Genetics and intelligence differences: Five special findings

Molecular Psychiatry

Volumn 20, Issue 1, 2015, Pages 98-108

  Plomin, R ^a   Deary, I J ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULTHOOD; ASSORTATIVE MATING; BODY HEIGHT; BODY WEIGHT; DISEASES; EDUCATION; GENE; GENETIC STABILITY; GENETIC VARIABILITY; GENETICS; GENOTYPE; HEALTH; HEREDITY; HERITABILITY; HUMAN; INFANCY; INTELLIGENCE; LEARNING; MENTAL DISEASE; MORTALITY; PERSONALITY; PHENOTYPE; POLYGENIC SCORE; PRIORITY JOURNAL; REVIEW; SCORING SYSTEM; SOCIAL CLASS; BEHAVIOR GENETICS; GENETIC PREDISPOSITION; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; META ANALYSIS (TOPIC);

GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENETICS, BEHAVIORAL; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INTELLIGENCE; META-ANALYSIS AS TOPIC; PHENOTYPE;

EID: 84922225767     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2014.105     Document Type: Review

References (120)

1. Burks B. The relative influence of nature and nurture upon mental development: A comparative study on foster parent-foster child resemblance. In: Whipple GM (ed). Whipple GMYearbook of the National Society for the Study of Education, Part 1. Public School Publishing Co: Bloomington, IL, 1928, 27, pp 219-316.
2. Freeman FN, Holzinger KJ, Mitchell B. The influence of environment on the intelligence, school achievement, and conduct of foster children. In: Whipple GM (ed). Yearbook of the National Society for the Study of Education, Part 1. Public School Publishing Co: Bloomington, IL, 1928, 27, pp 103-217.
3. Merriman C. The intellectual resemblance of twins. Psychological Monographs 1924; 33: 1-57.
4. Theis SVS. How foster children turn out. State Charities Aid Association: New York, 1924.
5. Deary IJ, Johnson W, Houlihan LM. Genetic foundations of human intelligence. Hum Genet 2009; 126: 215-232.
6. Plomin R, DeFries JC, Knopik VS, Neiderhiser JM. Behavioral genetics, 6th edn. Worth Publishers: New York, 2013.
7. Turkheimer E. Three laws of behavior genetics and what they mean. Curr Dir Psychol Sci 2000; 9: 160-164.
8. McGuffin P. The past, present and future of psychiatric genetics. In Bloch S, Green SA, Holmes J (eds) Psychiatry: Past, present, and prospect. Oxford University Press: Oxford, UK, 2014 pp 22-44.
9. Pinker S. The blank slate: The modern denial of human nature. Penguin: New York, 2002.
10. Haworth CMA, Plomin R. Genetics and education: Towards a genetically sensitive classroom. In Harris KR, Graham S, Urdan T (eds) The American Psychological Association Handbook of Educational Psychology. APA: Washington, DC, 2011, pp 529-559.
11. Check Hayden E. Ethics: Taboo genetics. Nature 2013; 502: 26-28.
12. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJet al. Finding the missing heritability of complex diseases. Nature 2009; 461: 747-753.
13. Fisher RA. The correlation between relatives on the supposition of Mendelian inheritance. Transactions of the Royal Society of Edinburgh 1918; 52: 399-433.
14. Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion MJ et al. Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Mol Psychiatry 2014; 19: 253-258.
15. Desrivieres S, Lourdusamy A, Tao C, Toro R, Jia T, Loth Eet al. Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. Mol Psychiatry 11 February 2014. e-pub ahead of print.doi:10.1038/mp.2013.197.
16. Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW et al. GWAS of 126 559 individuals identifies genetic variants associated with educational attainment. Science 2013; 340: 1467-1471.
17. Spearman C. General intelligence, objectively determined and measured. Am J Psychol 1904; 15: 201-292.
18. Carroll JB. Human cognitive abilities. Cambridge University Press: New York, 1993.
19. Jensen AR. The g factor: The science of mental ability. Praeger: Westport, CT, 1998.
20. Johnson W, Bouchard TJ, Krueger RF, McGue M, Gottesman II. Just one g: Consistent results from three test batteries. Intelligence 2004; 32: 95-107.
21. Gottfredson LS. Mainstream science on intelligence: An editorial with 52 signatories, history and bibliography. Intelligence 1997; 24: 13-23.
