Toll-like receptor 4 deficiency increases resistance in sepsis-induced immune dysfunction

International Immunopharmacology

Volumn 54, Issue , 2018, Pages 169-176

  Cao, Chao ^a   Chai, Yanfen ^a   Shou, Songtao ^a   Wang, Jun ^a   Huang, Ying ^a   Ma, Tao ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Immune dysfunction; Inflammatory mediator; Regulatory T cell; Sepsis; Toll like receptor 4

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CELL SUSPENSION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE EXPRESSION; IMMUNOPATHOLOGY; INFECTION RESISTANCE; INFLAMMATION; LIVER TISSUE; LUNG ALVEOLUS MACROPHAGE; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SEPSIS; ANIMAL; APOPTOSIS; C57BL MOUSE; CECUM; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNE DEFICIENCY; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; LUNG; MACROPHAGE; METABOLISM; SIGNAL TRANSDUCTION; SURGERY;

ANIMALS; APOPTOSIS; CECUM; CTLA-4 ANTIGEN; CYTOKINES; DISEASE MODELS, ANIMAL; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; IMMUNOLOGIC DEFICIENCY SYNDROMES; LIPOPOLYSACCHARIDES; LUNG; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SEPSIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTOR 4;

EID: 85034069368     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2017.11.006     Document Type: Article

References (32)

