Time to treatment and mortality during mandated emergency care for sepsis

New England Journal of Medicine

Volumn 376, Issue 23, 2017, Pages 2235-2244

  Seymour, Christopher W ^a   Gesten, Foster ^b   Prescott, Hallie C ^d   Friedrich, Marcus E ^b   Iwashyn, Theodore J ^d   Phillips, Gary S ^c   Lemeshow, Stanley ^e   Osborn, Tiffany ^f   Terry, Kathleen M ^c   Levy, Mitchell M ^g  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NEW YORK STATE DEPARTMENT OF HEALTH   (United States)

^c IPRO Inc   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f WASHINGTON UNIVERSITY   (United States)

^g BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ADULT; AGED; ARTICLE; BLOOD CULTURE; CONTROLLED STUDY; EMERGENCY CARE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MORTALITY RISK; PRIORITY JOURNAL; RISK ASSESSMENT; SEPSIS; SEPTIC SHOCK; TIME TO TREATMENT; CLINICAL AUDIT; EMERGENCY TREATMENT; FLUID THERAPY; HOSPITAL MORTALITY; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDY; SHOCK, SEPTIC; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CLINICAL AUDIT; COMBINED MODALITY THERAPY; EMERGENCY TREATMENT; FEMALE; FLUID THERAPY; HOSPITAL MORTALITY; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; SEPSIS; SHOCK, SEPTIC; TIME-TO-TREATMENT;

EID: 85020468010     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1703058     Document Type: Article

References (26)

1. Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med 2013; 41: 1167-74.
2. Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 2017; 43: 304-77.
3. Rhee C, Gohil S, Klompas M. Regulatory mandates for sepsis care-reasons for caution. N Engl J Med 2014; 370: 1673-6.
4. Kumar A, Haery C, Paladugu B, et al. The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: Association with serum lactate and inflammatory cytokine levels. J Infect Dis 2006; 193: 251-8.
5. Ferrer R, Martin-Loeches I, Phillips G, et al. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med 2014; 42: 1749-55.
6. Sterling SA, Miller WR, Pryor J, Puskarich MA, Jones AE. The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: A systematic review and meta-Analysis. Crit Care Med 2015; 43: 1907-15.
7. New York codes, rules and regulations: 405.4 medical staff. Thomson Reuters, 2017 (https://govt .westlaw .com/nycrr/Document/I4fe39657cd1711dda432a117e6e0f345?view Type=FullText&%3BoriginationContext= documenttoc&%3BtransitionType=Category PageItem&%3BcontextData=(sc .Default) (last .)=Default=(sc .Default)).
8. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31: 1250-6.
9. Dimick JB, Staiger DO, Birkmeyer JD. Ranking hospitals on surgical mortality: The importance of reliability adjustment. Health Serv Res 2010; 45: 1614-29.
10. Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315: 762-74.
11. Banta JE, Joshi KP, Beeson L, Nguyen HB. Patient and hospital characteristics associated with inpatient severe sepsis mortality in California, 2005-2010. Crit Care Med 2012; 40: 2960-6.
12. Reineck LA, Pike F, Le TQ, Cicero BD, Iwashyna TJ, Kahn JM. Hospital factors associated with discharge bias in ICU performance measurement. Crit Care Med 2014; 42: 1055-64.
13. Lash TL, Fox MP, Fink AK. Applying quantitative bias analysis to epidemiologic data. New York: Springer-Verlag, 2009.
14. Royston P, Sauerbrei W. Building multivariable regression models with continuous covariates in clinical epidemiology-with an emphasis on fractional polynomials. Methods Inf Med 2005; 44: 561-71.
15. Puskarich MA, Trzeciak S, Shapiro NI, et al. Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med 2011; 39: 2066-71.
16. Liu VX, Fielding-Singh V, Greene JD, et al. The timing of early antibiotics and hospital mortality in sepsis. Am J Respir Crit Care Med 2017 March 27 (Epub ahead of print).
17. The PRISM Investigators. Early, goaldirected therapy for septic shock-A patient-level meta-Analysis. N Engl J Med 2017; 376: 2223-34.
18. Jansen TC, van Bommel J, Schoonderbeek FJ, et al. Early lactate-guided therapy in intensive care unit patients: A multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 2010; 182: 752-61.
19. Rhee C, Kadri SS, Danner RL, et al. Diagnosing sepsis is subjective and highly variable: A survey of intensivists using case vignettes. Crit Care 2016; 20: 89.
20. Psaty BM, Koepsell TD, Lin D, et al. Assessment and control for confounding by indication in observational studies. J Am Geriatr Soc 1999; 47: 749-54.
21. Vincent JL, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006; 34: 344-53.
22. Gropen TI, Gagliano PJ, Blake CA, et al. Quality improvement in acute stroke: The New York State Stroke Center Designation Project. Neurology 2006; 67: 88-93.
23. Cooke CR, Iwashyna TJ. Sepsis mandates: improving inpatient care while advancing quality improvement. JAMA 2014; 312: 1397-8.
24. Walkey AJ, Wiener RS. Hospital case volume and outcomes among patients hospitalized with severe sepsis. Am J Respir Crit Care Med 2014; 189: 548-55.
25. Vazquez-Guillamet C, Scolari M, Zilberberg MD, Shorr AF, Micek ST, Kollef M. Using the number needed to treat to assess appropriate antimicrobial therapy as a determinant of outcome in severe sepsis and septic shock. Crit Care Med 2014; 42: 2342-9.
26. Wang HE, Devereaux RS, Yealy DM, Safford MM, Howard G. National variation in United States sepsis mortality: A descriptive study. Int J Health Geogr 2010; 9: 9.