22. Deary IJ. Intelligence. Curr Biol 2013; 23: R673-R676.
23. Carroll JB. Psychometrics, intelligence, and public policy. Intelligence 1997; 24: 25-52.
24. Deary I. Looking down on human intelligence: From psychometrics to the brain. Oxford University Press: Oxford, UK, 2000.
25. Deary IJ, Penke L, Johnson W. The neuroscience of human intelligence differences. Nat Rev Neurosci 2010; 11: 201-211.
26. Duncan J. How intelligence happens. Yale University Press: New Haven, CT, 2010.
27. Salthouse T. Major issues in cognitive aging. Oxford University Press: Oxford, UK, 2010.
28. Deary IJ, Whalley LJ, Lemmon H, Crawford JR, Starr JM. The stability of individual differences in mental ability from childhood to old age: Follow-up of the 1932 Scottish Mental Survey. Intelligence 2000; 28: 49-55.
29. Strenze T. Intelligence and socioeconomic success: A meta-analytic review of longitudinal research. Intelligence 2007; 35: 401-426.
30. Deary IJ, Weiss A, Batty GD. Intelligence and personality as predictors of illness and death: How researchers in differential psychology and chronic disease epidemiology are collaborating to understand and address health inequalities. Psychol Sci Publ Interest 2010; 11: 53-79.
31. Plomin R. Genetics, genes, genomics and g. Mol Psychiatry 2003; 8: 1-5.
32. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR et al. Common SNPs explain a large proportion of the heritability for human height. Nat Genet 2010; 42: 565-569.
33. Yang JA, Lee SH, Goddard ME, Visscher PM. GCTA: A tool for genome-wide complex trait analysis. Am J Hum Genet 2011; 88: 76-82.
34. Yang J, Manolio TA, Pasquale LR, Boerwinkle E, Caporaso N, Cunningham JM et al. Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet 2011; 43: 519-525.
35. Yang J, Lee SH, Goddard ME, Visscher PM. Genome-wide complex trait analysis (GCTA): Methods, data analyses, and interpretations. Methods Mol Biol 2013; 1019: 215-236.
36. So HC, Li MX, Sham PC. Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study. Genet Epidemiol 2011; 35: 447-456.
37. Gray A, Stewart I, Tenesa A. Advanced complex trait analysis. Bioinformatics 2012; 28: 3134-3136.
38. Speed D, Hemani G, Johnson MR, Balding DJ. Improved heritability estimation from genome-wide SNPs. Am J Hum Genet 2012; 91: 1011-1021.
39. Zaitlen N, Kraft P. Heritability in the genome-wide association era. Hum Genet 2012; 131: 1655-1664.
40. Zhou X, Carbonetto P, Stephens M. Polygenic modeling with Bayesian sparse linear mixed models. PLoS Genet 2013; 9: e1003264.
41. Plomin R, Haworth CMA, Meaburn EL, Price T, Wellcome Trust Case Control Consortium 2, Davis OS. Common DNA markers can account for more than half of the genetic influence on cognitive abilities. Psychol Sci 2013; 24: 562-568.
42. Vinkhuyzen AA, Wray NR, Yang J, Goddard ME, Visscher PM. Estimation and partition of heritability in human populations using whole-genome analysis methods. Annu Rev Genet 2013; 47: 75-95.
43. Lee SH, Yang J, Goddard ME, Visscher PM, Wray NR. Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood. Bioinformatics 2012; 28: 2540-2542.
44. Visscher PM, Hemani G, Vinkhuyzen AAE, Chen G-B, Lee SH, Wray NR et al. Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples. PLoS Genet 2014; 10: e1004269.
45. Zhou X, Stephens M. Efficient algorithms for multivariate linear mixed models in genome-wide association studies. Nat Methods 2014; 11: 407-409.
46. Deary IJ, Yang J, Davies G, Harris SE, Tenesa A, Liewald D et al. Genetic contributions to stability and change in intelligence from childhood to old age. Nature 2012; 482: 212-215.
47. Panizzon MS, Vuoksimaa E, Spoon KM, Jacobson KC, Lyons MJ, Franz CE et al. Genetic and environmental influences on general cognitive ability: Is g a valid latent construct? Intelligence 2014; 43: 65-76.
48. Lee T, Henry JD, Trollor JN, Sachdev PS. Genetic influences on cognitive functions in the elderly: A selective review of twin studies. Brain Res Brain Res Rev 2010; 64: 1-13.
