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Volumn 7, Issue 11, 2012, Pages

Quantification of Regulatory T Cells in Septic Patients by Real-Time PCR-Based Methylation Assay and Flow Cytometry

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD4 ANTIGEN; DNA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

EID: 84870260524     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049962     Document Type: Article
Times cited : (26)

References (38)
  • 1
    • 31344461826 scopus 로고    scopus 로고
    • Sepsis in European intensive care units: results of the SOAP study
    • Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, et al. (2006) Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 34: 344-353. 00003246-200602000-00010 [pii].
    • (2006) Crit Care Med , vol.34 , pp. 344-353
    • Vincent, J.L.1    Sakr, Y.2    Sprung, C.L.3    Ranieri, V.M.4    Reinhart, K.5
  • 2
    • 31944440897 scopus 로고    scopus 로고
    • [Epidemiology, economy and practice - results of the German study on prevalence by the competence network sepsis (SepNet)]
    • Brunkhorst FM, (2006) [Epidemiology, economy and practice - results of the German study on prevalence by the competence network sepsis (SepNet)]. Anasthesiol Intensivmed Notfallmed Schmerzther 41: 43-44. 10.1055/s-2005-921227 [doi].
    • (2006) Anasthesiol Intensivmed Notfallmed Schmerzther , vol.41 , pp. 43-44
    • Brunkhorst, F.M.1
  • 3
    • 52949118458 scopus 로고    scopus 로고
    • Harmful molecular mechanisms in sepsis
    • Rittirsch D, Flierl MA, Ward PA, (2008) Harmful molecular mechanisms in sepsis. Nat Rev Immunol 8: 776-787. nri2402 [pii];10.1038/nri2402 [doi].
    • (2008) Nat Rev Immunol , vol.8 , pp. 776-787
    • Rittirsch, D.1    Flierl, M.A.2    Ward, P.A.3
  • 4
    • 34548774630 scopus 로고    scopus 로고
    • Long-term outcomes from sepsis
    • Yende S, Angus DC, (2007) Long-term outcomes from sepsis. Curr Infect Dis Rep 9: 382-386.
    • (2007) Curr Infect Dis Rep , vol.9 , pp. 382-386
    • Yende, S.1    Angus, D.C.2
  • 5
    • 0030917203 scopus 로고    scopus 로고
    • Monocyte deactivation in septic patients: restoration by IFN-gamma treatment
    • Docke WD, Randow F, Syrbe U, Krausch D, Asadullah K, et al. (1997) Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 3: 678-681.
    • (1997) Nat Med , vol.3 , pp. 678-681
    • Docke, W.D.1    Randow, F.2    Syrbe, U.3    Krausch, D.4    Asadullah, K.5
  • 6
    • 62949142070 scopus 로고    scopus 로고
    • Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients
    • Venet F, Chung CS, Kherouf H, Geeraert A, Malcus C, et al. (2009) Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 35: 678-686. 10.1007/s00134-008-1337-8 [doi].
    • (2009) Intensive Care Med , vol.35 , pp. 678-686
    • Venet, F.1    Chung, C.S.2    Kherouf, H.3    Geeraert, A.4    Malcus, C.5
  • 7
    • 0041365362 scopus 로고    scopus 로고
    • Marked elevation of human circulating CD4+ CD25+ regulatory T cells in sepsis-induced immunoparalysis
    • Monneret G, Debard AL, Venet F, Bohe J, Hequet O, et al. (2003) Marked elevation of human circulating CD4+ CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med 31: 2068-2071. 10.1097/01.CCM.0000069345.78884.0F [doi].
    • (2003) Crit Care Med , vol.31 , pp. 2068-2071
    • Monneret, G.1    Debard, A.L.2    Venet, F.3    Bohe, J.4    Hequet, O.5
  • 8
    • 77949473424 scopus 로고    scopus 로고
    • The relationship between CD4+ CD25+ CD127- regulatory T cells and inflammatory response and outcome during shock states
    • Hein F, Massin F, Cravoisy-Popovic A, Barraud D, Levy B, et al. (2010) The relationship between CD4+ CD25+ CD127- regulatory T cells and inflammatory response and outcome during shock states. Crit Care 14: R19. cc8876 [pii];10.1186/cc8876 [doi].
    • (2010) Crit Care , vol.14
    • Hein, F.1    Massin, F.2    Cravoisy-Popovic, A.3    Barraud, D.4    Levy, B.5
  • 9
    • 33751576739 scopus 로고    scopus 로고
    • Increased natural CD4+ CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis
    • Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, et al. (2006) Increased natural CD4+ CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol 177: 7943-7949. 177/11/7943 [pii].
