Role of D-galactose-induced brain aging and its potential used for therapeutic interventions

Experimental Gerontology

Volumn 101, Issue , 2018, Pages 13-36

  Shwe, Thazin ^a,b   Pratchayasakul, Wasana ^a,b   Chattipakorn, Nipon ^a,b   Chattipakorn, Siriporn C ^a,b  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

Brain aging; Cognitive function; D galactose; Mitochondria; Therapeutic

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DNA; GALACTOSE;

AGING; APOPTOSIS; BRAIN AGING; BRAIN MITOCHONDRION; BRAIN SIZE; COGNITION; COGNITIVE DEFECT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA MUTATIONAL ANALYSIS; ENCEPHALITIS; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SENESCENCE; ANIMAL MODEL; BRAIN; CELL AGING; DEMENTIA; DRUG DEVELOPMENT; DRUG EFFECT; HUMAN; METABOLISM; MITOCHONDRION; PHYSIOLOGY; PROCEDURES;

AGING; BRAIN; CELLULAR SENESCENCE; COGNITION; DEMENTIA; DRUG DISCOVERY; GALACTOSE; HUMANS; MITOCHONDRIA; MODELS, ANIMAL;

EID: 85034035818     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2017.10.029     Document Type: Review

References (67)

1. Acosta, P.B., Gross, K.C., Hidden sources of galactose in the environment. Eur. J. Pediatr. 154 (1995), S87–92.
2. Ali, T. et al., Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model. J. Pineal Res. 58 (2015), 71–85.
3. Ames, B.N., Delaying the mitochondrial decay of aging. Ann. N. Y. Acad. Sci. 1019 (2004), 406–411.
4. Ansari, N.A., Dash, D., Amadori glycated proteins: role in production of autoantibodies in diabetes mellitus and effect of inhibitors on non-enzymatic glycation. Aging Dis. 4 (2013), 50–56.
5. Aydin, S. et al., Comparison of oxidative stress biomarkers in renal tissues of D-galactose induced, naturally aged and young rats. Biogerontology 13 (2012), 251–260.
6. Banji, O.J., Banji, D., Ch, K., Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain. Food Chem. Toxicol. 74 (2014), 51–59.
7. Benn, S.C., Woolf, C.J., Adult neuron survival strategies-slamming on the brakes. Nat. Rev. Neurosci. 5 (2004), 686–700.
8. Benner, E.J. et al., Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 9435–9440.
9. Berry, G.T., Classic galactosemia and clinical variant galactosemia. Pagon, R.A., Adam, M.P., Ardinger, H.H., Wallace, S.E., Amemiya, A., Bean, L.J.H., Bird, T.D., Ledbetter, N., Mefford, H.C., Smith, R.J.H., Stephens, K., (eds.) GeneReviews(R), 1993, University of Washington, Seattle University of Washington, Seattle (GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved., Seattle (WA)).
10. Bjelakovic, G. et al., Hypoglycemia as a Pathological Result in Medical Praxis. 2011.
11. Boespflug, E.L. et al., Enhanced neural activation with blueberry supplementation in mild cognitive impairment. Nutr. Neurosci., 2017, 1–9.
12. Çakatay, U., Protein redox-regulation mechanisms in aging. Bondy, S., Maiese, K., (eds.) Aging and age-related disorders, 2010, Humana Press, Totowa, NJ, 3–25.
13. Carayon, P., Portier, M., Dussossoy, D., Bord, A., Petitpretre, G., Canat, X., Le Fur, G., Casellas, P., Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage. Blood 87 (1996), 3170–3178.
14. Cebe, T. et al., A comprehensive study of myocardial redox homeostasis in naturally and mimetically aged rats. Age (Dordr.), 36, 2014, 9728.
15. Chen, C. et al., Treatment with dehydroepiandrosterone increases peripheral benzodiazepine receptors of mitochondria from cerebral cortex in D-galactose-induced aged rats. Basic Clin. Pharmacol. Toxicol. 103 (2008), 493–501.
16. Chen, B. et al., Age-related changes in the central auditory system: comparison of D-galactose-induced aging rats and naturally aging rats. Brain Res. 1344 (2010), 43–53.
17. Chen, B. et al., Increased mitochondrial DNA damage and decreased base excision repair in the auditory cortex of D-galactose-induced aging rats. Mol. Biol. Rep. 38 (2011), 3635–3642.
