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Volumn 14, Issue 12, 2017, Pages 697-710

Proton-pump inhibitors: Understanding the complications and risks

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; ESOMEPRAZOLE; LANSOPRAZOLE; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; RABEPRAZOLE;

EID: 85035356646     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2017.117     Document Type: Review
Times cited : (208)

References (152)
  • 3
    • 85035325769 scopus 로고    scopus 로고
    • Omeprazole (correction of omepraxole) and ocular damage
    • Lessell, S. Omeprazole (correction of omepraxole) and ocular damage. Concerns on safety of drug are unwarranted. BMJ 316, 7124-7167 (1998).
    • (1998) Concerns on Safety of Drug Are Unwarranted. BMJ , vol.316 , pp. 7124-7167
    • Lessell, S.1
  • 4
    • 0026574382 scopus 로고
    • Omeprazole-induced pseudohypertrophy of gastric parietal cells
    • Stolte, M., Bethke, B., Rühl, G. & Ritter, M. Omeprazole-induced pseudohypertrophy of gastric parietal cells. Z. Gastroenterol. 30, 134-138 (1992).
    • (1992) Z. Gastroenterol. , vol.30 , pp. 134-138
    • Stolte, M.1    Bethke, B.2    Rühl, G.3    Ritter, M.4
  • 5
    • 84867574793 scopus 로고    scopus 로고
    • Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy: Results of a 5?year follow?up in the LOTUS tria
    • Fiocca, R. et al. Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy: results of a 5?year follow?up in the LOTUS trial. Aliment. Pharmacol. Ther. 36, 959-971 (2012).
    • (2012) Aliment. Pharmacol. Ther. , vol.36 , pp. 959-971
    • Fiocca, R.1
  • 6
    • 0033938551 scopus 로고    scopus 로고
    • Parietal cell protrusions and fundic gland cysts during omeprazole maintenance treatment
    • Cats, A. et al. Parietal cell protrusions and fundic gland cysts during omeprazole maintenance treatment. Hum. Pathol. 31, 684-690 (2000).
    • (2000) Hum. Pathol. , vol.31 , pp. 684-690
    • Cats, A.1
  • 7
    • 0035713891 scopus 로고    scopus 로고
    • Effects of very long (up to 10 years) proton pump blockade on human gastric mucosa
    • Lamberts, R., Brunner, G. & Solcia, E. Effects of very long (up to 10 years) proton pump blockade on human gastric mucosa. Digestion 64, 205-213 (2001).
    • (2001) Digestion , vol.64 , pp. 205-213
    • Lamberts, R.1    Brunner, G.2    Solcia, E.3
  • 8
    • 84939562887 scopus 로고    scopus 로고
    • Systematic review: The effects of long?term proton pump inhibitor use on serum gastrin levels and gastric histology
    • Lundell, L., Vieth, M., Gibson, F., Nagy, P. & Kahrilas, P. J. Systematic review: the effects of long?term proton pump inhibitor use on serum gastrin levels and gastric histology. Aliment. Pharmacol. Ther. 42, 649-663 (2015).
    • (2015) Aliment. Pharmacol. Ther. , vol.42 , pp. 649-663
    • Lundell, L.1    Vieth, M.2    Gibson, F.3    Nagy, P.4    Kahrilas, P.J.5
  • 10
    • 67649222366 scopus 로고    scopus 로고
    • Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy
    • Reimer, C., Søndergaard, B., Hilsted, L. & Bytzer, P. Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology 137, 80-87 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 80-87
    • Reimer, C.1    Søndergaard, B.2    Hilsted, L.3    Bytzer, P.4
  • 11
    • 77955708825 scopus 로고    scopus 로고
    • Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: A prospective study in Japan
    • Hongo, M., Fujimoto, K. & Gastric Polyps Study Group. Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan. J. Gastroenterol. 45, 618-624 (2010).
    • (2010) J. Gastroenterol. , vol.45 , pp. 618-624
    • Hongo, M.1    Fujimoto, K.2
  • 12
    • 84991106511 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: Fundic gland polyps and proton pump inhibitors
    • Martin, F. C., Chenevix-Trench, G. & Yeomans, N. D. Systematic review with meta-analysis: fundic gland polyps and proton pump inhibitors. Aliment. Pharmacol. Ther. 44, 915-925 (2016).
    • (2016) Aliment. Pharmacol. Ther. , vol.44 , pp. 915-925
    • Martin, F.C.1    Chenevix-Trench, G.2    Yeomans, N.D.3
  • 13
    • 85015649552 scopus 로고    scopus 로고
    • Use of proton pump inhibitors and risks of fundic gland polyps and gastric cancer: Systematic review and meta-analysis
    • Tran-Duy, A., Spaetgens, B., Hoes, A. W., de Wit, N. J. & Stehouwer, C. D. Use of proton pump inhibitors and risks of fundic gland polyps and gastric cancer: systematic review and meta-analysis. Clin. Gastroenterol. Hepatol. 14, 1706-1719 (2016).
    • (2016) Clin. Gastroenterol. Hepatol. , vol.14 , pp. 1706-1719
    • Tran-Duy, A.1    Spaetgens, B.2    Hoes, A.W.3    De Wit, N.J.4    Stehouwer, C.D.5
  • 14
    • 84859575477 scopus 로고    scopus 로고
    • Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): A new autosomal dominant syndrome
    • Worthley, D. L. et al. Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. Gut 61, 774-779 (2012).
    • (2012) Gut , vol.61 , pp. 774-779
    • Worthley, D.L.1
  • 15
    • 84861557768 scopus 로고    scopus 로고
    • Familial fundic gland polyposis with gastric cancer
    • Yanaru-Fujisawa, R. et al. Familial fundic gland polyposis with gastric cancer. Gut 61, 1103-1104 (2012).
    • (2012) Gut , vol.61 , pp. 1103-1104
    • Yanaru-Fujisawa, R.1
  • 16
    • 0035725743 scopus 로고    scopus 로고
    • Serum chromogranin A as a screening test for gastric enterochromaffin-like cell hyperplasia during acid-suppressive therapy
    • Sanduleanu, S. et al. Serum chromogranin A as a screening test for gastric enterochromaffin-like cell hyperplasia during acid-suppressive therapy. Eur. J. Clin. Invest. 31, 802-811 (2001).
    • (2001) Eur. J. Clin. Invest. , vol.31 , pp. 802-811
    • Sanduleanu, S.1
  • 17
    • 84990945103 scopus 로고    scopus 로고
    • Are proton pump inhibitors really so dangerous?
    • Savarino, V., Dulbecco, P. & Savarino, E. Are proton pump inhibitors really so dangerous? Dig. Liver Dis. 48, 851-859 (2016).
    • (2016) Dig. Liver Dis. , vol.48 , pp. 851-859
    • Savarino, V.1    Dulbecco, P.2    Savarino, E.3
  • 18
    • 84958054641 scopus 로고    scopus 로고
    • Does long-term profound inhibition of gastric acid secretion increase the risk of ECL cell-derived tumors in man?
    • Waldum, H. L., Hauso, Ø., Brenna, E., Qvigstad, G. & Fossmark, R. Does long-term profound inhibition of gastric acid secretion increase the risk of ECL cell-derived tumors in man? Scand. J. Gastroenterol. 51, 767-773 (2016).
    • (2016) Scand. J. Gastroenterol. , vol.51 , pp. 767-773
    • Waldum, H.L.1    Hauso, Ø.2    Brenna, E.3    Qvigstad, G.4    Fossmark, R.5
  • 19
    • 84866234607 scopus 로고    scopus 로고
    • Gastric carcinoids after long-term use of a proton pump inhibitor
    • Jianu, C. S. et al. Gastric carcinoids after long-term use of a proton pump inhibitor. Aliment. Pharmacol. Ther. 36, 644-649 (2012).