    • (2006) J Immunol , vol.177 , pp. 7943-7949
    • Scumpia, P.O.1    Delano, M.J.2    Kelly, K.M.3    O'Malley, K.A.4    Efron, P.A.5
  • 10
    • 43349107987 scopus 로고    scopus 로고
    • Regulatory T cell populations in sepsis and trauma
    • Venet F, Chung CS, Monneret G, Huang X, Horner B, et al. (2008) Regulatory T cell populations in sepsis and trauma. J Leukoc Biol 83: 523-535. jlb.0607371 [pii];10.1189/jlb.0607371 [doi].
    • (2008) J Leukoc Biol , vol.83 , pp. 523-535
    • Venet, F.1    Chung, C.S.2    Monneret, G.3    Huang, X.4    Horner, B.5
  • 11
    • 33646240855 scopus 로고    scopus 로고
    • Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
    • Gavin MA, Torgerson TR, Houston E, DeRoos P, Ho WY, et al. (2006) Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A 103: 6659-6664. 0509484103 [pii];10.1073/pnas.0509484103 [doi].
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 6659-6664
    • Gavin, M.A.1    Torgerson, T.R.2    Houston, E.3    DeRoos, P.4    Ho, W.Y.5
  • 12
    • 33846340789 scopus 로고    scopus 로고
    • FOXP3: not just for regulatory T cells anymore
    • Ziegler SF, (2007) FOXP3: not just for regulatory T cells anymore. Eur J Immunol 37: 21-23. 10.1002/eji.200636929 [doi].
    • (2007) Eur J Immunol , vol.37 , pp. 21-23
    • Ziegler, S.F.1
  • 13
    • 58349116249 scopus 로고    scopus 로고
    • Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue
    • Wieczorek G, Asemissen A, Model F, Turbachova I, Floess S, et al. (2009) Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Res 69: 599-608. 69/2/599 [pii];10.1158/0008-5472.CAN-08-2361 [doi].
    • (2009) Cancer Res , vol.69 , pp. 599-608
    • Wieczorek, G.1    Asemissen, A.2    Model, F.3    Turbachova, I.4    Floess, S.5
  • 14
    • 34548755672 scopus 로고    scopus 로고
    • DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    • Baron U, Floess S, Wieczorek G, Baumann K, Grutzkau A, et al. (2007) DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol 37: 2378-2389. 10.1002/eji.200737594 [doi].
    • (2007) Eur J Immunol , vol.37 , pp. 2378-2389
    • Baron, U.1    Floess, S.2    Wieczorek, G.3    Baumann, K.4    Grutzkau, A.5
  • 15
    • 0006371989 scopus 로고    scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, et al. (2009) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992. Chest 136: e28.
    • (2009) Chest , vol.136
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5
  • 17
    • 19244365868 scopus 로고    scopus 로고
    • A novel real-time PCR assay for quantitative analysis of methylated alleles (QAMA): analysis of the retinoblastoma locus
    • Zeschnigk M, Bohringer S, Price EA, Onadim Z, Masshofer L, et al. (2004) A novel real-time PCR assay for quantitative analysis of methylated alleles (QAMA): analysis of the retinoblastoma locus. Nucleic Acids Res 32: e125. 10.1093/nar/gnh122 [doi];32/16/e125 [pii].
    • (2004) Nucleic Acids Res , vol.32
    • Zeschnigk, M.1    Bohringer, S.2    Price, E.A.3    Onadim, Z.4    Masshofer, L.5
  • 18
    • 70449411313 scopus 로고    scopus 로고
    • GARP: a key receptor controlling FOXP3 in human regulatory T cells
    • Probst-Kepper M, Geffers R, Kroger A, Viegas N, Erck C, et al. (2009) GARP: a key receptor controlling FOXP3 in human regulatory T cells. J Cell Mol Med 13: 3343-3357. JCMM782 [pii];10.1111/j.1582-4934.2009.00782.x [doi].
    • (2009) J Cell Mol Med , vol.13 , pp. 3343-3357
    • Probst-Kepper, M.1    Geffers, R.2    Kroger, A.3    Viegas, N.4    Erck, C.5
  • 19
    • 54049149050 scopus 로고    scopus 로고
    • Sepsis is characterized by the increases in percentages of circulating CD4+ CD25+ regulatory T cells and plasma levels of soluble CD25
    • Saito K, Wagatsuma T, Toyama H, Ejima Y, Hoshi K, et al. (2008) Sepsis is characterized by the increases in percentages of circulating CD4+ CD25+ regulatory T cells and plasma levels of soluble CD25. Tohoku J Exp Med 216: 61-68. JST.JSTAGE/tjem/216.61 [pii].