18. Chen, X. et al., Protective effect of hyperbaric oxygen on cognitive impairment induced by D-galactose in mice. Neurochem. Res. 41 (2016), 3032–3041.
19. Coelho, A.I., Berry, G.T., Rubio-Gozalbo, M.E., Galactose metabolism and health. Curr. Opin. Clin. Nutr. Metab. Care 18 (2015), 422–427.
20. Cui, X. et al., Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J. Neurosci. Res. 83 (2006), 1584–1590.
21. Cura, A.J., Carruthers, A., Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis. Compr. Physiol. 2 (2012), 863–914.
22. Dauer, W., Przedborski, S., Parkinson's disease: mechanisms and models. Neuron 39 (2003), 889–909.
23. Du, Z. et al., NADPH oxidase-dependent oxidative stress and mitochondrial damage in hippocampus of D-galactose-induced aging rats. J. Huazhong Univ. Sci. Technolog. Med. Sci. 32 (2012), 466–472.
24. Du, Z. et al., NADPH oxidase 2-dependent oxidative stress, mitochondrial damage and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging rats. Neuroscience 286 (2015), 281–292.
25. Gao, J. et al., Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer's disease. Behav. Brain Res. 293 (2015), 27–33.
26. van Gelder, B.M. et al., Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study. Eur. J. Clin. Nutr. 61 (2007), 226–232.
27. Gillum, R.F., Yorrick, R., Obisesan, T.O., Population surveillance of dementia mortality. Int. J. Environ. Res. Public Health 8 (2011), 1244–1257.
28. Golubev, A., Hanson, A.D., Gladyshev, V.N., Non-enzymatic molecular damage as a prototypic driver of aging. J. Biol. Chem. 292 (2017), 6029–6038.
29. Grimm, A., Eckert, A., Brain aging and neurodegeneration: from a mitochondrial point of view. J. Neurochem., 2017, 10.1111/jnc.14037.
30. Haider, S. et al., A high dose of short term exogenous D-galactose administration in young male rats produces symptoms simulating the natural aging process. Life Sci. 124 (2015), 110–119.
31. Hsieh, H.M., Wu, W.M., Hu, M.L., Soy isoflavones attenuate oxidative stress and improve parameters related to aging and Alzheimer's disease in C57BL/6J mice treated with D-galactose. Food Chem. Toxicol. 47 (2009), 625–632.
32. Inman, D.M. et al., Alpha-lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction. PLoS One, 8, 2013, e65389.
33. Kumar, A., Dogra, S., Prakash, A., Effect of carvedilol on behavioral, mitochondrial dysfunction, and oxidative damage against D-galactose induced senescence in mice. Naunyn Schmiedeberg's Arch. Pharmacol. 380 (2009), 431–441.
34. Lei, M. et al., Impairments of astrocytes are involved in the d-galactose-induced brain aging. Biochem. Biophys. Res. Commun. 369 (2008), 1082–1087.
35. Long, J. et al., D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology 8 (2007), 373–381.
36. Lu, J. et al., Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Biochem. Pharmacol. 74 (2007), 1078–1090.
37. Lu, J. et al., Chronic administration of troxerutin protects mouse brain against D-galactose-induced impairment of cholinergic system. Neurobiol. Learn. Mem. 93 (2010), 157–164.
38. Lu, J. et al., Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-kappaB pathway activation. Cereb. Cortex 20 (2010), 2540–2548.
39. Morava, E., Galactose supplementation in phosphoglucomutase-1 deficiency; review and outlook for a novel treatable CDG. Mol. Genet. Metab. 112 (2014), 275–279.
40. Nagy, G., Pohl, N.L., Complete hexose isomer identification with mass spectrometry. J. Am. Soc. Mass Spectrom. 26 (2015), 677–685.
41. Pak, J.W. et al., Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging. Aging Cell 2 (2003), 1–7.
42. Panossian, A. et al., Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: an interactive pathway analysis of the downstream effects using RNA microarray data. Phytomedicine 21 (2014), 1325–1348.
