Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling

Immunity

Volumn 47, Issue 5, 2017, Pages 959-973.e9

  Da Ros, Francesco ^a,b   Carnevale, Raimondo ^c   Cifelli, Giuseppe ^c   Bizzotto, Dario ^a   Casaburo, Manuel ^c   Perrotta, Marialuisa ^c   Carnevale, Lorenzo ^c   Vinciguerra, Iolanda ^c   Fardella, Stefania ^c   Iacobucci, Roberta ^c   Bressan, Giorgio M ^a   Braghetta, Paola ^a   Lembo, Giuseppe ^b,c   Carnevale, Daniela ^b,c  

^a UNIVERSITY OF PADOVA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c IRCCS NEUROMED   (Italy)

Author keywords

aortic aneurysm; CCR2; elastic lamellae; IL 1 ; innate immunity; macrophages; MCP1; SMAD4; smooth muscle cells; TGF

Indexed keywords

ANTIBODY; CD11B ANTIGEN; CD68 ANTIGEN; CRYOPYRIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; CCR2 PROTEIN, MOUSE; CHEMOKINE RECEPTOR CCR2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMAD4 PROTEIN, MOUSE; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA;

ABDOMINAL AORTIC ANEURYSM; ADULT; ADVENTITIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTIC ANEURYSM; AORTIC WALL; ARTICLE; ASCENDING AORTA; AUTOCRINE EFFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; GENE DELETION; GENE INACTIVATION; GENE MUTATION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; INFLAMMATORY INFILTRATE; INNATE IMMUNITY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMAD4 GENE; SMOOTH MUSCLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; IMMUNOLOGY; PHYSIOLOGY;

ANIMALS; AORTIC ANEURYSM; CELLS, CULTURED; CHEMOKINE CCL2; INTERLEUKIN-1BETA; MICE; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; RECEPTORS, CCR2; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA;

EID: 85034242815     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.10.016     Document Type: Article

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