin Lipidol , vol.19 , pp. 248-256
    • Flowers, M.T.1    Ntambi, J.M.2
  • 39
    • 77956263958 scopus 로고    scopus 로고
    • Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue
    • PMID: 20655875
    • Hyun CK, Kim ED, Flowers MT, Liu X, Kim E, Strable M, Ntambi JM. Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue. Biochem Biophys Res Commun 2010; 399: 480-486 [PMID: 20655875 DOI:10.1016/j.bbrc.2010.07.072].
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 480-486
    • Hyun, C.K.1    Kim, E.D.2    Flowers, M.T.3    Liu, X.4    Kim, E.5    Strable, M.6    Ntambi, J.M.7
  • 40
    • 60849136007 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice
    • PMID: 19338759
    • Miyazaki M, Sampath H, Liu X, Flowers MT, Chu K, Dobrzyn A, Ntambi JM. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun 2009; 380: 818-822 [PMID: 19338759 DOI:10.1016/j.bbrc.2009.01.183].
    • (2009) Biochem Biophys Res Commun , vol.380 , pp. 818-822
    • Miyazaki, M.1    Sampath, H.2    Liu, X.3    Flowers, M.T.4    Chu, K.5    Dobrzyn, A.6    Ntambi, J.M.7
  • 42
    • 85018583000 scopus 로고    scopus 로고
    • MiR-29a modulates SCD expression and is regulated in response to a saturated fatty acid diet in juvenile genetically improved farmed tilapia (Oreochromis niloticus)
    • PMID: 28167804
    • Qiang J, Tao YF, He J, Sun YL, Xu P. miR-29a modulates SCD expression and is regulated in response to a saturated fatty acid diet in juvenile genetically improved farmed tilapia (Oreochromis niloticus). J Exp Biol 2017; 220: 1481-1489 [PMID: 28167804 DOI:10.1242/jeb.151506].
    • (2017) J Exp Biol , vol.220 , pp. 1481-1489
    • Qiang, J.1    Tao, Y.F.2    He, J.3    Sun, Y.L.4    Xu, P.5
  • 43
    • 84931572130 scopus 로고    scopus 로고
    • Towards a molecular understanding of microRNA-mediated gene silencing
    • PMID: 26077373
    • Jonas S, Izaurralde E. Towards a molecular understanding of microRNA-mediated gene silencing. Nat Rev Genet 2015; 16: 421-433 [PMID: 26077373 DOI:10.1038/nrg3965].
    • (2015) Nat Rev Genet , vol.16 , pp. 421-433
    • Jonas, S.1    Izaurralde, E.2


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