A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

Cell

Volumn 171, Issue 7, 2017, Pages 1625-1637.e13

  Amin Wetzel, Niko ^a   Saunders, Reuben A ^a   Kamphuis, Maarten J ^a   Rato, Claudia ^a   Preissler, Steffen ^a   Harding, Heather P ^a   Ron, David ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Allosteric Regulation; Biological Feedback; Endoplasmic Reticulum; Fluorescence Resonance Energy Transfer; HSP70 Heat Shock Proteins; Protein Dimerization; Protein Folding; Repressor Protein; Stress; Unfolded Protein Response

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CRISPR ASSOCIATED PROTEIN; GLUTATHIONE TRANSFERASE; PROTEIN DNAJ; PROTEIN IRE1; CHAPERONE; DNAJB9 PROTEIN, HUMAN; ERN1 PROTEIN, HUMAN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 40; MEMBRANE PROTEIN; MOLECULAR CHAPERONE GRP78; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIMERIZATION; ENDOPLASMIC RETICULUM; HOMEOSTASIS; HOMOLOGOUS RECOMBINATION; HYDROLYSIS; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN UNFOLDING; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; HAMSTER; HUMAN; METABOLISM;

ANIMALS; CRICETINAE; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE PROTEINS; MOLECULAR CHAPERONES; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; UNFOLDED PROTEIN RESPONSE;

EID: 85035794333     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.10.040     Document Type: Article

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