    • (2012) Aliment. Pharmacol. Ther. , vol.36 , pp. 644-649
    • Jianu, C.S.1
  • 20
    • 79551632075 scopus 로고    scopus 로고
    • Effect of proton-pump inhibitor therapy on serum chromogranin a leve
    • Pregun, I. et al. Effect of proton-pump inhibitor therapy on serum chromogranin a level. Digestion 84, 22-28 (2011).
    • (2011) Digestion , vol.84 , pp. 22-28
    • Pregun, I.1
  • 21
    • 77949653296 scopus 로고    scopus 로고
    • PPI-delayed diagnosis of gastrinoma: Oncologic victim of pharmacologic success
    • Wong, H. et al. PPI-delayed diagnosis of gastrinoma: oncologic victim of pharmacologic success. Pathol. Oncol. Res. 16, 87-91 (2010).
    • (2010) Pathol. Oncol. Res. , vol.16 , pp. 87-91
    • Wong, H.1
  • 22
    • 84927522220 scopus 로고    scopus 로고
    • Role of proton pump inhibitors in preventing hypergastrinemia-associated carcinogenesis and in antagonizing the trophic effect of gastrin
    • Han, Y. M. et al. Role of proton pump inhibitors in preventing hypergastrinemia-associated carcinogenesis and in antagonizing the trophic effect of gastrin. J. Physiol. Pharmacol. 66, 159-167 (2015).
    • (2015) J. Physiol. Pharmacol. , vol.66 , pp. 159-167
    • Han, Y.M.1
  • 23
    • 65549096192 scopus 로고    scopus 로고
    • Proton pump inhibitors and risk of gastric cancer: A population-based cohort study
    • Poulsen, A. H. et al. Proton pump inhibitors and risk of gastric cancer: a population-based cohort study. Br. J. Cancer. 100, 1503-1507 (2009).
    • (2009) Br. J. Cancer. , vol.100 , pp. 1503-1507
    • Poulsen, A.H.1
  • 24
    • 34548680296 scopus 로고    scopus 로고
    • Long-term use of proton pump inhibitors does not affect the frequency, growth, or histologic caracteristics of colon adenomas
    • Singh, M., Dhindsa, G., Friedland, S. & Triadafilopoulos, G. Long-term use of proton pump inhibitors does not affect the frequency, growth, or histologic caracteristics of colon adenomas. Aliment. Pharmacol. Ther. 26, 1051-1061 (2007).
    • (2007) Aliment. Pharmacol. Ther. , vol.26 , pp. 1051-1061
    • Singh, M.1    Dhindsa, G.2    Friedland, S.3    Triadafilopoulos, G.4
  • 25
    • 34548566069 scopus 로고    scopus 로고
    • Proton pump inhibitor use and risk of colorectal cancer: A population-based, case-control study
    • Robertson, D. J. et al. Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study. Gastroenterology 133, 755-760 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 755-760
    • Robertson, D.J.1
  • 26
    • 85007575329 scopus 로고    scopus 로고
    • Proton pump inhibitors on pancreatic cancer risk and surviva
    • Kearns, M. D., Boursi, B. & Yang, Y. X. Proton pump inhibitors on pancreatic cancer risk and survival. Cancer Epidemiol. 46, 80-84 (2017).
    • (2017) Cancer Epidemiol. , vol.46 , pp. 80-84
    • Kearns, M.D.1    Boursi, B.2    Yang, Y.X.3
  • 27
    • 0029146892 scopus 로고
    • Increase of Helicobacter pylori-associated corpus gastritis during acid suppressive therapy: Implications for long-term safety
    • Kuipers, E. J. et al. Increase of Helicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for long-term safety. Am. J. Gastroenterol. 90, 1401-1406 (1995).
    • (1995) Am. J. Gastroenterol. , vol.90 , pp. 1401-1406
    • Kuipers, E.J.1
  • 29
    • 84941341036 scopus 로고    scopus 로고
    • The stomach in health and disease
    • Hunt, R. H. et al. The stomach in health and disease. Gut 64, 1650-1668 (2015).
    • (2015) Gut , vol.64 , pp. 1650-1668
    • Hunt, R.H.1
  • 31
    • 0031898529 scopus 로고    scopus 로고
    • Changes in Helicobacter pylori-induced gastritis in the antrum and corpus during 12 months of treatment with omeprazole and lansoprazole in patients with gastro-oesophageal reflux disease
    • Stolte, M., Meining, A., Schmitz, J. M., Alexandridis, T. & Seifert, E. Changes in Helicobacter pylori-induced gastritis in the antrum and corpus during 12 months of treatment with omeprazole and lansoprazole in patients with gastro-oesophageal reflux disease. Aliment. Pharmacol. Ther. 12, 247-253 (1998).
    • (1998) Aliment. Pharmacol. Ther. , vol.12 , pp. 247-253
    • Stolte, M.1    Meining, A.2    Schmitz, J.M.3    Alexandridis, T.4    Seifert, E.5
  • 32
    • 15844369552 scopus 로고    scopus 로고
    • Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication
    • Kuipers, E. J. et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N. Engl. J. Med. 334, 1018-1022 (1996).
    • (1996) N. Engl. J. Med. , vol.334 , pp. 1018-1022
    • Kuipers, E.J.1
  • 33
    • 0031056626 scopus 로고    scopus 로고
    • Gastric mucosa during treatment with lansoprazole: Helicobacter pylori is a risk factor for argyrophil cell hyperplasia
    • Eissele, R., Brunner, G., Simon, B., Solcia, E. & Arnold, R. Gastric mucosa during treatment with lansoprazole: Helicobacter pylori is a risk factor for argyrophil cell hyperplasia. Gastroenterology 112, 707-717 (1997).
    • (1997) Gastroenterology , vol.112 , pp. 707-717
    • Eissele, R.1    Brunner, G.2    Simon, B.3    Solcia, E.4    Arnold, R.5
  • 34
    • 33645006153 scopus 로고    scopus 로고
    • Changes of gastric mucosal architecture during long-term omeprazole therapy: Results of a randomized clinical tria
    • Lundell, L. et al. Changes of gastric mucosal architecture during long-term omeprazole therapy: results of a randomized clinical trial. Aliment. Pharmacol. Ther. 23, 639-647 (2006).
    • (2006) Aliment. Pharmacol. Ther. , vol.23 , pp. 639-647
    • Lundell, L.1
  • 35
    • 84991677089 scopus 로고    scopus 로고
    • Management of Helicobacter pylori infection-The Maastricht V/Florence Consensus Report
    • Malfertheiner, P. et al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut 66, 6-30 (2017).
    • (2017) Gut , vol.66 , pp. 6-30
    • Malfertheiner, P.1
  • 36
    • 0034920472 scopus 로고    scopus 로고
    • Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: Increase of pro-inflammatory cytokines and development of atrophic gastritis
    • Sanduleanu, S., Jonkers, D., De Bruïne, A., Hameeteman, W. & Stockbrügger, R. W. Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis. Aliment. Pharmacol. Ther. 8, 1163-1175 (2001).
    • (2001) Aliment. Pharmacol. Ther. , vol.8 , pp. 1163-1175
    • Sanduleanu, S.1    Jonkers, D.2    De Bruïne, A.3    Hameeteman, W.4    Stockbrügger, R.W.5
  • 38
    • 84942342601 scopus 로고    scopus 로고
    • Proton pump inhibitors alter specific taxa in the human gastrointestinal microbiome: A crossover tria
    • Freedberg, D. E. et al. Proton pump inhibitors alter specific taxa in the human gastrointestinal microbiome: a crossover trial. Gastroenterology 149, 883-885 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 883-885
    • Freedberg, D.E.1
  • 39
    • 84954286470 scopus 로고    scopus 로고
    • Proton pump inhibitors alter the composition of the gut microbiota
    • Jackson, M. A. et al. Proton pump inhibitors alter the composition of the gut microbiota. Gut 65, 749-756 (2016).
