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Volumn 2015, Issue 7, 2015, Pages

Mepolizumab versus placebo for asthma

Author keywords

[No Author keywords available]

Indexed keywords

MEPOLIZUMAB; PLACEBO; MONOCLONAL ANTIBODY;

EID: 84957414816     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD010834.pub2     Document Type: Review
Times cited : (34)

References (174)
  • 1
    • 0037718532 scopus 로고    scopus 로고
    • Monoclonal anti-interleukin-5 treatment suppresses eosinophil but not T-cell functions
    • CRS-ID: 4900100000015258]
    • Buttner C, Lun A, Splettstoesser T, Kunkel G, Renz H. Monoclonal anti-interleukin-5 treatment suppresses eosinophil but not T-cell functions. European Respiratory Journal 2003;21(5):799-803. [CRS-ID: 4900100000015258]
    • (2003) European Respiratory Journal , vol.21 , Issue.5 , pp. 799-803
    • Buttner, C.1    Lun, A.2    Splettstoesser, T.3    Kunkel, G.4    Renz, H.5
  • 2
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway [comment]
    • CRS-ID: 4900100000013790;: 4900100000013790]
    • Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway [comment]. American Journal of Respiratory and Critical Care Medicine 2003;167(2):199-204. [CRS-ID: 4900100000013790;: 4900100000013790]
    • (2003) American Journal of Respiratory and Critical Care Medicine , vol.167 , Issue.2 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 3
    • 0002318513 scopus 로고    scopus 로고
    • Reduction of tissue eosinophils in mild atopic asthmatics by an anti-IL-5 monoclonal antibody (Mepolizumab) is associated with inhibition of tenascin deposition with the bronchial epithelial basement [Abstract]
    • CRS-ID: 4900100000013133]
    • Flood-Page PT, Menzies-Gow AN, Phipps S, Compton C, Walls C, Barnes NC, et al. Reduction of tissue eosinophils in mild atopic asthmatics by an anti-IL-5 monoclonal antibody (Mepolizumab) is associated with inhibition of tenascin deposition with the bronchial epithelial basement [Abstract]. American Journal of Respiratory and Critical Care Medicine 2002;165(Suppl 8):B42. [CRS-ID: 4900100000013133]
    • (2002) American Journal of Respiratory and Critical Care Medicine , vol.165 , pp. B42
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Phipps, S.3    Compton, C.4    Walls, C.5    Barnes, N.C.6
  • 4
    • 85047693849 scopus 로고    scopus 로고
    • Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    • CRS-ID: 4900100000015627]
    • Flood-Page PT, Menzies-Gow AN, Phipps S, Ying S, Wangoo A, Ludwig MS, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. Journal of Clinical Investigation 2003;112(7):1029-36. [CRS-ID: 4900100000015627]
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.7 , pp. 1029-1036
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Phipps, S.3    Ying, S.4    Wangoo, A.5    Ludwig, M.S.6
  • 6
    • 39849099089 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, parallel group study to assess the effect of mepolizumab (humanised monoclonal anti-il-5-antibody) on bone marrow and peripheral blood eosinophils and eosinophil progenitors in atopic asthmatics [Abstract]
    • [CRS-ID: 4900100000013192]
    • Menzies-Gow AN, Flood-Page PT, Compton C, Walls C, Sehmi R, Robinson DS, et al. A double-blind placebo-controlled, parallel group study to assess the effect of mepolizumab (humanised monoclonal anti-il-5-antibody) on bone marrow and peripheral blood eosinophils and eosinophil progenitors in atopic asthmatics [Abstract]. American Journal of Respiratory and Critical Care Medicine. 2002; Vol. 165, issue Suppl 8:B50. [CRS-ID: 4900100000013192]
    • (2002) American Journal of Respiratory and Critical Care Medicine , vol.165 , pp. B50
    • Menzies-Gow, A.N.1    Flood-Page, P.T.2    Compton, C.3    Walls, C.4    Sehmi, R.5    Robinson, D.S.6
  • 7
    • 0037393468 scopus 로고    scopus 로고
    • Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
    • CRS-ID: 4900100000015225;: 4900100000015225]
    • Menzies-Gow AN, Flood-Page PT, Sehmi R, Burman J, Hamid Q, Robinson DS, et al. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. The Journal of Allergy and Clinical Immunology 2003;111(4):714-9. [CRS-ID: 4900100000015225;: 4900100000015225]
    • (2003) The Journal of Allergy and Clinical Immunology , vol.111 , Issue.4 , pp. 714-719
    • Menzies-Gow, A.N.1    Flood-Page, P.T.2    Sehmi, R.3    Burman, J.4    Hamid, Q.5    Robinson, D.S.6
  • 8
    • 0038360363 scopus 로고    scopus 로고
    • Anti-IL-5 (mepolizumab) reduces the expression of tenascin procollagen III and lumican in the reticular basement membrane of human atopic asthmatics [Abstract]
    • [CRS-ID: 4900100000018828]
    • Phipps S, Flood-Page PT, Menzies-Gow AN, Wangoo A, Barnes N, Barkans J, et al. Anti-IL-5 (mepolizumab) reduces the expression of tenascin procollagen III and lumican in the reticular basement membrane of human atopic asthmatics [Abstract]. The Journal of Allergy and Clinical Immunology. 2003; Vol. 111, issue 2 Suppl:S278. [CRS-ID: 4900100000018828]
    • (2003) The Journal of Allergy and Clinical Immunology , vol.111 , Issue.2 , pp. S278
    • Phipps, S.1    Flood-Page, P.T.2    Menzies-Gow, A.N.3    Wangoo, A.4    Barnes, N.5    Barkans, J.6
  • 10
    • 85029878413 scopus 로고    scopus 로고
    • Assessment of changes in airways dimensions with mepolizumab treatment in refractory eosinophilic asthma [Abstract]
    • 2009 May 15-20 San Diego. [CRS-ID: 4900100000024535]
    • Gupta S, Halder P, Hargadon B, Sousa A, Marshall RP, Wardlaw AJ, et al. Assessment of changes in airways dimensions with mepolizumab treatment in refractory eosinophilic asthma [Abstract]. American Thoracic Society International Conference; 2009 May 15-20 San Diego. 2009:A3641. [CRS-ID: 4900100000024535]
    • (2009) American Thoracic Society International Conference , pp. A3641
    • Gupta, S.1    Halder, P.2    Hargadon, B.3    Sousa, A.4    Marshall, R.P.5    Wardlaw, A.J.6
  • 11
    • 71749099373 scopus 로고    scopus 로고
    • Mepolizumab (Anti-IL5) and exacerbation frequency in refractory eosinophilic asthma [Abstract]. Proceedings of the American Thoracic Society International Conference; 2009 May 15-20; San Diego
    • [CRS-ID: 4900100000024597]
    • Haldar P, Brightling C, Hargadon B, Gupta S, Monteiro W, Sousa A, et al. Mepolizumab (Anti-IL5) and exacerbation frequency in refractory eosinophilic asthma [Abstract]. Proceedings of the American Thoracic Society International Conference; 2009 May 15-20; San Diego. American Journal of Critical Care and Respiratory Medicine. 2009; Vol. 179:A3638. [CRS-ID: 4900100000024597]
    • (2009) American Journal of Critical Care and Respiratory Medicine , vol.179 , pp. A3638
    • Haldar, P.1    Brightling, C.2    Hargadon, B.3    Gupta, S.4    Monteiro, W.5    Sousa, A.6
  • 13
    • 84896701005 scopus 로고    scopus 로고
    • Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis
    • CRS: 4900126000009453; EMBASE: 2014156329; PUBMED: 24418480]
    • Haldar P, Brightling CE, Singapuri A, Hargadon B, Gupta S, Monteiro W, et al. Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis. The Journal of Allergy and Clinical Immunology 2014;133(3):921-3. [CRS: 4900126000009453; EMBASE: 2014156329; PUBMED: 24418480]
    • (2014) The Journal of Allergy and Clinical Immunology , vol.133 , Issue.3 , pp. 921-923
    • Haldar, P.1    Brightling, C.E.2    Singapuri, A.3    Hargadon, B.4    Gupta, S.5    Monteiro, W.6
  • 14
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • CRS-ID: 4900100000010079]
    • Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. The Lancet 2000;356(9248):2144-8. [CRS-ID: 4900100000010079]
    • (2000) The Lancet , vol.356 , Issue.9248 , pp. 2144-2148
    • Leckie, M.J.1    ten Brinke, A.2    Khan, J.3    Diamant, Z.4    O'Connor, B.J.5    Walls, C.M.6
  • 17
    • 85041825451 scopus 로고    scopus 로고
    • The effects of a humanized anti-IL-5 monoclonal antibody (SB-240563) on asthma control, airway eosinophilia and the degree to which corticosteroid treatment can be reduced to maintain control
    • (accessed 16 January 2015). [CRS-ID: 4900100000020456]
    • NCT00292877. The effects of a humanized anti-IL-5 monoclonal antibody (SB-240563) on asthma control, airway eosinophilia and the degree to which corticosteroid treatment can be reduced to maintain control. https://clinicaltrials.gov/ct2/show/NCT00292877 (accessed 16 January 2015). [CRS-ID: 4900100000020456]
  • 18
    • 85041816100 scopus 로고    scopus 로고
    • Prednisone sparing effect of mepolizumab on eosinophilic bronchitis with or without asthma a randomized placebo controlled trial [Abstract]
    • 2008 May 16-21; Toronto.[CRS-ID: 4900100000023006]
    • Nair P, Pizzichini M, Kjarsgaard M, Inman M, Efthimiadis A, Pizzichini E, et al. Prednisone sparing effect of mepolizumab on eosinophilic bronchitis with or without asthma a randomized placebo controlled trial [Abstract]. American Thoracic Society International Conference; 2008 May 16-21; Toronto. 2008:A568[#509]. [CRS-ID: 4900100000023006]
    • (2008)
    • Nair, P.1    Pizzichini, M.2    Kjarsgaard, M.3    Inman, M.4    Efthimiadis, A.5    Pizzichini, E.6
  • 20
    • 85029879364 scopus 로고    scopus 로고
    • MEA115588 A randomised, double-blind, double-dummy, placebo-controlled, parallel-group, multi-centre study of the efficacy and safety of mepolizumab adjunctive therapy in subjects with severe uncontrolled refractory asthma
    • (accessed 16 January 2015). [CRS-ID: 4900126000001339]
    • NCT01691521. MEA115588 A randomised, double-blind, double-dummy, placebo-controlled, parallel-group, multi-centre study of the efficacy and safety of mepolizumab adjunctive therapy in subjects with severe uncontrolled refractory asthma. https://clinicaltrials.gov/ct2/show/NCT01691521 (accessed 16 January 2015). [CRS-ID: 4900126000001339]
  • 21
    • 84907424177 scopus 로고    scopus 로고
    • Mepolizumab treatment in patients with severe eosinophilic asthma
    • CRS: 4900126000019751; EMBASE: 25199059; PUBMED: 25199059]
    • Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. New England Journal of Medicine 2014;371(13):1198-207. [CRS: 4900126000019751; EMBASE: 25199059; PUBMED: 25199059]
    • (2014) New England Journal of Medicine , vol.371 , Issue.13 , pp. 1198-1207