49. Haworth CMA, Wright MJ, Luciano M, Martin NG, de Geus EJC, van Beijsterveldt CEM et al. The heritability of general cognitive ability increases linearly from childhood to young adulthood. Mol Psychiatry 2010; 15: 1112-1120.
50. Mackintosh N. IQ and human intelligence, 2nd edn. Oxford University Press: Oxford, UK, 2011.
51. Plomin R, Fulker DW, Corley R, DeFries JC. Nature, nurture and cognitive development from 1 to 16 years: A parent-offspring adoption study. Psychol Sci 1997; 8: 442-447.
52. Skodak M, Skeels HM. A final follow-up on one hundred adopted children. J Genet Psychol 1949; 75: 84-125.
53. Davis OSP, Haworth CMA, Plomin R. Dramatic increase in heritability of cognitive development from early to middle childhood: An 8-year longitudinal study of 8700 pairs of twins. Psychol Sci 2009; 20: 1301-1308.
54. Wilson RS. The Louisville Twin Study: Developmental synchronies in behavior. Child Dev 1983; 54: 298-316.
55. Trzaskowski M, Yang J, Visscher PM, Plomin R. DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12. Mol Psychiatry 2014; 19: 380-384.
56. Trzaskowski M, Harlaar N, Arden R, Krapohl E, Rimfeld K, McMillan A et al. Genetic influence on family socioeconomic status and children's intelligence. Intelligence 2014; 42: 83-88.
57. Plomin R. Development, genetics, and psychology. Erlbaum: Hillsdale, NJ, 1986.
58. Briley DA, Tucker-Drob EM. Explaining the increasing heritability of cognitive ability across development: A meta-analysis of longitudinal twin and adoption studies. Psychol Sci 2013; 24: 1704-1713.
59. Plomin R. Genetics and experience: The interplay between nature and nurture. Sage Publications Inc.: Thousand Oaks, CA, 1994.
60. Plomin R, Kovas Y. Generalist genes and learning disabilities. Psychol Bull 2005; 131: 592-617.
61. Calvin CM, Deary IJ, Webbink D, Smith P, Fernandes C, Lee SH et al. Multivariate genetic analyses of cognition and academic achievement from two population samples of 174 000 and 166 000 school children. Behav Genet 2012; 42: 699-710.
62. Davis OSP, Haworth CMA, Plomin R. Learning abilities and disabilities: Generalist genes in early adolescence. Cogn Neuropsychiatry 2009; 14: 312-331.
63. Trzaskowski M, Davis OS, DeFries JC, Yang J, Visscher PM, Plomin R. DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities. Behav Genet 2013; 43: 267-273.
64. Trzaskowski M, Shakeshaft NG, Plomin R. Intelligence indexes generalist genes for cognitive abilities. Intelligence 2013; 41: 560-565.
65. Baddeley A. Working memory: Theories, models, and controversies. Annu Rev Psychol 2012; 63: 1-29.
66. Giedd JN, Rapoport JL. Structural MRI of pediatric brain development: What have we learned and where are we going? Neuron 2010; 67: 728-734.
67. Kovas Y, Plomin R. Generalist genes: Implications for the cognitive sciences. Trends Cogn Sci 2006; 10: 198-203.
68. Keller MC, Garver-Apgar CE, Wright MJ, Martin NG, Corley RP, Stallings MC et al. The genetic correlation between height and IQ: Shared genes or assortative mating? PLoS Genet 2013; 9: e1003451.
69. Whitaker KL, Jarvis MJ, Beeken RJ, Boniface D, Wardle J. Comparing maternal and paternal intergenerational transmission of obesity risk in a large populationbased sample. Am J Clin Nutr 2010; 91: 1560-1567.
70. Vandenberg SG. Assortative mating, or who marries whom? Behav Genet 1972; 2: 127-157.
71. Bouchard TJ Jr., McGue M. Familial studies of intelligence: A review. Science 1981; 212: 1055-1059.
72. Mascie-Taylor CGN. Spouse similarity for IQ and personality and convergence. Behav Genet 1989; 19: 223-227.
73. Vinkhuyzen AAE, van der Sluis S, Maes HHM, Posthuma D. Reconsidering the heritability of intelligence in adulthood: Taking assortative mating and cultural transmission into account. Behav Genet 2012; 42: 187-198.
