메뉴 건너뛰기




Volumn 24, Issue 1, 2018, Pages 83-93

Controversies and opportunities in severe asthma

Author keywords

anti immunoglobulin E; anti interleukin 5; asthma; biologics; biomarker; endotype; oral corticosteroid; pediatric asthma; phenotype; severe asthma

Indexed keywords

BENRALIZUMAB; CORTICOSTEROID; DUPILUMAB; IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 5 ANTIBODY; OMALIZUMAB; ANTI-IGE ANTIBODIES; ANTIASTHMATIC AGENT; ANTIIDIOTYPIC ANTIBODY; BIOLOGICAL MARKER; BIOLOGICAL PRODUCT; IL5 PROTEIN, HUMAN; INTERLEUKIN 5;

EID: 85036605211     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0000000000000438     Document Type: Review
Times cited : (10)

References (99)
  • 1
    • 84942787538 scopus 로고    scopus 로고
    • A summary of the new gina strategy: A roadmap to asthma control
    • Reddel HK, Bateman ED, Becker A, et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J 2015; 46:622-639.
    • (2015) Eur Respir J , vol.46 , pp. 622-639
    • Reddel, H.K.1    Bateman, E.D.2    Becker, A.3
  • 3
    • 84948698441 scopus 로고    scopus 로고
    • Severe asthma: Epidemiology, burden of illness, and heterogeneity
    • Lang DM. Severe asthma: epidemiology, burden of illness, and heterogeneity. Allergy Asthma Proc 2015; 36:418-424.
    • (2015) Allergy Asthma Proc , vol.36 , pp. 418-424
    • Lang, D.M.1
  • 4
    • 70449635683 scopus 로고    scopus 로고
    • The impact of uncontrolled asthma on absenteeism and health-related quality of life
    • Dean BB, Calimlim BM, Kindermann SL, et al. The impact of uncontrolled asthma on absenteeism and health-related quality of life. J Asthma 2009; 46:861-866.
    • (2009) J Asthma , vol.46 , pp. 861-866
    • Dean, B.B.1    Calimlim, B.M.2    Kindermann, S.L.3
  • 5
    • 84942770527 scopus 로고    scopus 로고
    • Biomarkers and severe asthma: A critical appraisal
    • Chiappori A, De Ferrari L, Folli C, et al. Biomarkers and severe asthma: a critical appraisal. Clin Mol Allergy 2015; 13:20.
    • (2015) Clin Mol Allergy , vol.13 , pp. 20
    • Chiappori, A.1    De Ferrari, L.2    Folli, C.3
  • 6
    • 79960847916 scopus 로고    scopus 로고
    • Updates on the use of inhaled corticosteroids in asthma
    • Stoloff SW, Kelly HW. Updates on the use of inhaled corticosteroids in asthma. Curr Opin Allergy Clin Immunol 2011; 11:337-344.
    • (2011) Curr Opin Allergy Clin Immunol , vol.11 , pp. 337-344
    • Stoloff, S.W.1    Kelly, H.W.2
  • 7
    • 33745153759 scopus 로고    scopus 로고
    • Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma
    • O'Byrne PM, Pedersen S, Busse WW, et al. Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. Chest 2006; 129:1478-1485.
    • (2006) Chest , vol.129 , pp. 1478-1485
    • O'Byrne, P.M.1    Pedersen, S.2    Busse, W.W.3
  • 8
    • 42749086913 scopus 로고    scopus 로고
    • The inhaled steroid treatment as regular therapy in early asthma (start) study 5-year follow-up: Effectiveness of early intervention with budesonide in mild persistent asthma
    • Busse WW, Pedersen S, Pauwels RA, et al. The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma. J Allergy Clin Immunol 2008; 121:1167-1174.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 1167-1174
    • Busse, W.W.1    Pedersen, S.2    Pauwels, R.A.3
  • 9
    • 84856845581 scopus 로고    scopus 로고
    • Severe asthma: From characteristics to phenotypes to endotypes
    • Wenzel S. Severe asthma: from characteristics to phenotypes to endotypes. Clin Exp Allergy 2012; 42:650-658.
    • (2012) Clin Exp Allergy , vol.42 , pp. 650-658
    • Wenzel, S.1
  • 11
    • 84958073595 scopus 로고    scopus 로고
    • Treatable traits: Toward precision medicine of chronic airway diseases
    • Agusti A, Bel E, Thomas M, et al. Treatable traits: toward precision medicine of chronic airway diseases. Eur Respir J 2016; 47:410-419.
    • (2016) Eur Respir J , vol.47 , pp. 410-419
    • Agusti, A.1    Bel, E.2    Thomas, M.3
  • 12
    • 85019110286 scopus 로고    scopus 로고
    • Severe eosinophilic asthma: A roadmap to consensus
    • the expert group of the European Consensus Meeting for Severe Eosinophilic Asthma
    • Buhl R, Humbert M, Bjermer L, et al., the expert group of the European Consensus Meeting for Severe Eosinophilic Asthma. Severe eosinophilic asthma: a roadmap to consensus. Eur Respir J 2017; 49:1700634.