    • (2008) Tohoku J Exp Med , vol.216 , pp. 61-68
    • Saito, K.1    Wagatsuma, T.2    Toyama, H.3    Ejima, Y.4    Hoshi, K.5
  • 20
    • 77954909395 scopus 로고    scopus 로고
    • Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis
    • Nascimento DC, Alves-Filho JC, Sonego F, Fukada SY, Pereira MS, et al. (2010) Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis. Crit Care Med 38: 1718-1725. 10.1097/CCM.0b013e3181e78ad0 [doi].
    • (2010) Crit Care Med , vol.38 , pp. 1718-1725
    • Nascimento, D.C.1    Alves-Filho, J.C.2    Sonego, F.3    Fukada, S.Y.4    Pereira, M.S.5
  • 21
    • 8544236263 scopus 로고    scopus 로고
    • Increased percentage of CD4+ CD25+ regulatory T cells during septic shock is due to the decrease of CD4+
    • Venet F, Pachot A, Debard AL, Bohe J, Bienvenu J, et al. (2004) Increased percentage of CD4+ CD25+ regulatory T cells during septic shock is due to the decrease of CD4+. Crit Care Med 32: 2329-2331. 00003246-200411000-00023 [pii].
    • (2004) Crit Care Med , vol.32 , pp. 2329-2331
    • Venet, F.1    Pachot, A.2    Debard, A.L.3    Bohe, J.4    Bienvenu, J.5
  • 22
    • 78649526238 scopus 로고    scopus 로고
    • Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases
    • Buckner JH, (2010) Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol 10: 849-859. nri2889 [pii];10.1038/nri2889 [doi].
    • (2010) Nat Rev Immunol , vol.10 , pp. 849-859
    • Buckner, J.H.1
  • 23
    • 34047174849 scopus 로고    scopus 로고
    • Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    • Allan SE, Crome SQ, Crellin NK, Passerini L, Steiner TS, et al. (2007) Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 19: 345-354. dxm014 [pii];10.1093/intimm/dxm014 [doi].
    • (2007) Int Immunol , vol.19 , pp. 345-354
    • Allan, S.E.1    Crome, S.Q.2    Crellin, N.K.3    Passerini, L.4    Steiner, T.S.5
  • 24
    • 35448930435 scopus 로고    scopus 로고
    • Induction of FOXP3 expression in naive human CD4+ FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype
    • Tran DQ, Ramsey H, Shevach EM, (2007) Induction of FOXP3 expression in naive human CD4+ FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 110: 2983-2990. blood-2007-06-094656 [pii];10.1182/blood-2007-06-094656 [doi].
    • (2007) Blood , vol.110 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 25
    • 77954141914 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells in the human immune system
    • Sakaguchi S, Miyara M, Costantino CM, Hafler DA, (2010) FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 10: 490-500. nri2785 [pii];10.1038/nri2785 [doi].
    • (2010) Nat Rev Immunol , vol.10 , pp. 490-500
    • Sakaguchi, S.1    Miyara, M.2    Costantino, C.M.3    Hafler, D.A.4
  • 26
    • 84857416489 scopus 로고    scopus 로고
    • Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
    • Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, et al. (2012) Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36: 262-275. S1074-7613(12)00040-4 [pii];10.1016/j.immuni.2011.12.012 [doi].
    • (2012) Immunity , vol.36 , pp. 262-275
    • Miyao, T.1    Floess, S.2    Setoguchi, R.3    Luche, H.4    Fehling, H.J.5
  • 27
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • Reik W, Dean W, Walter J, (2001) Epigenetic reprogramming in mammalian development. Science 293: 1089-1093. 10.1126/science.1063443 [doi];293/5532/1089 [pii].
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 28
    • 84865307645 scopus 로고    scopus 로고
    • Homeostasis and function of regulatory T cells in aging
    • Raynor J, Lages CS, Shehata H, Hildeman DA, Chougnet CA, (2012) Homeostasis and function of regulatory T cells in aging. Curr Opin Immunol 24: 482-487. S0952-7915(12)00065-9 [pii];10.1016/j.coi.2012.04.005 [doi].
    • (2012) Curr Opin Immunol , vol.24 , pp. 482-487
    • Raynor, J.1    Lages, C.S.2    Shehata, H.3    Hildeman, D.A.4    Chougnet, C.A.5
  • 29
    • 34447629515 scopus 로고    scopus 로고
    • Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration
    • Rosenkranz D, Weyer S, Tolosa E, Gaenslen A, Berg D, et al. (2007) Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. J Neuroimmunol 188: 117-127. S0165-5728(07)00174-9 [pii];10.1016/j.jneuroim.2007.05.011 [doi].