43. Prakash, A., Kumar, A., Pioglitazone alleviates the mitochondrial apoptotic pathway and mito-oxidative damage in the d-galactose-induced mouse model. Clin. Exp. Pharmacol. Physiol. 40 (2013), 644–651.
44. Qian, Y.F. et al., Aqueous extract of the Chinese medicine, Danggui-Shaoyao-San, inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Cell Biol. Int. 32 (2008), 304–311.
45. Qu, Z. et al., Protective effect of tetrahydropalmatine against d-galactose induced memory impairment in rat. Physiol. Behav. 154 (2016), 114–125.
46. Rehman, S.U. et al., Anthocyanins reversed D-galactose-induced oxidative stress and Neuroinflammation mediated cognitive impairment in adult rats. Mol. Neurobiol. 54 (2017), 255–271.
47. Ritchie, K. et al., The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology 69 (2007), 536–545.
48. Rogatsky, G.G., Stambler, I., Hyperbaric oxygenation for resuscitation and therapy of elderly patients with cerebral and cardio-respiratory dysfunction. Front. Biosci. (Schol. Ed.) 9 (2017), 230–243.
49. Ronaldson, P.T., Bendayan, R., HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells. J. Neurochem. 106 (2008), 1298–1313.
50. Salehpour, F. et al., Transcranial low-level laser therapy improves brain mitochondrial function and cognitive impairment in D-galactose-induced aging mice. Neurobiol. Aging 58 (2017), 140–150.
51. Sander, M. et al., The challenges of human population ageing. Age Ageing 44 (2015), 185–187.
52. Sanz, A., Stefanatos, R.K., The mitochondrial free radical theory of aging: a critical view. Curr. Aging Sci. 1 (2008), 10–21.
53. Schriner, S.E. et al., Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308 (2005), 1909–1911.
54. Takeda, M., Takahashi, M., Matsumoto, S., Inflammation enhanced brain-derived neurotrophic factor-induced suppression of the voltage-gated potassium currents in small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone. Neuroscience 261 (2014), 223–231.
55. de la Torre, J.C., Treating cognitive impairment with transcranial low level laser therapy. J. Photochem. Photobiol. B 168 (2017), 149–155.
56. Ullah, F. et al., Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. Neurochem. Int. 90 (2015), 114–124.
57. Wortmann, M., Dementia: a global health priority - highlights from an ADI and World Health Organization report. Alzheimers Res. Ther., 4, 2012, 40.
58. Wright, A.F. et al., Lifespan and mitochondrial control of neurodegeneration. Nat. Genet. 36 (2004), 1153–1158.
59. Wu, D.C. et al., Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J. Neurosci. 22 (2002), 1763–1771.
60. Xian, Y.F. et al., Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice. Neurochem. Int. 76 (2014), 42–49.
61. Yanar, K. et al., Protein and DNA oxidation in different anatomic regions of rat brain in a mimetic ageing model. Basic Clin. Pharmacol. Toxicol. 109 (2011), 423–433.
62. Yang, H. et al., Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model. Int. J. Food Sci. Nutr. 67 (2016), 806–817.
63. Yu, Y. et al., Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation. Pharmacol. Biochem. Behav. 133 (2015), 122–131.
64. Zeng, L. et al., Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model. PLoS One, 9, 2014, e88019.
65. Zhang, X. et al., Systemic administration of catalpol prevents d-galactose induced mitochondrial dysfunction in mice. Neurosci. Lett. 473 (2010), 224–228.
66. Zhang, W.W. et al., Chronic administration of Liu Wei Dihuang protects rat's brain against D-galactose-induced impairment of cholinergic system. Sheng Li Xue Bao 63 (2011), 245–255.
67. Zhu, J. et al., Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. PLoS One, 9, 2014, e101291.