    • (2016) Gut , vol.65 , pp. 749-756
    • Jackson, M.A.1
  • 40
    • 84954286591 scopus 로고    scopus 로고
    • Proton pump inhibitors affect the gut microbiome
    • Imhann, F. et al. Proton pump inhibitors affect the gut microbiome. Gut 65, 740-748 (2016).
    • (2016) Gut , vol.65 , pp. 740-748
    • Imhann, F.1
  • 41
    • 84959269366 scopus 로고    scopus 로고
    • A comparison of the gut microbiome between long-term users and non-users of proton pump inhibitors
    • Clooney, A. G. et al. A comparison of the gut microbiome between long-term users and non-users of proton pump inhibitors. Aliment. Pharmacol. Ther. 43, 974-984 (2016).
    • (2016) Aliment. Pharmacol. Ther. , vol.43 , pp. 974-984
    • Clooney, A.G.1
  • 42
    • 77952744764 scopus 로고    scopus 로고
    • Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy
    • Lombardo, L., Foti, M., Ruggia, O. & Chiecchio, A. Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy. Clin. Gastroenterol. Hepatol. 8, 504-508 (2010).
    • (2010) Clin. Gastroenterol. Hepatol. , vol.8 , pp. 504-508
    • Lombardo, L.1    Foti, M.2    Ruggia, O.3    Chiecchio, A.4
  • 43
    • 84862339507 scopus 로고    scopus 로고
    • Proton pump inhibitor therapy use does not predispose to small intestinal bacterial overgrowth
    • Ratuapli, S. K. et al. Proton pump inhibitor therapy use does not predispose to small intestinal bacterial overgrowth. Am. J. Gastroenterol.107, 730-735 (2012)
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 730-735
    • Ratuapli, S.K.1
  • 44
    • 84876711968 scopus 로고    scopus 로고
    • Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: A meta-analysis
    • Lo, W. K. & Chan, W. W. Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis. Clin. Gastroenterol. Hepatol. 11, 483-490 (2013).
    • (2013) Clin. Gastroenterol. Hepatol. , vol.11 , pp. 483-490
    • Lo, W.K.1    Chan, W.W.2
  • 45
    • 84877631800 scopus 로고    scopus 로고
    • Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth
    • Jacobs, C., Coss Adame, E., Attaluri, A., Valestin, J. & Rao, S. S. Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth. Aliment. Pharmacol. Ther. 37, 1103-1111 (2013).
    • (2013) Aliment. Pharmacol. Ther. , vol.37 , pp. 1103-1111
    • Jacobs, C.1    Coss Adame, E.2    Attaluri, A.3    Valestin, J.4    Rao, S.S.5
  • 46
    • 84977618678 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage
    • Giamarellos-Bourboulis, E. J., Pyleris, E., Barbatzas, C., Pistiki, A. & Pimentel, M. Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage. BMC Gastroenterol. 16, 67 (2016).
    • (2016) BMC Gastroenterol. , vol.16 , pp. 67
    • Giamarellos-Bourboulis, E.J.1    Pyleris, E.2    Barbatzas, C.3    Pistiki, A.4    Pimentel, M.5
  • 47
    • 34548142191 scopus 로고    scopus 로고
    • Systematic review of the risk of enteric infection in patients taking acid suppression
    • Leonard, J., Marshall, J. K. & Moayyedi, P. Systematic review of the risk of enteric infection in patients taking acid suppression. Am. J. Gastroenterol. 102, 2047-2056 (2007).
    • (2007) Am. J. Gastroenterol. , vol.102 , pp. 2047-2056
    • Leonard, J.1    Marshall, J.K.2    Moayyedi, P.3
  • 48
    • 33646156654 scopus 로고    scopus 로고
    • Risk factors for Salmonella Enteritidis and Typhimurium (DT104 and non?DT104) infections in the Netherlands: Predominant roles for raw eggs in Enteritidis and sandboxes in Typhimurium infections
    • Doorduyn, Y., Van Den Brandhof, W. E., Van Duynhoven, Y. T., Wannet, W. J. & Van Pelt, W. Risk factors for Salmonella Enteritidis and Typhimurium (DT104 and non?DT104) infections in the Netherlands: predominant roles for raw eggs in Enteritidis and sandboxes in Typhimurium infections. Epidemiol. Infect. 134, 617-626 (2006).
    • (2006) Epidemiol. Infect. , vol.134 , pp. 617-626
    • Doorduyn, Y.1    Van Den Brandhof, W.E.2    Van Duynhoven, Y.T.3    Wannet, W.J.4    Van Pelt, W.5
  • 49
    • 81355160270 scopus 로고    scopus 로고
    • Systematic review: The use of proton pump inhibitors and increased susceptibility to enteric infection
    • Bavishi, C. & Dupont, H. L. Systematic review: the use of proton pump inhibitors and increased susceptibility to enteric infection. Aliment. Pharmacol. Ther. 34, 1269-1281 (2011).
    • (2011) Aliment. Pharmacol. Ther. , vol.34 , pp. 1269-1281
    • Bavishi, C.1    Dupont, H.L.2
  • 51
    • 84863717616 scopus 로고    scopus 로고
    • Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: Meta-analysis
    • Kwok, C. S. et al. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. Am. J. Gastroenterol. 107, 1011-1019 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 1011-1019
    • Kwok, C.S.1
  • 52
    • 84870946567 scopus 로고    scopus 로고
    • Association between proton pump inhibitor therapy and clostridium difficile infection: A contemporary systematic review and meta-analysis
    • Tleyjeh, I. M. et al. Association between proton pump inhibitor therapy and clostridium difficile infection: a contemporary systematic review and meta-analysis. PLoS ONE 7, e50836 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e50836
    • Tleyjeh, I.M.1
  • 53
    • 85035354441 scopus 로고    scopus 로고
    • Assessing the risk of hospital-acquired Clostridium difficile infection with proton pump inhibitor use: A meta-analysis
    • Arriola, V. et al. Assessing the risk of hospital-acquired Clostridium difficile infection with proton pump inhibitor use: a meta-analysis. Infect. Control Hosp. Epidemiol. 28, 1-10 (2016).
    • (2016) Infect. Control Hosp. Epidemiol. , vol.28 , pp. 1-10
    • Arriola, V.1
  • 54
    • 84979084917 scopus 로고    scopus 로고
    • Reducing co?administration of proton pump inhibitors and antibiotics using a computerized order entry alert and prospective audit and feedback
    • Kandel, C. E., Gill, S. E.,McCready, J., Matelski, J. & Powis, J. E. Reducing co?administration of proton pump inhibitors and antibiotics using a computerized order entry alert and prospective audit and feedback. BMC Infect. Dis. 16, 355 (2016).
    • (2016) BMC Infect. Dis. , vol.16 , pp. 355
    • Kandel, C.E.1    Gill, S.E.2    McCready, J.3    Matelski, J.4    Powis, J.E.5
  • 55
    • 34147103977 scopus 로고    scopus 로고
    • Microscopic colitis associated with lansoprazole: Report of two cases and a review of the literature
    • Chande, N. & Driman, D. K. Microscopic colitis associated with lansoprazole: report of two cases and a review of the literature. Scand. J. Gastroenterol. 42, 530-533 (2007).
    • (2007) Scand. J. Gastroenterol. , vol.42 , pp. 530-533
    • Chande, N.1    Driman, D.K.2
  • 56
    • 67651092059 scopus 로고    scopus 로고
    • Microscopic colitis associated with omeprazole and esomeprazole exposure
    • Wilcox, G. M. & Mattia, A. R. Microscopic colitis associated with omeprazole and esomeprazole exposure. J. Clin. Gastroenterol. 43, 551-553 (2009).
    • (2009) J. Clin. Gastroenterol. , vol.43 , pp. 551-553
    • Wilcox, G.M.1    Mattia, A.R.2
  • 57
    • 78649486172 scopus 로고    scopus 로고
    • Proton pump inhibitor use is associated with an increased risk for microscopic colitis: A case-control study
    • Keszthelyi, D. et al. Proton pump inhibitor use is associated with an increased risk for microscopic colitis: a case-control study. Aliment. Pharmacol. Ther. 32, 1124-1128 (2010).
