Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: An interactive pathway analysis of the downstream effects using RNA microarray data

Phytomedicine

Volumn 21, Issue 11, 2014, Pages 1325-1348

  Panossian, Alexander ^a   Hamm, Rebecca ^b   Wikman, Georg ^a   Efferth, Thomas ^b  

^a Swedish Herbal Institute   (Sweden)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Pharmacogenomics; Rhodiola rosea; Salidroside; Triandrin; Tyrosol

Indexed keywords

CYCLIC AMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPHRIN RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR; NATURAL PRODUCT; RHODIOLA ROSEA EXTRACT; SALIDROSIDE; TRIANDRIN; TYROSOL; UNCLASSIFIED DRUG; 4-HYDROXYPHENYLETHANOL; GLUCOSIDE; PHENETHYL ALCOHOL; PHENOL DERIVATIVE; PLANT EXTRACT; TRANSCRIPTOME;

ADAPTIVE IMMUNITY; AGGRESSION; ARTICLE; ATHEROSCLEROSIS; B LYMPHOCYTE; CARDIOVASCULAR DISEASE; CELL FUNCTION; CHEMOTAXIS; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; EMOTION; ENDOCRINE DISEASE; GASTROINTESTINAL DISEASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REGULATORY NETWORK; GLIA CELL; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MENTAL DISEASE; METABOLIC DISORDER; MICROARRAY ANALYSIS; NERVE FIBER; NEUROLOGIC DISEASE; PHARMACOGENOMICS; PREDICTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RHODIOLA ROSEA; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION; ANALOGS AND DERIVATIVES; CELL LINE; CHEMISTRY; DNA MICROARRAY; DRUG EFFECTS; GLIA; RHODIOLA;

CELL LINE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUCOSIDES; HUMANS; NEUROGLIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOLS; PHENYLETHYL ALCOHOL; PLANT EXTRACTS; RHODIOLA; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84906731468     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.07.008     Document Type: Article

References (48)