    • (2017) Eur Respir J , vol.49 , pp. 1700634
    • Buhl, R.1    Humbert, M.2    Bjermer, L.3
  • 13
    • 84924187758 scopus 로고    scopus 로고
    • Biologic therapies targeting eosinophils: Current status and future prospects
    • Legrand F, Klion AD. Biologic therapies targeting eosinophils: current status and future prospects. J Allergy Clin Immunol Pract 2015; 3:167-174.
    • (2015) J Allergy Clin Immunol Pract , vol.3 , pp. 167-174
    • Legrand, F.1    Klion, A.D.2
  • 14
    • 85007306396 scopus 로고    scopus 로고
    • Role of biologics targeting type 2 airway inflammation in asthma: What have we learned so far?
    • Parulekar AD, Diamant Z, Hanania NA. Role of biologics targeting type 2 airway inflammation in asthma: what have we learned so far? Curr Opin Pulm Med 2017; 23:3-11.
    • (2017) Curr Opin Pulm Med , vol.23 , pp. 3-11
    • Parulekar, A.D.1    Diamant, Z.2    Hanania, N.A.3
  • 15
    • 85019967441 scopus 로고    scopus 로고
    • Prospects for new and emerging therapeutics in severe asthma: The role of biologics
    • Kepil Ozdemir S, Bavbek S. Prospects for new and emerging therapeutics in severe asthma: the role of biologics. Expert Rev Respir Med 2017; 11:505-512.
    • (2017) Expert Rev Respir Med , vol.11 , pp. 505-512
    • Kepil Ozdemir, S.1    Bavbek, S.2
  • 17
    • 84876883293 scopus 로고    scopus 로고
    • Exploring the effects of omalizumab in allergic asthma: An analysis of biomarkers in the extra study
    • Hanania NA, Wenzel S, Rosen K, et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med 2013; 187:804-811.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 804-811
    • Hanania, N.A.1    Wenzel, S.2    Rosen, K.3
  • 18
    • 84881172210 scopus 로고    scopus 로고
    • High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects
    • e11
    • Busse W, Spector S, Rosen K, et al. High eosinophil count: a potential biomarker for assessing successful omalizumab treatment effects. J Allergy Clin Immunol 2013; 132:485-486.e11.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 485-486
    • Busse, W.1    Spector, S.2    Rosen, K.3
  • 19
    • 85036665644 scopus 로고    scopus 로고
    • Response to omalizumab treatment according to blood eosinophil count: Results of a French real-world study (stellair)
    • Milan, Italy
    • Humbert MML, Molimard M. Response to omalizumab treatment according to blood eosinophil count: Results of a French real-world study (STELLAIR). European Respiratory Society Annual Congress 2017; Milan, Italy
    • (2017) European Respiratory Society Annual Congress
    • Humbert, M.M.L.1    Molimard, M.2
  • 21
    • 84907424177 scopus 로고    scopus 로고
    • Mepolizumab treatment in patients with severe eosinophilic asthma
    • MENSA Investigators
    • Ortega HG, Liu MC, Pavord ID, et al., MENSA Investigators. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 2014; 371:1198-1207.
    • (2014) N Engl J Med , vol.371 , pp. 1198-1207
    • Ortega, H.G.1    Liu, M.C.2    Pavord, I.D.3
  • 23
    • 84929026123 scopus 로고    scopus 로고
    • Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: Results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials
    • Castro M, Zangrilli J, Wechsler ME, et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir Med 2015; 3:355-366.
    • (2015) Lancet Respir Med , vol.3 , pp. 355-366
    • Castro, M.1    Zangrilli, J.2    Wechsler, M.E.3
  • 24
    • 85017526462 scopus 로고    scopus 로고
    • The efficacy and safety of reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: A systematic review and meta-Analysis
    • Li J, Wang F, Lin C, et al. The efficacy and safety of reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: a systematic review and meta-Analysis. J Asthma 2017; 54:300-307.
    • (2017) J Asthma , vol.54 , pp. 300-307
    • Li, J.1    Wang, F.2    Lin, C.3
  • 25
    • 84994908383 scopus 로고    scopus 로고
    • Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-Acting b2-Agonists (sirocco): A randomised, multicentre, placebo-controlled phase 3 trial
    • SIROCCO study investigators
    • Bleecker ER, FitzGerald JM, Chanez P, et al., SIROCCO study investigators. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-Acting b2-Agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet 2016; 388:2115-2127.
