Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 40, 2014, Pages 14430-14435

  Qiu, Yongzhi ^a,b,c   Brown, Ashley C ^a,d   Myers, David R ^a,b,c   Sakurai, Yumiko ^a,b,c   Mannino, Robert G ^a,b,c   Tran, Reginald ^a,b,c   Ahn, Byungwook ^a,b,c   Hardy, Elaissa T ^a,b,c   Kee, Matthew F ^a   Kumar, Sanjay ^e   Bao, Gang ^a,d   Barker, Thomas H ^a,d   Lam, Wilbur A ^a,b,c,d  

^a Emory University   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^e University of California   (United States)

Author keywords

Biomaterials; Cell mechanics; Mechanotransduction; Platelet cytoskeleton

Indexed keywords

ACRYLIC ACID RESIN; FIBRIN; FIBRINOGEN; FIBRINOGEN RECEPTOR; IMMOBILIZED PROTEIN; PADGEM PROTEIN; PHOSPHATIDYLSERINE; POLYACRYLAMIDE; RAC1 PROTEIN;

BLOOD CLOTTING; CELL MOTION; CONFOCAL MICROSCOPY; CYTOLOGY; HUMAN; MECHANICAL STRESS; MECHANOTRANSDUCTION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOSIS; TUMOR MICROENVIRONMENT;

ACRYLIC RESINS; BLOOD COAGULATION; BLOOD PLATELETS; CELL MOVEMENT; CELLULAR MICROENVIRONMENT; FIBRIN; FIBRINOGEN; HUMANS; IMMOBILIZED PROTEINS; MECHANOTRANSDUCTION, CELLULAR; MICROSCOPY, CONFOCAL; P-SELECTIN; PHOSPHATIDYLSERINES; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RAC1 GTP-BINDING PROTEIN; STRESS, MECHANICAL; THROMBOSIS;

EID: 84907755511     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322917111     Document Type: Article

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