    • (2010) Aliment. Pharmacol. Ther. , vol.32 , pp. 1124-1128
    • Keszthelyi, D.1
  • 58
    • 84960171827 scopus 로고    scopus 로고
    • High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors
    • Verhaegh, B. P. et al. High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors. Aliment. Pharmacol. Ther. 43, 1004-1013 (2016).
    • (2016) Aliment. Pharmacol. Ther. , vol.43 , pp. 1004-1013
    • Verhaegh, B.P.1
  • 59
    • 84953716163 scopus 로고    scopus 로고
    • Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: A systematic review and meta-analysis
    • Xu, H. B. et al. Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis. Genet. Mol. Res. 14, 7490-7501 (2015).
    • (2015) Genet. Mol. Res. , vol.14 , pp. 7490-7501
    • Xu, H.B.1
  • 60
    • 84927799218 scopus 로고    scopus 로고
    • Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: A multicenter prospective study
    • Terg, R. et al. Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study. J. Hepatol. 62, 1056-1060 (2015).
    • (2015) J. Hepatol. , vol.62 , pp. 1056-1060
    • Terg, R.1
  • 61
    • 84988335993 scopus 로고    scopus 로고
    • Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites
    • Dam, G., Vilstrup, H., Watson, H. & Jepsen, P. Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites. Hepatology 64, 1265-1272 (2016).
    • (2016) Hepatology , vol.64 , pp. 1265-1272
    • Dam, G.1    Vilstrup, H.2    Watson, H.3    Jepsen, P.4
  • 62
    • 84861094277 scopus 로고    scopus 로고
    • Proton pump inhibitor-associated pneumonia: Not a breath of fresh air after all?
    • Fohl, A. L. & Regal, R. E. Proton pump inhibitor-associated pneumonia: not a breath of fresh air after all? World J. Gastrointest. Pharmacol. Ther. 2, 17-26 (2011).
    • (2011) World J. Gastrointest. Pharmacol. Ther. , vol.2 , pp. 17-26
    • Fohl, A.L.1    Regal, R.E.2
  • 63
    • 85008656029 scopus 로고    scopus 로고
    • Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: A systematic review and meta-analysis of randomized trials
    • Alshamsi, F. et al. Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials. Crit. Care 20, 120 (2016).
    • (2016) Crit. Care , vol.20 , pp. 120
    • Alshamsi, F.1
  • 65
    • 79951983392 scopus 로고    scopus 로고
    • Use of acid-suppressive drugs and risk of pneumonia: A systematic review and meta-analysis
    • Eom, C. S. et al. Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis. CMAJ 183, 310-319 (2011).
    • (2011) CMAJ , vol.183 , pp. 310-319
    • Eom, C.S.1
  • 66
    • 84895479775 scopus 로고    scopus 로고
    • Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: Replicated cohort studies with meta-analysis
    • Filion, K. B. et al. Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis. Gut 63, 552-558 (2014).
    • (2014) Gut , vol.63 , pp. 552-558
    • Filion, K.B.1
  • 67
    • 84938548378 scopus 로고    scopus 로고
    • Frequency and time to onset of community-acquired respiratory tract infections in patients receiving esomeprazole: A retrospective analysis of patient-level data in placebo-controlled studies
    • Estborn, L. & Joelson, S. Frequency and time to onset of community-acquired respiratory tract infections in patients receiving esomeprazole: a retrospective analysis of patient-level data in placebo-controlled studies. Aliment. Pharmacol. Ther. 42, 607-613 (2015).
    • (2015) Aliment. Pharmacol. Ther. , vol.42 , pp. 607-613
    • Estborn, L.1    Joelson, S.2
  • 68
    • 84989829163 scopus 로고    scopus 로고
    • Adverse event reporting for proton pump inhibitor therapy: An overview of systematic reviews
    • Abramowitz, J. et al. Adverse event reporting for proton pump inhibitor therapy: an overview of systematic reviews. Otolaryngol. Head Neck Surg. 155, 547-554 (2016).
    • (2016) Otolaryngol. Head Neck Surg. , vol.155 , pp. 547-554
    • Abramowitz, J.1
  • 69
    • 84963820918 scopus 로고    scopus 로고
    • Association of proton pump inhibitors with risk of dementia: A pharmacoepidemiological claims data analysis
    • Gomm, W. et al. Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurol. 73, 410-416 (2016).
    • (2016) JAMA Neurol. , vol.73 , pp. 410-416
    • Gomm, W.1
  • 70
    • 84953738066 scopus 로고    scopus 로고
    • Risk factors for dementia diagnosis in German primary care practices
    • Booker, A., Jacob, L. E., Rapp, M., Bohlken, J. & Kostev, K. Risk factors for dementia diagnosis in German primary care practices. Int. Psychogeriatr. 28, 1059-1065 (2016).
    • (2016) Int. Psychogeriatr. , vol.28 , pp. 1059-1065
    • Booker, A.1    Jacob, L.E.2    Rapp, M.3    Bohlken, J.4    Kostev, K.5
  • 71
    • 33745043032 scopus 로고    scopus 로고
    • Myopathy including polymyositis: A likely class adverse effect of proton pump inhibitors?
    • Clark, D. W. & Strandell, J. Myopathy including polymyositis: a likely class adverse effect of proton pump inhibitors? Eur. J. Clin. Pharmacol. 62, 473-479 (2006).
    • (2006) Eur. J. Clin. Pharmacol. , vol.62 , pp. 473-479
    • Clark, D.W.1    Strandell, J.2
  • 72
    • 0026761460 scopus 로고
    • Acute interstitial nephritis due to omeprazole
    • Ruffenach, S. J., Siskind, M. S. & Lien, Y. H. Acute interstitial nephritis due to omeprazole. Am. J. Med. 93, 472-473 (1992).
    • (1992) Am. J. Med. , vol.93 , pp. 472-473
    • Ruffenach, S.J.1    Siskind, M.S.2    Lien, Y.H.3
  • 73
    • 77955086666 scopus 로고    scopus 로고
    • Drug-induced acute interstitial nephritis
    • Perazella, M. A. & Markowitz, G. S. Drug-induced acute interstitial nephritis. Nat. Rev. Nephrol. 6, 461-470 (2010).
    • (2010) Nat. Rev. Nephrol. , vol.6 , pp. 461-470
    • Perazella, M.A.1    Markowitz, G.S.2
  • 74
    • 84908120421 scopus 로고    scopus 로고
    • Biopsy-proven acute interstitial nephritis, 1993?2011: A case series
    • Muriithi, A. K. et al. Biopsy-proven acute interstitial nephritis, 1993?2011: a case series. Am. J. Kidney Dis. 64, 558-566 (2014).
    • (2014) Am. J. Kidney Dis. , vol.64 , pp. 558-566
    • Muriithi, A.K.1
  • 75
    • 84987732320 scopus 로고    scopus 로고
    • PPIs and kidney disease: From AIN to CKD
    • Moledina, D.,G. & Perazella, M. A. PPIs and kidney disease: from AIN to CKD. J. Nephrol. 29, 611-616 (2016).
    • (2016) J. Nephrol. , vol.29 , pp. 611-616
    • Moledina, D.G.1    Perazella, M.A.2
  • 76
    • 84926166138 scopus 로고    scopus 로고
    • A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use
    • Blank, M. L., Parkin, L., Paul, C. & Herbison, P. A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use. Kidney Int. 86, 837-844 (2014).
    • (2014) Kidney Int. , vol.86 , pp. 837-844
    • Blank, M.L.1    Parkin, L.2    Paul, C.3    Herbison, P.4
  • 77
    • 84969400493 scopus 로고    scopus 로고
    • Proton pump inhibitors and the risk of acute kidney injury in older patients: A population-based cohort study
    • Antoniou, T. et al. Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study. CMAJ Open 3, E166-E171 (2015).