    • (2016) Lancet , vol.388 , pp. 2115-2127
    • Bleecker, E.R.1    FitzGerald, J.M.2    Chanez, P.3
  • 26
    • 85025149684 scopus 로고    scopus 로고
    • The association between blood eosinophil count and benralizumab efficacy for patients with severe, uncontrolled asthma: Subanalyses of the phase III sirocco and calima studies
    • Goldman M, Hirsch I, Zangrilli JG, et al. The association between blood eosinophil count and benralizumab efficacy for patients with severe, uncontrolled asthma: subanalyses of the phase III SIROCCO and CALIMA studies. Curr Med Res Opin 2017; 33:1605-1613.
    • (2017) Curr Med Res Opin , vol.33 , pp. 1605-1613
    • Goldman, M.1    Hirsch, I.2    Zangrilli, J.G.3
  • 27
    • 84994910846 scopus 로고    scopus 로고
    • Benralizumab, an antiinterleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (calima): A randomised, doubleblind, placebo-controlled phase 3 trial
    • FitzGerald JM, Bleecker ER, Nair P, et al. Benralizumab, an antiinterleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, doubleblind, placebo-controlled phase 3 trial. Lancet 2016; 388:2128-2141.
    • (2016) Lancet , vol.388 , pp. 2128-2141
    • FitzGerald, J.M.1    Bleecker, E.R.2    Nair, P.3
  • 28
    • 85021080137 scopus 로고    scopus 로고
    • Zonda trial investigators. Oral glucocorticoid-sparing effect of benralizumab in severe asthma
    • Nair P, Wenzel S, Rabe KF, et al., ZONDA Trial Investigators. Oral glucocorticoid-sparing effect of benralizumab in severe asthma. N Engl J Med 2017; 376:2448-2458.
    • (2017) N Engl J Med , vol.376 , pp. 2448-2458
    • Nair, P.1    Wenzel, S.2    Rabe, K.F.3
  • 29
    • 84941182925 scopus 로고    scopus 로고
    • Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: A randomised, double-blind, placebo-controlled, phase 2b trial
    • Brightling CE, Chanez P, Leigh R, et al. Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Respir Med 2015; 3:692-701.
    • (2015) Lancet Respir Med , vol.3 , pp. 692-701
    • Brightling, C.E.1    Chanez, P.2    Leigh, R.3
  • 30
    • 84940733208 scopus 로고    scopus 로고
    • Lebrikizumab in moderate-to-severe asthma: Pooled data from two randomised placebo-controlled studies
    • Hanania NA, Noonan M, Corren J, et al. Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies. Thorax 2015; 70:748-756.
    • (2015) Thorax , vol.70 , pp. 748-756
    • Hanania, N.A.1    Noonan, M.2    Corren, J.3
  • 31
    • 84989808988 scopus 로고    scopus 로고
    • Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (lavolta i and lavolta II): Replicate, phase 3, randomised, double-blind, placebo-controlled trials
    • Hanania NA, Korenblat P, Chapman KR, et al. Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir Med 2016; 4:781-796.
    • (2016) Lancet Respir Med , vol.4 , pp. 781-796
    • Hanania, N.A.1    Korenblat, P.2    Chapman, K.R.3
  • 32
    • 84964573673 scopus 로고    scopus 로고
    • Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-Acting b2 agonist: A randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial
    • Wenzel S, Castro M, Corren J, et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-Acting b2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet 2016; 388:31-44.
    • (2016) Lancet , vol.388 , pp. 31-44
    • Wenzel, S.1    Castro, M.2    Corren, J.3
  • 33
    • 0035888742 scopus 로고    scopus 로고
    • The role of immunoglobulin e in allergy and asthma
    • Platts-Mills TA. The role of immunoglobulin E in allergy and asthma. Am J Respir Crit Care Med 2001; 164:S1-S5.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. S1-S5
    • Platts-Mills, T.A.1
  • 35
    • 84969524586 scopus 로고    scopus 로고
    • What is the current role of biologics in the management of patients with severe refractory asthma?
    • Draikiwicz S, Oppenheimer J. What is the current role of biologics in the management of patients with severe refractory asthma? Ann Allergy Asthma Immunol 2016; 116:383-387.
    • (2016) Ann Allergy Asthma Immunol , vol.116 , pp. 383-387
    • Draikiwicz, S.1    Oppenheimer, J.2
  • 36
  • 37
    • 85020510907 scopus 로고    scopus 로고
    • Novel monoclonal treatments in severe asthma
    • [Epub ahead of print]
    • Meteran H, Meteran H, Porsbjerg C, Backer V. Novel monoclonal treatments in severe asthma. J Asthma 2017; 1-21. [Epub ahead of print]
    • (2017) J Asthma , pp. 1-21
    • Meteran, H.1    Meteran, H.2    Porsbjerg, C.3    Backer, V.4
  • 38
    • 85018368188 scopus 로고    scopus 로고
    • Omalizumab in children with uncontrolled allergic asthma: Review of clinical trial and real-world experience
    • Chipps BE, Lanier B, Milgrom H, et al. Omalizumab in children with uncontrolled allergic asthma: review of clinical trial and real-world experience. J Allergy Clin Immunol 2017; 139:1431-1444.
