-
1
-
-
85005965070
-
The human intestinal microbiome in health and disease
-
Lynch, S. V. & Pedersen, O. The human intestinal microbiome in health and disease. N. Engl. J. Med. 375, 2369-2379 (2016).
-
(2016)
N. Engl. J. Med.
, vol.375
, pp. 2369-2379
-
-
Lynch, S.V.1
Pedersen, O.2
-
2
-
-
85011578596
-
Personalized microbiome-based approaches to metabolic syndrome management and prevention
-
Shapiro, H., Suez, J. & Elinav, E. Personalized microbiome-based approaches to metabolic syndrome management and prevention. J. Diabetes 9, 226-236 (2017).
-
(2017)
J. Diabetes
, vol.9
, pp. 226-236
-
-
Shapiro, H.1
Suez, J.2
Elinav, E.3
-
3
-
-
84867074831
-
A metagenome-wide association study of gut microbiota in type 2 diabetes
-
Qin, J. et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55-60 (2012).
-
(2012)
Nature
, vol.490
, pp. 55-60
-
-
Qin, J.1
-
4
-
-
84878709716
-
Gut metagenome in European women with normal, impaired and diabetic glucose control
-
Karlsson, F. H. et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498, 99-103 (2013).
-
(2013)
Nature
, vol.498
, pp. 99-103
-
-
Karlsson, F.H.1
-
5
-
-
84867221193
-
The importance of the gut microbiota after bariatric surgery
-
Aron-Wisnewsky, J., Dore, J. & Clement, K. The importance of the gut microbiota after bariatric surgery. Nat. Rev. Gastroenterol. Hepatol. 9, 590-598 (2012).
-
(2012)
Nat. Rev. Gastroenterol. Hepatol.
, vol.9
, pp. 590-598
-
-
Aron-Wisnewsky, J.1
Dore, J.2
Clement, K.3
-
6
-
-
84876139394
-
Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity
-
Liou, A. P. et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci. Transl. Med. 5, 178ra141 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 178ra141
-
-
Liou, A.P.1
-
7
-
-
85021320590
-
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
-
Wu, H. et al. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nat. Med. 23, 850-858 (2017).
-
(2017)
Nat. Med.
, vol.23
, pp. 850-858
-
-
Wu, H.1
-
8
-
-
84949772416
-
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
-
Forslund, K. et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature 528, 262-266 (2015).
-
(2015)
Nature
, vol.528
, pp. 262-266
-
-
Forslund, K.1
-
9
-
-
84896769099
-
Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk
-
Lien, F. et al. Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk. J. Clin. Invest. 124, 1037-1051 (2014).
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 1037-1051
-
-
Lien, F.1
-
10
-
-
84978081339
-
Human gut microbes impact host serum metabolome and insulin sensitivity
-
Pedersen, H. K. et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 535, 376-381 (2016).
-
(2016)
Nature
, vol.535
, pp. 376-381
-
-
Pedersen, H.K.1
-
11
-
-
85023608430
-
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
-
Liu, R. et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat. Med. 23, 859-868 (2017).
-
(2017)
Nat. Med.
, vol.23
, pp. 859-868
-
-
Liu, R.1
-
12
-
-
84991053856
-
Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism
-
Wahlstrom, A., Sayin, S. I., Marschall, H. U. & Backhed, F. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell. Metab. 24, 41-50 (2016).
-
(2016)
Cell. Metab.
, vol.24
, pp. 41-50
-
-
Wahlstrom, A.1
Sayin, S.I.2
Marschall, H.U.3
Backhed, F.4
-
13
-
-
84952695427
-
Increased bile acid synthesis and deconjugation after biliopancreatic diversion
-
Ferrannini, E. et al. Increased bile acid synthesis and deconjugation after biliopancreatic diversion. Diabetes 64, 3377-3385 (2015).
