Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy

Journal of Thrombosis and Haemostasis

Volumn 15, Issue 12, 2017, Pages 2396-2407

  Lee, M Y ^a   Verni, C C ^a   Herbig, B A ^a   Diamond, S L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

coagulopathy; fibrin; GPVI; platelet; thrombin; trauma

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; CALCIUM; CONVULXIN; FIBRILLAR COLLAGEN; FIBRIN; FIBRINOGEN; GLYCOPROTEIN VI; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; ALANYL-TYROSYL-PROLYL-GLYCYL-LYSYL-PHENYLALANINE; COLLAGEN; FIBRINOGEN RECEPTOR; LECTIN; OLIGOPEPTIDE; PAR-1-ACTIVATING PEPTIDE; PLATELET MEMBRANE GLYCOPROTEIN VI; SNAKE VENOM;

ARTICLE; BLOOD CLOTTING DISORDER; CALCIUM MOBILIZATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE RICH PLASMA; BLOOD; CALCIUM SIGNALING; DRUG EFFECT; IN VITRO STUDY; METABOLISM; SOLUBILITY;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADENOSINE DIPHOSPHATE; BLOOD COAGULATION DISORDERS; BLOOD PLATELETS; CALCIUM SIGNALING; COLLAGEN; CROTALID VENOMS; FIBRIN; HUMANS; IN VITRO TECHNIQUES; LECTINS, C-TYPE; OLIGOPEPTIDES; PLATELET ACTIVATION; PLATELET MEMBRANE GLYCOPROTEINS; SIGNAL TRANSDUCTION; SOLUBILITY; THROMBIN;

EID: 85037030817     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.13863     Document Type: Article

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