    • Ortega, H.G.1    Liu, M.C.2    Pavord, I.D.3    Brusselle, G.G.4    FitzGerald, J.M.5    Chetta, A.6
  • 22
    • 85041820815 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, placebo-controlled, parallel group, dose ranging study to determine the effect of mepolizumab on exacerbation rates in subjects with severe uncontrolled refractory asthma
    • (accesssed 16 January 2015). [CRS-ID: 4900126000001337]
    • NCT01000506. A multicenter, randomized, double-blind, placebo-controlled, parallel group, dose ranging study to determine the effect of mepolizumab on exacerbation rates in subjects with severe uncontrolled refractory asthma. https://clinicaltrials.gov/ct2/show/NCT01000506 (accesssed 16 January 2015). [CRS-ID: 4900126000001337]
  • 23
    • 84911874054 scopus 로고    scopus 로고
    • Cluster analysis and characterization of response to mepolizumab: A step closer to personalized medicine for patients with severe asthma
    • CRS: 4900126000015693; PUBMED: 24983709]
    • Ortega H, Li H, Suruki R, Albers F, Gordon D, Yancey S. Cluster analysis and characterization of response to mepolizumab: A step closer to personalized medicine for patients with severe asthma. Annals of the American Thoracic Society 2014;11(7):1011-7. [CRS: 4900126000015693; PUBMED: 24983709]
    • (2014) Annals of the American Thoracic Society , vol.11 , Issue.7 , pp. 1011-1017
    • Ortega, H.1    Li, H.2    Suruki, R.3    Albers, F.4    Gordon, D.5    Yancey, S.6
  • 24
    • 85073290303 scopus 로고    scopus 로고
    • Mepolizumab (anti-IL-5) reduces exacerbations in patients with refractory eosinophilic asthma [Abstract]. Proceedings of the European Respiratory Society 22nd Annual Congress; 2012 Sep 1-5; Vienna
    • [349][CRS-ID: 4900100000068022]
    • Pavord I, Korn S, Howarth P, Bleecker E, Buhl R, Keene O, et al. Mepolizumab (anti-IL-5) reduces exacerbations in patients with refractory eosinophilic asthma [Abstract]. Proceedings of the European Respiratory Society 22nd Annual Congress; 2012 Sep 1-5; Vienna. European Respiratory Journal. 2012; Vol. 40, issue Suppl 56:36s [349]. [CRS-ID: 4900100000068022]
    • (2012) European Respiratory Journal , vol.40 , pp. 36s
    • Pavord, I.1    Korn, S.2    Howarth, P.3    Bleecker, E.4    Buhl, R.5    Keene, O.6
  • 25
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
    • CRS-ID: 4900100000063432]
    • Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. The Lancet 2012;380(9842):651-9. [CRS-ID: 4900100000063432]
    • (2012) The Lancet , vol.380 , Issue.9842 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3    Bleecker, E.R.4    Buhl, R.5    Keene, O.N.6
  • 27
    • 0026485226 scopus 로고
    • Evaluation of immune complexes after immunotherapy with wheat flour in bakers' asthma
    • CRS-ID: 4900100000003916]
    • Armentia A, Arranz M, Martin JM, de la Fuente R, Sanchez P, Barber D, et al. Evaluation of immune complexes after immunotherapy with wheat flour in bakers' asthma. Annals of Allergy 1992;69(5):441-4. [CRS-ID: 4900100000003916]
    • (1992) Annals of Allergy , vol.69 , Issue.5 , pp. 441-444
    • Armentia, A.1    Arranz, M.2    Martin, J.M.3    de la Fuente, R.4    Sanchez, P.5    Barber, D.6
  • 28
    • 3042786151 scopus 로고    scopus 로고
    • Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma
    • CRS-ID: 4900100000017042]
    • Ayres JG, Higgins B, Chilvers ER, Ayre G, Blogg M, Fox H. Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma. Allergy 2004;59(7):701-8. [CRS-ID: 4900100000017042]
    • (2004) Allergy , vol.59 , Issue.7 , pp. 701-708
    • Ayres, J.G.1    Higgins, B.2    Chilvers, E.R.3    Ayre, G.4    Blogg, M.5    Fox, H.6
  • 29
    • 84907423833 scopus 로고    scopus 로고
    • Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma
    • CENTRAL: 1013105; CRS: 4900126000019750; EMBASE: 25199060; PUBMED: 25199060]
    • Bel EH, Wenzel SE, Thompson PJ, Prazma CM, Keene ON, Yancey SW, et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. New England Journal of Medicine 2014;371(13):1189-97. [CENTRAL: 1013105; CRS: 4900126000019750; EMBASE: 25199060; PUBMED: 25199060]
    • (2014) New England Journal of Medicine , vol.371 , Issue.13 , pp. 1189-1197
    • Bel, E.H.1    Wenzel, S.E.2    Thompson, P.J.3    Prazma, C.M.4    Keene, O.N.5    Yancey, S.W.6
  • 30
    • 85041847270 scopus 로고    scopus 로고
    • MEA115575: A randomised, double-blind, placebo-controlled, parallel-group, multicenter study of mepolizumab adjunctive therapy to reduce steroid use in subjects with severe refractory asthma
    • (accessed 15 July 2015). [CRS-ID: 4900126000001341]
    • NCT01691508. MEA115575: A randomised, double-blind, placebo-controlled, parallel-group, multicenter study of mepolizumab adjunctive therapy to reduce steroid use in subjects with severe refractory asthma. https://clinicaltrials.gov/ct2/show/NCT01691508 (accessed 15 July 2015). [CRS-ID: 4900126000001341]
  • 31
    • 0043240429 scopus 로고    scopus 로고
    • Evaluation of long-term safety of the anti-IgE antibody, omalizumab, in children with allergic asthma
    • CRS-ID: 4900102000000524;: 4900102000000524]
    • Berger W, Gupta N, McAlary M, Fowler-Taylor A, McAlary M, Fowler-Taylor A. Evaluation of long-term safety of the anti-IgE antibody, omalizumab, in children with allergic asthma. Annals of Allergy, Asthma & Immunology 2003;91(2):182-8. [CRS-ID: 4900102000000524;: 4900102000000524]
    • (2003) Annals of Allergy, Asthma & Immunology , vol.91 , Issue.2 , pp. 182-188
    • Berger, W.1    Gupta, N.2    McAlary, M.3    Fowler-Taylor, A.4    McAlary, M.5    Fowler-Taylor, A.6
  • 32
    • 84867198166 scopus 로고    scopus 로고
    • Ethical considerations and rationale of the MAKI trial: a multicenter double-blind randomized placebo-controlled trial into the preventive effect of palivizumab on recurrent wheezing associated with respiratory syncytial virus infection in children with a gestational age of 33-35 weeks
    • CRS-ID: 4900100000067009]
    • Blanken M, Rovers M, Sanders E, Bont L. Ethical considerations and rationale of the MAKI trial: a multicenter double-blind randomized placebo-controlled trial into the preventive effect of palivizumab on recurrent wheezing associated with respiratory syncytial virus infection in children with a gestational age of 33-35 weeks. Contemporary Clinical Trials 2012;33(6):1287-92. [CRS-ID: 4900100000067009]
    • (2012) Contemporary Clinical Trials , vol.33 , Issue.6 , pp. 1287-1292
    • Blanken, M.1    Rovers, M.2    Sanders, E.3    Bont, L.4
  • 35
    • 3442891695 scopus 로고    scopus 로고
    • Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma
    • CRS-ID: 4900100000016325]
    • Bousquet J, Wenzel S, Holgate S, Lumry W, Freeman P, Fox H. Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma. Chest 2004;125(4):1378-86. [CRS-ID: 4900100000016325]
    • (2004) Chest , vol.125 , Issue.4 , pp. 1378-1386
    • Bousquet, J.1    Wenzel, S.2    Holgate, S.3    Lumry, W.4    Freeman, P.5    Fox, H.6
  • 36
    • 79953737882 scopus 로고    scopus 로고
    • Persistency of response to omalizumab therapy in severe allergic (IgE-mediated) asthma
    • CRS-ID: 4900100000026344]
    • Bousquet J, Siergiejko Z, Swiebocka E, Humbert M, Rabe KF, Smith N, et al. Persistency of response to omalizumab therapy in severe allergic (IgE-mediated) asthma. Allergy 2011;66(5):671-8. [CRS-ID: 4900100000026344]
    • (2011) Allergy , vol.66 , Issue.5 , pp. 671-678
    • Bousquet, J.1    Siergiejko, Z.2    Swiebocka, E.3    Humbert, M.4    Rabe, K.F.5    Smith, N.6
  • 37
    • 33846166114 scopus 로고    scopus 로고
    • Cost-effectiveness of omalizumab in patients with severe persistent allergic asthma
    • CRS-ID: 4900100000019948;: 4900100000019948]
    • Brown R, Turk F, Dale P, Bousquet J. Cost-effectiveness of omalizumab in patients with severe persistent allergic asthma. Allergy 2007;62(2):149-53. [CRS-ID: 4900100000019948;: 4900100000019948]
    • (2007) Allergy , vol.62 , Issue.2 , pp. 149-153
    • Brown, R.1    Turk, F.2    Dale, P.3    Bousquet, J.4
  • 38
    • 0016829436 scopus 로고
    • Identification of IgG antibody as a carrier of reaginic activity in asthmatic patients
    • CRS-ID: 4900100000024002]
    • Bryant DH, Burns MW, Lazarus L. Identification of IgG antibody as a carrier of reaginic activity in asthmatic patients. The Journal of Allergy and Clinical Immunology 1975;56(6):417-28. [CRS-ID: 4900100000024002]
    • (1975) The Journal of Allergy and Clinical Immunology , vol.56 , Issue.6 , pp. 417-428
    • Bryant, D.H.1    Burns, M.W.2    Lazarus, L.3
  • 39
    • 0016694297 scopus 로고
    • The correlation between skin tests, bronchial provocation tests and the serum level of IgE specific for common allergens in patients with asthma
    • CRS-ID: 4900100000023985]
    • Bryant DH, Burns MW, Lazarus L. The correlation between skin tests, bronchial provocation tests and the serum level of IgE specific for common allergens in patients with asthma. Clinical Allergy 1975;5(2):145-57. [CRS-ID: 4900100000023985]
    • (1975) Clinical Allergy , vol.5 , Issue.2 , pp. 145-157
    • Bryant, D.H.1    Burns, M.W.2    Lazarus, L.3
  • 40
    • 0001560285 scopus 로고    scopus 로고
    • RhuMAb-25 improves asthma-specific quality of life in patients with allergic asthma
    • CRS-ID: 4900100000013847]
    • Buhl R, Kunkel G, Soler M, Bensch G, Wolfe J, Noga O, et al. RhuMAb-25 improves asthma-specific quality of life in patients with allergic asthma. European Respiratory Journal 2000;16(Suppl 31):465s. [CRS-ID: 4900100000013847]
    • (2000) European Respiratory Journal , vol.16 , pp. 465s
    • Buhl, R.1    Kunkel, G.2    Soler, M.3    Bensch, G.4    Wolfe, J.5    Noga, O.6
  • 41
    • 0001546324 scopus 로고    scopus 로고
    • Recombinant humanized monoclonal antibody (rhuMAb) E25 in the prevention of serious asthma exacerbations
    • CRS-ID: 4900100000013848]
    • Buhl R, Soler M, Fox H, Ashby M, McAlary M, Cooper J, et al. Recombinant humanized monoclonal antibody (rhuMAb) E25 in the prevention of serious asthma exacerbations. European Respiratory Journal 2000;16(Suppl 31):277s. [CRS-ID: 4900100000013848]
    • (2000) European Respiratory Journal , vol.16 , pp. 277s
    • Buhl, R.1    Soler, M.2    Fox, H.3    Ashby, M.4    McAlary, M.5    Cooper, J.6
  • 42
    • 0035989332 scopus 로고    scopus 로고