    • (2015) CMAJ Open , vol.3 , pp. E166-E171
    • Antoniou, T.1
  • 79
    • 84957998974 scopus 로고    scopus 로고
    • Proton pump inhibitor use and the risk of chronic kidney disease
    • Lazarus, B. et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern. Med. 176, 238-246 (2016).
    • (2016) JAMA Intern. Med. , vol.176 , pp. 238-246
    • Lazarus, B.1
  • 80
    • 85011431641 scopus 로고    scopus 로고
    • Proton pump inhibitors and risk of incident CKD and progression to ESRD
    • Xie, Y. et al. Proton pump inhibitors and risk of incident CKD and progression to ESRD. J. Am. Soc. Nephrol. 10, 3153-3163 (2016).
    • (2016) J. Am. Soc. Nephrol. , vol.10 , pp. 3153-3163
    • Xie, Y.1
  • 81
    • 84876018043 scopus 로고    scopus 로고
    • Proton pump inhibitors and risk of 1?year mortality and rehospitalization in older patients discharged from acute care hospitals
    • Maggio, M. et al. Proton pump inhibitors and risk of 1?year mortality and rehospitalization in older patients discharged from acute care hospitals. JAMA Intern. Med. 173, 518-523 (2013).
    • (2013) JAMA Intern. Med. , vol.173 , pp. 518-523
    • Maggio, M.1
  • 82
    • 33847409654 scopus 로고    scopus 로고
    • Proton pump inhibitor therapy for peptic ulcer bleeding: Cochrane collaboration meta-analysis of randomized controlled trials
    • Leontiadis, G. I., Sharma, V. K. & Howden, C. W. Proton pump inhibitor therapy for peptic ulcer bleeding: Cochrane collaboration meta-analysis of randomized controlled trials. Mayo Clin. Proc. 82, 286-296 (2007).
    • (2007) Mayo Clin. Proc. , vol.82 , pp. 286-296
    • Leontiadis, G.I.1    Sharma, V.K.2    Howden, C.W.3
  • 83
    • 84889821934 scopus 로고    scopus 로고
    • Proton pump inhibitor and histamine 2 receptor antagonist use and vitamine B12 deficiency
    • Lam, J. R., Schneider, J. L., Zhao, W. & Corley, D. A. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamine B12 deficiency. JAMA 310, 2435-2442 (2013).
    • (2013) JAMA , vol.310 , pp. 2435-2442
    • Lam, J.R.1    Schneider, J.L.2    Zhao, W.3    Corley, D.A.4
  • 84
    • 61949324352 scopus 로고    scopus 로고
    • Effect of proton pump inhibitors on vitamins and iron
    • McColl, K. E. Effect of proton pump inhibitors on vitamins and iron. Am. J. Gastroenterol. 104, S5-S9 (2009).
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. S5-S9
    • McColl, K.E.1
  • 85
    • 84982918829 scopus 로고    scopus 로고
    • Oxyntic gastric atrophy in Helicobacter pylori gastritis is distinct from autoimmune gastritis
    • Venerito, M. et al. Oxyntic gastric atrophy in Helicobacter pylori gastritis is distinct from autoimmune gastritis. J. Clin. Pathol. 69, 677-685 (2016).
    • (2016) J. Clin. Pathol. , vol.69 , pp. 677-685
    • Venerito, M.1
  • 86
    • 0028092199 scopus 로고
    • Magnesium deficiency: Pathophysiologic and clinical overview
    • al?Ghamdi, S. M., Cameron, E. C. & Sutton, R. A. Magnesium deficiency: pathophysiologic and clinical overview. Am. J. Kidney Dis. 24, 737-752 (1994).
    • (1994) Am. J. Kidney Dis. , vol.24 , pp. 737-752
    • Alghamdi, S.M.1    Cameron, E.C.2    Sutton, R.A.3
  • 87
    • 33750320388 scopus 로고    scopus 로고
    • Proton-pump inhibitors and hypomagnesemic hypoparathyroidism
    • Epstein, M., McGrath, S. & Law, F. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism. N. Engl. J. Med. 355, 1834-1836 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1834-1836
    • Epstein, M.1    McGrath, S.2    Law, F.3
  • 88
    • 77953807102 scopus 로고    scopus 로고
    • A case series of proton pump inhibitor-induced hypomagnesemia
    • Hoorn, E. J. et al. A case series of proton pump inhibitor-induced hypomagnesemia. Am. J. Kidney Dis. 56, 112-116 (2010).
    • (2010) Am. J. Kidney Dis. , vol.56 , pp. 112-116
    • Hoorn, E.J.1
  • 89
    • 77957328950 scopus 로고    scopus 로고
    • Hypomagnesaemia due to proton-pump inhibitor therapy: A clinical case series
    • Mackay, J. D. & Bladon, P. T. Hypomagnesaemia due to proton-pump inhibitor therapy: a clinical case series. QJM 103, 387-395 (2010).
    • (2010) QJM , vol.103 , pp. 387-395
    • Mackay, J.D.1    Bladon, P.T.2
  • 90
    • 84878515354 scopus 로고    scopus 로고
    • Proton pump inhibitor-associated hypomagnesemia: What do FDA data tell us?
    • Luk, C. P., Parsons, R., Lee, Y. P. & Hughes, J. D. Proton pump inhibitor-associated hypomagnesemia: what do FDA data tell us? Ann. Pharmacother. 47, 773-780 (2013).
    • (2013) Ann. Pharmacother. , vol.47 , pp. 773-780
    • Luk, C.P.1    Parsons, R.2    Lee, Y.P.3    Hughes, J.D.4
  • 91
    • 40049101450 scopus 로고    scopus 로고
    • Recent developments in intestinal magnesium absorption
    • Quamme, G. A. Recent developments in intestinal magnesium absorption. Curr. Opin. Gastroenterol. 24, 230-235 (2008).
    • (2008) Curr. Opin. Gastroenterol. , vol.24 , pp. 230-235
    • Quamme, G.A.1
  • 92
    • 0347683487 scopus 로고    scopus 로고
    • TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption
    • Voets, T. et al. TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J. Biol. Chem. 279, 19-25 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 19-25
    • Voets, T.1
  • 93
    • 18544369466 scopus 로고    scopus 로고
    • Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
    • Schlingmann, K. P. et al. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat. Genet. 31, 166-170 (2002).
    • (2002) Nat. Genet. , vol.31 , pp. 166-170
    • Schlingmann, K.P.1
  • 94
    • 84907952319 scopus 로고    scopus 로고
    • Proton pump inhibitors and hospitalization with hypomagnesemia: A population-based case-control study
    • Zipursky, J. et al. Proton pump inhibitors and hospitalization with hypomagnesemia: a population-based case-control study. PLoS Med. 11, e1001736 (2014).
    • (2014) PLoS Med. , vol.11 , pp. e1001736
    • Zipursky, J.1
  • 95
    • 84856844214 scopus 로고    scopus 로고
    • Proton pump inhibitors are associated with lower magnesium levels in older people with chronic kidney disease
    • Sumukadas, D., McMurdo, M. E. T. & Habicht, D. Proton pump inhibitors are associated with lower magnesium levels in older people with chronic kidney disease. J. Am. Geriatr. Soc. 60, 392-393 (2012).
    • (2012) J. Am. Geriatr. Soc. , vol.60 , pp. 392-393
    • Sumukadas, D.1    McMurdo, M.E.T.2    Habicht, D.3
  • 96
    • 84875728378 scopus 로고    scopus 로고
    • Proton-pump inhibitor use is associated with low serum magnesium concentrations
    • Danziger, J. et al. Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int. 83, 692-699 (2013).
    • (2013) Kidney Int. , vol.83 , pp. 692-699
    • Danziger, J.1
  • 97
    • 84938919716 scopus 로고    scopus 로고
    • The relationship between proton pump inhibitor use and serum magnesium concentration among hemodialysis patients: A cross-sectional study
    • Misra, P. S., Alam, A., Lipman, M. L. & Nessim, S. J. The relationship between proton pump inhibitor use and serum magnesium concentration among hemodialysis patients: a cross-sectional study. BMC Nephrol. 16, 136 (2015).