    • (2017) J Allergy Clin Immunol , vol.139 , pp. 1431-1444
    • Chipps, B.E.1    Lanier, B.2    Milgrom, H.3
  • 39
    • 85029537251 scopus 로고    scopus 로고
    • Omalizumab versus mepolizumab as add-on therapy in asthma patients not well controlled on at least an inhaled corticosteroid: A network meta-Analysis
    • [Epub ahead of print]
    • Nachef Z, Krishnan A, Mashtare T, et al. Omalizumab versus mepolizumab as add-on therapy in asthma patients not well controlled on at least an inhaled corticosteroid: a network meta-Analysis. J Asthma 2017; 1-12. [Epub ahead of print]
    • (2017) J Asthma , pp. 1-12
    • Nachef, Z.1    Krishnan, A.2    Mashtare, T.3
  • 40
    • 85008938103 scopus 로고    scopus 로고
    • Comparative effectiveness of mepolizumab and omalizumab in severe asthma: An indirect treatment comparison
    • Cockle SM, Stynes G, Gunsoy NB, et al. Comparative effectiveness of mepolizumab and omalizumab in severe asthma: an indirect treatment comparison. Respir Med 2017; 123:140-148.
    • (2017) Respir Med , vol.123 , pp. 140-148
    • Cockle, S.M.1    Stynes, G.2    Gunsoy, N.B.3
  • 41
    • 84959420164 scopus 로고    scopus 로고
    • Real-life' effectiveness studies of omalizumab in adult patients with severe allergic asthma: Systematic review
    • Abraham I, Alhossan A, Lee CS, et al. 'Real-life' effectiveness studies of omalizumab in adult patients with severe allergic asthma: systematic review. Allergy 2016; 71:593-610.
    • (2016) Allergy , vol.71 , pp. 593-610
    • Abraham, I.1    Alhossan, A.2    Lee, C.S.3
  • 42
    • 84942862413 scopus 로고    scopus 로고
    • Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: A systematic review and meta-Analysis
    • Lai T, Wang S, Xu Z, et al. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-Analysis. Sci Rep 2015; 5:8191.
    • (2015) Sci Rep , vol.5 , pp. 8191
    • Lai, T.1    Wang, S.2    Xu, Z.3
  • 43
    • 84941260242 scopus 로고    scopus 로고
    • Systematic review on the use of omalizumab for the treatment of asthmatic children and adolescents
    • Rodrigo GJ, Neffen H. Systematic review on the use of omalizumab for the treatment of asthmatic children and adolescents. Pediatr Allergy Immunol 2015; 26:551-556.
    • (2015) Pediatr Allergy Immunol , vol.26 , pp. 551-556
    • Rodrigo, G.J.1    Neffen, H.2
  • 44
    • 85021768930 scopus 로고    scopus 로고
    • Efficacy and safety of omalizumab in children and adolescents with moderate-to-severe asthma: A systematic literature review
    • Corren J, Kavati A, Ortiz B, et al. Efficacy and safety of omalizumab in children and adolescents with moderate-to-severe asthma: a systematic literature review. Allergy Asthma Proc 2017; 38:250-263.
    • (2017) Allergy Asthma Proc , vol.38 , pp. 250-263
    • Corren, J.1    Kavati, A.2    Ortiz, B.3
  • 45
    • 85016043320 scopus 로고    scopus 로고
    • Real-life' effectiveness studies of omalizumab in adult patients with severe allergic asthma: Meta-Analysis
    • e2
    • Alhossan A, Lee CS, MacDonald K, et al. Real-life' effectiveness studies of omalizumab in adult patients with severe allergic asthma: meta-Analysis. J Allergy Clin Immunol Pract 2017; 5:1362-1370.e2.
    • (2017) J Allergy Clin Immunol Pract , vol.5 , pp. 1362-1370
    • Alhossan, A.1    Lee, C.S.2    MacDonald, K.3
  • 46
    • 84874079268 scopus 로고    scopus 로고
    • Does omalizumabmake a difference to the real-life treatment of asthma exacerbations?: Results from a large cohort of patients with severe uncontrolled asthma
    • Pharmacoepidemiology of Asthma and Xolair (PAX) StudyGroup
    • Grimaldi-Bensouda L, Zureik M, Aubier M, et al., Pharmacoepidemiology of Asthma and Xolair (PAX) StudyGroup. Does omalizumabmake a difference to the real-life treatment of asthma exacerbations?: Results from a large cohort of patients with severe uncontrolled asthma. Chest 2013; 143: 398-405.
    • (2013) Chest , vol.143 , pp. 398-405
    • Grimaldi-Bensouda, L.1    Zureik, M.2    Aubier, M.3
  • 47
    • 85019253126 scopus 로고    scopus 로고
    • Real-life efficacy of omalizumab after 9 years of follow-up
    • Menzella F, Galeone C, Formisano D, et al. Real-life efficacy of omalizumab after 9 years of follow-up. Allergy Asthma Immunol Res 2017; 9:368-372.