    • Omalizumab provides long-term control in patients with moderate-to- severe allergic asthma
    • CRS-ID: 4900100000012867]
    • Buhl R, Soler M, Matz J, Townley R, O'Brien J, Noga O, et al. Omalizumab provides long-term control in patients with moderate-to- severe allergic asthma. European Respiratory Journal 2002;20(1):73-8. [CRS-ID: 4900100000012867]
    • (2002) European Respiratory Journal , vol.20 , Issue.1 , pp. 73-78
    • Buhl, R.1    Soler, M.2    Matz, J.3    Townley, R.4    O'Brien, J.5    Noga, O.6
  • 44
    • 0034907372 scopus 로고    scopus 로고
    • Omalizumab, Anti-Ige Recombinant Humanized Monoclonal Antibody, for the Treatment of Severe Allergic Asthma
    • CRS-ID: 4900100000010636;: 4900100000010636]
    • Busse WW, Corren J, Lanier BQ, Mcalary M, Fowler-Taylor A, Della Cioppa G, et al. Omalizumab, Anti-Ige Recombinant Humanized Monoclonal Antibody, for the Treatment of Severe Allergic Asthma. The Journal of Allergy and Clinical Immunology 2001;108(2):184-90. [CRS-ID: 4900100000010636;: 4900100000010636]
    • (2001) The Journal of Allergy and Clinical Immunology , vol.108 , Issue.2 , pp. 184-190
    • Busse, W.W.1    Corren, J.2    Lanier, B.Q.3    Mcalary, M.4    Fowler-Taylor, A.5    Della Cioppa, G.6
  • 45
    • 57349179165 scopus 로고    scopus 로고
    • Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial
    • CRS-ID: 4900100000022833]
    • Busse WW, Israel E, Nelson HS, Baker JW, Charous BL, Young DY, et al. Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial. American Journal of Respiratory and Critical Care Medicine 2008;178(10):1002-8. [CRS-ID: 4900100000022833]
    • (2008) American Journal of Respiratory and Critical Care Medicine , vol.178 , Issue.10 , pp. 1002-1008
    • Busse, W.W.1    Israel, E.2    Nelson, H.S.3    Baker, J.W.4    Charous, B.L.5    Young, D.Y.6
  • 46
    • 0033773546 scopus 로고    scopus 로고
    • Preseasonal local allergoid immunotherapy to grass pollen in children: a double-blind, placebo-controlled, randomized trial
    • CRS-ID: 4900100000009985]
    • Caffarelli C, Sensi LG, Marcucci F, Cavagni G. Preseasonal local allergoid immunotherapy to grass pollen in children: a double-blind, placebo-controlled, randomized trial. Allergy 2000;55(12):1142-7. [CRS-ID: 4900100000009985]
    • (2000) Allergy , vol.55 , Issue.12 , pp. 1142-1147
    • Caffarelli, C.1    Sensi, L.G.2    Marcucci, F.3    Cavagni, G.4
  • 47
    • 84859981430 scopus 로고    scopus 로고
    • Reslizumab in the treatment of poorly controlled asthma in patients with eosinophilic airway inflammation [Abstract]
    • CRS-ID: 4900100000054093]
    • Castro M, Mathur S, Hargreave F, Xie F, Young J, Wilkins HJ, et al. Reslizumab in the treatment of poorly controlled asthma in patients with eosinophilic airway inflammation [Abstract]. Annals of Allergy, Asthma & Immunology 2010;105(5 Suppl):A43. [CRS-ID: 4900100000054093]
    • (2010) Annals of Allergy, Asthma & Immunology , vol.105 , Issue.5 , pp. A43
    • Castro, M.1    Mathur, S.2    Hargreave, F.3    Xie, F.4    Young, J.5    Wilkins, H.J.6
  • 49
    • 0024329917 scopus 로고
    • Effect of feeding whey hydrolysate, soy and conventional cow milk formulas on incidence of atopic disease in high risk infants
    • CRS-ID: 4900100000002896]
    • Chandra RK, Singh G, Shridhara B. Effect of feeding whey hydrolysate, soy and conventional cow milk formulas on incidence of atopic disease in high risk infants. Annals of Allergy 1989;63(2):102-6. [CRS-ID: 4900100000002896]
    • (1989) Annals of Allergy , vol.63 , Issue.2 , pp. 102-106
    • Chandra, R.K.1    Singh, G.2    Shridhara, B.3
  • 50
    • 0041737745 scopus 로고    scopus 로고
    • Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis
    • CRS-ID: 4900100000015346;: 4900100000015346]
    • Chervinsky P, Casale T, Townley R, Tripathy I, Hedgecock S, Fowler-Taylor A, et al. Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis. Annals of Allergy, Asthma & Immunology 2003;91(2):160-7. [CRS-ID: 4900100000015346;: 4900100000015346]
    • (2003) Annals of Allergy, Asthma & Immunology , vol.91 , Issue.2 , pp. 160-167
    • Chervinsky, P.1    Casale, T.2    Townley, R.3    Tripathy, I.4    Hedgecock, S.5    Fowler-Taylor, A.6
  • 51
    • 0031864005 scopus 로고    scopus 로고
    • Clinical efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis
    • CRS-ID: 4900100000023536]
    • Clavel R, Bousquet J, Andre C. Clinical efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled trial of a standardized five-grass-pollen extract in rhinitis. Allergy 1998;53(5):493-8. [CRS-ID: 4900100000023536]
    • (1998) Allergy , vol.53 , Issue.5 , pp. 493-498
    • Clavel, R.1    Bousquet, J.2    Andre, C.3
  • 52
    • 0037248058 scopus 로고    scopus 로고
    • Omalizumab, a recombinant humanized anti-IgE antibody, reduces asthma-related emergency room visits and hospitalizations in patients with allergic asthma
    • CRS-ID: 4900100000015187]
    • Corren J, Casale T, Deniz Y, Ashby M. Omalizumab, a recombinant humanized anti-IgE antibody, reduces asthma-related emergency room visits and hospitalizations in patients with allergic asthma. The Journal of Allergy and Clinical Immunology 2003;111(1):87-90. [CRS-ID: 4900100000015187]
    • (2003) The Journal of Allergy and Clinical Immunology , vol.111 , Issue.1 , pp. 87-90
    • Corren, J.1    Casale, T.2    Deniz, Y.3    Ashby, M.4
  • 54
    • 0036620279 scopus 로고    scopus 로고
    • Omalizumab: Treatment of allergic rhinitis, treatment of asthma
    • CRS-ID: 4900100000050549]
    • Cullell-Young M, Bayes M, Leeson PA. Omalizumab: Treatment of allergic rhinitis, treatment of asthma. Drugs of the Future 2002;27(6):537-45. [CRS-ID: 4900100000050549]
    • (2002) Drugs of the Future , vol.27 , Issue.6 , pp. 537-545
    • Cullell-Young, M.1    Bayes, M.2    Leeson, P.A.3
  • 55
    • 84897379012 scopus 로고    scopus 로고
    • Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: A randomized trial
    • CENTRAL: 984687; CRS: 4900126000011203; EMBASE: 2014224342; PUBMED: 24582316]
    • De Boever EH, Ashman C, Cahn AP, Locantore NW, Overend P, Pouliquen IJ, et al. Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: A randomized trial. The Journal of Allergy and Clinical Immunology 2014;133(4):989-996. [CENTRAL: 984687; CRS: 4900126000011203; EMBASE: 2014224342; PUBMED: 24582316]
    • (2014) The Journal of Allergy and Clinical Immunology , vol.133 , Issue.4 , pp. 989-996
    • De Boever, E.H.1    Ashman, C.2    Cahn, A.P.3    Locantore, N.W.4    Overend, P.5    Pouliquen, I.J.6
  • 57
    • 0024308166 scopus 로고
    • Vergleichende Untersuchungen zur Wirksamkeit einer spezifischen Immuntherapie bei Hausstaubmilben-Allergie
    • [CRS-ID: 4900100000002906]
    • Ebner H, Neuchrist C, Havelec L, Kraft D. [Comparative studies of the effectiveness of specific immunotherapy in house dust mite allergy] [Vergleichende Untersuchungen zur Wirksamkeit einer spezifischen Immuntherapie bei Hausstaubmilben-Allergie]. Wiener Klinische Wochenschrift 1989;101(15):504-11. [CRS-ID: 4900100000002906]
    • (1989) Wiener Klinische Wochenschrift , vol.101 , Issue.15 , pp. 504-511
    • Ebner, H.1    Neuchrist, C.2    Havelec, L.3    Kraft, D.4
  • 58
    • 77950296135 scopus 로고    scopus 로고
    • Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge
    • CRS-ID: 4900100000024734]
    • Eckman JA, Sterba PM, Kelly D, Alexander V, Liu MC, Bochner BS, et al. Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge. The Journal of Allergy and Clinical Immunology 2010;125(4):889-895.e7. [CRS-ID: 4900100000024734]
    • (2010) The Journal of Allergy and Clinical Immunology , vol.125 , Issue.4 , pp. 889-895e7
    • Eckman, J.A.1    Sterba, P.M.2    Kelly, D.3    Alexander, V.4    Liu, M.C.5    Bochner, B.S.6
  • 59
    • 0033974545 scopus 로고    scopus 로고
    • Pulmonary tuberculosis as a cause of recurrent wheezy chest: the value of serological diagnosis using IgG antibodies to mycobacterium 38 kDa antigen
    • CRS-ID: 4900100000008353]
    • El-Nawawy AA, Massoud MN, El-Nazzar SY, Ramy BB. Pulmonary tuberculosis as a cause of recurrent wheezy chest: the value of serological diagnosis using IgG antibodies to mycobacterium 38 kDa antigen. Journal of Tropical Pediatrics 2000;46(1):53-4. [CRS-ID: 4900100000008353]
    • (2000) Journal of Tropical Pediatrics , vol.46 , Issue.1 , pp. 53-54
    • El-Nawawy, A.A.1    Massoud, M.N.2    El-Nazzar, S.Y.3    Ramy, B.B.4
  • 60
    • 0030956903 scopus 로고    scopus 로고
    • The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects
    • CRS-ID: 4900100000005711]
    • Fahy JV, Fleming HE, Wong HH, Liu JT, Su JQ, Reimann J, et al. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. American Journal of Respiratory and Critical Care Medicine 1997;155(6):1828-34. [CRS-ID: 4900100000005711]
    • (1997) American Journal of Respiratory and Critical Care Medicine , vol.155 , Issue.6 , pp. 1828-1834
    • Fahy, J.V.1    Fleming, H.E.2    Wong, H.H.3    Liu, J.T.4    Su, J.Q.5    Reimann, J.6
  • 62
    • 0037329457 scopus 로고    scopus 로고
    • Omalizumab improves asthma-related quality of life in patients with severe allergic asthma
    • CRS-ID: 4900100000013800]
    • Finn A, Gross G, Van Bavel J, Lee T, Windom H, Everhard F, et al. Omalizumab improves asthma-related quality of life in patients with severe allergic asthma. The Journal of Allergy and Clinical Immunology 2003;111(2):278-84. [CRS-ID: 4900100000013800]
    • (2003) The Journal of Allergy and Clinical Immunology , vol.111 , Issue.2 , pp. 278-284
    • Finn, A.1    Gross, G.2    Van Bavel, J.3    Lee, T.4    Windom, H.5    Everhard, F.6
  • 63
    • 0031712547 scopus 로고    scopus 로고
    • Effects of anti-IgE in asthmatic subjects
    • [CRS-ID: 4900100000010183;: 4900100000010183]
    • Frew AJ. Effects of anti-IgE in asthmatic subjects. Thorax 1998;53(Suppl 2):S52-7. [CRS-ID: 4900100000010183;: 4900100000010183]
    • (1998) Thorax , vol.53 , pp. S52-S57
    • Frew, A.J.1
  • 64
    • 84880851544 scopus 로고    scopus 로고
    • A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma
    • CENTRAL: 872766; CRS: 4900100000089187; EMBASE: 2013508319; PUBMED: 23579324]
    • Garcia G, Magnan A, Chiron R, Contin-Bordes C, Berger P, Taillé C, et al. A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma. Chest 2013;144(2):411-9. [CENTRAL: 872766; CRS: 4900100000089187; EMBASE: 2013508319; PUBMED: 23579324]