    • (2015) BMC Nephrol. , vol.16 , pp. 136
    • Misra, P.S.1    Alam, A.2    Lipman, M.L.3    Nessim, S.J.4
  • 98
    • 84959016813 scopus 로고    scopus 로고
    • Low prevalence of hypomagnesemia in long-term recipients of proton pump inhibitors in a managed care cohort
    • Sharara, A. I. et al. Low prevalence of hypomagnesemia in long-term recipients of proton pump inhibitors in a managed care cohort. Clin. Gastroenterol. Hepatol. 14, 317-321 (2016).
    • (2016) Clin. Gastroenterol. Hepatol. , vol.14 , pp. 317-321
    • Sharara, A.I.1
  • 99
    • 85009802378 scopus 로고    scopus 로고
    • Hypomagnesemia among outpatient long-term proton pump inhibitor users
    • Biyik, M. et al. Hypomagnesemia among outpatient long-term proton pump inhibitor users. Am. J. Ther. 24, e52-e55 (2017).
    • (2017) Am. J. Ther. , vol.24 , pp. e52-e55
    • Biyik, M.1
  • 100
    • 80054115001 scopus 로고    scopus 로고
    • Hypomagnesaemia/hypokalemia associated with the use of esomeprazole
    • Negri, A. L. & Valle, E. E. Hypomagnesaemia/hypokalemia associated with the use of esomeprazole. Curr. Drug Saf. 6, 204-206 (2011).
    • (2011) Curr. Drug Saf. , vol.6 , pp. 204-206
    • Negri, A.L.1    Valle, E.E.2
  • 101
    • 84912527272 scopus 로고    scopus 로고
    • Severe acute neurological symptoms related to proton pump inhibitors induced hypomagnesemia responsible for profound hypoparathyroidism with hypocalcemia
    • Deroux, A., Khouri, C., Chabre, O., Bouillet, L. & Casez, O. Severe acute neurological symptoms related to proton pump inhibitors induced hypomagnesemia responsible for profound hypoparathyroidism with hypocalcemia. Clin. Res. Hepatol. Gastroenterol. 38, e103-e105 (2014).
    • (2014) Clin. Res. Hepatol. Gastroenterol. , vol.38 , pp. e103-e105
    • Deroux, A.1    Khouri, C.2    Chabre, O.3    Bouillet, L.4    Casez, O.5
  • 103
    • 84869784910 scopus 로고    scopus 로고
    • Apical acidity decreases inhibitory effect of omeprazole on Mg(2+) absorption and claudin?7 and-12 expression in Caco?2 monolayers
    • Thongon, N. & Krishnamra, N. Apical acidity decreases inhibitory effect of omeprazole on Mg(2+) absorption and claudin?7 and-12 expression in Caco?2 monolayers. Exp. Mol. Med. 44, 684-693 (2012).
    • (2012) Exp. Mol. Med. , vol.44 , pp. 684-693
    • Thongon, N.1    Krishnamra, N.2
  • 105
    • 84946962339 scopus 로고    scopus 로고
    • Dietary inulin fibers prevent proton-pump inhibitor (PPI)-induced hypocalcemia in mice
    • Hess, M. W., de Baaij, J. H. F., Gommers, L. M. M., Hoenderop, J. G. J. & Bindels, R. J. M. Dietary inulin fibers prevent proton-pump inhibitor (PPI)-induced hypocalcemia in mice. PLoS ONE 10, e0138881 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0138881
    • Hess, M.W.1    De Baaij, J.H.F.2    Gommers, L.M.M.3    Hoenderop, J.G.J.4    Bindels, R.J.M.5
  • 106
    • 77957672464 scopus 로고    scopus 로고
    • Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical tria
    • Wright, M. J. et al. Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: a randomized, crossover, controlled clinical trial. J. Bone Miner. Res. 25, 2205-2211 (2010).
    • (2010) J. Bone Miner. Res. , vol.25 , pp. 2205-2211
    • Wright, M.J.1
  • 107
    • 77957012883 scopus 로고    scopus 로고
    • Do proton pump inhibitors decrease calcium absorption?
    • Hansen, K. E. et al. Do proton pump inhibitors decrease calcium absorption? J. Bone Miner. Res. 25, 2786-2795 (2010).
    • (2010) J. Bone Miner. Res. , vol.25 , pp. 2786-2795
    • Hansen, K.E.1
  • 108
    • 84929134452 scopus 로고    scopus 로고
    • Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: Data from the SOPRAN and LOTUS studies
    • Attwood, S. E. et al. Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: data from the SOPRAN and LOTUS studies. Aliment. Pharmacol. Ther. 41, 1162-1174 (2015).
    • (2015) Aliment. Pharmacol. Ther. , vol.41 , pp. 1162-1174
    • Attwood, S.E.1
  • 109
    • 33748105475 scopus 로고    scopus 로고
    • Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture
    • Vestergaard, P., Rejnmark, L. & Mosekilde, L. Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture. Calcif. Tissue Int. 79, 76-83 (2006).
    • (2006) Calcif. Tissue Int. , vol.79 , pp. 76-83
    • Vestergaard, P.1    Rejnmark, L.2    Mosekilde, L.3
  • 110
    • 33845864487 scopus 로고    scopus 로고
    • Long-term proton pump inhibitor therapy and risk of hip fracture
    • Yang, Y. X., Lewis, J. D., Epstein, S. & Metz, D. C. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA 296, 2947-2953 (2006).
    • (2006) JAMA , vol.296 , pp. 2947-2953
    • Yang, Y.X.1    Lewis, J.D.2    Epstein, S.3    Metz, D.C.4
  • 111
    • 49749141653 scopus 로고    scopus 로고
    • Use of proton pump inhibitors and risk of osteoporosis-related fractures
    • Targownik, L. E. et al. Use of proton pump inhibitors and risk of osteoporosis-related fractures. CMAJ 179, 319-326 (2008).
    • (2008) CMAJ , vol.179 , pp. 319-326
    • Targownik, L.E.1
  • 112
    • 80051790502 scopus 로고    scopus 로고
    • Proton pump inhibitors therapy and risk of hip fracture: A systematic review and meta-analysis
    • Ye, X. et al. Proton pump inhibitors therapy and risk of hip fracture: a systematic review and meta-analysis. Eur. J. Gastroenterol. Hepatol. 9, 794-800 (2011).
    • (2011) Eur. J. Gastroenterol. Hepatol. , vol.9 , pp. 794-800
    • Ye, X.1
  • 113
    • 79960055410 scopus 로고    scopus 로고
    • Proton pump inhibitors and risk of fracture: A systematic review and meta-analysis of observational studies
    • Ngamruengphong, S., Leontiadis, G., Radhi, S., Dentino, A. & Nugent, K. Proton pump inhibitors and risk of fracture: a systematic review and meta-analysis of observational studies. Am. J. Gastroenterol. 106, 1209-1218 (2011).
    • (2011) Am. J. Gastroenterol. , vol.106 , pp. 1209-1218
    • Ngamruengphong, S.1    Leontiadis, G.2    Radhi, S.3    Dentino, A.4    Nugent, K.5
  • 114
    • 77953880651 scopus 로고    scopus 로고
    • Proton pump inhibitors and histamine?2 receptor antagonists are associated with hip fractures among at?risk patients
    • Corley, D. A., Kubo, A., Zhao, W. & Quesenberry, C. Proton pump inhibitors and histamine?2 receptor antagonists are associated with hip fractures among at?risk patients. Gastroenterology 139, 93-101 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 93-101
    • Corley, D.A.1    Kubo, A.2    Zhao, W.3    Quesenberry, C.4
  • 115
    • 48249103083 scopus 로고    scopus 로고
    • Proton pump inhibitor use and risk of hip fractures in patients without major risk factors
    • Kaye, J. A. & Jick, H. Proton pump inhibitor use and risk of hip fractures in patients without major risk factors. Pharmacotherapy 28, 951-959 (2008).