-
(2015)
Diabetes
, vol.64
, pp. 3377-3385
-
-
Ferrannini, E.1
-
14
-
-
84891760775
-
Human insulin resistance is associated with increased plasma levels of 12alpha-hydroxylated bile acids
-
Haeusler, R. A., Astiarraga, B., Camastra, S., Accili, D. & Ferrannini, E. Human insulin resistance is associated with increased plasma levels of 12alpha-hydroxylated bile acids. Diabetes 62, 4184-4191 (2013).
-
(2013)
Diabetes
, vol.62
, pp. 4184-4191
-
-
Haeusler, R.A.1
Astiarraga, B.2
Camastra, S.3
Accili, D.4
Ferrannini, E.5
-
15
-
-
84898455521
-
Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin
-
Wewalka, M., Patti, M. E., Barbato, C., Houten, S. M. & Goldfine, A. B. Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin. J. Clin. Endocrinol. Metab. 99, 1442-1451 (2014).
-
(2014)
J. Clin. Endocrinol. Metab.
, vol.99
, pp. 1442-1451
-
-
Wewalka, M.1
Patti, M.E.2
Barbato, C.3
Houten, S.M.4
Goldfine, A.B.5
-
16
-
-
84898051705
-
FXR is a molecular target for the effects of vertical sleeve gastrectomy
-
Ryan, K. K. et al. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 509, 183-188 (2014).
-
(2014)
Nature
, vol.509
, pp. 183-188
-
-
Ryan, K.K.1
-
17
-
-
84979527286
-
Standards of care for type 2 diabetes in China
-
Weng, J. et al. Standards of care for type 2 diabetes in China. Diabetes. Metab. Res. Rev. 32, 442-458 (2016).
-
(2016)
Diabetes. Metab. Res. Rev.
, vol.32
, pp. 442-458
-
-
Weng, J.1
-
18
-
-
84861970240
-
2011 clinical practice guidelines for type 2 diabetes in Korea
-
Ko, S. H. et al. 2011 clinical practice guidelines for type 2 diabetes in Korea. Diabetes Metab. J. 35, 431-436 (2011).
-
(2011)
Diabetes Metab. J.
, vol.35
, pp. 431-436
-
-
Ko, S.H.1
-
19
-
-
84973855895
-
Efficacy of acarbose and metformin in newly diagnosed type 2 diabetes patients stratified by HbA1c levels
-
Zhang, J. P. et al. Efficacy of acarbose and metformin in newly diagnosed type 2 diabetes patients stratified by HbA1c levels. J. Diabetes 8, 559-567 (2016).
-
(2016)
J. Diabetes
, vol.8
, pp. 559-567
-
-
Zhang, J.P.1
-
20
-
-
84896495719
-
Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present, and future
-
Kahn, S. E., Cooper, M. E. & Del Prato, S. Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 383, 1068-1083 (2014).
-
(2014)
Lancet
, vol.383
, pp. 1068-1083
-
-
Kahn, S.E.1
Cooper, M.E.2
Del Prato, S.3
-
22
-
-
84859247836
-
Executive summary: Standards of medical care in diabetes - 2012
-
American Diabetes Association
-
American Diabetes Association. Executive summary: standards of medical care in diabetes-2012. Diabetes Care 35, S4-S10 (2012).
-
(2012)
Diabetes Care
, vol.35
, pp. S4-S10
-
-
-
23
-
-
84964056053
-
Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults
-
Xu, Y. et al. Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults. J. Diabetes 8, 378-386 (2016).
-
(2016)
J. Diabetes
, vol.8
, pp. 378-386
-
-
Xu, Y.1
-
24
-
-
84945458460
-
Postprandial glucose, insulin and incretin responses to different carbohydrate tolerance tests
-
Deng, Y. et al. Postprandial glucose, insulin and incretin responses to different carbohydrate tolerance tests. J. Diabetes 7, 820-829 (2015).
-
(2015)
J. Diabetes
, vol.7
, pp. 820-829
-
-
Deng, Y.1
-
25
-
-
33751246499
-
The fatty liver index: A simple and accurate predictor of hepatic steatosis in the general population
-
Bedogni, G. et al. The fatty liver index: A simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol. 6, 33 (2006).