    • (2013) Chest , vol.144 , Issue.2 , pp. 411-419
    • Garcia, G.1    Magnan, A.2    Chiron, R.3    Contin-Bordes, C.4    Berger, P.5    Taillé, C.6
  • 66
    • 84901759301 scopus 로고    scopus 로고
    • Effects of an anti-TSLP antibody on allergen-induced asthmatic responses
    • CENTRAL: 991614; CRS: 4900126000014666;: 4900126000014666; PUBMED: 24846652]
    • Gauvreau GM, O'Byrne PM, Boulet LP, Wang Y, Cockcroft D, Bigler J, et al. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. New England Journal of Medicine 2014;370(22):2102-10. [CENTRAL: 991614; CRS: 4900126000014666;: 4900126000014666; PUBMED: 24846652]
    • (2014) New England Journal of Medicine , vol.370 , Issue.22 , pp. 2102-2110
    • Gauvreau, G.M.1    O'Byrne, P.M.2    Boulet, L.P.3    Wang, Y.4    Cockcroft, D.5    Bigler, J.6
  • 67
    • 84890816552 scopus 로고    scopus 로고
    • OX40L blockade and allergen-induced airway responses in subjects with mild asthma
    • CENTRAL: 961627; CRS: 4900126000003111; EMBASE: 2013812052; PUBMED: 24224471]
    • Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Mayers I, Carlsten C, et al. OX40L blockade and allergen-induced airway responses in subjects with mild asthma. Clinical and Experimental Allergy 2014;44(1):29-37. [CENTRAL: 961627; CRS: 4900126000003111; EMBASE: 2013812052; PUBMED: 24224471]
    • (2014) Clinical and Experimental Allergy , vol.44 , Issue.1 , pp. 29-37
    • Gauvreau, G.M.1    Boulet, L.P.2    Cockcroft, D.W.3    Fitzgerald, J.M.4    Mayers, I.5    Carlsten, C.6
  • 68
    • 84904490534 scopus 로고    scopus 로고
    • Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production
    • CENTRAL: 994063; CRS: 4900126000015683; PUBMED: 24990880]
    • Gauvreau GM, Harris JM, Boulet LP, Scheerens H, Fitzgerald JM, Putnam WS, et al. Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production. Science Translational Medicine 2014;6(243):243ra85. [CENTRAL: 994063; CRS: 4900126000015683; PUBMED: 24990880]
    • (2014) Science Translational Medicine , vol.6 , Issue.243
    • Gauvreau, G.M.1    Harris, J.M.2    Boulet, L.P.3    Scheerens, H.4    Fitzgerald, J.M.5    Putnam, W.S.6
  • 70
    • 0015403659 scopus 로고
    • Correlation of type specific fluorescent antibodies to ragweed with symptomatology: double-blind study
    • CRS-ID: 4900100000000354]
    • Gordon VH, Caplinger KJ, Meade JHJ, Thompson C. Correlation of type specific fluorescent antibodies to ragweed with symptomatology: double-blind study. Annals of Allergy 1972;30(9):507-17. [CRS-ID: 4900100000000354]
    • (1972) Annals of Allergy , vol.30 , Issue.9 , pp. 507-517
    • Gordon, V.H.1    Caplinger, K.J.2    Meade, J.H.J.3    Thompson, C.4
  • 71
    • 0025997952 scopus 로고
    • Randomized, double-blind phase II study of anti-endotoxin antibody (E5) as adjuvant therapy in humans with serious gram-negative infections
    • CRS-ID: 4900100000003509]
    • Greenberg RN, Wilson KM, Kunz AY, Wedel NI, Gorelick KJ. Randomized, double-blind phase II study of anti-endotoxin antibody (E5) as adjuvant therapy in humans with serious gram-negative infections. Progress in Clinical and Biological Research 1991;367:179-86. [CRS-ID: 4900100000003509]
    • (1991) Progress in Clinical and Biological Research , vol.367 , pp. 179-186
    • Greenberg, R.N.1    Wilson, K.M.2    Kunz, A.Y.3    Wedel, N.I.4    Gorelick, K.J.5
  • 72
    • 68349086795 scopus 로고    scopus 로고
    • Efficacy and regulation of humoral immunity of jade screen powder as an adjunct therapy in children with asthma
    • [CRS-ID: 4900100000024253]
    • Han JQ, Zhu YX. Efficacy and regulation of humoral immunity of jade screen powder as an adjunct therapy in children with asthma. Zhongguo Dang Dai Er Ke Za Zhi [Chinese Journal of Contemporary Pediatrics] 2009;11(7):587-8. [CRS-ID: 4900100000024253]
    • (2009) Zhongguo Dang Dai Er Ke Za Zhi [Chinese Journal of Contemporary Pediatrics] , vol.11 , Issue.7 , pp. 587-588
    • Han, J.Q.1    Zhu, Y.X.2
  • 73
    • 79955751312 scopus 로고    scopus 로고
    • Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial [Summary for patients]
    • CRS-ID: 4900100000026408]
    • Hanania NA, Alpan O, Hamilos DL, Condemi JJ, Reyes-Rivera I, Zhu J, et al. Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial [Summary for patients]. Annals of Internal Medicine 2011;154(9):573-82. [CRS-ID: 4900100000026408]
    • (2011) Annals of Internal Medicine , vol.154 , Issue.9 , pp. 573-582
    • Hanania, N.A.1    Alpan, O.2    Hamilos, D.L.3    Condemi, J.J.4    Reyes-Rivera, I.5    Zhu, J.6
  • 74
    • 84876883293 scopus 로고    scopus 로고
    • Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study
    • CRS-ID: 4900100000077549;: 4900100000077549]
    • Hanania NA, Wenzel S, Rosen K, Hsieh HJ, Mosesova S, Choy DF, et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. American Journal of Respiratory and Critical Care Medicine 2013;187(8):804-11. [CRS-ID: 4900100000077549;: 4900100000077549]
    • (2013) American Journal of Respiratory and Critical Care Medicine , vol.187 , Issue.8 , pp. 804-811
    • Hanania, N.A.1    Wenzel, S.2    Rosen, K.3    Hsieh, H.J.4    Mosesova, S.5    Choy, D.F.6
  • 75
    • 84908293545 scopus 로고    scopus 로고
    • Efficacy and safety of lebrikizumab in severe uncontrolled asthma: Results from the lute and verse phase II randomized, double-blind, placebo-controlled trials
    • CENTRAL: 985853; CRS: 4900126000010490; EMBASE: 71351759]
    • Hanania NA, Noonan MJ, Corren J, Korenblat P, Zheng Y, Putnam W, et al. Efficacy and safety of lebrikizumab in severe uncontrolled asthma: Results from the lute and verse phase II randomized, double-blind, placebo-controlled trials. The Journal of Allergy and Clinical Immunology 2014;133(2 Suppl):AB402. [CENTRAL: 985853; CRS: 4900126000010490; EMBASE: 71351759]
    • (2014) The Journal of Allergy and Clinical Immunology , vol.133 , Issue.2
    • Hanania, N.A.1    Noonan, M.J.2    Corren, J.3    Korenblat, P.4    Zheng, Y.5    Putnam, W.6
  • 76
    • 85004720719 scopus 로고
    • Specific cellular and humoral immunity in children with grass pollen asthma
    • CRS-ID: 4900100000001231]
    • Hill DJ, Smart IJ, Hosking CS. Specific cellular and humoral immunity in children with grass pollen asthma. Clinical Allergy 1982;12(1):83-9. [CRS-ID: 4900100000001231]
    • (1982) Clinical Allergy , vol.12 , Issue.1 , pp. 83-89
    • Hill, D.J.1    Smart, I.J.2    Hosking, C.S.3
  • 77
    • 84871156077 scopus 로고    scopus 로고
    • A phase 1, randomized, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics
    • CRS-ID: 4900100000070660]
    • Hodsman P, Ashman C, Cahn A, De Boever E, Locantore N, Serone A, et al. A phase 1, randomized, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics. British Journal of Clinical Pharmacology 2013;75(1):118-28. [CRS-ID: 4900100000070660]
    • (2013) British Journal of Clinical Pharmacology , vol.75 , Issue.1 , pp. 118-128
    • Hodsman, P.1    Ashman, C.2    Cahn, A.3    De Boever, E.4    Locantore, N.5    Serone, A.6
  • 78
    • 11144356805 scopus 로고    scopus 로고
    • Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma
    • CRS-ID: 4900100000016275]
    • Holgate ST, Chuchalin AG, Hebert J, Lotvall J, Persson GB, Chung KF, et al. Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clinical and Experimental Allergy 2004;34(4):632-8. [CRS-ID: 4900100000016275]
    • (2004) Clinical and Experimental Allergy , vol.34 , Issue.4 , pp. 632-638
    • Holgate, S.T.1    Chuchalin, A.G.2    Hebert, J.3    Lotvall, J.4    Persson, G.B.5    Chung, K.F.6
  • 79
    • 84862760305 scopus 로고    scopus 로고
    • Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma
    • [CRS-ID: 4900100000062323]
    • Hoshino M, Ohtawa J. Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma. Respiration; International Review of Thoracic Diseases 2012;83(6):520-8. [CRS-ID: 4900100000062323]
    • (2012) Respiration; International Review of Thoracic Diseases , vol.83 , Issue.6 , pp. 520-528
    • Hoshino, M.1    Ohtawa, J.2
  • 80
    • 20044362008 scopus 로고    scopus 로고
    • Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
    • CRS-ID: 4900100000018078]
    • Humbert M, Beasley R, Ayres J, Slavin R, Hebert J, Bousquet J, et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy 2005;60(3):309-16. [CRS-ID: 4900100000018078]
    • (2005) Allergy , vol.60 , Issue.3 , pp. 309-316
    • Humbert, M.1    Beasley, R.2    Ayres, J.3    Slavin, R.4    Hebert, J.5    Bousquet, J.6
  • 81
    • 41749115772 scopus 로고    scopus 로고
    • Add-on omalizumab improves day-to-day symptoms in inadequately controlled severe persistent allergic asthma
    • CRS-ID: 4900100000021856;: 4900100000021856]
    • Humbert M, Berger W, Rapatz G, Turk F. Add-on omalizumab improves day-to-day symptoms in inadequately controlled severe persistent allergic asthma. Allergy 2008;63(5):592-6. [CRS-ID: 4900100000021856;: 4900100000021856]
    • (2008) Allergy , vol.63 , Issue.5 , pp. 592-596
    • Humbert, M.1    Berger, W.2    Rapatz, G.3    Turk, F.4
  • 82
    • 58149119978 scopus 로고    scopus 로고
    • Omalizumab therapy: patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis
    • CRS-ID: 4900100000023513]
    • Humbert M, Boulet LP, Niven RM, Panahloo Z, Blogg M, Ayre G. Omalizumab therapy: patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis. Allergy 2009;64(1):81-4. [CRS-ID: 4900100000023513]
    • (2009) Allergy , vol.64 , Issue.1 , pp. 81-84
    • Humbert, M.1    Boulet, L.P.2    Niven, R.M.3    Panahloo, Z.4    Blogg, M.5    Ayre, G.6
  • 83
    • 0029126333 scopus 로고
    • Specific down-regulation of anti-allergen IgE and IgG antibodies in humans associated with injections of allergen-specific antibody complexes
    • [CRS-ID: 4900100000004951]
    • Jacquemin MG, Saint-Remy JM. Specific down-regulation of anti-allergen IgE and IgG antibodies in humans associated with injections of allergen-specific antibody complexes. Therapeutic Immunology 1995;2(1):41-52. [CRS-ID: 4900100000004951]
    • (1995) Therapeutic Immunology , vol.2 , Issue.1 , pp. 41-52
    • Jacquemin, M.G.1    Saint-Remy, J.M.2
  • 85
    • 0023720357 scopus 로고
    • The role of immunotherapy in cockroach asthma