    • (2017) Allergy Asthma Immunol Res , vol.9 , pp. 368-372
    • Menzella, F.1    Galeone, C.2    Formisano, D.3
  • 48
    • 84880851544 scopus 로고    scopus 로고
    • A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma
    • Garcia G, Magnan A, Chiron R, et al. A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma. Chest 2013; 144:411-419.
    • (2013) Chest , vol.144 , pp. 411-419
    • Garcia, G.1    Magnan, A.2    Chiron, R.3
  • 49
    • 85006154489 scopus 로고    scopus 로고
    • Omalizumab reduces bronchial mucosal ige and improves lung function in nonatopic asthma
    • Pillai P, Chan YC, Wu SY, et al. Omalizumab reduces bronchial mucosal IgE and improves lung function in nonatopic asthma. Eur Respir J 2016; 48:1593-1601.
    • (2016) Eur Respir J , vol.48 , pp. 1593-1601
    • Pillai, P.1    Chan, Y.C.2    Wu, S.Y.3
  • 50
    • 85006166551 scopus 로고    scopus 로고
    • Targeting immunoglobulin e in nonatopic asthma: Crossing the red line?
    • Gaga M, Zervas E, Humbert M. Targeting immunoglobulin E in nonatopic asthma: crossing the red line? Eur Respir J 2016; 48:1538-1540.
    • (2016) Eur Respir J , vol.48 , pp. 1538-1540
    • Gaga, M.1    Zervas, E.2    Humbert, M.3
  • 54
    • 85006386654 scopus 로고    scopus 로고
    • Comparison of antiinterleukin-5 therapies in patients with severe asthma: Global and indirect meta-Analyses of randomized placebo-controlled trials
    • Cabon Y, Molinari N, Marin G, et al. Comparison of antiinterleukin-5 therapies in patients with severe asthma: global and indirect meta-Analyses of randomized placebo-controlled trials. Clin Exp Allergy 2017; 47:129-138.
    • (2017) Clin Exp Allergy , vol.47 , pp. 129-138
    • Cabon, Y.1    Molinari, N.2    Marin, G.3
  • 55
    • 85018439318 scopus 로고    scopus 로고
    • Biologics and biomarkers for asthma, urticaria, and nasal polyposis
    • Casale TB. Biologics and biomarkers for asthma, urticaria, and nasal polyposis. J Allergy Clin Immunol 2017; 139:1411-1421.
    • (2017) J Allergy Clin Immunol , vol.139 , pp. 1411-1421
    • Casale, T.B.1
  • 56
    • 84907423833 scopus 로고    scopus 로고
    • Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma
    • Bel EH, Wenzel SE, Thompson PJ, et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med 2014; 371:1189-1197.
    • (2014) N Engl J Med , vol.371 , pp. 1189-1197
    • Bel, E.H.1    Wenzel, S.E.2    Thompson, P.J.3
  • 57
    • 84982949062 scopus 로고    scopus 로고
    • A critical evaluation of anti-il-13 and anti-il-4 strategies in severe asthma
    • Bagnasco D, Ferrando M, Varricchi G, et al. A critical evaluation of anti-IL-13 and anti-IL-4 strategies in severe asthma. Int Arch Allergy Immunol 2016; 170:122-131.
    • (2016) Int Arch Allergy Immunol , vol.170 , pp. 122-131
    • Bagnasco, D.1    Ferrando, M.2    Varricchi, G.3
  • 59
    • 84979770584 scopus 로고    scopus 로고
    • Molecularly targeted therapies for asthma: Current development, challenges and potential clinical translation
    • Sulaiman I, Lim JC, Soo HL, et al. Molecularly targeted therapies for asthma: current development, challenges and potential clinical translation. Pulm Pharmacol Ther 2016; 40:52-68.
    • (2016) Pulm Pharmacol Ther , vol.40 , pp. 52-68
    • Sulaiman, I.1    Lim, J.C.2    Soo, H.L.3
  • 61
    • 10744231300 scopus 로고    scopus 로고
    • European network for understanding mechanisms of severe asthma
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma
    • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for understanding mechanisms of severe asthma. Eur Respir J 2003; 22:470-477.
    • (2003) Eur Respir J , vol.22 , pp. 470-477
  • 62
    • 84890026323 scopus 로고    scopus 로고
    • Randomized, double-blind, placebocontrolled study of brodalumab, a human anti-il-17 receptor monoclonal antibody, in moderate to severe asthma
    • Busse WW, Holgate S, Kerwin E, et al. Randomized, double-blind, placebocontrolled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med 2013; 188:1294-1302.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 1294-1302
    • Busse, W.W.1    Holgate, S.2    Kerwin, E.3
  • 63
    • 84941584712 scopus 로고    scopus 로고
    • Targeting the interleukin pathway in the treatment of asthma
    • Chung KF. Targeting the interleukin pathway in the treatment of asthma. Lancet 2015; 386:1086-1096.
