The role of toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation

Injury

Volumn 43, Issue 2, 2012, Pages 129-136

  McGhan, Lee J ^a   Jaroszewski, Dawn E ^a,b  

^a MAYO CLINIC   (United States)

^b Mayo Clinic   (United States)

Author keywords

'Shock primed' neutrophils; 'Two hit' hypothesis; Haemorrhagic shock; Innate immune system; Multi organ failure; Resuscitation; TLR4; Toll like receptors

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; APOCYNIN; BACTERIUM LIPOPOLYSACCHARIDE; DIPHENYLENE INDONIUM; ERITORAN; HEME OXYGENASE 1; HIGH MOBILITY GROUP B1 PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 6; KETAMINE; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDOREDUCTASE INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESATORVID; STILBAZULENYL NITRONE; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 2; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANTIOXIDANT ACTIVITY; CELL DAMAGE; CHEMOTAXIS; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FLUID RESUSCITATION; HEART MUSCLE ISCHEMIA; HEMORRHAGIC SHOCK; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; INJURY; INNATE IMMUNITY; INTRACELLULAR SIGNALING; KIDNEY ISCHEMIA; KUPFFER CELL; LIVER INJURY; LUNG ALVEOLUS MACROPHAGE; MESENTERY LYMPH NODE; MORBIDITY; MORTALITY; MULTIPLE ORGAN FAILURE; NEUTROPHIL; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY; REVIEW; SEPSIS; SEPTIC SHOCK; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; HUMANS; MULTIPLE ORGAN FAILURE; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; RESUSCITATION; SHOCK, HEMORRHAGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; WOUNDS AND INJURIES;

EID: 84855846181     PISSN: 00201383     EISSN: 18790267     Source Type: Journal    
DOI: 10.1016/j.injury.2011.05.032     Document Type: Review

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