    • CRS-ID: 4900100000008263]
    • Kang BC, Johnson J, Morgan C, Chang JL. The role of immunotherapy in cockroach asthma. Journal of Asthma 1988;25(4):205-18. [CRS-ID: 4900100000008263]
    • (1988) Journal of Asthma , vol.25 , Issue.4 , pp. 205-218
    • Kang, B.C.1    Johnson, J.2    Morgan, C.3    Chang, J.L.4
  • 87
    • 0034906753 scopus 로고    scopus 로고
    • The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma
    • CRS-ID: 4900100000011111;: 4900100000011111]
    • Kon OM, Sihra BS, Loh LC, Barkans J, Compton CH, Barnes NC, et al. The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma. European Respiratory Journal 2001;18(1):45-52. [CRS-ID: 4900100000011111;: 4900100000011111]
    • (2001) European Respiratory Journal , vol.18 , Issue.1 , pp. 45-52
    • Kon, O.M.1    Sihra, B.S.2    Loh, L.C.3    Barkans, J.4    Compton, C.H.5    Barnes, N.C.6
  • 88
    • 58849143492 scopus 로고    scopus 로고
    • Combination of omalizumab and specific immunotherapy is superior to immunotherapy in patients with seasonal allergic rhinoconjunctivitis and co-morbid seasonal allergic asthma
    • CRS-ID: 4900100000023284]
    • Kopp MV, Hamelmann E, Zielen S, Kamin W, Bergmann KC, Sieder C, et al. Combination of omalizumab and specific immunotherapy is superior to immunotherapy in patients with seasonal allergic rhinoconjunctivitis and co-morbid seasonal allergic asthma. Clinical and Experimental Allergy 2009;39(2):271-9. [CRS-ID: 4900100000023284]
    • (2009) Clinical and Experimental Allergy , vol.39 , Issue.2 , pp. 271-279
    • Kopp, M.V.1    Hamelmann, E.2    Zielen, S.3    Kamin, W.4    Bergmann, K.C.5    Sieder, C.6
  • 89
    • 84880926706 scopus 로고    scopus 로고
    • Transient impact of omalizumab in pollen allergic patients undergoing specific immunotherapy
    • CENTRAL: 870929; CRS: 4900100000087210; EMBASE: 2013483684; PUBMED: 23799935]
    • Kopp MV, Hamelmann E, Bendiks M, Zielen S, Kamin W, Bergmann KC, et al. Transient impact of omalizumab in pollen allergic patients undergoing specific immunotherapy. Pediatric Allergy and Immunology 2013;24(5):427-33. [CENTRAL: 870929; CRS: 4900100000087210; EMBASE: 2013483684; PUBMED: 23799935]
    • (2013) Pediatric Allergy and Immunology , vol.24 , Issue.5 , pp. 427-433
    • Kopp, M.V.1    Hamelmann, E.2    Bendiks, M.3    Zielen, S.4    Kamin, W.5    Bergmann, K.C.6
  • 91
    • 0041989617 scopus 로고    scopus 로고
    • Omalizumab is effective in the long-term control of severe allergic asthma
    • CENTRAL: 440250; CRS: 4900100000015345; PUBMED: 12952109]
    • Lanier BQ, Corren J, Lumry W, Liu J, Fowler-Taylor A, Gupta N. Omalizumab is effective in the long-term control of severe allergic asthma. Annals of Allergy, Asthma & Immunology 2003;91(2):154-9. [CENTRAL: 440250; CRS: 4900100000015345; PUBMED: 12952109]
    • (2003) Annals of Allergy, Asthma & Immunology , vol.91 , Issue.2 , pp. 154-159
    • Lanier, B.Q.1    Corren, J.2    Lumry, W.3    Liu, J.4    Fowler-Taylor, A.5    Gupta, N.6
  • 92
    • 71249102935 scopus 로고    scopus 로고
    • Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma
    • CENTRAL: 731495; CRS: 4900100000024431; EMBASE: 2009623072; PUBMED: 19910033]
    • Lanier B, Bridges T, Kulus M, Taylor AF, Berhane I, Vidaurre CF. Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma. The Journal of Allergy and Clinical Immunology 2009;124(6):1210-6. [CENTRAL: 731495; CRS: 4900100000024431; EMBASE: 2009623072; PUBMED: 19910033]
    • (2009) The Journal of Allergy and Clinical Immunology , vol.124 , Issue.6 , pp. 1210-1216
    • Lanier, B.1    Bridges, T.2    Kulus, M.3    Taylor, A.F.4    Berhane, I.5    Vidaurre, C.F.6
  • 93
    • 84887020563 scopus 로고    scopus 로고
    • Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia
    • CENTRAL: 874819; CRS: 4900126000001561; EMBASE: 2013693094; PUBMED: 23866823]
    • Laviolette M, Gossage DL, Gauvreau G, Leigh R, Olivenstein R, Katial R, et al. Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia. The Journal of Allergy and Clinical Immunology 2013;132(5):1086-96.e5. [CENTRAL: 874819; CRS: 4900126000001561; EMBASE: 2013693094; PUBMED: 23866823]
    • (2013) The Journal of Allergy and Clinical Immunology , vol.132 , Issue.5 , pp. 1086-1096
    • Laviolette, M.1    Gossage, D.L.2    Gauvreau, G.3    Leigh, R.4    Olivenstein, R.5    Katial, R.6
  • 95
    • 38149013369 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled Alternaria alternata immunotherapy: in vivo and in vitro parameters
    • CRS-ID: 4900100000021781]
    • Lizaso MT, Tabar AI, Garcia BE, Gomez B, Algorta J, Asturias JA, et al. Double-blind, placebo-controlled Alternaria alternata immunotherapy: in vivo and in vitro parameters. Pediatric Allergy and Immunology 2008;19(1):76-81. [CRS-ID: 4900100000021781]
    • (2008) Pediatric Allergy and Immunology , vol.19 , Issue.1 , pp. 76-81
    • Lizaso, M.T.1    Tabar, A.I.2    Garcia, B.E.3    Gomez, B.4    Algorta, J.5    Asturias, J.A.6
  • 96
    • 73249121855 scopus 로고    scopus 로고
    • Efficacy of omalizumab in cat-allergic patients with moderate-to-severe persistent asthma
    • CENTRAL: 728392; CRS: 4900100000024363; PUBMED: 19467177]
    • Massanari M, Kianifard F, Zeldin R K, Geba G P. Efficacy of omalizumab in cat-allergic patients with moderate-to-severe persistent asthma. Allergy and Asthma Proceedings 2009;30(5):534-9. [CENTRAL: 728392; CRS: 4900100000024363; PUBMED: 19467177]
    • (2009) Allergy and Asthma Proceedings , vol.30 , Issue.5 , pp. 534-539
    • Massanari, M.1    Kianifard, F.2    Zeldin, R.K.3    Geba, G.P.4
  • 97
    • 75849151415 scopus 로고    scopus 로고
    • Effect of pretreatment with omalizumab on the tolerability of specific immunotherapy in allergic asthma
    • CRS-ID: 4900100000024484]
    • Massanari M, Nelson H, Casale T, Busse W, Kianifard F, Geba GP, et al. Effect of pretreatment with omalizumab on the tolerability of specific immunotherapy in allergic asthma. The Journal of Allergy and Clinical Immunology 2010;125(2):383-9. [CRS-ID: 4900100000024484]
    • (2010) The Journal of Allergy and Clinical Immunology , vol.125 , Issue.2 , pp. 383-389
    • Massanari, M.1    Nelson, H.2    Casale, T.3    Busse, W.4    Kianifard, F.5    Geba, G.P.6
  • 98
    • 81455124395 scopus 로고    scopus 로고
    • Efficacy of reslizumab in patients with poorly controlled eosinophilic asthma: subgroup analysis of patients with nasal polyps [Abstract]
    • [CRS-ID: 4900100000026800]
    • Mathur S, Castro M, Hargreave F, Xie F, Wilkins HJ, Henkel T, et al. Efficacy of reslizumab in patients with poorly controlled eosinophilic asthma: subgroup analysis of patients with nasal polyps [Abstract]. Journal of Allergy and Clinical Immunology. 2011; Vol. 127, issue 2 Suppl 1:AB84. [CRS-ID: 4900100000026800]
    • (2011) Journal of Allergy and Clinical Immunology , vol.127 , Issue.2
    • Mathur, S.1    Castro, M.2    Hargreave, F.3    Xie, F.4    Wilkins, H.J.5    Henkel, T.6
  • 99
    • 0001515796 scopus 로고    scopus 로고
    • Corticosteroid (CS) withdrawal in a study of recombinant humanized monoclonal antibody to IgE (rhu MAbE25) [Abstract]
    • CRS-ID: 4900100000023644]
    • Metzger WJ, Fick RB, Bush RK, Busse W, Casale T, Chodosh S. Corticosteroid (CS) withdrawal in a study of recombinant humanized monoclonal antibody to IgE (rhu MAbE25) [Abstract]. The Journal of Allergy and Clinical Immunology 1998;101(1 Suppl):S231. [CRS-ID: 4900100000023644]
    • (1998) The Journal of Allergy and Clinical Immunology , vol.101 , Issue.1 , pp. S231
    • Metzger, W.J.1    Fick, R.B.2    Bush, R.K.3    Busse, W.4    Casale, T.5    Chodosh, S.6
  • 100
    • 0033599043 scopus 로고    scopus 로고
    • Treatment of allergic asthma with monoclonal anti-IgE antibody. RhuMAb-E25 Study Group
    • CRS-ID: 4900100000007996]
    • Milgrom H, Fick RB, Su JQ, Reimann JD, Bush RK, Watrous ML, et al. Treatment of allergic asthma with monoclonal anti-IgE antibody. RhuMAb-E25 Study Group. New England Journal of Medicine 1999;341(26):1966-73. [CRS-ID: 4900100000007996]
    • (1999) New England Journal of Medicine , vol.341 , Issue.26 , pp. 1966-1973
    • Milgrom, H.1    Fick, R.B.2    Su, J.Q.3    Reimann, J.D.4    Bush, R.K.5    Watrous, M.L.6
  • 101
    • 0035434688 scopus 로고    scopus 로고
    • Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab)
    • CRS-ID: 4900100000010744]
    • Milgrom H, Berger W, Nayak A, Gupta N, Pollard S, McAlary M, et al. Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab). Pediatrics 2001;108(2):E36. [CRS-ID: 4900100000010744]
    • (2001) Pediatrics , vol.108 , Issue.2 , pp. E36
    • Milgrom, H.1    Berger, W.2    Nayak, A.3    Gupta, N.4    Pollard, S.5    McAlary, M.6
  • 102
    • 0017587559 scopus 로고
    • Clinical trials of bivalent A/New Jersey/76-A/Victoria/75 influenza vaccines in high-risk children
    • CRS-ID: 4900100000000785]
    • Modlin JF, Smith DH, Harding L. Clinical trials of bivalent A/New Jersey/76-A/Victoria/75 influenza vaccines in high-risk children. Journal of Infectious Diseases 1977;136(Suppl):S626-31. [CRS-ID: 4900100000000785]
    • (1977) Journal of Infectious Diseases , vol.136 , pp. S626-S631
    • Modlin, J.F.1    Smith, D.H.2    Harding, L.3
  • 103
    • 0023144302 scopus 로고
    • Isotypic and antigenic restriction of the blocking antibody response to ryegrass pollen: correlation of rye group I antigen-specific IgG1 with clinical response
    • CRS-ID: 4900100000002212]
    • Moss RB, Hsu YP, Kwasnicki JM, Sullivan MM, Reid MJ. Isotypic and antigenic restriction of the blocking antibody response to ryegrass pollen: correlation of rye group I antigen-specific IgG1 with clinical response. The Journal of Allergy and Clinical Immunology 1987;79(2):387-98. [CRS-ID: 4900100000002212]
    • (1987) The Journal of Allergy and Clinical Immunology , vol.79 , Issue.2 , pp. 387-398
    • Moss, R.B.1    Hsu, Y.P.2    Kwasnicki, J.M.3    Sullivan, M.M.4    Reid, M.J.5
  • 104
    • 77955922813 scopus 로고    scopus 로고
    • Nitric oxide in exhaled breath is poorly correlated to sputum eosinophils in patients with prednisone-dependent asthma
    • CENTRAL: 759797; CRS: 4900100000025377; PUBMED: 20621343]
