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1
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44449135817
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Mechanisms and disorders of magnesium metabolism
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Hebert SC, Alpern RJ, editors, 4th ed. Elsevier: San Diego USA;, This is a review of the many ways of active and passive magnesium transport in the kidney and the disorders affecting these transport pathways
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Quamme GA, Schlingmann KP, Konrad M. Mechanisms and disorders of magnesium metabolism. In: Hebert SC, Alpern RJ, editors. The kidney: physiology and pathophysiology, 4th ed. Elsevier: San Diego USA; 2007. pp. 1747-1768. This is a review of the many ways of active and passive magnesium transport in the kidney and the disorders affecting these transport pathways.
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(2007)
The kidney: Physiology and pathophysiology
, pp. 1747-1768
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Quamme, G.A.1
Schlingmann, K.P.2
Konrad, M.3
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2
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33645963995
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Claudins and epithelial paracellular transport
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This paper discusses the importance of tight-junction proteins in the control of permeation and selectivity of cation transport through the paracellular pathway
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Van Itallie CM, Anderson JM. Claudins and epithelial paracellular transport. Annu Rev Physiol 2006; 68:403-429. This paper discusses the importance of tight-junction proteins in the control of permeation and selectivity of cation transport through the paracellular pathway.
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(2006)
Annu Rev Physiol
, vol.68
, pp. 403-429
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Van Itallie, C.M.1
Anderson, J.M.2
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3
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34547438722
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Schlingmann KP, Waldegger S, Konrad M, et al. TRPM6 and TRPM7-gatekeepers of human magnesium metabolism. Biochim Biophys Acta 2007; 1772:813-821. Here is a balanced discussion of the interaction of TRPM6 and TRPM7 proteins and a functional characterization of these heteromers. It includes a description of the various TRPM6 and TRPM7 mutations identified to date.
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Schlingmann KP, Waldegger S, Konrad M, et al. TRPM6 and TRPM7-gatekeepers of human magnesium metabolism. Biochim Biophys Acta 2007; 1772:813-821. Here is a balanced discussion of the interaction of TRPM6 and TRPM7 proteins and a functional characterization of these heteromers. It includes a description of the various TRPM6 and TRPM7 mutations identified to date.
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4
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33846934950
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(2+)-nucleotide- regulated channel-kinase TRPM7. Handb Exp Pharmacol 2007; 179:313-328. This is a review of the physiology of TRPM7 channels including their functions, regulation and importance in cellular magnesium homeostasis.
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(2+)-nucleotide- regulated channel-kinase TRPM7. Handb Exp Pharmacol 2007; 179:313-328. This is a review of the physiology of TRPM7 channels including their functions, regulation and importance in cellular magnesium homeostasis.
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5
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34548823801
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2+ transport
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This article discusses the regulation of TPRM6 expression in relation to epithelial calcium transport
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2+ transport. Rev Physiol Biochem Pharmacol 2007; 158:77-160. This article discusses the regulation of TPRM6 expression in relation to epithelial calcium transport.
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(2007)
Rev Physiol Biochem Pharmacol
, vol.158
, pp. 77-160
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van de Graaf, S.F.1
Bindels, R.J.2
Hoenderop, J.G.3
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6
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34147109145
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Chubanov V, Schlingmann KP, Waring J, et al. Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative poreforming region of TRPM6. J Biol Chem 2007; 282:7656-7667. Using various mutations identified in patients demonstrating hypomagnesemia with secondary hypocalcemia, heterologous expression systems, and voltageclamp studies, the authors identify a putative pore-forming region of TRPM6.
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Chubanov V, Schlingmann KP, Waring J, et al. Hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative poreforming region of TRPM6. J Biol Chem 2007; 282:7656-7667. Using various mutations identified in patients demonstrating hypomagnesemia with secondary hypocalcemia, heterologous expression systems, and voltageclamp studies, the authors identify a putative pore-forming region of TRPM6.
