Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical trial

Journal of Bone and Mineral Research

Volumn 25, Issue 10, 2010, Pages 2205-2211

  Wright, Matthew J ^a   Sullivan, Rebecca R ^b   Gaffney Stomberg, Erin ^a   Caseria, Donna M ^c   O'Brien, Kimberly O ^d   Proctor, Deborah D ^b   Simpson, Christine A ^b   Kerstetter, Jane E ^a   Insogna, Karl L ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE NEW HAVEN HOSPITAL   (United States)

^d Department of Obstetrics Gynecology   (United States)

Author keywords

Gastric pH; Intestinal calcium absorption; Proton pump inhibitors; Urine calcium

Indexed keywords

CALCIUM; CALCIUM 42; CALCIUM 44; ESOMEPRAZOLE; PLACEBO; TRACER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CALCIUM ABSORPTION; CALCIUM HOMEOSTASIS; CALCIUM INTAKE; CALCIUM URINE LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; MALE; NORMAL HUMAN; PATIENT COMPLIANCE; PH MEASUREMENT; PROTEIN DIET; RANDOMIZED CONTROLLED TRIAL; STOMACH ACID; STOMACH ACID SECRETION; STOMACH PH;

ADULT; CALCIUM; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GASTRIC ACID; HUMANS; INTESTINAL ABSORPTION; MALE; PLACEBOS;

EID: 77957672464     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.108     Document Type: Article

References (26)

1. Yang YX, Lewis JD, Epstein S, Metz DC. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006;296:2947-2953. (Pubitemid 46021498)
2. +-ATPase. Annu Rev Pharmacol Toxicol. 1995;35:277-305.
3. Vestergaard P, Rejnmark L, Mosekilde L. Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture. Calcif Tissue Int. 2006;79:76-83. (Pubitemid 44306164)
4. Roux C, Briot K, Gossec L, et al. Increase in vertebral fracture risk in postmenopausal women using omeprazole. Calcif Tissue Int. 2009;84:13-19.
5. Kaye JA, Jick H. Proton pump inhibitor use and risk of hip fractures in patients without major risk factors. Pharmacotherapy. 2008;28:951-959.
6. Recker RR. Calcium absorption and achlorhydria. N Engl J Med. 1985;313:70-73.
7. O'Connell MB, Madden DM, Murray AM, Heaney RP, Kerzner LJ. Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med. 2005;118:778-781.
8. Bo-Linn GW, Davis GR, Buddrus DJ, Morawski SG, Santa Ana C, Fordtran JS. An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium. J Clin Invest. 1984;73: 640-647. (Pubitemid 14156843)
9. Serfaty-Lacrosniere C, Wood RJ, Voytko D, et al. Hypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium or zinc from food in humans. J Am Coll Nutr. 1995;14:364-368.
10. Busque SM, Kerstetter JE, Geibel JP, Insogna K. L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. Am J Physiol Gastrointest Liver Physiol. 2005;289:G664-G669. (Pubitemid 41377172)
11. Konturek SJ, Tasler J, Cieszkowski M, Jaworek J. Comparison of intravenous amino acids in the stimulation of gastric secretion. Gastroenterology. 1978;75:817-824. (Pubitemid 9040962)
12. Richardson CT, Walsh JH, Hicks MI, Fordtran JS. Studies on the mechanisms of food-stimulated gastric acid secretion in normal human subjects. J Clin Invest. 1976;58:623-631.
13. Kerstetter JE, O'Brien KO, Caseria DM, Wall DE, Insogna KL. The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. J Clin Endocrinol Metab. 2005;90:26-31.
14. Knox TA, Kassarjian Z, Dawson-Hughes B, et al. Calcium absorption in elderly subjects on high- and low-fiber diets: effect of gastric acidity. Am J Clin Nutr. 1991;53:1480-1486. (Pubitemid 21898903)
15. Heaney RP, Smith KT, Recker RR, Hinders SM. Meal effects on calcium absorption. Am J Clin Nutr. 1989;49:372-376.
16. Chonan O, Takahashi R, Yasui H, Watanuki M. Effect of L-lactic acid on the absorption of calcium in gastrectomized rats. J Nutr Sci Vitaminol (Tokyo). 1998;44:869-875. (Pubitemid 29091153)
17. Hara H, Suzuki T, Kasai T, Aoyama Y, Ohta A. Ingestion of guar-gum hydrolysate partially restores calcium absorption in the large intestine lowered by suppression of gastric acid secretion in rats. Br J Nutr. 1999;81:315-321. (Pubitemid 29248503)
18. Mahoney AW, Hendricks DG. Role of gastric acid in the utilization of dietary calcium by the rat. Nutr Metab. 1974;16:375-382.
19. Mahoney AW, Holbrook RS, Hendricks DG. Effects of calcium solubility on adsorption by rats with induced achlorhydria. Nutr Metab. 1975;18:310-317.
20. Mizunashi K, Furukawa Y, Katano K, Abe K. Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans. Calcif Tissue Int. 1993;53:21-25.
21. Kocsis I, Arato A, Bodanszky H, et al. Short-term omeprazole treatment does not influence biochemical parameters of bone turnover in children. Calcif Tissue Int. 2002;71:129-132. (Pubitemid 36935477)
22. Tuukkanen J, Vaananen HK. Omeprazole, a specific inhibitor of H+-K+- ATPase, inhibits bone resorption in vitro. Calcif Tissue Int. 1986;38:123-125.
23. Sachs G, Shin JM, Howden CW. Review article: the clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther. 2006; 23(Suppl 2):2-8. (Pubitemid 44383831)
24. Hunt RH, Armstrong D, James C, et al. Effect on intragastric pH of a PPI with a prolonged plasma half-life: comparison between tenatoprazole and esomeprazole on the duration of acid suppression in healthy male volunteers. Am J Gastroenterol. 2005;100:1949-1956. (Pubitemid 43919386)
25. Evenepoel P. Alteration in digestion and absorption of nutrients during profound acid suppression. Best Pract Res Clin Gastroenterol. 2001;15:539-551. (Pubitemid 32590885)
26. Kaunitz JD, Akiba Y. Acid-sensing protective mechanisms of duodenum. J Physiol Pharmacol. 2003;54(Suppl 4): 19-26.