    • (2008) Pharmacotherapy , vol.28 , pp. 951-959
    • Kaye, J.A.1    Jick, H.2
  • 116
    • 77249135057 scopus 로고    scopus 로고
    • Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss
    • Targownik, L. E., Lix, L. M., Leung, S. & Leslie, W. D. Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss. Gastroenterology 138, 896-904 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 896-904
    • Targownik, L.E.1    Lix, L.M.2    Leung, S.3    Leslie, W.D.4
  • 117
    • 84957649268 scopus 로고    scopus 로고
    • Gastroesophageal reflux disease with proton pump inhibitor use is associated with an increased risk of osteoporosis: A nationwide population-based analysis
    • Chen, C. H., Lin, C. L. & Kao, C. H. Gastroesophageal reflux disease with proton pump inhibitor use is associated with an increased risk of osteoporosis: a nationwide population-based analysis. Osteoporos. Int. 27, 2117-2126 (2016).
    • (2016) Osteoporos. Int. , vol.27 , pp. 2117-2126
    • Chen, C.H.1    Lin, C.L.2    Kao, C.H.3
  • 118
    • 84986295281 scopus 로고    scopus 로고
    • Clopidogrel-proton pump inhibitor drug-drug interaction and risk of adverse clinical outcomes among PCI-treated ACS patients: A meta-analysis
    • Serbin, M. A., Guzauskas, G. F. & Veenstra, D. L. Clopidogrel-proton pump inhibitor drug-drug interaction and risk of adverse clinical outcomes among PCI-treated ACS patients: a meta-analysis. J. Manag. Care Spec. Pharm. 22, 939-947 (2016).
    • (2016) J. Manag. Care Spec. Pharm. , vol.22 , pp. 939-947
    • Serbin, M.A.1    Guzauskas, G.F.2    Veenstra, D.L.3
  • 119
    • 84976402228 scopus 로고    scopus 로고
    • Individual proton pump inhibitors and outcomes in patients with coronary artery disease on dual antiplatelet therapy: A systematic review
    • Sherwood, M. W. et al. Individual proton pump inhibitors and outcomes in patients with coronary artery disease on dual antiplatelet therapy: a systematic review. J. Am. Heart Assoc. 4, e002245 (2015).
    • (2015) J. Am. Heart Assoc. , vol.4 , pp. e002245
    • Sherwood, M.W.1
  • 120
    • 84926353509 scopus 로고    scopus 로고
    • Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: Systematic review
    • Melloni, C. et al. Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review. Circ. Cardiovasc. Qual. Outcomes 8, 47-55 (2015).
    • (2015) Circ. Cardiovasc. Qual. Outcomes , vol.8 , pp. 47-55
    • Melloni, C.1
  • 121
    • 33750079553 scopus 로고    scopus 로고
    • Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin
    • Gilard, M., Arnaud, B., le Gal, G., Abgrall, J. F. & Boschat, J. Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin. J. Thromb. Haemost. 4, 2508-2509 (2006).
    • (2006) J. Thromb. Haemost. , vol.4 , pp. 2508-2509
    • Gilard, M.1    Arnaud, B.2    Le Gal, G.3    Abgrall, J.F.4    Boschat, J.5
  • 122
    • 84875242008 scopus 로고    scopus 로고
    • Concomitant use of clopidogrel and proton pump inhibitors: Impact on platelet function and clinical outcome: A systematic review
    • Focks, J. J. et al. Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome: a systematic review. Heart 99, 520-527 (2013).
    • (2013) Heart , vol.99 , pp. 520-527
    • Focks, J.J.1
  • 123
    • 57149104093 scopus 로고    scopus 로고
    • Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogre
    • Siller-Matula, J. M. et al. Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. Am. Heart J. 157, 148.e1-148.e5 (2009).
    • (2009) Am. Heart J. , vol.157 , pp. 148e1-148e5
    • Siller-Matula, J.M.1
  • 124
    • 40749094082 scopus 로고    scopus 로고
    • Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogre
    • Small, D. S. et al. Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel. J. Clin. Pharmacol. 48, 475-484 (2008).
    • (2008) J. Clin. Pharmacol. , vol.48 , pp. 475-484
    • Small, D.S.1
  • 125
    • 78149487926 scopus 로고    scopus 로고
    • Clopidogrel with or without omeprazole in coronary artery disease
    • Bhatt, D. L., et al. Clopidogrel with or without omeprazole in coronary artery disease. N. Engl. J. Med. 363, 1909-1917 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1909-1917
    • Bhatt, D.L.1
  • 126
    • 70349097288 scopus 로고    scopus 로고
    • Early use of omeprazole benefits patients with acute myocardial infarction
    • Gao, Q. P. Sun, Y., Sun, Y. X., Wang, L. F. & Fu, L. Early use of omeprazole benefits patients with acute myocardial infarction. J. Thromb. Thrombolysis 28, 282-287 (2009).
    • (2009) J. Thromb. Thrombolysis , vol.28 , pp. 282-287
    • Gao, Q.P.1    Sun, Y.2    Sun, Y.X.3    Wang, L.F.4    Fu, L.5
  • 128
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • Simon, T. et al. Genetic determinants of response to clopidogrel and cardiovascular events. N. Engl. J. Med. 360, 363-375 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 363-375
    • Simon, T.1
  • 129
    • 34248347478 scopus 로고    scopus 로고
    • The pharmacogenetics of CYP 2C9 and CYP2C19: Ethnic variation and clinical significance
    • Rosemary, J. & Adithan, C. The pharmacogenetics of CYP 2C9 and CYP2C19: ethnic variation and clinical significance. Curr. Clin. Pharmacol. 2, 93-109 (2007).
    • (2007) Curr. Clin. Pharmacol. , vol.2 , pp. 93-109
    • Rosemary, J.1    Adithan, C.2
  • 130
    • 78049351476 scopus 로고    scopus 로고
    • Dilemma between gastroprotection and cardiovascular prevention
    • Venerito, M., Kandulski, A. & Malfertheiner, P. Dilemma between gastroprotection and cardiovascular prevention. Dtsch. Med. Wochenschr. 135, 2193-2198 (2010).
    • (2010) Dtsch. Med. Wochenschr. , vol.135 , pp. 2193-2198
    • Venerito, M.1    Kandulski, A.2    Malfertheiner, P.3
  • 131
    • 84921840460 scopus 로고    scopus 로고
    • Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction
    • Depta, J. P. et al. Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction. Pharmacogenomics J. 15, 20-25 (2015).
    • (2015) Pharmacogenomics J. , vol.15 , pp. 20-25
    • Depta, J.P.1
  • 132
    • 73849084548 scopus 로고    scopus 로고
    • Proton pump inhibitor and clopidogrel interaction: Fact or fiction?
    • Laine, L. & Hennekens, C. Proton pump inhibitor and clopidogrel interaction: fact or fiction? Am. J. Gastroenterol. 105, 34-41 (2010).
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 34-41
    • Laine, L.1    Hennekens, C.2
  • 134
    • 76249083093 scopus 로고    scopus 로고
    • Systematic review: Impaired drug absorption related to the co?administration of antisecretory therapy
    • Lahner, E., Annibale, B. & Delle Fave, G. Systematic review: impaired drug absorption related to the co?administration of antisecretory therapy. Aliment. Pharmacol. Ther. 29, 1219-1229 (2009).
    • (2009) Aliment. Pharmacol. Ther. , vol.29 , pp. 1219-1229
    • Lahner, E.1    Annibale, B.2    Delle Fave, G.3
  • 135
    • 0017081695 scopus 로고
    • The absorption of warfarin from the rat stomach in situ
    • Julkunen, R. J. The absorption of warfarin from the rat stomach in situ. Med. Biol. 54, 260-263 (1976).