74. Bashi J. Effects of inbreeding on cognitive performance. Nature 1977; 266: 440-442.
75. Chipuer HM, Rovine MJ, Plomin R. LISREL modeling: Genetic and environmental influences on IQ revisited. Intelligence 1990; 14: 11-29.
76. Falconer DS, MacKay TFC. Introduction to quantitative genetics, Vol 4. Longman: Harlow, UK, 1996.
77. Rietveld CA, Cesarini D, Benjamin DJ, Koellinger PD, De Neve JE, Tiemeier H et al. Molecular genetics and subjective well-being. Proc Natl Acad Sci USA 2013; 110: 9692-9697.
78. Trzaskowski M, Dale PS, Plomin R. No genetic influence for childhood behavior problems from DNA analysis. J Am Acad Child Adolesc Psychiatry 2013; 52: 1048-1056.
79. Vinkhuyzen AAE, Pedersen NL, Yang J, Lee SH, Magnusson PKE, Iacono WG et al. Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. Transl Psychiatry 2012; 2: e102.
80. Davies G, Tenesa A, Payton A, Yang J, Harris SE, Liewald D et al. Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry 2011; 16: 996-1005.
81. Domingue BW, Fletcher J, Conley D, Boardman JD. Genetic and educational assortative mating among US adults. Proc Natl Acad Sci USA 2014; 111: 7996-8000.
82. Kell HJ, Lubinski D, Benbow CP. Who rises to the top? Early indicators. Psychol Sci 2013; 24: 648-659.
83. Haworth CMA, Wright MJ, Martin NW, Martin NG, Boomsma DI, Bartels M et al. A twin study of the genetics of high cognitive ability selected from 11 000 twin pairs in six studies from four countries. Behav Genet 2009; 39: 359-370.
84. Plomin R, Simpson MA, Cederlf M, Lichtenstein P. The genetics of high cognitive abilities. ISIR: Melbourne, Australia, 2013 Available at http://www.isironline.org/ wp-content/uploads/2014/05/program2013.pdf; Accessed 19 May 2014.
85. DeFries JC, Fulker DW. Multiple regression analysis of twin data: Etiology of deviant scores versus individual differences. Acta Genet Med Gemellol 1988; 37: 205-216.
86. Petrill SA, Kovas Y, Hart SA, Thompson LA, Plomin R. The genetic and environmental etiology of high math performance in 10-year-old twins. Behav Genet 2009; 39: 371-379.
87. Lykken DT. The genetics of genius. In Steptoe A (ed) Genius and the mind: Studies of creativity and temperament in the historical record. Oxford University Press: New York, 1998 pp 15-37.
88. Lykken DT. The mechanism of emergenesis. Genes Brain Behav 2006; 5: 306-310.
89. Galton F. Heredity genius: An enquiry into its laws and consequences. World: Cleveland, OH, 1869.
90. Plomin R, Cederlf M, Lichtenstein P. Low IQ and mild mental retardation are heritable but severe mental retardation is not: A genetic analysis of 740 000 siblings and 18 000 twins. ISIR: Melbourne, Australia, 2013 Available at http://www.isir online.org/wp-content/uploads/2014/05/program2013.pdf; Accessed 19 May 2014.
91. Penrose LS. A clinical and genetic study of 1280 cases of mental defect. HM Stationery Office: London, UK, 1938.
92. Ellison JW, Rosenfeld JA, Shaffer LG. Genetic basis of intellectual disability. Annu Rev Med 2013; 64: 441-450.
93. Marioni RE, Penke L, Davies G, Huffman JE, Hayward C, Deary IJ. The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability. Proc R Soc Lond B Biol Sci 2014; 281: 20140117.
94. Kirkpatrick RM, McGue M, Iacono WG, Miller MB, Basu S, Pankratz N. Lowfrequency copy-number variants and general cognitive ability: No evidence of association. Intelligence 2014; 42: 98-106.
95. Plomin R, Haworth CMA, Davis OSP. Common disorders are quantitative traits. Nat Rev Genet 2009; 10: 872-878.
96. Deary IJ, Taylor MD, Hart CL, Wilson V, Smith GD, Blane D et al. Intergenerational social mobility and mid-life status attainment: Influences of childhood intelligence, childhood social factors, and education. Intelligence 2005; 33: 455-472.