    • Nair P, Kjarsgaard M, Armstrong S, Efthimiadis A, O'Byrne PM, Hargreave FE. Nitric oxide in exhaled breath is poorly correlated to sputum eosinophils in patients with prednisone-dependent asthma. The Journal of Allergy and Clinical Immunology 2010;126(2):404-6. [CENTRAL: 759797; CRS: 4900100000025377; PUBMED: 20621343]
    • (2010) The Journal of Allergy and Clinical Immunology , vol.126 , Issue.2 , pp. 404-406
    • Nair, P.1    Kjarsgaard, M.2    Armstrong, S.3    Efthimiadis, A.4    O'Byrne, P.M.5    Hargreave, F.E.6
  • 105
    • 85041846982 scopus 로고    scopus 로고
    • Eosinophilic airway inflammation: relationship to remodeling and modulation by mepolizumab
    • (accessed 15 July 2015). [CRS-ID: 4900126000001344]
    • NCT00802438. Eosinophilic airway inflammation: relationship to remodeling and modulation by mepolizumab. https://clinicaltrials.gov/ct2/show/NCT00802438 (accessed 15 July 2015). [CRS-ID: 4900126000001344]
  • 106
    • 85041810586 scopus 로고    scopus 로고
    • A multicenter, open-label, dose ranging study to determine the pharmacokinetics and pharmacodynamics of mepolizumab administered intravenously or subcutaneously to adult asthmatic subjects with elevated blood eosinophil levels
    • (accessed 15 July 2015). [CRS-ID: 4900126000001335]
    • NCT01366521. A multicenter, open-label, dose ranging study to determine the pharmacokinetics and pharmacodynamics of mepolizumab administered intravenously or subcutaneously to adult asthmatic subjects with elevated blood eosinophil levels. https://clinicaltrials.gov/ct2/show/NCT01366521 (accessed 15 July 2015). [CRS-ID: 4900126000001335]
  • 107
    • 85041810574 scopus 로고    scopus 로고
    • A single blind, placebo controlled, parallel group, single ascending intravenous dose study to assess safety, olerability, pharmacokinetics and pharmacodynamics of SB-240563 (mepolizumab) in healthy japanese male subjects
    • (accessed 15 July 2015). [CRS-ID: 4900126000001343]
    • NCT01471327. A single blind, placebo controlled, parallel group, single ascending intravenous dose study to assess safety, olerability, pharmacokinetics and pharmacodynamics of SB-240563 (mepolizumab) in healthy japanese male subjects. https://clinicaltrials.gov/ct2/show/NCT01471327 (accessed 15 July 2015). [CRS-ID: 4900126000001343]
  • 108
    • 85041863293 scopus 로고    scopus 로고
    • MEA115666: A multi-centre, open-label, long term safety study of mepolizumab in asthmatic subjects who participated in the MEA112997 trial
    • (accessed 15 July 2015). [CRS-ID: 4900126000001338]
    • NCT01691859. MEA115666: A multi-centre, open-label, long term safety study of mepolizumab in asthmatic subjects who participated in the MEA112997 trial. https://clinicaltrials.gov/ct2/show/NCT01691859 (accessed 15 July 2015). [CRS-ID: 4900126000001338]
  • 109
    • 85041813646 scopus 로고    scopus 로고
    • MEA115661: A multi-centre, open-label, long-term safety study of mepolizumab in asthmatic subjects who participated in the MEA115588 or MEA115575 trials
    • (accessed 15 July 2015). [CRS-ID: 4900126000001336]
    • NCT01842607. MEA115661: A multi-centre, open-label, long-term safety study of mepolizumab in asthmatic subjects who participated in the MEA115588 or MEA115575 trials. https://clinicaltrials.gov/ct2/show/NCT01842607 (accessed 15 July 2015). [CRS-ID: 4900126000001336]
  • 110
    • 85041810495 scopus 로고    scopus 로고
    • Study 201312: a multi-centre, open-label, study of mepolizumab in a subset of subjects with a history of life threatening/seriously debilitating asthma who participated in the MEA115661 trial
    • (accessed 15 July 2015). [CRS: 4900126000021136]
    • NCT02135692. Study 201312: a multi-centre, open-label, study of mepolizumab in a subset of subjects with a history of life threatening/seriously debilitating asthma who participated in the MEA115661 trial. http://clinicaltrials.gov/show/NCT02135692 (accessed 15 July 2015). [CRS: 4900126000021136]
  • 111
    • 85041841212 scopus 로고    scopus 로고
    • Identification and description of severe asthma patients in a cross-sectional study - the IDEAL study
    • (accessed 15 July 2015). [CRS: 4900126000021134]
    • NCT02293265. Identification and description of severe asthma patients in a cross-sectional study - the IDEAL study. http://clinicaltrials.gov/show/NCT02293265 (accessed 15 July 2015). [CRS: 4900126000021134]
  • 112
    • 50549102147 scopus 로고    scopus 로고
    • Effectiveness of omalizumab in patients with inadequately controlled severe persistent allergic asthma: an open-label study
    • CRS-ID: 4900100000023545]
    • Niven R, Chung KF, Panahloo Z, Blogg M, Ayre G. Effectiveness of omalizumab in patients with inadequately controlled severe persistent allergic asthma: an open-label study. Respiratory Medicine 2008;102(10):1371-8. [CRS-ID: 4900100000023545]
    • (2008) Respiratory Medicine , vol.102 , Issue.10 , pp. 1371-1378
    • Niven, R.1    Chung, K.F.2    Panahloo, Z.3    Blogg, M.4    Ayre, G.5
  • 113
    • 0038693651 scopus 로고    scopus 로고
    • Immunological and clinical changes in allergic asthmatics following treatment with omalizumab
    • CRS-ID: 4900100000015254;: 4900100000015254]
    • Noga O, Hanf G, Kunkel G. Immunological and clinical changes in allergic asthmatics following treatment with omalizumab. International Archives of Allergy and Immunology 2003;131(1):46-52. [CRS-ID: 4900100000015254;: 4900100000015254]
    • (2003) International Archives of Allergy and Immunology , vol.131 , Issue.1 , pp. 46-52
    • Noga, O.1    Hanf, G.2    Kunkel, G.3
  • 114
    • 42449113839 scopus 로고    scopus 로고
    • Basophil histamine release decreases during omalizumab therapy in allergic asthmatics
    • CENTRAL: 628876; CRS: 4900100000021809; PUBMED: 18087163]
    • Noga O, Hanf G, Kunkel G, Kleine-Tebbe J. Basophil histamine release decreases during omalizumab therapy in allergic asthmatics. International Archives of Allergy and Immunology 2008;146(1):66-70. [CENTRAL: 628876; CRS: 4900100000021809; PUBMED: 18087163]
    • (2008) International Archives of Allergy and Immunology , vol.146 , Issue.1 , pp. 66-70
    • Noga, O.1    Hanf, G.2    Kunkel, G.3    Kleine-Tebbe, J.4
  • 115
    • 84883256475 scopus 로고    scopus 로고
    • Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids
    • CENTRAL: 872124; CRS: 4900100000088876; EMBASE: 2013545353; PUBMED: 23726041]
    • Noonan M, Korenblat P, Mosesova S, Scheerens H, Arron JR, Zheng Y, et al. Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids. The Journal of Allergy and Clinical Immunology 2013;132(3):567-74.e12. [CENTRAL: 872124; CRS: 4900100000088876; EMBASE: 2013545353; PUBMED: 23726041]
    • (2013) The Journal of Allergy and Clinical Immunology , vol.132 , Issue.3 , pp. 567-574
    • Noonan, M.1    Korenblat, P.2    Mosesova, S.3    Scheerens, H.4    Arron, J.R.5    Zheng, Y.6
  • 116
    • 4344622274 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of omalizumab in adults and adolescents with moderate-to-severe allergic asthma
    • [CRS-ID: 4900100000016686]
    • Oba Y, Salzman GA. Cost-effectiveness analysis of omalizumab in adults and adolescents with moderate-to-severe allergic asthma. The Journal of Allergy and Clinical Immunology 2004;114(2):265-9. [CRS-ID: 4900100000016686]
    • (2004) The Journal of Allergy and Clinical Immunology , vol.114 , Issue.2 , pp. 265-269
    • Oba, Y.1    Salzman, G.A.2
  • 117
    • 84884504092 scopus 로고    scopus 로고
    • A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma
    • CENTRAL: 871533; CRS: 4900100000090024; EMBASE: 2013599844;: 4900100000090024; PUBMED: 24050312]
    • Oh CK, Leigh R, McLaurin KK, Kim K, Hultquist M, Molfino NA. A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma. Respiratory Research 2013;14(1):93. [CENTRAL: 871533; CRS: 4900100000090024; EMBASE: 2013599844;: 4900100000090024; PUBMED: 24050312]
    • (2013) Respiratory Research , vol.14 , Issue.1 , pp. 93
    • Oh, C.K.1    Leigh, R.2    McLaurin, K.K.3    Kim, K.4    Hultquist, M.5    Molfino, N.A.6
  • 118
    • 0030666503 scopus 로고    scopus 로고
    • Serum levels of specific IgE, soluble interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in seasonal allergic rhinitis
    • CRS-ID: 4900100000005807]
    • Ohashi Y, Nakai Y, Tanaka A, Kakinoki Y, Ohno Y, Masamoto T, et al. Serum levels of specific IgE, soluble interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in seasonal allergic rhinitis. Annals of Allergy, Asthma & Immunology 1997;79(3):213-20. [CRS-ID: 4900100000005807]
    • (1997) Annals of Allergy, Asthma & Immunology , vol.79 , Issue.3 , pp. 213-220
    • Ohashi, Y.1    Nakai, Y.2    Tanaka, A.3    Kakinoki, Y.4    Ohno, Y.5    Masamoto, T.6
  • 119
    • 0021177244 scopus 로고
    • Immunotherapy in cat-induced asthma. Double-blind trial with evaluation of in vivo and in vitro responses
    • CRS-ID: 4900100000007076]
    • Ohman JLJ, Findlay SR, Leitermann KM. Immunotherapy in cat-induced asthma. Double-blind trial with evaluation of in vivo and in vitro responses. The Journal of Allergy and Clinical Immunology 1984;74(3 Pt 1):230-9. [CRS-ID: 4900100000007076]
    • (1984) The Journal of Allergy and Clinical Immunology , vol.74 , Issue.3 , pp. 230-239
    • Ohman, J.L.J.1    Findlay, S.R.2    Leitermann, K.M.3
  • 120
    • 70350444881 scopus 로고    scopus 로고
    • Efficacy and safety of omalizumab in an Asian population with moderate-to-severe persistent asthma
    • CRS-ID: 4900100000024432]
    • Ohta K, Miyamoto T, Amagasaki T, Yamamoto M, 1304 Study Group. Efficacy and safety of omalizumab in an Asian population with moderate-to-severe persistent asthma. Respirology 2009;14(8):1156-65. [CRS-ID: 4900100000024432]
    • (2009) Respirology , vol.14 , Issue.8 , pp. 1156-1165
    • Ohta, K.1    Miyamoto, T.2    Amagasaki, T.3    Yamamoto, M.4
  • 121
    • 24644448011 scopus 로고    scopus 로고
    • Anti-IgE (omalizumab) inhibits late-phase reactions and inflammatory cells after repeat skin allergen challenge
    • CRS-ID: 4900100000019018]
    • Ong YE, Menzies-Gow A, Barkans J, Benyahia F, Ou TT, Ying S, et al. Anti-IgE (omalizumab) inhibits late-phase reactions and inflammatory cells after repeat skin allergen challenge. The Journal of Allergy and Clinical Immunology 2005;116(3):558-64. [CRS-ID: 4900100000019018]
    • (2005) The Journal of Allergy and Clinical Immunology , vol.116 , Issue.3 , pp. 558-564