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7
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34247369421
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Topala CN, Groenestege WT, Thebault S, et al. Molecular determinants of permeation through the cation channel TRPM6. Cell Calcium 2007; 41:513-523. Here site-directed mutagenesis is used to determine molecular properties of the TRPM6 channel.
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Topala CN, Groenestege WT, Thebault S, et al. Molecular determinants of permeation through the cation channel TRPM6. Cell Calcium 2007; 41:513-523. Here site-directed mutagenesis is used to determine molecular properties of the TRPM6 channel.
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8
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33646140352
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Li M, Jiang J, Yue L. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol 2006; 127:525-537. This is a report of a number of electrophysiologic and biochemical differences between TRPM6 and TRPM7 homo- and heteromers. including divalent cation permeability, pH sensitivity, and inhibition by 2-aminoethoxydiphenylborate.
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Li M, Jiang J, Yue L. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol 2006; 127:525-537. This is a report of a number of electrophysiologic and biochemical differences between TRPM6 and TRPM7 homo- and heteromers. including divalent cation permeability, pH sensitivity, and inhibition by 2-aminoethoxydiphenylborate.
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9
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34548498843
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2+ permeability and pH sensitivity in TRPM6 and TRPM7
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This is a report of a number of electrophysiologic and biochemical differences between TRPM6 and TRPM7 homo- and heteromers
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2+ permeability and pH sensitivity in TRPM6 and TRPM7. J Biol Chem 2007; 282:25817-25830. This is a report of a number of electrophysiologic and biochemical differences between TRPM6 and TRPM7 homo- and heteromers.
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(2007)
J Biol Chem
, vol.282
, pp. 25817-25830
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Li, M.1
Du, J.2
Jiang, J.3
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10
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34547527287
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TRPM7 and TRPM2-candidate susceptibility genes for Western Pacific ALS and PD?
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Hermosura MC, Garruto RM. TRPM7 and TRPM2-candidate susceptibility genes for Western Pacific ALS and PD? Biochim Biophys Acta 2007; 1772:822-835.
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(2007)
Biochim Biophys Acta
, vol.1772
, pp. 822-835
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Hermosura, M.C.1
Garruto, R.M.2
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11
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27844523226
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The channel kinases TRPM6 and TRPM7 are functionally nonredundant
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Schmitz C, Dorovkov MV, Zhao X, et al. The channel kinases TRPM6 and TRPM7 are functionally nonredundant. J Biol Chem 2005; 280:37763-37771.
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(2005)
J Biol Chem
, vol.280
, pp. 37763-37771
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Schmitz, C.1
Dorovkov, M.V.2
Zhao, X.3
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12
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33645325125
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TRPM7 channel is regulated by magnesium nucleotides via its kinase domain
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This is the original report demonstrating that the TRPM7 channel is regulated by intracellular magnesium and magnesium-nucleotides and modulation by TRPM7 phosphotransferase activity
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Demeuse P, Penner R, Fleig A. TRPM7 channel is regulated by magnesium nucleotides via its kinase domain. J Gen Physiol 2006; 127:421-434. This is the original report demonstrating that the TRPM7 channel is regulated by intracellular magnesium and magnesium-nucleotides and modulation by TRPM7 phosphotransferase activity.
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(2006)
J Gen Physiol
, vol.127
, pp. 421-434
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Demeuse, P.1
Penner, R.2
Fleig, A.3
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13
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20144366217
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Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1
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Matsushita M, Kozak JA, Shimizu Y, et al. Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J Biol Chem 2005; 280:20793-20803.
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(2005)
J Biol Chem
, vol.280
, pp. 20793-20803
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Matsushita, M.1
Kozak, J.A.2
Shimizu, Y.3
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14
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26444490563
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TRPM2 and TRPM7: Channel/enzyme fusions to generate novel intracellular sensors
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Scharenberg AM. TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors. Pflügers Arch 2005; 451:220-227.