-
(2006)
BMC Gastroenterol.
, vol.6
, pp. 33
-
-
Bedogni, G.1
-
26
-
-
84955209323
-
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
-
Degirolamo, C., Sabbà, C. & Moschetta, A. Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. Nat. Rev. Drug Discov. 15, 51-69 (2015).
-
(2015)
Nat. Rev. Drug Discov.
, vol.15
, pp. 51-69
-
-
Degirolamo, C.1
Sabbà, C.2
Moschetta, A.3
-
27
-
-
84959882996
-
Bile acid modifications at the microbe-host interface: Potential for nutraceutical and pharmaceutical interventions in host health
-
Joyce, S. A., Gahan, C. G. Bile acid modifications at the microbe-host interface: potential for nutraceutical and pharmaceutical interventions in host health. Annu. Rev. Food. Sci. Technol. 7, 313-333 (2016).
-
(2016)
Annu. Rev. Food. Sci. Technol.
, vol.7
, pp. 313-333
-
-
Joyce, S.A.1
Gahan, C.G.2
-
28
-
-
84905730165
-
An integrated catalog of reference genes in the human gut microbiome
-
Li, J. et al. An integrated catalog of reference genes in the human gut microbiome. Nat. Biotechnol. 32, 834-841 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 834-841
-
-
Li, J.1
-
29
-
-
84898546855
-
Bile acids and the gut microbiome
-
Ridlon, J. M., Kang, D. J., Hylemon, P. B. & Bajaj, J S. Bile acids and the gut microbiome. Curr. Opin. Gastroenterol. 30, 332-338 (2014).
-
(2014)
Curr. Opin. Gastroenterol.
, vol.30
, pp. 332-338
-
-
Ridlon, J.M.1
Kang, D.J.2
Hylemon, P.B.3
Bajaj, J.S.4
-
30
-
-
84898023722
-
Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice
-
Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S. & Moschetta, A. Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice. Cell Rep. 7, 12-18 (2014).
-
(2014)
Cell Rep.
, vol.7
, pp. 12-18
-
-
Degirolamo, C.1
Rainaldi, S.2
Bovenga, F.3
Murzilli, S.4
Moschetta, A.5
-
31
-
-
84901020405
-
Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
-
Joyce, S. A. et al. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc. Natl Acad. Sci. USA 11, 7421-7426 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.11
, pp. 7421-7426
-
-
Joyce, S.A.1
-
32
-
-
33244467651
-
Bile salt biotransformations by human intestinal bacteria
-
Ridlon, J. M., Kang, D. J. & Hylemon, P. B. Bile salt biotransformations by human intestinal bacteria. J. Lipid Res. 47, 241-259 (2006).
-
(2006)
J. Lipid Res.
, vol.47
, pp. 241-259
-
-
Ridlon, J.M.1
Kang, D.J.2
Hylemon, P.B.3
-
33
-
-
0024374964
-
Lactobacilli and bile salt hydrolase in the murine intestinal tract
-
Tannock, G. W., Dashkevicz, M. P. & Feighner, S. D. Lactobacilli and bile salt hydrolase in the murine intestinal tract. Appl. Environ. Microbiol. 55, 1848-1851 (1989).
-
(1989)
Appl. Environ. Microbiol.
, vol.55
, pp. 1848-1851
-
-
Tannock, G.W.1
Dashkevicz, M.P.2
Feighner, S.D.3
-
34
-
-
0028542871
-
Absence of cholic acid 7 alpha-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium
-
Takahashi, T. & Morotomi, M. Absence of cholic acid 7 alpha-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J. Dairy Sci. 77, 3275-3286 (1994).
-
(1994)
J. Dairy Sci.
, vol.77
, pp. 3275-3286
-
-
Takahashi, T.1
Morotomi, M.2
-
35
-
-
0025159181
-
The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure
-
Deitch, E. A. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch. Surg. 125, 403-404 (1990).