    • (2015) Lancet , vol.386 , pp. 1086-1096
    • Chung, K.F.1
  • 64
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360:973-984.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 65
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (dream): A multicentre, double-blind, placebo-controlled trial
    • Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012; 380:651-659.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3
  • 66
    • 85036654464 scopus 로고    scopus 로고
    • European Medicines Agency. 9 September. [Available from
    • European Medicines Agency. Xolair: EPAR-product information. 9 September 2016. [Available from: http://www.ema.europa.eu/docs/en-GB/document-library/EPAR-Product-Information/human/000606/WC500057298.pdf]
    • (2016) Xolair: EPAR-Product Information
  • 68
    • 84948577865 scopus 로고    scopus 로고
    • Asthma phenotypes and endotypes: A personalized approach to treatment
    • Skloot GS. Asthma phenotypes and endotypes: a personalized approach to treatment. Curr Opin Pulm Med 2016; 22:3-9.
    • (2016) Curr Opin Pulm Med , vol.22 , pp. 3-9
    • Skloot, G.S.1
  • 69
  • 70
    • 85020788838 scopus 로고    scopus 로고
    • Inflammatory biomarkers for asthma endotyping and consequent personalized therapy
    • Ciprandi G, Tosca MA, Silvestri M, et al. Inflammatory biomarkers for asthma endotyping and consequent personalized therapy. Expert Rev Clin Immunol 2017; 13:715-721.
    • (2017) Expert Rev Clin Immunol , vol.13 , pp. 715-721
    • Ciprandi, G.1    Tosca, M.A.2    Silvestri, M.3
  • 71
    • 84973138132 scopus 로고    scopus 로고
    • Endotypes of allergic diseases and asthma: An important step in building blocks for the future of precision medicine
    • Agache I, Akdis CA. Endotypes of allergic diseases and asthma: an important step in building blocks for the future of precision medicine. Allergol Int 2016; 65:243-252.
    • (2016) Allergol Int , vol.65 , pp. 243-252
    • Agache, I.1    Akdis, C.A.2
  • 72
    • 85013649593 scopus 로고    scopus 로고
    • Phenotype-driven therapeutics in severe asthma
    • Opina MT, Moore WC. Phenotype-driven therapeutics in severe asthma. Curr Allergy Asthma Rep 2017; 17:10.
    • (2017) Curr Allergy Asthma Rep , vol.17 , pp. 10
    • Opina, M.T.1    Moore, W.C.2
  • 73
    • 85013827427 scopus 로고    scopus 로고
    • Asthma phenotypes in children and stratified pharmacological treatment regimens
    • Iordanidou M, Loukides S, Paraskakis E. Asthma phenotypes in children and stratified pharmacological treatment regimens. Expert Rev Clin Pharmacol 2017; 10:293-303.
    • (2017) Expert Rev Clin Pharmacol , vol.10 , pp. 293-303
    • Iordanidou, M.1    Loukides, S.2    Paraskakis, E.3
  • 75
    • 84893513577 scopus 로고    scopus 로고
    • International ers/ats guidelines on definition, evaluation and treatment of severe asthma
    • Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014; 43:343-373.
    • (2014) Eur Respir J , vol.43 , pp. 343-373
    • Chung, K.F.1    Wenzel, S.E.2    Brozek, J.L.3
  • 76
    • 84995642283 scopus 로고    scopus 로고
    • Healthcare resource use and costs associated with possible side effects of high oral corticosteroid use in asthma: A claims-based analysis
    • Luskin AT, Antonova EN, Broder MS, et al. Healthcare resource use and costs associated with possible side effects of high oral corticosteroid use in asthma: a claims-based analysis. Clinicoecon Outcomes Res 2016; 8:641-648.
    • (2016) Clinicoecon Outcomes Res , vol.8 , pp. 641-648
    • Luskin, A.T.1    Antonova, E.N.2    Broder, M.S.3
  • 77
    • 84883236598 scopus 로고    scopus 로고
    • A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy
    • Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol 2013; 9:30.
    • (2013) Allergy Asthma Clin Immunol , vol.9 , pp. 30
    • Liu, D.1    Ahmet, A.2    Ward, L.3
  • 78
    • 85007523437 scopus 로고    scopus 로고
    • Long-course oral corticosteroid toxicity in children
    • Aljebab F, Choonara I, Conroy S. Long-course oral corticosteroid toxicity in children. Arch Dis Child 2016; 101:e2.
    • (2016) Arch Dis Child , vol.101 , pp. e2
    • Aljebab, F.1    Choonara, I.2    Conroy, S.3
  • 79
    • 84880826189 scopus 로고    scopus 로고
    • The experience registry: The 'realworld' effectiveness of omalizumab in allergic asthma
    • Braunstahl GJ, Chen CW, Maykut R, et al. The eXpeRience registry: the 'realworld' effectiveness of omalizumab in allergic asthma. Respir Med 2013; 107:1141-1151.