97. Calvin CM, Deary IJ, Fenton C, Roberts BA, Der G, Leckenby N et al. Intelligence in youth and all-cause-mortality: Systematic review with meta-analysis. Int J Epidemiol 2011; 40: 626-644.
98. Erikson R, Goldthorpe JH. Has social mobility in Britain decreased? Reconciling divergent findings on income and class mobility. Br J Sociol 2010; 61: 211-230.
99. Saunders P. Social mobility myths. Civitas: London, UK, 2010.
100. Chandola T, Clarke P, Morris JN, Blane D. Pathways between education and health: A causal modelling approach. J R Stat Soc Ser A Stat Soc 2006; 169: 337-359.
101. Davey Smith G, Hart C, Hole D, MacKinnon P, Gillis C, Watt G et al. Education and occupational social class: Which is the more important indicator of mortality risk? J Epidemiol Community Health 1998; 52: 153-160.
102. Galobardes B, Lynch JW, Smith GD. Is the association between childhood socioeconomic circumstances and cause-specific mortality established? Update of a systematic review. J Epidemiol Community Health 2008; 62: 387-390.
103. Lawlor DA, Sterne JAC, Tynelius P, Davey Smith G, Rasmussen F. Association of childhood socioeconomic position with cause-specific mortality in a prospective record linkage study of 1 839 384 individuals. Am J Epidemiol 2006; 164: 907-915.
104. Deary IJ, Batty GD. Cognitive epidemiology. J Epidemiol Community Health 2007; 61: 378-384.
105. Deary IJ, Strand S, Smith P, Fernandes C. Intelligence and educational achievement. Intelligence 2007; 35: 13-21.
106. Deary IJ, Johnson W. Intelligence and education: Causal perceptions drive analytic processes and therefore conclusions. Int J Epidemiol 2010; 39: 1362-1369.
107. Gray L, Davey Smith G, McConnachie A, Watt GC, Hart CL, Upton MN et al. Parental height in relation to offspring coronary heart disease: Examining transgenerational influences on health using the West of Scotland Midspan Family Study. Int J Epidemiol 2012; 41: 1776-1785.
108. Marioni RE, Batty GD, Hayward C, Kerr SM, Campbell A, Hocking LJ et al. Common genetic variants explain the majority of the correlation between height and intelligence: The Generation Scotland Study. Intelligence 2014; 44: 91-96.
109. Luciano M, Batty GD, McGilchrist M, Linksted P, Fitzpatrick B, Jackson C et al. Shared genetic aetiology between cognitive ability and cardiovascular disease risk factors: Generation Scotland's Scottish family health study. Intelligence 2010; 38: 304-313.
110. Johnson W, Deary IJ, McGue M, Christensen K. Genetic and environmental links between cognitive and physical functions in old age. J Gerontol B Psychol Sci Soc Sci 2009; 64: 65-72.
111. Johnson W, Deary IJ, McGue M, Christensen K. Genetic and environmental transactions linking cognitive ability, physical fitness, and education in late life. Psychol Aging 2009; 24: 48-62.
112. Marioni RE, Davies G, Hayward C, Liewald D, Kerr SM, Campbell A et al. Molecular genetic contributions to socioeconomic status and intelligence. Behav Genet 2014; 44: 26-32.
113. Singh-Manoux A. Commentary: Is it time to redefine cognitive epidemiology? Int J Epidemiol 2010; 39: 1369-1371.
114. Deary IJ. Looking for 'system integrity' in cognitive epidemiology. Gerontology 2012; 58: 545-553.
115. Plomin R, Simpson M. The future of genomics for developmentalists. Dev Psychopathol 2013; 25: 1263-1278.
116. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU et al. Association analyses of 249 796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010; 42: 937-948.
117. Dudbridge F. Power and predictive accuracy of polygenic risk scores. PLoS Genet 2013; 9: e1003348.
118. Wray NR, Lee SH, Mehta D, Vinkhuyzen AAE, Dudbridge F, Middeldorp CM. Polygenic methods and their application to psychiatric disorders and related traits. J Child Psychol Psychiatry advance online publication, 1 August 2014; doi:10.1111/jcpp.12295 (e-pub ahead of print).
119. Hill WD, Davies G, van de Lagemaat LN, Christoforou A, Marioni RE, Fernandes CPD et al. Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins. Transl Psychiatry 2014; 4: e341.
120. Lykken DT. Research with twins: The concept of emergenesis. Psychophysiology 1982; 19: 361-373.