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(2005)
Pflügers Arch
, vol.451
, pp. 220-227
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Scharenberg, A.M.1
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15
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0036092076
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The TRPM7 channel is inactivated by PIP(2) hydrolysis
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Runnels LW, Yue L, Clapham DE. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol 2002; 4:329-336.
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(2002)
Nat Cell Biol
, vol.4
, pp. 329-336
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Runnels, L.W.1
Yue, L.2
Clapham, D.E.3
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16
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1942437482
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Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain
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Takezawa R, Schmitz C, Demeuse P, et al. Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. Proc Natl Acad Sci USA 2004; 101:6009-6014.
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(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6009-6014
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Takezawa, R.1
Schmitz, C.2
Demeuse, P.3
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17
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10944269137
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Phosphorylation of annexin I by TRPM7 channelkinase
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Dorovkov MV, Ryazanov AG. Phosphorylation of annexin I by TRPM7 channelkinase. J Biol Chem 2004; 279:50643-50646.
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(2004)
J Biol Chem
, vol.279
, pp. 50643-50646
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Dorovkov, M.V.1
Ryazanov, A.G.2
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18
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31444441418
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TRPM7, a novel regulator of actomyosin contractility and cell adhesion
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This study found myosin IIA heavy chain to be involved in cell-cell adhesions as a substrate of TRPM7 phosphotransferase
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Clark K, Langeslag M, van Leeuwen B, et al. TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J 2006; 25:290-301. This study found myosin IIA heavy chain to be involved in cell-cell adhesions as a substrate of TRPM7 phosphotransferase.
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(2006)
EMBO J
, vol.25
, pp. 290-301
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Clark, K.1
Langeslag, M.2
van Leeuwen, B.3
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19
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33744961824
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Su LT, Agapito MA, Li M, et al. TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem 2006; 281:11260-11270. Overexpression of TRPM6 did not mimic the morphologic changes of cells that were observed with TRPM7-expressing cells, indicating cellular distinctive roles.
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Su LT, Agapito MA, Li M, et al. TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem 2006; 281:11260-11270. Overexpression of TRPM6 did not mimic the morphologic changes of cells that were observed with TRPM7-expressing cells, indicating cellular distinctive roles.
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20
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26444555458
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TRPMs and neuronal cell death
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Aarts MM, Tymianski M. TRPMs and neuronal cell death. Pflügers Arch 2005; 451:243-249.
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(2005)
Pflügers Arch
, vol.451
, pp. 243-249
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Aarts, M.M.1
Tymianski, M.2
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21
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33846951483
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Activation of TRPM7 channels by phospholipase C-coupled receptor agonists
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This paper demonstrates the activation of TRPM7 channels by phospholipase C-coupled receptor agonists
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Langeslag M, Clark K, Moolenaar WH, et al. Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. J Biol Chem 2007; 282:232-239. This paper demonstrates the activation of TRPM7 channels by phospholipase C-coupled receptor agonists.
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(2007)
J Biol Chem
, vol.282
, pp. 232-239
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Langeslag, M.1
Clark, K.2
Moolenaar, W.H.3
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22
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33645472354
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2+ content and estrogens
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Some of the regulatory influences controlling TRPM6 expression are discussed here
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2+ content and estrogens. J Am Soc Nephrol 2006; 17:1035-1043. Some of the regulatory influences controlling TRPM6 expression are discussed here.
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(2006)
J Am Soc Nephrol
, vol.17
, pp. 1035-1043
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Groenestege, W.M.1
Hoenderop, J.G.2
van den Heuvel, L.3
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24
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20444432260
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2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia
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2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest 2005; 115:1651-1658.