    • (2013) Respir Med , vol.107 , pp. 1141-1151
    • Braunstahl, G.J.1    Chen, C.W.2    Maykut, R.3
  • 80
  • 81
    • 85011977145 scopus 로고    scopus 로고
    • Burden of chronic oral corticosteroid use by adults with persistent asthma
    • e9
    • Zeiger RS, Schatz M, Li Q, et al. Burden of chronic oral corticosteroid use by adults with persistent asthma. J Allergy Clin Immunol Pract 2017; 5: 1050-1060.e9.
    • (2017) J Allergy Clin Immunol Pract , vol.5 , pp. 1050-1060
    • Zeiger, R.S.1    Schatz, M.2    Li, Q.3
  • 82
    • 80054947972 scopus 로고    scopus 로고
    • Incidence and us costs of corticosteroid-Associated adverse events: A systematic literature review
    • Sarnes E, Crofford L, Watson M, et al. Incidence and US costs of corticosteroid-Associated adverse events: a systematic literature review. Clin Ther 2011; 33:1413-1432.
    • (2011) Clin Ther , vol.33 , pp. 1413-1432
    • Sarnes, E.1    Crofford, L.2    Watson, M.3
  • 83
    • 80054703208 scopus 로고    scopus 로고
    • Oral corticosteroid sparing with omalizumab in severe allergic (ige-mediated) asthma patients
    • Siergiejko Z, Swiebocka E, Smith N, et al. Oral corticosteroid sparing with omalizumab in severe allergic (IgE-mediated) asthma patients. Curr Med Res Opin 2011; 27:2223-2228.
    • (2011) Curr Med Res Opin , vol.27 , pp. 2223-2228
    • Siergiejko, Z.1    Swiebocka, E.2    Smith, N.3
  • 84
    • 84878134498 scopus 로고    scopus 로고
    • Effectiveness of omalizumab in severe allergic asthma: A retrospective UK real-world study
    • Barnes N, Menzies-Gow A, Mansur AH, et al. Effectiveness of omalizumab in severe allergic asthma: a retrospective UK real-world study. J Asthma 2013; 50:529-536.
    • (2013) J Asthma , vol.50 , pp. 529-536
    • Barnes, N.1    Menzies-Gow, A.2    Mansur, A.H.3
  • 85
    • 84896107644 scopus 로고    scopus 로고
    • Management of severe asthma in childhood: State of the art and novel perspectives
    • Hedlin G. Management of severe asthma in childhood: state of the art and novel perspectives. Pediatr Allergy Immunol 2014; 25:111-121.
    • (2014) Pediatr Allergy Immunol , vol.25 , pp. 111-121
    • Hedlin, G.1
  • 86
    • 80053498278 scopus 로고    scopus 로고
    • Pharmacological treatment of severe, therapyresistant asthma in children: What can we learn from where?
    • PSACI (Problematic Severe Asthma in Childhood Initiative) group
    • Bush A, Pedersen S, Hedlin G, et al., PSACI (Problematic Severe Asthma in Childhood Initiative) group. Pharmacological treatment of severe, therapyresistant asthma in children: what can we learn from where? Eur Respir J 2011; 38:947-958.
    • (2011) Eur Respir J , vol.38 , pp. 947-958
    • Bush, A.1    Pedersen, S.2    Hedlin, G.3
  • 87
    • 84898837280 scopus 로고    scopus 로고
    • Safety of long-Acting beta agonists and inhaled corticosteroids in children and adolescents with asthma
    • Xia Y, Kelton CM, Xue L, et al. Safety of long-Acting beta agonists and inhaled corticosteroids in children and adolescents with asthma. Ther Adv Drug Saf 2013; 4:254-263.
    • (2013) Ther Adv Drug Saf , vol.4 , pp. 254-263
    • Xia, Y.1    Kelton, C.M.2    Xue, L.3
  • 88
    • 84981523378 scopus 로고    scopus 로고
    • The use of inhaled corticosteroids in pediatric asthma: Update
    • Hossny E, Rosario N, Lee BW, et al. The use of inhaled corticosteroids in pediatric asthma: update. World Allergy Organ J 2016; 9:26.
    • (2016) World Allergy Organ J , vol.9 , pp. 26
    • Hossny, E.1    Rosario, N.2    Lee, B.W.3
  • 89
    • 85002141934 scopus 로고    scopus 로고
    • Salmeterol and fluticasone propionate in children with asthma
    • Stempel DA, Szefler SJ, Pascoe SJ. Salmeterol and fluticasone propionate in children with asthma. N Engl J Med 2016; 375:e46.