1. M. Abidov, F. Crendal, S. Grachev, R. Seifulla, and T. Ziegenfuss Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles Bull. Exp. Biol. Med. 136 2003 585 587 (Pubitemid 39137285)
2. R.A. Aksenova, M.I. Zotova, M.F. Nekhoda, and S.G. Cherdintsev Comparative characteristics of the stimulating and adaptogenic effects of Rhodiola rosea preparations A.S. Saratikov, Stimulants of the Central Nervous System vol. 2 1968 Tomsk University Press Tomsk 3 12
3. B. Amilhon, E. Lepicard, T. Renoir, R. Mongeau, D. Popa, O. Poirel, S. Miot, C. Gras, A.M. Gardier, J. Gallego, M. Hamon, L. Lanfumey, B. Gasnier, B. Giros, and S. El Mestikawy VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety J. Neurosci. 30 February (6) 2010 2198 2210
4. A. Asea, P. Kaur, A. Panossian, and K.G. Wikman Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts Phytomedicine 20 November (14) 2013 1323 1329
5. I.F. Bielsky, S.B. Hu, K.L. Szegda, H. Westphal, and L.J. Young Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice Neuropsychopharmacology 29 March (3) 2004 483 493 (Pubitemid 38372087)
6. O.A. Bocharova, B.P. Matveev, Baryshnikov AIu, K.M. Figurin, R.V. Serebriakova, and N.B. Bodrova The effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer (experimental clinical research) Urol. Nefrol. (Mosk) March-April (2) 1995 46 47 (Russian). PMID: 7785120
7. A. Bystritsky, L. Kerwin, and J.D. Feusner A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD) J. Altern. Complement. Med. 14 2008 175 180 (Pubitemid 351364412)
8. Z. Cai, W. Li, H. Wang, W. Yan, Y. Zhou, G. Wang, J. Cui, and F. Wang Antitumor effects of a purified polysaccharide from Rhodiola rosea and its action mechanism Carbohydr. Polym. 90 September (1) 2012 296 300
9. V. Darbinyan, A. Kteyan, A. Panossian, E. Gabrielian, G. Wikman, and H. Wagner Rhodiola rosea in stress induced fatigue - a double blind cross-over study of a standardized extract SHA-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty Phytomedicine 7 5 1999 365 371
10. V. Darbinyan, G. Aslanyan, E. Amroyan, E. Gabrielyan, C. Malmström, and A. Panossian Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression Nordic J. Psychiat. 61 5 2007 2343 2348
11. L.A. Dement'eva, and K.V. Iaremenko Effect of a Rhodiola extract on the tumor process in an experiment Vopr. Onkol. 33 7 1987 57 60 (Russian). PMID: 3617612
12. EMA Community herbal monograph on Rhodiola rosea L., rhizoma et radix. Committee on Herbal Medicinal Products (HMPC) EMA/HMPC/232091/2011, 27 March 2012 2012
13. S. Ko, M.G. Zhao, H. Toyoda, C.S. Qiu, and M. Zhuo Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice J. Neurosci. 25 January (4) 2005 977 984 (Pubitemid 40171014)
14. Iu.B. Lishmanov, Zh.V. Trifonova, A.N. Tsibin, L.V. Maslova, and L.A. Dement'eva Plasma beta-endorphin and stress hormones in stress and adaptation Biull. Eksp. Biol. Med. 103 1987 422 424
15. Y.u.B. Lishmanov, A.V. Krylatov, L.N. Maslov, N.V. Nariznaya, and Zamotinkii Effect of Rhodiola rosea on the level of inducible Hsp-70 in miocard in stress Bull. Exp. Biol. Med. 121 1996 256 258
16. Z. Liu, X. Li, A.R. Simoneau, M. Jafari, and X. Zi Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy Mol. Carcinog. 51 March (3) 2012 257 267
17. L.A. MaÄ-meskulova, L.N. Maslov, I.u.B. Lishmanov, and E.A. Krasnov The participation of the mu-, delta- and kappa-opioid receptors in the realization of the anti-arrhythmia effect of Rhodiola rosea Eksp. Klin. Farmakol. 60 1997 38 39
18. M. Martin, C. Ledent, M. Parmentier, R. Maldonado, and O. Valverde Involvement of CB1 cannabinoid receptors in emotional behaviour Psychopharmacology (Berl) 159 February (4) 2002 379 387 (Pubitemid 34143362)
19. L.N. Maslov, I.u.B. Lishmanov, A.V. Naumova, and T.V. Lasukova Do endogenous ligands of peripheral mu- and delta-opiate receptors mediate anti-arrhythmic and cardioprotective effects of Rhodiola rosea extract? Biull. Eksp. Biol. Med. 124 1997 151 153
20. L. Mattioli, C. Funari, and M. Perfumi Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats J. Psychopharmacol. 23 2 2009 130 142 PubMed PMID: 18515456
21. T. Nekrasova, M.L. Jobes, J.H. Ting, G.C. Wagner, and A. Minden Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion Dev. Biol. 322 October (1) 2008 95 108