-
(1990)
Arch. Surg.
, vol.125
, pp. 403-404
-
-
Deitch, E.A.1
-
36
-
-
18344368289
-
Intestinal permeability and systemic infections in critically ill patients: Effect of glutamine
-
De-Souza, D. A. & Greene, L. J. Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. Crit. Care Med. 33, 1125-1135 (2005).
-
(2005)
Crit. Care Med.
, vol.33
, pp. 1125-1135
-
-
De-Souza, D.A.1
Greene, L.J.2
-
37
-
-
84882312793
-
Metabolic niche of a prominent sulfate-reducing human gut bacterium
-
Rey, F. E. et al. Metabolic niche of a prominent sulfate-reducing human gut bacterium. Proc. Natl Acad. Sci. USA 110, 13582-13587 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 13582-13587
-
-
Rey, F.E.1
-
38
-
-
84867208167
-
The gut microbiota in IBD
-
Manichanh, C., Borruel, N., Casellas, F. & Guarner, F. The gut microbiota in IBD. Nat. Rev. Gastroenterol. Hepatol. 9, 599-608 (2012).
-
(2012)
Nat. Rev. Gastroenterol. Hepatol.
, vol.9
, pp. 599-608
-
-
Manichanh, C.1
Borruel, N.2
Casellas, F.3
Guarner, F.4
-
39
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
Cani, P. D. et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761-1772 (2007).
-
(2007)
Diabetes
, vol.56
, pp. 1761-1772
-
-
Cani, P.D.1
-
40
-
-
79951702804
-
Endotoxemia is associated with an increased risk of incident diabetes
-
Pussinen, P. J., Havulinna, A. S., Lehto, M., Sundvall, J. & Salomaa, V. Endotoxemia is associated with an increased risk of incident diabetes. Diabetes Care 34, 392-397 (2011).
-
(2011)
Diabetes Care
, vol.34
, pp. 392-397
-
-
Pussinen, P.J.1
Havulinna, A.S.2
Lehto, M.3
Sundvall, J.4
Salomaa, V.5
-
41
-
-
85027927719
-
Enterotypes of the human gut microbiome
-
Arumugam, M. et al. Enterotypes of the human gut microbiome. Nature 473, 174-180 (2011).
-
(2011)
Nature
, vol.473
, pp. 174-180
-
-
Arumugam, M.1
-
42
-
-
80053618114
-
Linking long-Term dietary patterns with gut microbial enterotypes
-
Wu, G. D. et al. Linking long-Term dietary patterns with gut microbial enterotypes. Science 334, 105-108 (2011).
-
(2011)
Science
, vol.334
, pp. 105-108
-
-
Wu, G.D.1
-
43
-
-
84908067044
-
Rethinking "enterotypes
-
Knights, D. et al. Rethinking "enterotypes". Cell Host Microbe. 16, 433-437 (2014).
-
(2014)
Cell Host Microbe.
, vol.16
, pp. 433-437
-
-
Knights, D.1
-
44
-
-
84890171908
-
Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: An open-label, non-inferiority randomised trial
-
Yang, W. et al. Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: An open-label, non-inferiority randomised trial. Lancet Diabetes Endocrinol. 2, 46-55 (2014).
-
(2014)
Lancet Diabetes Endocrinol.
, vol.2
, pp. 46-55
-
-
Yang, W.1
-
45
-
-
0037097039
-
Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomised trial
-
Chiasson, J.L. et al. Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomised trial. Lancet 359, 2072-2077 (2002).
-
(2002)
Lancet
, vol.359
, pp. 2072-2077
-
-
Chiasson, J.L.1
-
46
-
-
32244447570
-
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
-
Zhang, Y. et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc. Natl Acad. Sci. USA 103, 1006-1011 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 1006-1011
-
-
Zhang, Y.1
-
47
-
-
84905257719
-
Bile acid signaling in metabolic disease and drug therapy
-
Li, T. & Chiang, J. Y. Bile acid signaling in metabolic disease and drug therapy. Pharmacol. Rev. 66, 948-983 (2014).