    • (2007) J Neuroimmunol , vol.188 , pp. 117-127
    • Rosenkranz, D.1    Weyer, S.2    Tolosa, E.3    Gaenslen, A.4    Berg, D.5
  • 30
    • 49649117750 scopus 로고    scopus 로고
    • Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
    • Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, et al. (2008) Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol 181: 1835-1848. 181/3/1835 [pii].
    • (2008) J Immunol , vol.181 , pp. 1835-1848
    • Lages, C.S.1    Suffia, I.2    Velilla, P.A.3    Huang, B.4    Warshaw, G.5
  • 31
    • 67650705116 scopus 로고    scopus 로고
    • Aging and human CD4(+) regulatory T cells
    • Hwang KA, Kim HR, Kang I, (2009) Aging and human CD4(+) regulatory T cells. Mech Ageing Dev 130: 509-517. S0047-6374(09)00084-0 [pii];10.1016/j.mad.2009.06.003 [doi].
    • (2009) Mech Ageing Dev , vol.130 , pp. 509-517
    • Hwang, K.A.1    Kim, H.R.2    Kang, I.3
  • 32
    • 40049098445 scopus 로고    scopus 로고
    • Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype
    • Santner-Nanan B, Seddiki N, Zhu E, Quent V, Kelleher A, et al. (2008) Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype. Int Immunol 20: 375-383. dxm151 [pii];10.1093/intimm/dxm151 [doi].
    • (2008) Int Immunol , vol.20 , pp. 375-383
    • Santner-Nanan, B.1    Seddiki, N.2    Zhu, E.3    Quent, V.4    Kelleher, A.5
  • 33
    • 78149419897 scopus 로고    scopus 로고
    • T regulatory cells in cord blood-FOXP3 demethylation as reliable quantitative marker
    • Liu J, Llui A, Illi S, Layland L, Olek S, et al. (2010) T regulatory cells in cord blood-FOXP3 demethylation as reliable quantitative marker. PLoS One 5: e13267. 10.1371/journal.pone.0013267 [doi].
    • (2010) PLoS One , vol.5
    • Liu, J.1    Llui, A.2    Illi, S.3    Layland, L.4    Olek, S.5
  • 35
    • 16844378685 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
    • Ormandy LA, Hillemann T, Wedemeyer H, Manns MP, Greten TF, et al. (2005) Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res 65: 2457-2464. 65/6/2457 [pii];10.1158/0008-5472.CAN-04-3232 [doi].
    • (2005) Cancer Res , vol.65 , pp. 2457-2464
    • Ormandy, L.A.1    Hillemann, T.2    Wedemeyer, H.3    Manns, M.P.4    Greten, T.F.5
  • 36
    • 34247261531 scopus 로고    scopus 로고
    • Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    • Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, et al. (2006) Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J Clin Oncol 24: 5373-5380. 24/34/5373 [pii];10.1200/JCO.2006.05.9584 [doi].
    • (2006) J Clin Oncol , vol.24 , pp. 5373-5380
    • Bates, G.J.1    Fox, S.B.2    Han, C.3    Leek, R.D.4    Garcia, J.F.5
  • 37
    • 84855782582 scopus 로고    scopus 로고
    • Neutralization of interleukin-10 or transforming growth factor-beta decreases the percentages of CD4+ CD25+ Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival
    • Hiraki S, Ono S, Tsujimoto H, Kinoshita M, Takahata R, et al. (2012) Neutralization of interleukin-10 or transforming growth factor-beta decreases the percentages of CD4+ CD25+ Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival. Surgery 151: 313-322. S0039-6060(11)00370-9 [pii];10.1016/j.surg.2011.07.019 [doi].
    • (2012) Surgery , vol.151 , pp. 313-322
    • Hiraki, S.1    Ono, S.2    Tsujimoto, H.3    Kinoshita, M.4    Takahata, R.5
  • 38
    • 79960955688 scopus 로고    scopus 로고
    • Flow cytometry developments and perspectives in clinical studies: examples in ICU patients
    • Venet F, Guignant C, Monneret G, (2011) Flow cytometry developments and perspectives in clinical studies: examples in ICU patients. Methods Mol Biol 761: 261-275. 10.1007/978-1-61779-182-6_18 [doi].
    • (2011) Methods Mol Biol , vol.761 , pp. 261-275
    • Venet, F.1    Guignant, C.2    Monneret, G.3


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