1. Seymour, C.W., Gesten, F., Prescott, H.C., Friedrich, M.E., Iwashyna, T.J., Phillips, G.S., Lemeshow, S., Osborn, T., Terry, K.M., Levy, M.M., Time to treatment and mortality during mandated emergency care for sepsis. N. Engl. J. Med. 376:23 (2017), 2235–2244.
2. Russell, J.A., Lee, T., Singer, J., Boyd, J.H., Walley, K.R., Vasopressin and Septic Shock Trial (VASST) Group, The septic shock 3.0 definition and trials: a vasopressin and septic shock trial experience. Crit. Care Med. 45:6 (2017), 940–948.
3. Barochia, A.V., Cui, X., Eichacker, P.Q., The surviving sepsis campaign's revised sepsis bundles. Curr. Infect. Dis. Rep. 15:5 (2013), 385–393.
4. Kondo, T., Kawai, T., Akira, S., Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol. 33:9 (2012), 449–458.
5. Jin, B., Sun, T., Yu, X.H., Yang, Y.X., Yeo, A.E., The effects of TLR activation on T-cell development and differentiation. Clin. Dev. Immunol., 2012, 2012, 836485.
6. Xu, Y., Jagannath, C., Liu, X.D., Sharafkhaneh, A., Kolodziejska, K.E., Eissa, N.T., Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27:1 (2007), 135–144.
7. Ono, Y., Sakamoto, K., Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α. PLoS One, 12(7), 2017, e0182040.
8. McGhan, L.J., Jaroszewski, D.E., The role of toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation. Injury 43:2 (2012), 129–136.
9. Kompoti, M., Michopoulos, A., Michalia, M., Clouva-Molyvdas, P.M., Germenis, A.E., Speletas, M., Genetic polymorphisms of innate and adaptive immunity as predictors of outcome in critically ill patients. Immunobiology 220:3 (2015), 414–421.
10. E, Gambineri, Torgerson, T.R., Ochs, H.D., Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr. Opin. Rheumatol. 15:4 (2003), 430–435.
11. Wildin, R.S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J.L., Buist, N., Levy-Lahad, E., Mazzella, M., Goulet, O., Perroni, L., Bricarelli, F.D., Byrne, G., McEuen, M., Proll, S., Appleby, M., Brunkow, M.E., X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 27:1 (2001), 18–20.
12. Tatura, R., Zeschnigk, M., Adamzik, M., Probst-Kepper, M., Buer, J., Kehrmann, J., Quantification of regulatory T cells in septic patients by real-time PCR-based methylation assay and flow cytometry. PLoS One, 7(11), 2012, e49962.
13. Gupta, D.L., Bhoi, S., Mohan, T., Galwnkar, S., Rao, D.N., Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with post traumatic sepsis. Cytokine 88 (2016), 214–221.
14. Luan, Y.Y., Yin, C.Y., Qin, Q.H., Dong, N., Zhu, X.M., Sheng, Z.Y., Zhang, Q.H., Yao, Y.M., Effect of regulatory T cells on promoting apoptosis of T lymphocyte and its regulatory mechanism in sepsis. J. Interf. Cytokine Res. 35:12 (2015), 969–980.
15. + regulatory T cells for early and late phases of murine sepsis. Immunology 146:1 (2015), 144–156.
16. + Regulatory T cells and improves survival rate in septic mice. Oncotarget 7:49 (2016), 81791–81805.
17. Nascimento, D.C., Alves-Filho, J.C., Sônego, F., Fukada, S.Y., Pereira, M.S., Benjamim, C., Zamboni, D.S., Silva, J.S., Cunha, F.Q., Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis. Crit. Care Med. 38:8 (2010), 1718–1725.
18. Otto, G.P., Sossdorf, M., Claus, R.A., Rödel, J., Menge, K., Reinhart, K., Bauer, M., Riedemann, N.C., The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit. Care, 15(4), 2011, R183.
19. Fahy, R.J., Exline, M.C., Gavrilin, M.A., Bhatt, N.Y., Besecker, B.Y., Sarkar, A., Hollyfield, J.L., Duncan, M.D., Nagaraja, H.N., Knatz, N.L., Hall, M., Wewers, M.D., Inflammasome mRNA expression in human monocytes during early septic shock. Am. J. Respir. Crit. Care Med. 177:9 (2008), 983–988.
20. Arancibia, S.A., Beltrán, C.J., Aguirre, I.M., Silva, P., Peralta, A.L., Malinarich, F., Hermoso, M.A., Toll-like receptors are key participants in innate immune responses. Biol. Res. 40:2 (2007), 97–112.
21. Aderem, A., Ulevitch, R.J., Toll-like receptors in the induction of the innate immune response. Nature 406:6797 (2000), 782–787.
22. Bonfim, C.V., Mamoni, R.L., Blotta, M.H., TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by Paracoccidioides brasiliensis. Med. Mycol. 47:7 (2009), 722–733.
23. Kurt-Jones, E.A., Popova, L., Kwinn, L., Haynes, L.M., Jones, L.P., Tripp, R.A., Walsh, E.E., Freeman, M.W., Golenbock, D.T., Anderson, L.J., Finberg, R.W., Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1:5 (2000), 398–401.
24. Ferwerda, B., McCall, M.B., Alonso, S., Giamarellos-Bourboulis, E.J., Mouktaroudi, M., Izagirre, N., Syafruddin, D., Kibiki, G., Cristea, T., Hijmans, A., Hamann, L., Israel, S., ElGhazali, G., Troye-Blomberg, M., Kumpf, O., Maiga, B., Dolo, A., Doumbo, O., Hermsen, C.C., Stalenhoef, A.F., van Crevel, R., Brunner, H.G., DY, Oh., Schumann, R.R., de la Rúa, C., Sauerwein, R., Kullberg, B.J., van der Ven, A.J., van der Meer, J.W., Netea, M.G., TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc. Natl. Acad. Sci. U. S. A. 104:42 (2007), 16645–16650.
25. Wang, X., Ge, Q.M., Bian, F., Dong, Y., Huang, C.M., Inhibition of TLR4 protects rat islets against lipopolysaccharide-induced dysfunction. Mol. Med. Rep. 15:2 (2017), 805–812.
26. Wang, Y., Zhang, L., Zhao, X., Yang, W., Zhang, R., An experimental study of the protective effect of simvastatin on sepsis-induced myocardial depression in rats. Biomed Pharmacother 94 (2017), 705–711.
27. Arens, C., Bajwa, S.A., Koch, C., Siegler, B.H., Schneck, E., Hecker, A., Weiterer, S., Lichtenstern, C., Weigand, M.A., Uhle, F., Sepsis-induced long-term immune paralysis-results of a descriptive, explorative study. Crit. Care, 20, 2016, 93.
28. Kjaergaard, A.G., Nielsen, J.S., Tønnesen, E., Krog, J., Expression of NK cell and monocyte receptors in critically ill patients-potential biomarkers of sepsis. Scand. J. Immunol. 81:4 (2015), 249–258.
29. Yang, J.C., SC, Wu, Rau, C.S., TH, Lu, YC, Wu, Chen, Y.C., Lin, M.W., Tzeng, S.L., CJ, Wu, Hsieh, C.H., Inhibition of the phosphoinositide 3-kinase pathway decreases innate resistance to lipopolysaccharide toxicity in TLR4 deficient mice. J. Biomed. Sci., 21, 2014, 20.
30. + T regulatory cells inhibit neutrophil function and promote their apoptosis and death. J. Immunol. 177:10 (2006), 7155–7163.
31. Kessel, A., Bamberger, E., Masalha, M., Toubi, E., The role of T regulatory cells in human sepsis. J. Autoimmun. 32:3–4 (2009), 211–215.
32. Jiang, L.N., Yao, Y.M., Sheng, Z.Y., The role of regulatory T cells in the pathogenesis of sepsis and its clinical implication. J. Interf. Cytokine Res. 32:8 (2012), 341–349.