Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice

Circulation Research

Volumn 117, Issue 2, 2015, Pages e13-e26

  Martín Alonso, Mara ^a   García Redondo, Ana B ^b   Guo, Dongchuan ^c   Camafeita, Emilio ^a   Martínez, Fernando ^a   Alfranca, Arántzazu ^a   Méndez Barbero, Nerea ^a   Pollán, Ángela ^a   Sánchez Camacho, Cristina ^d   Denhardt, David T ^e   Seiki, Motoharu ^b   Vázquez, Jesús ^a   Salaices, Mercedes ^f   Redondo, Juan Miguel ^a   Milewicz, Dianna ^c   Arroyo, Alicia G ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSIDAD EUROPEA DE MADRID   (Spain)

^e RUTGERS UNIVERSITY   (United States)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

aneurysm; aorta; cardiovascular diseases; matrix metalloproteinase 17; matrix metalloproteinases; osteopontin

Indexed keywords

ANGIOTENSIN II; MATRIX METALLOPROTEINASE 17; OSTEOPONTIN; STRESS ACTIVATED PROTEIN KINASE; MATRIX METALLOPROTEINASE; MMP17 PROTEIN, HUMAN; MMP17 PROTEIN, MOUSE; SCLEROPROTEIN; SPP1 PROTEIN, MOUSE;

ADULT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; AORTA DISSECTION; AORTA WALL; ARTERY WALL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE THERAPY; HEK293 CELL LINE; HUMAN; HUMAN CELL; LENTIVIRINAE; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE CELL; AMINO ACID SUBSTITUTION; ANIMAL; AORTA; AORTIC ANEURYSM, THORACIC; AORTIC RUPTURE; C57BL MOUSE; CHEMISTRY; DEFICIENCY; DISSECTING ANEURYSM; EMBRYOLOGY; GENE VECTOR; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; THERAPEUTIC USE; VASCULAR SMOOTH MUSCLE;

ADULT; AMINO ACID SUBSTITUTION; ANEURYSM, DISSECTING; ANGIOTENSIN II; ANIMALS; AORTA; AORTIC ANEURYSM, THORACIC; AORTIC RUPTURE; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; GENETIC PREDISPOSITION TO DISEASE; GENETIC THERAPY; GENETIC VECTORS; HEK293 CELLS; HUMANS; LENTIVIRUS; MALE; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MUTATION, MISSENSE; OSTEOPONTIN; PROTEIN CONFORMATION;

EID: 84937723140     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.305108     Document Type: Article

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