-
(2014)
Pharmacol. Rev.
, vol.66
, pp. 948-983
-
-
Li, T.1
Chiang, J.Y.2
-
48
-
-
33645509321
-
Farnesoid X receptor is essential for normal glucose homeostasis
-
Ma, K., Saha, P. K., Chan, L. & Moore, D. D. Farnesoid X receptor is essential for normal glucose homeostasis. J. Clin. Invest. 116, 1102-1109 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1102-1109
-
-
Ma, K.1
Saha, P.K.2
Chan, L.3
Moore, D.D.4
-
49
-
-
84859419232
-
Bariatric surgery versus conventional medical therapy for type 2 diabetes
-
Mingrone, G. et al. Bariatric surgery versus conventional medical therapy for type 2 diabetes. N. Eng. J. Med. 366, 1577-1585 (2012).
-
(2012)
N. Eng. J. Med.
, vol.366
, pp. 1577-1585
-
-
Mingrone, G.1
-
50
-
-
58949097425
-
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
-
Song, K. H., Li, T., Owsley, E., Strom, S. & Chiang, J. Y. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 49, 297-305 (2009).
-
(2009)
Hepatology
, vol.49
, pp. 297-305
-
-
Song, K.H.1
Li, T.2
Owsley, E.3
Strom, S.4
Chiang, J.Y.5
-
51
-
-
84920401295
-
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
-
Jiang, C. et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J. Clin. Invest. 125, 386-402 (2015).
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 386-402
-
-
Jiang, C.1
-
52
-
-
0033865136
-
The1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes
-
Gabir, M. M. et al. The1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. Diabetes Care 23, 1108-1112 (2000).
-
(2000)
Diabetes Care
, vol.23
, pp. 1108-1112
-
-
Gabir, M.M.1
-
53
-
-
84948461699
-
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
-
Vetizou, M. et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079-1084 (2015).
-
(2015)
Science
, vol.350
, pp. 1079-1084
-
-
Vetizou, M.1
-
54
-
-
84938817346
-
The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
-
Zhang, X. et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat. Med. 21, 895-905 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 895-905
-
-
Zhang, X.1
-
55
-
-
84917686843
-
A liquid chromatography-Tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids
-
John, C. et al. A liquid chromatography-Tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids. J. Chromatogr. A 1371, 184-195 (2014).
-
(2014)
J. Chromatogr. A
, vol.1371
, pp. 184-195
-
-
John, C.1
-
56
-
-
84888884475
-
Metagenomic species profiling using universal phylogenetic marker genes
-
Sunagawa, S. et al. Metagenomic species profiling using universal phylogenetic marker genes. Nat. Methods 10, 1196-1199 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 1196-1199
-
-
Sunagawa, S.1
-
57
-
-
84883110880
-
Richness of human gut microbiome correlates with metabolic markers
-
Le Chatelier, E. et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500, 541-546 (2013).
-
(2013)
Nature
, vol.500
, pp. 541-546
-
-
Le Chatelier, E.1
-
58
-
-
84929297936
-
Dynamics and stabilization of the human gut microbiome during the first year of life
-
Backhed, F. et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17, 690-703 (2015).
-
(2015)
Cell Host Microbe
, vol.17
, pp. 690-703
-
-
Backhed, F.1
-
59
-
-
84959528568
-
BlastKOALA and GhostKOALA: KEGG tools for functional characterization of genome and metagenome sequences
-
Kanehisa, M., Sato, Y. & Morishima, K. BlastKOALA and GhostKOALA: KEGG tools for functional characterization of genome and metagenome sequences. J. Mol. Biol. 428, 726-731 (2016).
-
(2016)
J. Mol. Biol.
, vol.428
, pp. 726-731
-
-
Kanehisa, M.1
Sato, Y.2
Morishima, K.3
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