    • (2016) N Engl J Med , vol.375 , pp. e46
    • Stempel, D.A.1    Szefler, S.J.2    Pascoe, S.J.3
  • 90
    • 84865687594 scopus 로고    scopus 로고
    • Effect of inhaled glucocorticoids in childhood on adult height
    • Kelly HW, Sternberg AL, Lescher R, et al. Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med 2012; 367:904-912.
    • (2012) N Engl J Med , vol.367 , pp. 904-912
    • Kelly, H.W.1    Sternberg, A.L.2    Lescher, R.3
  • 91
    • 84941209816 scopus 로고    scopus 로고
    • Impact of inhaled corticosteroids on growth in children with asthma: Systematic review and meta-Analysis
    • Loke YK, Blanco P, Thavarajah M, Wilson AM. Impact of inhaled corticosteroids on growth in children with asthma: systematic review and meta-Analysis. PLoS One 2015; 10:e0133428.
    • (2015) PLoS One , vol.10 , pp. e0133428
    • Loke, Y.K.1    Blanco, P.2    Thavarajah, M.3    Wilson, A.M.4
  • 92
    • 84978250278 scopus 로고    scopus 로고
    • Influence of inhaled corticosteroids on pubertal growth and final height in asthmatic children
    • De Leonibus C, Attanasi M, Roze Z, et al. Influence of inhaled corticosteroids on pubertal growth and final height in asthmatic children. Pediatr Allergy Immunol 2016; 27:499-506.
    • (2016) Pediatr Allergy Immunol , vol.27 , pp. 499-506
    • De Leonibus, C.1    Attanasi, M.2    Roze, Z.3
  • 93
    • 84942774097 scopus 로고    scopus 로고
    • Real-life long-term omalizumab therapy in children with severe allergic asthma
    • Deschildre A, Marguet C, Langlois C, et al. Real-life long-term omalizumab therapy in children with severe allergic asthma. Eur Respir J 2015; 46:856-859.
    • (2015) Eur Respir J , vol.46 , pp. 856-859
    • Deschildre, A.1    Marguet, C.2    Langlois, C.3
  • 94
    • 84947723618 scopus 로고    scopus 로고
    • Four-year follow-up in children with moderate/severe uncontrolled asthma after withdrawal of a 1-year omalizumab treatment
    • Baena-Cagnani CE, Teijeiro A, Canonica GW. Four-year follow-up in children with moderate/severe uncontrolled asthma after withdrawal of a 1-year omalizumab treatment. Curr Opin Allergy Clin Immunol 2015; 15:267-271.
    • (2015) Curr Opin Allergy Clin Immunol , vol.15 , pp. 267-271
    • Baena-Cagnani, C.E.1    Teijeiro, A.2    Canonica, G.W.3
  • 95
    • 84908278609 scopus 로고    scopus 로고
    • Proteomics of bronchial biopsies: Galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumabtreated severe asthma patients
    • Mauri P, Riccio AM, Rossi R, et al. Proteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumabtreated severe asthma patients. Immunol Lett 2014; 162:2-10.
    • (2014) Immunol Lett , vol.162 , pp. 2-10
    • Mauri, P.1    Riccio, A.M.2    Rossi, R.3
  • 96
    • 84862760305 scopus 로고    scopus 로고
    • Effects of adding omalizumab, an anti-immunoglobulin e antibody, on airway wall thickening in asthma
    • Hoshino M, Ohtawa J. Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma. Respiration 2012; 83: 520-528.
    • (2012) Respiration , vol.83 , pp. 520-528
    • Hoshino, M.1    Ohtawa, J.2
  • 97
    • 84863698582 scopus 로고    scopus 로고
    • Omalizumab modulates bronchial reticular basement membrane thickness and eosinophil infiltration in severe persistent allergic asthma patients
    • Riccio AM, Dal Negro RW, Micheletto C, et al. Omalizumab modulates bronchial reticular basement membrane thickness and eosinophil infiltration in severe persistent allergic asthma patients. Int J Immunopathol Pharmacol 2012; 25:475-484.
    • (2012) Int J Immunopathol Pharmacol , vol.25 , pp. 475-484
    • Riccio, A.M.1    Dal Negro, R.W.2    Micheletto, C.3
  • 98
    • 84952639005 scopus 로고    scopus 로고
    • Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations
    • Teach SJ, Gill MA, Togias A, et al. Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations. J Allergy Clin Immunol 2015; 136:1476-1485.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 1476-1485
    • Teach, S.J.1    Gill, M.A.2    Togias, A.3
  • 99
    • 85031699574 scopus 로고    scopus 로고
    • Effects of omalizumab on rhinovirus infections, illnesses and exacerbations of asthma
    • [Epub ahead of print]
    • Esquivel A, Busse WW, Calatroni A, et al. Effects of omalizumab on rhinovirus infections, illnesses and exacerbations of asthma. Am J Respir Crit Care Med 2017. [Epub ahead of print]
    • (2017) Am J Respir Crit Care Med
    • Esquivel, A.1    Busse, W.W.2    Calatroni, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.