Paradoxical sensitivity to an integrated stress response blocking mutation in vanishing white matter cells

PLoS ONE

Volumn 11, Issue 11, 2016, Pages

  Sekine, Yusuke ^a,b   Zyryanova, Alisa ^a   Crespillo Casado, Ana ^a   Amin Wetzel, Niko ^a   Harding, Heather P ^a   Ron, David ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; INITIATION FACTOR 2ALPHA;

ANIMAL CELL; ARTICLE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; EIF2A GENE; EIF2B4 GENE; EIF2S1 GENE; ENDOPLASMIC RETICULUM STRESS; GENE; GENE EXPRESSION; GENE SEQUENCE; GENOTYPE; HUMAN; HUMAN CELL; INTEGRATED STRESS RESPONSE; LIMIT OF QUANTITATION; MISSENSE MUTATION; NONHUMAN; PROTEIN MISFOLDING; VANISHING WHITE MATTER; WHITE MATTER; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; CHO CELL LINE; CRICETULUS; CYTOLOGY; GENETIC RECOMBINATION; GENETICS; HAMSTER; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; UNFOLDED PROTEIN RESPONSE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2B; HUMANS; MUTATION; RECOMBINATION, GENETIC; UNFOLDED PROTEIN RESPONSE; WHITE MATTER;

EID: 84994316243     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0166278     Document Type: Article

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