Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development

Circulation

Volumn 131, Issue 20, 2015, Pages 1783-1795

  Raaz, Uwe ^a,b   Zöllner, Alexander M ^a   Schellinger, Isabel N ^a,b   Toh, Ryuji ^a   Nakagami, Futoshi ^a   Brandt, Moritz ^a   Emrich, Fabian C ^a   Kayama, Yosuke ^a,b   Eken, Suzanne ^c   Adam, Matti ^a,b   Maegdefessel, Lars ^c   Hertel, Thomas ^d   Deng, Alicia ^a,b   Jagger, Ann ^a,b   Buerke, Michael ^e   Dalman, Ronald L ^a   Spin, Joshua M ^a,b   Kuhl, Ellen ^a   Tsao, Philip S ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d Center for Vascular Medicine   (Germany)

^e St Mary's Hospital Siegen   (Germany)

Author keywords

Aneurysm; Aorta; Arterial stiffness; Mechanical; Stress; Vascular remodeling

Indexed keywords

COLLAGEN; ELASTIN; GELATINASE A; GELATINASE B; INTERLEUKIN 6; MICRORNA 29B; MONOCYTE CHEMOTACTIC PROTEIN 1; PANCREATIC ELASTASE; REACTIVE OXYGEN METABOLITE; TISSUE ADHESIVE;

ABDOMINAL AORTA; ABDOMINAL AORTA ANEURYSM; ADULT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA FLOW; AORTA MEDIA; AORTA WALL; APOPTOSIS; ARTERIAL STIFFNESS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; EX VIVO STUDY; EXTRACELLULAR MATRIX; FINITE ELEMENT ANALYSIS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPERTENSION; IMMUNOFLUORESCENCE; LASER CAPTURE MICRODISSECTION; MACROPHAGE; MALE; MECHANICAL STIMULATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; SEGMENTAL AORTIC STIFFENING; SHEAR STRESS; UPREGULATION; WALL STRESS; ANIMAL; AORTIC ANEURYSM, ABDOMINAL; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; ECHOGRAPHY; GENE EXPRESSION PROFILING; INFLAMMATION; MECHANICAL STRESS; METABOLISM; MIDDLE AGED; MOUSE; PATHOLOGY;

ADULT; AGED; AGING; ANIMALS; AORTIC ANEURYSM, ABDOMINAL; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PANCREATIC ELASTASE; STRESS, MECHANICAL; TISSUE ADHESIVES; VASCULAR STIFFNESS;

EID: 84935479187     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.012377     Document Type: Article

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