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(2005)
J Clin Invest
, vol.115
, pp. 1651-1658
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Nijenhuis, T.1
Vallon, V.2
van der Kemp, A.W.3
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25
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33646711450
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Increased renal calcium and magnesium transporter abundance in streptozotocin-induced diabetes mellitus
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Lee CT, Lien YH, Lai LW, et al. Increased renal calcium and magnesium transporter abundance in streptozotocin-induced diabetes mellitus. Kidney Int 2006; 69:1786-1791.
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(2006)
Kidney Int
, vol.69
, pp. 1786-1791
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Lee, C.T.1
Lien, Y.H.2
Lai, L.W.3
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26
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33644854944
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Going with the flow: Smooth muscle TRPM7 channels and the vascular response to blood flow
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Gurney AM. Going with the flow: smooth muscle TRPM7 channels and the vascular response to blood flow. Circ Res 2006; 98:163-164.
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(2006)
Circ Res
, vol.98
, pp. 163-164
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Gurney, A.M.1
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27
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34547100281
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TRPM7 channel is sensitive to osmotic gradients in human kidney cells
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Bessac BF, Fleig A. TRPM7 channel is sensitive to osmotic gradients in human kidney cells. J Physiol 2007; 582:1073-1086.
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(2007)
J Physiol
, vol.582
, pp. 1073-1086
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Bessac, B.F.1
Fleig, A.2
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28
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34250807708
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Differential expression of intestinal membrane transporters in cholera patients
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Flach CF, Qadri F, Bhuiyan TR, et al. Differential expression of intestinal membrane transporters in cholera patients. FEBS Lett 2007; 581:3183-3188.
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(2007)
FEBS Lett
, vol.581
, pp. 3183-3188
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Flach, C.F.1
Qadri, F.2
Bhuiyan, T.R.3
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29
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34548658196
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Regulation of transient receptor potential (TRP) channels by phosphoinositides
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Rohacs T, Nilius B. Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflügers Arch 2007; 455:157-168.
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(2007)
Pflügers Arch
, vol.455
, pp. 157-168
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Rohacs, T.1
Nilius, B.2
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31
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25144525351
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2+ transporter with channel-like properties
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2+ transporter with channel-like properties. BMC Genomics 2005; 6:48.
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(2005)
BMC Genomics
, vol.6
, pp. 48
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Goytain, A.1
Quamme, G.A.2
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33
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0347899279
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a congenital dysfunctional bladder be diagnosed from a smile? The Ochoa syndrome updated
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Ochoa B. Can a congenital dysfunctional bladder be diagnosed from a smile? The Ochoa syndrome updated. Pediatr Nephrol 2004; 19:6-12.
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(2004)
Pediatr Nephrol
, vol.19
, pp. 6-12
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Can, O.B.1
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34
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25144506445
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Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter
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Goytain A, Quamme GA. Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter. Physiol Genomics 2005; 22:382-389.
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(2005)
Physiol Genomics
, vol.22
, pp. 382-389
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Goytain, A.1
Quamme, G.A.2
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35
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39449100579
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Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2
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in press
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Goytain A, Quamme GA. Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2. Am J Physiol Cell Physiol (in press).
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Am J Physiol Cell Physiol
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Goytain, A.1
Quamme, G.A.2
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36
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34247275788
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2+ transporter
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2+ transporter, as the basis of hereditary spastic paraplegia. Mutated NIPA1 is retained in the endoplasmic reticulum rather than its normal location in the plasma membrane
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2+ transporter, as the basis of hereditary spastic paraplegia. Mutated NIPA1 is retained in the endoplasmic reticulum rather than its normal location in the plasma membrane.
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(2007)
J Biol Chem
, vol.282
, pp. 8060-8068
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Goytain, A.1
Hines, R.M.2
El-Husseini, A.3
Quamme, G.A.4
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37
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31544466788
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Hereditary spastic paraplegia
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Fink JK. Hereditary spastic paraplegia. Curr Neurol Neurosci Rep 2006; 6:65-76.
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(2006)
Curr Neurol Neurosci Rep
, vol.6
, pp. 65-76
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Fink, J.K.1
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