    • Ong, Y.E.1    Menzies-Gow, A.2    Barkans, J.3    Benyahia, F.4    Ou, T.T.5    Ying, S.6
  • 122
    • 79955448185 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, multicenter phase 2A study to evaluate the effect of a humanized interleukin-9 monoclonal antibody (MEDI-528) on exercise-induced bronchospasm [Abstract]
    • Meeting Abstracts, CRS-ID: 4900100000025282]
    • Parker J, Brazinsky S, Miller DS, Nayak A, Korenblat PE, Sari S, et al. Randomized, double-blind, placebo-controlled, multicenter phase 2A study to evaluate the effect of a humanized interleukin-9 monoclonal antibody (MEDI-528) on exercise-induced bronchospasm [Abstract]. American Journal of Respiratory and Critical Care Medicine 2010;181(Meeting Abstracts):A5394. [CRS-ID: 4900100000025282]
    • (2010) American Journal of Respiratory and Critical Care Medicine , vol.181 , pp. A5394
    • Parker, J.1    Brazinsky, S.2    Miller, D.S.3    Nayak, A.4    Korenblat, P.E.5    Sari, S.6
  • 123
    • 0021747488 scopus 로고
    • Clinical and immunologic evaluation of tyrosine-adsorbed Dermatophagoides pteronyssinus extract: a double-blind placebo-controlled trial
    • CRS-ID: 4900100000007226]
    • Pauli G, Bessot JC, Bigot H, Delaume G, Hordle DA, Hirth C, et al. Clinical and immunologic evaluation of tyrosine-adsorbed Dermatophagoides pteronyssinus extract: a double-blind placebo-controlled trial. The Journal of Allergy and Clinical Immunology 1984;74(4 Pt 1):524-35. [CRS-ID: 4900100000007226]
    • (1984) The Journal of Allergy and Clinical Immunology , vol.74 , Issue.4 , pp. 524-535
    • Pauli, G.1    Bessot, J.C.2    Bigot, H.3    Delaume, G.4    Hordle, D.A.5    Hirth, C.6
  • 124
    • 84873389433 scopus 로고    scopus 로고
    • A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
    • CRS-ID: 4900100000073595]
    • Piper E, Brightling C, Niven R, Oh C, Faggioni R, Poon K, et al. A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma. European Respiratory Journal 2013;41(2):330-8. [CRS-ID: 4900100000073595]
    • (2013) European Respiratory Journal , vol.41 , Issue.2 , pp. 330-338
    • Piper, E.1    Brightling, C.2    Niven, R.3    Oh, C.4    Faggioni, R.5    Poon, K.6
  • 126
    • 85029831828 scopus 로고    scopus 로고
    • Flow cytometry to identify leukocyte sub-populations in blood and induced sputum in asthmatic and healthy volunteers exposed to diesel exhaust [Abstract]
    • CRS-ID: 4900100000054152]
    • Pui M, Lay JC, Alexis NE, Carlsten C. Flow cytometry to identify leukocyte sub-populations in blood and induced sputum in asthmatic and healthy volunteers exposed to diesel exhaust [Abstract]. Allergy, Asthma, and Clinical Immunology 2010;6(Suppl 3):P7. [CRS-ID: 4900100000054152]
    • (2010) Allergy, Asthma, and Clinical Immunology , vol.6 , pp. P7
    • Pui, M.1    Lay, J.C.2    Alexis, N.E.3    Carlsten, C.4
  • 127
    • 67651102505 scopus 로고    scopus 로고
    • Safety and immunogenicity of sequential pneumococcal immunization in preschool asthmatics
    • CRS-ID: 4900100000024282]
    • Rose MA, Gruendler M, Schubert R, Kitz R, Schulze J, Zielen S. Safety and immunogenicity of sequential pneumococcal immunization in preschool asthmatics. Vaccine 2009;27(38):5259-64. [CRS-ID: 4900100000024282]
    • (2009) Vaccine , vol.27 , Issue.38 , pp. 5259-5264
    • Rose, M.A.1    Gruendler, M.2    Schubert, R.3    Kitz, R.4    Schulze, J.5    Zielen, S.6
  • 128
    • 0021278230 scopus 로고
    • Solid-phase radioimmunoassay for the measurement of IgG antibodies specific for the house dust mite, Dermatophagoides farinae
    • CRS-ID: 4900100000008622]
    • Sakamoto Y, Nakagawa T, Ito K, Miyamoto T. Solid-phase radioimmunoassay for the measurement of IgG antibodies specific for the house dust mite, Dermatophagoides farinae. Annals of Allergy 1984;52(4):303-8. [CRS-ID: 4900100000008622]
    • (1984) Annals of Allergy , vol.52 , Issue.4 , pp. 303-308
    • Sakamoto, Y.1    Nakagawa, T.2    Ito, K.3    Miyamoto, T.4
  • 129
    • 84860674334 scopus 로고    scopus 로고
    • Predictive and pharmacodynamic biomarkers of interleukin-13 blockade: effect of lebrikizumab on late phase asthmatic response to allergen challenge [Abstract]
    • [CRS-ID: 4900100000026957]
    • Scheerens H, Arron J R, Su Z, Zheng Y, Putnam W, Erickson RW, et al. Predictive and pharmacodynamic biomarkers of interleukin-13 blockade: effect of lebrikizumab on late phase asthmatic response to allergen challenge [Abstract]. The Journal of Allergy and Clinical Immunology. 2011; Vol. 127, issue 2 Suppl 1:AB164. [CRS-ID: 4900100000026957]
    • (2011) The Journal of Allergy and Clinical Immunology , vol.127 , Issue.2
    • Scheerens, H.1    Arron, J.R.2    Su, Z.3    Zheng, Y.4    Putnam, W.5    Erickson, R.W.6
  • 130
    • 84890850905 scopus 로고    scopus 로고
    • The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge
    • CENTRAL: 961626; CRS: 4900126000003110; EMBASE: 2013812053; PUBMED: 24131304]
    • Scheerens H, Arron JR, Zheng Y, Putnam WS, Erickson RW, Choy DF, et al. The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge. Clinical and Experimental Allergy 2014;44(1):38-46. [CENTRAL: 961626; CRS: 4900126000003110; EMBASE: 2013812053; PUBMED: 24131304]
    • (2014) Clinical and Experimental Allergy , vol.44 , Issue.1 , pp. 38-46
    • Scheerens, H.1    Arron, J.R.2    Zheng, Y.3    Putnam, W.S.4    Erickson, R.W.5    Choy, D.F.6
  • 131
    • 80054703208 scopus 로고    scopus 로고
    • Oral corticosteroid sparing with omalizumab in severe allergic (IgE-mediated) asthma patients
    • CRS-ID: 4900100000056233]
    • Siergiejko Z, Swiebocka E, Smith N, Peckitt C, Leo J, Peachey G, et al. Oral corticosteroid sparing with omalizumab in severe allergic (IgE-mediated) asthma patients. Current Medical Research and Opinion 2011;27(11):2223-8. [CRS-ID: 4900100000056233]
    • (2011) Current Medical Research and Opinion , vol.27 , Issue.11 , pp. 2223-2228
    • Siergiejko, Z.1    Swiebocka, E.2    Smith, N.3    Peckitt, C.4    Leo, J.5    Peachey, G.6
  • 132
    • 0031917304 scopus 로고    scopus 로고
    • Response to pneumococcal immunization in children with and without recurrent infections
    • CRS-ID: 4900100000008189]
    • Silk H, Zora J, Goldstein J, Tinkelman D, Schiffman G. Response to pneumococcal immunization in children with and without recurrent infections. Journal of Asthma 1998;35(1):101-12. [CRS-ID: 4900100000008189]
    • (1998) Journal of Asthma , vol.35 , Issue.1 , pp. 101-112
    • Silk, H.1    Zora, J.2    Goldstein, J.3    Tinkelman, D.4    Schiffman, G.5
  • 133
    • 2342577466 scopus 로고    scopus 로고
    • Exhaled nitric oxide in children with asthma receiving Xolair (omalizumab), a monoclonal anti-immunoglobulin E antibody
    • CRS-ID: 4900100000016337]
    • SilkoffPE, Romero FA, Gupta N, Townley RG, Milgrom H. Exhaled nitric oxide in children with asthma receiving Xolair (omalizumab), a monoclonal anti-immunoglobulin E antibody. Pediatrics 2004;113(4):e308-12. [CRS-ID: 4900100000016337]
    • (2004) Pediatrics , vol.113 , Issue.4
    • Silkoff, P.E.1    Romero, F.A.2    Gupta, N.3    Townley, R.G.4    Milgrom, H.5
  • 135
    • 76749141384 scopus 로고    scopus 로고
    • A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma
    • CRS-ID: 4900100000024732]
    • Singh D, Kane B, Molfino NA, Faggioni R, Roskos L, Woodcock A. A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma. BMC Pulmonary Medicine 2010;10:3. [CRS-ID: 4900100000024732]
    • (2010) BMC Pulmonary Medicine , vol.10 , pp. 3
    • Singh, D.1    Kane, B.2    Molfino, N.A.3    Faggioni, R.4    Roskos, L.5    Woodcock, A.6
  • 136
    • 58149129505 scopus 로고    scopus 로고
    • Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations
    • CRS-ID: 4900100000022846;: 4900100000022846]
    • Slavin RG, Ferioli C, Tannenbaum SJ, Martin C, Blogg M, Lowe PJ. Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations. The Journal of Allergy and Clinical Immunology 2009;123(1):107-113.e3. [CRS-ID: 4900100000022846;: 4900100000022846]
    • (2009) The Journal of Allergy and Clinical Immunology , vol.123 , Issue.1 , pp. 107-113e3
    • Slavin, R.G.1    Ferioli, C.2    Tannenbaum, S.J.3    Martin, C.4    Blogg, M.5    Lowe, P.J.6
  • 137
    • 0034881877 scopus 로고    scopus 로고
    • The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
    • CRS-ID: 4900100000011115]
    • Soler M, Matz J, Townley R, Buhl R, O'Brien J, Fox H, et al. The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. European Respiratory Journal 2001;18(2):254-61. [CRS-ID: 4900100000011115]
    • (2001) European Respiratory Journal , vol.18 , Issue.2 , pp. 254-261
    • Soler, M.1    Matz, J.2    Townley, R.3    Buhl, R.4    O'Brien, J.5    Fox, H.6
  • 138
  • 139
    • 34347227110 scopus 로고    scopus 로고
    • The beneficial effects of Xolair (Omalizumab) as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available treatment (GINA 2002 step IV - The Israeli arm of the INNOVATE study
    • CRS-ID: 4900100000021263]
    • Sthoeger ZM, Eliraz A, Asher I, Berkman N, Elbirt D. The beneficial effects of Xolair (Omalizumab) as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available treatment (GINA 2002 step IV - The Israeli arm of the INNOVATE study. Israel Medical Association Journal 2007;9(6):472-5. [CRS-ID: 4900100000021263]
    • (2007) Israel Medical Association Journal , vol.9 , Issue.6 , pp. 472-475
    • Sthoeger, Z.M.1    Eliraz, A.2    Asher, I.3    Berkman, N.4    Elbirt, D.5
  • 140
    • 84942947742 scopus 로고
    • Efficacy of inactivated vaccine in preventing antigenically drifted influenza type A and well-matched type B
    • CRS-ID: 4900100000004523]
    • Sugaya N, Nerome K, Ishida M, Matsumoto M, Mitamura K, Nirasawa M. Efficacy of inactivated vaccine in preventing antigenically drifted influenza type A and well-matched type B. JAMA 1994;272(14):1122-6. [CRS-ID: 4900100000004523]
    • (1994) JAMA , vol.272 , Issue.14 , pp. 1122-1126
    • Sugaya, N.1    Nerome, K.2    Ishida, M.3    Matsumoto, M.4    Mitamura, K.5    Nirasawa, M.6
  • 141
    • 85029857783 scopus 로고    scopus 로고
    • Exhaled nitric oxide (FENO) and t-helper 2 cell biomarkers: can they predict treatment response to dupilumab, an il-4ra antibody, in an eosinophilic asthma population?
