Structure-Based Design and Discovery of New M2 Receptor Agonists

Journal of Medicinal Chemistry

Volumn 60, Issue 22, 2017, Pages 9239-9250

  Fish, Inbar ^a,e   Stößel, Anne ^b   Eitel, Katrin ^b   Valant, Celine ^c   Albold, Sabine ^c   Huebner, Harald ^b   Möller, Dorothee ^b   Clark, Mary J ^d   Sunahara, Roger K ^d   Christopoulos, Arthur ^c   Shoichet, Brian K ^a   Gmeiner, Peter ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c MONASH UNIVERSITY   (Australia)

^d San Diego   (United States)

^e TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR AGONIST; MUSCARINIC M3 RECEPTOR; NICOTINIC RECEPTOR; 2-(2,3-DIHYDROBENZOFURAN-6-YL)-N,N,N-TRIMETHYLETHAN-1-AMINIUM; ACETYLCHOLINE; BENZOFURAN DERIVATIVE; CARBACHOL; IPEROXO; ISOXAZOLE DERIVATIVE; LIGAND; METHYLSCOPOLAMINE; MUSCARINIC AGENT; NICOTINIC RECEPTOR ALPHA4BETA2; QUATERNARY AMMONIUM DERIVATIVE; RETINA S ANTIGEN; TRITIUM;

ANIMAL CELL; ARTICLE; CHLOROCEBUS AETHIOPS; CHO CELL LINE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; EC50; EMBRYO; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; INOSITOL PHOSPHATE ACCUMULATION ASSAY; MOLECULAR DOCKING; MOLECULAR WEIGHT; NONHUMAN; NUCLEOPHILICITY; PHARMACOPHORE; PROTEIN PHOSPHORYLATION; STATIC ELECTRICITY; WHOLE CELL; AGONISTS; ANIMAL; CHEMISTRY; CRICETULUS; METABOLISM; SYNTHESIS;

ACETYLCHOLINE; ANIMALS; ARRESTIN; BENZOFURANS; CARBACHOL; CHO CELLS; CRICETULUS; DRUG DESIGN; HEK293 CELLS; HUMANS; ISOXAZOLES; LIGANDS; MOLECULAR DOCKING SIMULATION; MUSCARINIC AGONISTS; N-METHYLSCOPOLAMINE; QUATERNARY AMMONIUM COMPOUNDS; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTORS, NICOTINIC; TRITIUM;

EID: 85035068873     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.7b01113     Document Type: Article

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