Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling

EMBO Journal

Volumn 34, Issue 11, 2015, Pages 1589-1600

  Carrara, Marta ^a,b   Prischi, Filippo ^a   Nowak, Piotr R ^a   Ali, Maruf M U ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

cell signaling; ER stress; PERK; unfolded protein response

Indexed keywords

DIMER; INITIATION FACTOR 2ALPHA; PERK PROTEIN; PROTEIN; TETRAMER; UNCLASSIFIED DRUG; EIF2AK3 PROTEIN, HUMAN; INITIATION FACTOR 2; PERK KINASE; PROTEIN KINASE R;

ARTICLE; CELL STRESS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENDOPLASMIC RETICULUM; HUMAN; IN VITRO STUDY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY; ANIMAL; CELL CULTURE; CHEMISTRY; ENDOPLASMIC RETICULUM STRESS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; UNFOLDED PROTEIN RESPONSE;

MAMMALIA;

ANIMALS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; HUMANS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EID: 84931570190     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201489183     Document Type: Article

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