    • (1976) Med. Biol. , vol.54 , pp. 260-263
    • Julkunen, R.J.1
  • 136
    • 84994492963 scopus 로고    scopus 로고
    • Effective and safe proton pump inhibitor therapy in acid-related diseases-A position paper addressing benefits and potential harms of acid suppression
    • Scarpignato, C. et al. Effective and safe proton pump inhibitor therapy in acid-related diseases-a position paper addressing benefits and potential harms of acid suppression. BMC Med. 14, 179 (2016).
    • (2016) BMC Med. , vol.14 , pp. 179
    • Scarpignato, C.1
  • 137
    • 57449085402 scopus 로고    scopus 로고
    • Drug interaction studies with dexlansoprazole modified release (TAK?390MR), a proton pump inhibitor with a dual delayed-release formulation: Results of four randomized, double-blind, crossover, placebo-controlled, single-centre studies
    • Vakily, M., Lee, R. D., Wu, J., Gunawardhana, L. & Mulford, D. Drug interaction studies with dexlansoprazole modified release (TAK?390MR), a proton pump inhibitor with a dual delayed-release formulation: results of four randomized, double-blind, crossover, placebo-controlled, single-centre studies. Clin. Drug Investig. 29, 35-50 (2009).
    • (2009) Clin. Drug Investig. , vol.29 , pp. 35-50
    • Vakily, M.1    Lee, R.D.2    Wu, J.3    Gunawardhana, L.4    Mulford, D.5
  • 138
    • 85027948084 scopus 로고    scopus 로고
    • The potential drug-drug interaction between proton pump inhibitors and warfarin
    • Henriksen, D. P. et al. The potential drug-drug interaction between proton pump inhibitors and warfarin. Pharmacoepidemiol. Drug Saf. 24, 1337-1340 (2015).
    • (2015) Pharmacoepidemiol. Drug Saf. , vol.24 , pp. 1337-1340
    • Henriksen, D.P.1
  • 139
    • 84983123463 scopus 로고    scopus 로고
    • Does gastric acid suppression affect sunitinib efficacy in patients with advanced or metastatic renal cell cancer?
    • Ha, V. H. et al. Does gastric acid suppression affect sunitinib efficacy in patients with advanced or metastatic renal cell cancer? J. Oncol. Pharm. Pract. 21, 194-200 (2015).
    • (2015) J. Oncol. Pharm. Pract. , vol.21 , pp. 194-200
    • Ha, V.H.1
  • 140
    • 84927516432 scopus 로고    scopus 로고
    • Gastric acid suppression is associated with decreased erlotinib efficacy in non-small-cell lung cancer
    • Chu, M. P. et al. Gastric acid suppression is associated with decreased erlotinib efficacy in non-small-cell lung cancer. Clin. Lung Cancer 16, 33-39 (2015).
    • (2015) Clin. Lung Cancer , vol.16 , pp. 33-39
    • Chu, M.P.1
  • 141
    • 84963582649 scopus 로고    scopus 로고
    • Influence of the acidic beverage cola on the absorption of erlotinib in patients with non-small-cell lung cancer
    • van Leeuwen, R. W. et al. Influence of the acidic beverage cola on the absorption of erlotinib in patients with non-small-cell lung cancer. J. Clin. Oncol. 34, 1309-1314 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 1309-1314
    • Van Leeuwen, R.W.1
  • 142
    • 85014699568 scopus 로고    scopus 로고
    • Association of proton pump inhibitors and capecitabine efficacy in advanced gastroesophageal cancer: Secondary analysis of the TRIO?013/LOGiC randomized clinical tria
    • Chu, M. P. et al. Association of proton pump inhibitors and capecitabine efficacy in advanced gastroesophageal cancer: secondary analysis of the TRIO?013/LOGiC randomized clinical trial. JAMA Oncol. 3, 767-773 (2017).
    • (2017) JAMA Oncol. , vol.3 , pp. 767-773
    • Chu, M.P.1
  • 143
    • 84859756288 scopus 로고    scopus 로고
    • Effect of food and a proton pump inhibitor on the pharmacokinetics of S-1 following oral administration of S-1 in patients with advanced solid tumors
    • Scheulen, M. E. et al. Effect of food and a proton pump inhibitor on the pharmacokinetics of S-1 following oral administration of S-1 in patients with advanced solid tumors. Cancer Chemother. Pharmacol. 69, 753-761 (2012).
    • (2012) Cancer Chemother. Pharmacol. , vol.69 , pp. 753-761
    • Scheulen, M.E.1
  • 144
    • 84882810068 scopus 로고    scopus 로고
    • Unexpected effect of proton pump inhibitors: Elevation of the cardiovascular risk factor asymmetric dimethylarginine
    • Ghebremariam, Y. T. et al. Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine. Circulation 128, 845-853 (2013).
    • (2013) Circulation , vol.128 , pp. 845-853
    • Ghebremariam, Y.T.1
  • 145
    • 77955904372 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease
    • Wilson, A. M. et al. Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease. Vasc. Med. 15, 267-274 (2010).
    • (2010) Vasc. Med. , vol.15 , pp. 267-274
    • Wilson, A.M.1
  • 146
    • 79951693947 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease
    • Böger, R. H. et al. Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease. J. Intern. Med. 269, 349-361 (2011).
    • (2011) J. Intern. Med. , vol.269 , pp. 349-361
    • Böger, R.H.1
  • 147
    • 84938766921 scopus 로고    scopus 로고
    • Proton pump inhibitors and vascular function: A prospective cross-over pilot study
    • Ghebremariam, Y. T. et al. Proton pump inhibitors and vascular function: a prospective cross-over pilot study. Vasc. Med. 4, 309-316 (2015).
    • (2015) Vasc. Med. , vol.4 , pp. 309-316
    • Ghebremariam, Y.T.1
  • 148
    • 84969786563 scopus 로고    scopus 로고
    • Proton pump inhibitors accelerate endothelial senescence
    • Yepuri, G. et al. Proton pump inhibitors accelerate endothelial senescence. Circ. Res. 118, e36-e42 (2016).
    • (2016) Circ. Res. , vol.118 , pp. e36-e42
    • Yepuri, G.1
  • 149
    • 84937522335 scopus 로고    scopus 로고
    • Pathogenesis of endothelial cell dysfunction in chronic kidney disease: A retrospective and what the future may hold
    • Goligorsky, M. S. Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold. Kidney Res. Clin. Pract. 34, 76-82 (2015).
    • (2015) Kidney Res. Clin. Pract. , vol.34 , pp. 76-82
    • Goligorsky, M.S.1
  • 150
    • 84947046996 scopus 로고    scopus 로고
    • Vascular dysfunction in the pathogenesis of Alzheimer's disease-A review of endothelium-mediated mechanisms and ensuing vicious circles
    • Di Marco, L. Y. et al. Vascular dysfunction in the pathogenesis of Alzheimer's disease-a review of endothelium-mediated mechanisms and ensuing vicious circles. Neurobiol. Dis. 82, 593-606 (2015).
    • (2015) Neurobiol. Dis. , vol.82 , pp. 593-606
    • Di Marco, L.Y.1
  • 151
    • 84864696128 scopus 로고    scopus 로고
    • The assessment of endothelial function: From research into clinical practice
    • Flammer, A. J. et al. The assessment of endothelial function: from research into clinical practice. Circulation 126, 753-767 (2012).
    • (2012) Circulation , vol.126 , pp. 753-767
    • Flammer, A.J.1
  • 152
    • 84859589351 scopus 로고    scopus 로고
    • Management of Helicobacter pylori infection-The Maastricht IV/ florence consensus report
    • Malfertheiner, P. et al. Management of Helicobacter pylori infection-the Maastricht IV/ Florence Consensus Report. Gut 61, 646-664 (2012).
    • (2012) Gut , vol.61 , pp. 646-664
    • Malfertheiner, P.1


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