    • CENTRAL: 985863; CRS: 4900126000010595; EMBASE: 71351035]
    • Swanson BN, Wang L, Ming J, Hamilton JD, Teper A, Dicioccio T, et al. Exhaled nitric oxide (FENO) and t-helper 2 cell biomarkers: can they predict treatment response to dupilumab, an il-4ra antibody, in an eosinophilic asthma population?. The Journal of Allergy and Clinical Immunology 2014;133(2 Suppl):AB85. [CENTRAL: 985863; CRS: 4900126000010595; EMBASE: 71351035]
    • (2014) The Journal of Allergy and Clinical Immunology , vol.133 , Issue.2
    • Swanson, B.N.1    Wang, L.2    Ming, J.3    Hamilton, J.D.4    Teper, A.5    Dicioccio, T.6
  • 142
    • 18244414903 scopus 로고    scopus 로고
    • [Proba blokowania uwalniania histaminy z granulocytow zasadochlonnych przeciwcialami uzyskanymi w wyniku dlugotrwalej immunizacji bakteriami
    • [CRS-ID: 4900100000006192]
    • Szymaniak L. An attempt to block histamine release from basophils granulocytes with antibodies obtained as a result of long-term immunization [Proba blokowania uwalniania histaminy z granulocytow zasadochlonnych przeciwcialami uzyskanymi w wyniku dlugotrwalej immunizacji bakteriami]. Annales Academiae Medicae Stetinensis 1998;44:45-64. [CRS-ID: 4900100000006192]
    • (1998) Annales Academiae Medicae Stetinensis , vol.44 , pp. 45-64
    • Szymaniak, L.1
  • 143
    • 0027157285 scopus 로고
    • Trivalent cold recombinant influenza live vaccine in institutionalized children with bronchial asthma and patients with psychomotor retardation
    • CRS-ID: 4900100000004155]
    • Tanaka Y, Ueda K, Miyazaki C, Nakayama M, Kusuhara K, Okada K, et al. Trivalent cold recombinant influenza live vaccine in institutionalized children with bronchial asthma and patients with psychomotor retardation. Pediatric Infectious Disease Journal 1993;12(7):600-5. [CRS-ID: 4900100000004155]
    • (1993) Pediatric Infectious Disease Journal , vol.12 , Issue.7 , pp. 600-605
    • Tanaka, Y.1    Ueda, K.2    Miyazaki, C.3    Nakayama, M.4    Kusuhara, K.5    Okada, K.6
  • 144
    • 0014598088 scopus 로고
    • Immunologic bases for injection therapy of allergic diseases
    • [CRS-ID: 4900100000000151]
    • Terr AI. Immunologic bases for injection therapy of allergic diseases. Medical Clinics of North America 1969;53(6):1257-64. [CRS-ID: 4900100000000151]
    • (1969) Medical Clinics of North America , vol.53 , Issue.6 , pp. 1257-1264
    • Terr, A.I.1
  • 145
    • 58149113160 scopus 로고    scopus 로고
    • Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment
    • CRS-ID: 4900100000023512]
    • Van Rensen EL, Evertse CE, Van Schadewijk WA, Van Wijngaarden S, Ayre G, Mauad T, et al. Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment. Allergy 2009;64(1):72-80. [CRS-ID: 4900100000023512]
    • (2009) Allergy , vol.64 , Issue.1 , pp. 72-80
    • Van Rensen, E.L.1    Evertse, C.E.2    Van Schadewijk, W.A.3    Van Wijngaarden, S.4    Ayre, G.5    Mauad, T.6
  • 146
    • 3042781547 scopus 로고    scopus 로고
    • Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with concomitant allergic asthma and persistent allergic rhinitis: SOLAR
    • CRS-ID: 4900100000017155]
    • Vignola AM, Humbert M, Bousquet J, Boulet LP, Hedgecock S, Blogg M, et al. Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with concomitant allergic asthma and persistent allergic rhinitis: SOLAR. Allergy 2004;59(7):709-17. [CRS-ID: 4900100000017155]
    • (2004) Allergy , vol.59 , Issue.7 , pp. 709-717
    • Vignola, A.M.1    Humbert, M.2    Bousquet, J.3    Boulet, L.P.4    Hedgecock, S.5    Blogg, M.6
  • 147
    • 0038752563 scopus 로고    scopus 로고
    • Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: a randomized controlled trial
    • CRS-ID: 4900100000015247]
    • Wark PA, Hensley MJ, Saltos N, Boyle MJ, Toneguzzi RC, Epid GD, et al. Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: a randomized controlled trial. The Journal of Allergy and Clinical Immunology 2003;111(5):952-7. [CRS-ID: 4900100000015247]
    • (2003) The Journal of Allergy and Clinical Immunology , vol.111 , Issue.5 , pp. 952-957
    • Wark, P.A.1    Hensley, M.J.2    Saltos, N.3    Boyle, M.J.4    Toneguzzi, R.C.5    Epid, G.D.6
  • 148
    • 62549084077 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
    • CRS-ID: 4900100000023441;: 4900100000023441]
    • Wenzel SE, Barnes PJ, Bleecker ER, Bousquet J, Busse W, Dahlén SE, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. American Journal of Respiratory and Critical Care Medicine 2009;179(7):549-58. [CRS-ID: 4900100000023441;: 4900100000023441]
    • (2009) American Journal of Respiratory and Critical Care Medicine , vol.179 , Issue.7 , pp. 549-558
    • Wenzel, S.E.1    Barnes, P.J.2    Bleecker, E.R.3    Bousquet, J.4    Busse, W.5    Dahlén, S.E.6
  • 150
    • 0015290041 scopus 로고
    • An investigation of pollen extracts from different deciduous trees in patients with springtime allergy in Sweden
    • CRS-ID: 4900100000008122]
    • Zetterstrom O, Fagerberg E, Wide L. An investigation of pollen extracts from different deciduous trees in patients with springtime allergy in Sweden. Acta Allergologica 1972;27(1):15-21. [CRS-ID: 4900100000008122]
    • (1972) Acta Allergologica , vol.27 , Issue.1 , pp. 15-21
    • Zetterstrom, O.1    Fagerberg, E.2    Wide, L.3
  • 151
    • 84877071832 scopus 로고    scopus 로고
    • Population-based efficacy modelling of omalizumab in patients with severe allergic asthma inadequately controlled with standard therapy
    • CRS-ID: 4900126000000432]
    • Zhu R, Zheng Y, Putnam WS, Visich J, Eisner MD, Matthews JG, et al. Population-based efficacy modelling of omalizumab in patients with severe allergic asthma inadequately controlled with standard therapy. The AAPS Journal 2013;15(2):559-70. [CRS-ID: 4900126000000432]
    • (2013) The AAPS Journal , vol.15 , Issue.2 , pp. 559-570
    • Zhu, R.1    Zheng, Y.2    Putnam, W.S.3    Visich, J.4    Eisner, M.D.5    Matthews, J.G.6
  • 152
    • 84865588689 scopus 로고    scopus 로고
    • Omalizumab protects against allergen-induced bronchoconstriction in allergic (immunoglobulin E-mediated) asthma
    • CRS-ID: 4900100000072111]
    • Zielen S, Lieb A, De La Motte S, Wagner F, de Monchy J, Fuhr R, et al. Omalizumab protects against allergen-induced bronchoconstriction in allergic (immunoglobulin E-mediated) asthma. International Archives of Allergy and Immunology 2013;160(1):102-10. [CRS-ID: 4900100000072111]
    • (2013) International Archives of Allergy and Immunology , vol.160 , Issue.1 , pp. 102-110
    • Zielen, S.1    Lieb, A.2    De La Motte, S.3    Wagner, F.4    de Monchy, J.5    Fuhr, R.6
  • 153
    • 85041816528 scopus 로고    scopus 로고
    • The efficacy of mepolizumab treatment on rhinovirus induced asthma exacerbations
    • (accessed 15 July 2015). [CRS-ID: 4900126000001342]
    • NCT01520051. The efficacy of mepolizumab treatment on rhinovirus induced asthma exacerbations. https://clinicaltrials.gov/show/NCT01520051 (accessed 15 July 2015). [CRS-ID: 4900126000001342]
  • 154
    • 85018019689 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled, parallel-group, multi-centre 24-week study to evaluate the efficacy and safety of mepolizumab adjunctive therapy in subjects with severe eosinophilic asthma on markers of asthma control
    • (accessed 15 July 2015). [CRS: 4900126000021132]
    • NCT02281318. A randomised, double-blind, placebo-controlled, parallel-group, multi-centre 24-week study to evaluate the efficacy and safety of mepolizumab adjunctive therapy in subjects with severe eosinophilic asthma on markers of asthma control. http://clinicaltrials.gov/show/NCT02281318 (accessed 15 July 2015). [CRS: 4900126000021132]
  • 155
    • 33746294223 scopus 로고    scopus 로고
    • The global burden of asthma
    • Braman SS. The global burden of asthma. Chest 2006;130(1 Suppl):4S-12S.
    • (2006) Chest , vol.130 , Issue.1 , pp. 4S-12S
    • Braman, S.S.1
  • 156
    • 84922018069 scopus 로고    scopus 로고
    • British guideline on the management of asthma
    • British Thoracic Society, Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax 2014;69(Suppl. 1):i1-i192.
    • (2014) Thorax , vol.69 , pp. i1-i192
  • 157
    • 85040461723 scopus 로고    scopus 로고
    • Trends in asthma prevalence, health care, and mortality in the United States, 2001-2010
    • (accessed 10 December 2012)
    • Centers for Disease Control and Prevention. Trends in asthma prevalence, health care, and mortality in the United States, 2001-2010. www.cdc.gov/nchs/data/databriefs/db94.htm (accessed 10 December 2012).
  • 158
    • 0007523860 scopus 로고    scopus 로고
    • Vital signs
    • (accessed 10 December 2013)
    • Centers for Disease Control and Prevention. Vital signs. www.cdc.gov/vitalsigns/asthma/(accessed 10 December 2013).
  • 159
    • 15844414195 scopus 로고    scopus 로고
    • Paediatric asthma: overcoming barriers to an improved quality of life
    • Clayton S. Paediatric asthma: overcoming barriers to an improved quality of life. British Journal of Nursing 2005; Vol. 14, issue 2:80-5.
    • (2005) British Journal of Nursing , vol.14 , Issue.2 , pp. 80-85
    • Clayton, S.1
  • 161
    • 0027321152 scopus 로고
    • A prospective audit of asthma management following emergency asthma treatment at a teaching hospital
    • Gibson PG, Talbot PI, Hancock J, Hensley MJ. A prospective audit of asthma management following emergency asthma treatment at a teaching hospital. Medical Journal of Australia 1993;158:775-8.
    • (1993) Medical Journal of Australia , vol.158 , pp. 775-778
    • Gibson, P.G.1    Talbot, P.I.2    Hancock, J.3    Hensley, M.J.4
  • 162
    • 34547569572 scopus 로고    scopus 로고
    • Pocket guide for asthma management and prevention (for adults and children older than 5 years)
    • (accessed 5 November 2013)
    • Global Intitiative for Asthma. Pocket guide for asthma management and prevention (for adults and children older than 5 years). http://www.ginasthma.org/local/uploads/files/GINA_Pocket2013_May15.pdf (accessed 5 November 2013).
  • 163
    • 80052307183 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]
    • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org.
    • (2011) The Cochrane Collaboration
    • Higgins, J.P.T.1    Green, S.2
  • 166
    • 84875467652 scopus 로고    scopus 로고
    • Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: a meta-analysis of randomized placebo-controlled trials
    • Liu Y, Zhang S, Li DW, Jiang S-J. Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: a meta-analysis of randomized placebo-controlled trials. PLoS One 2013; Vol. 8, issue 3:e59872. [DOI: 10.1371/journal.pone.0059872]
    • (2013) PLoS One , vol.8 , Issue.3
    • Liu, Y.1    Zhang, S.2    Li, D.W.3    Jiang, S.-J.4
  • 167
    • 2342590065 scopus 로고    scopus 로고
    • The global burden of asthma: executive summary of the GINA Dissemination Committee Report
    • Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee Report. Allergy 2004;59:469-78.
    • (2004) Allergy , vol.59 , pp. 469-478
    • Masoli, M.1    Fabian, D.2    Holt, S.3    Beasley, R.4
  • 168
    • 79958148713 scopus 로고    scopus 로고
    • Hospital Episode Statistics
    • (accessed 10 December 2012)
    • Health and Social Care Information Centre. Hospital Episode Statistics. www.hesonline.nhs.uk (accessed 10 December 2012).
  • 169
    • 84865825750 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of asthma (EPR 3)
    • (accessed 10 December 2012)
    • National Heart, Lung, and Blood Institute. Guidelines for the diagnosis and management of asthma (EPR 3). www.nhlbi.nih.gov/guidelines/asthma/(accessed 10 December 2012).
  • 170
    • 58149289547 scopus 로고    scopus 로고
    • Systematic review of worldwide variations of the prevalence of wheezing symptoms in children
    • Patel S, Jarvelin MR, Little M. Systematic review of worldwide variations of the prevalence of wheezing symptoms in children. Environmental Health 2009;7:57. [DOI: doi.10.1186/1476-069X-7-57]
    • (2009) Environmental Health , vol.7 , pp. 57
    • Patel, S.1    Jarvelin, M.R.2    Little, M.3
  • 171
    • 79960705415 scopus 로고    scopus 로고
    • Review Manager (RevMan)
    • 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration
    • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
    • (2012)
  • 173
    • 84984806289 scopus 로고    scopus 로고
    • Health topics: asthma
    • (accessed 13 September 2011)
    • World Health Organization. Health topics: asthma. www.who.int/topics/asthma/en/(accessed 13 September 2011).
  • 174
    • 34250183462 scopus 로고    scopus 로고
    • Childhood asthma and environmental interventions
    • Wu F, Takaro TK. Childhood asthma and environmental interventions. Environmental Health Perspectives 2007;115(6):971-5.
    • (2007) Environmental Health Perspectives , vol.115 , Issue.6 , pp. 971-975
    • Wu, F.1    Takaro, T.K.2


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