Reducing co-administration of proton pump inhibitors and antibiotics using a computerized order entry alert and prospective audit and feedback

BMC Infectious Diseases

Volumn 16, Issue 1, 2016, Pages

  Kandel, Christopher E ^a   Gill, Suzanne ^b   McCready, Janine ^b   Matelski, John ^c   Powis, Jeff E ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO EAST GENERAL HOSPITAL   (Canada)

^c TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Antibiotic stewardship; Clostridium difficile infection; Computerized alerts; Prospective audit and feedback; Proton pump inhibitors

Indexed keywords

ANTIBIOTIC AGENT; PROTON PUMP INHIBITOR; ANTIINFECTIVE AGENT;

AGED; ANTIMICROBIAL STEWARDSHIP PROGRAM; ARTICLE; AWARENESS; CANADA; CLINICAL PRACTICE; CLOSTRIDIUM DIFFICILE INFECTION; COHORT ANALYSIS; COMPUTERIZED ORDER ENTRY ALERT; CONSULTATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG USE; FEEDBACK SYSTEM; FEMALE; HEALTH CARE CONCEPTS; HOSPITAL PATIENT; HUMAN; INFECTION RATE; MAJOR CLINICAL STUDY; MALE; MEDICAL AUDIT; MEDICAL INFORMATICS; PRESCRIBING PATTERN; PRESCRIPTION; PROSPECTIVE AUDIT AND FEEDBACK; TEACHING HOSPITAL; TREND STUDY; ADULT; CLINICAL AUDIT; CLINICAL DECISION SUPPORT SYSTEM; CLINICAL TRIAL; HOSPITALIZATION; INAPPROPRIATE PRESCRIBING; MIDDLE AGED; ONTARIO; PHYSICIAN ORDER ENTRY SYSTEM; PREVENTION AND CONTROL; PROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CANADA; CLINICAL AUDIT; DECISION SUPPORT SYSTEMS, CLINICAL; FEMALE; HOSPITALIZATION; HOSPITALS, TEACHING; HUMANS; INAPPROPRIATE PRESCRIBING; MALE; MEDICAL ORDER ENTRY SYSTEMS; MIDDLE AGED; ONTARIO; PROSPECTIVE STUDIES; PROTON PUMP INHIBITORS;

EID: 84979084917     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/s12879-016-1679-8     Document Type: Article

References (19)

1. Reid M, Keniston A, Heller JC, Miller M, Medvedev S, Albert RK. Inappropriate prescribing of proton pump inhibitors in hospitalized patients. J Hosp Med. 2012;7:421-5.
2. Kelly OB, Dillane C, Patchett SE, Harewood GC, Murray FE. The inappropriate prescription of oral proton pump inhibitors in the hospital setting: a prospective cross-sectional study. Dig Dis Sci. 2015;60:2280-6.
3. McDonald EG, Milligan J, Frenette C, Lee TC. Continuous proton pump inhibitor therapy and the associated risk of recurrent Clostridium difficile infection. JAMA Intern Med. 2015;175:784-91.
4. Janarthanan S, Ditah I, Adler DG, Ehrinpreis MN. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis. Am J Gastroenterol. 2012;107:1001-10.
5. Freedberg DE, Lamousé-Smith ES, Lightdale JR, Jin Z, Yang YX, Abrams JA. Use of acid suppression medication is associated with risk for C. difficile infection in infants and children: a population-based study. Clin Infect Dis. 2015;61(6):912-7.
6. Kwok CS, Arthur AK, Anibueze CI, Singh S, Cavallazzi R, Loke YK. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis. Am J Gastroenterol. 2012;107(7):1011-9.
7. King RN, Lager SL. Incidence of Clostridium difficile infections in patients receiving antimicrobial and acid-suppression therapy. Pharmacotherapy. 2011;31(7):642-8.
8. Slimings C, Riley TV. Antibiotics and hospital-acquired Clostridium difficile infection: update of systematic review and meta-analysis. J Antimicrob Chemother. 2014;69(4):881-91.
9. Gordon D, Young LR, Reddy S, Bergman C, Young JD. Incidence of Clostridium difficile infection in patients receiving high-risk antibiotics with or without a proton pump inhibitor. J Hosp Infect. 2016;92(2):173-7.
10. Freedberg DE, Salmasian H, Abrams JA, Green RA. Orders for intravenous proton pump inhibitors after implementation of an electronic alert. JAMA Intern Med. 2015;175:452-4.
11. Lesprit P, Duong T, Girou E, Hemery F, Brun-Buisson C. Impact of a computer-generated alert system prompting review of antibiotic use in hospitals. J Antimicrob Chemother. 2009;63(5):1058-63.
12. Dellit TH, Owens RC, McGowan JE, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44:159-77.
13. Ontario Ministry of Health and Long-Term Care. Provincial Case Definitions for Reportable Diseases. Available at: http://www.health.gov.on.ca/en/pro/programs/publichealth/oph_standards/docs/cdi_cd.pdf. Accessed 21 September 2015.
14. Dancer SJ, Kirkpatrick P, Corcoran DS, Christison F, Farmer D, Robertson C. Approaching zero: temporal effects of a restrictive antibiotic policy on hospital-acquired Clostridium difficile, extended-spectrum β-lactamase-producing coliforms and meticillin-resistant Staphylococcus aureus. Int J Antimicrob Agents. 2013;41:137-42.
15. Stevens V, Dumyati G, Fine LS, Fisher SG, van Wijngaarden E. Cumulative antibiotic exposures over time and the risk of Clostridium difficile infection. Clin Infect Dis. 2011;53(1):42-8.
16. Brown KA, Khanafer N, Daneman N, Fisman DN. Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection. Antimicrob Agents Chemother. 2013;57(5):2326-32.
17. Niklasson A, Lindström L, Simrén M, Lindberg G, Björnsson E. Dyspeptic symptom development after discontinuation of a proton pump inhibitor: a double-blind placebo-controlled trial. Am J Gastroenterol. 2010;105:1531-7.
18. Ojeleye O, Avery A, Gupta V, Boyd M. The evidence for the effectiveness of safety alerts in electronic patient medication record systems at the point of pharmacy order entry: a systematic review. BMC Med Inform Decis Mak. 2013;13:69.
19. Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med. 2015;372(16):1539-48.