22. D.J. Nutt, J.C. Ballenger, D. Sheehan, and H.U. Wittchen Generalized anxiety disorder: comorbidity, comparative biology and treatment Int. J. Neuropsychopharmacol. 5 2002 315 325 (Pubitemid 35470352)
23. S. Ogawa, D.B. Lubahn, K.S. Korach, and D.W. Pfaff Behavioral effects of estrogen receptor gene disruption in male mice Proc. Natl. Acad. Sci. U. S. A. 94 February (4) 1997 1476 1481 (Pubitemid 27087876)
24. E.M.G. Olsson, B. von Schéele, and A.G. Panossian A randomized double-blind placebo controlled parallel group study of SHR-5 extract of Rhodiola rosea roots as treatment for patients with stress related fatigue Planta Med. 75 2 2009 105 112
25. S. O'Rahilly, I.S. Farooqi, G.S. Yeo, and B.G. Challis Minireview: human obesity-lessons from monogenic disorders Endocrinology 144 September (9) 2003 3757 3764 (Pubitemid 37088726)
26. A. Panossian, G. Wikman, P. Kaur, and A. Asea Adaptogens stimulate neuropeptide Y and Hsp72 expression and release in neuroglia cells Front. Neurosci. 6 2012 6 10.3389/fnins.2012.00006 http://www.frontiersin.org/ neuroendocrine-science/10.3389/fnins.2012.00006/full
27. A. Panossian, G. Wikman, and J. Sarris Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy Phytomedicine 17 7 2010 481 493 http://www.ncbi.nlm.nih.gov/pubmed/20378318
28. A. Panossian, N. Nikoyan, N. Ohanyan, A. Hovhannisyan, H. Abrahamyan, E. Gabrielyan, and G. Wikman Comparative study of Rhodiola preparations on behavioural despair of rats Phytomedicine 15 1 2008 84 91
29. A.G. Panossian Adaptogens in mental and behavioral disorders Psychiatr. Clin. N. Am. 36 March (1) 2013 49 64
30. A. Panossian, G. Wikman, L. Andreeva, A. Boykova, D. Nikiforova, and N. Timonina Adaptogens exert a stress protective effect by modulation of expression of molecular chaperons Planta Med. 74 2008 1018
31. A. Panossian, and G. Wikman Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity Pharmaceuticals 3 2010 188 224
32. A. Panossian, M. Hambartsumyan, A. Hovanissian, E. Gabrielyan, and G. Wikman The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol Drug Targets Insights 1 2007 39 54 http://www.la-press.com/the-adaptogens-rhodiola-and-schizandra- modify-the-response-to-immobili-a260
33. A. Panossian, and G. Wikman Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity Curr. Clin. Pharmacol. 4 3 2009 198 219 10.2174/157488409789375311 PMID: 19500070
34. A. Panossian, G. Wikman, P. Kaur, and A. Asea Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones Phytomedicine 16 6-7 2009 617 622 10.1016/j.phymed.2008.12.003 PMID: 19188053
35. A.G. Panossian, R. Hamm, O. Kadioglu, G. Wikman, and T. Efferth Synergy and antagonism of active constituents of ADAPT-232 on transcriptional level of metabolic regulation of isolated neuroglial cells Front. Neurosci. 7 2013 16 10.3389/fnins.2013.00016 http://journal.frontiersin.org/Journal/10.3389/fnins. 2013.00016/full
36. M. Perfumi, and L. Mattioli Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice Phytother. Res. 21 1 2007 37 43 PubMed PMID: 17072830 (Pubitemid 46173906)
37. P.A. Prodius, E.B. Manukhina, A.E. Bulanov, G. Wikman, and I.I. Malyshev Adaptogen ADAPT modulates synthesis of inducible stress protein HSP 70 and increases organism resistance to heat shock Biull. Eksp. Biol. Med. 123 1997 629 633
38. A. Rizzi, R. Vergura, G. Marzola, C. Ruzza, R. Guerrini, S. Salvadori, D. Regoli, and G. Calo Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice Br. J. Pharmacol. 154 May (2) 2008 471 479 (Pubitemid 351670609)
39. V.A. Shevtsov, B.I. Zholus, V.I. Shervarly, V.B. Vol'skij, Y.P. Korovin, M.P. Khristich, N.A. Roslyakova, and G. Wikman A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work Phytomedicine 10 2003 95 105 (Pubitemid 36433202)
40. A.A. Spasov, V.B. Mandrikov, and I.A. Mironova The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load Eksp. Klin. Farmakol. 63 January-February (1) 2000 76 78 (in Russian)
41. A.A. Spasov, G.K. Wikman, V.B. Mandrikov, I.A. Mironova, and V.V. Neumoin A double blind placebo controlled pilot study of the stimulating effect of Rhodiola rosea SHR-5 extract on the physical and mental work capacity of students during a stressful examination period with a repeated low-dose regimen Phytomedicine 7 2 2000 85 89 (Pubitemid 30307605)
42. S.L. Stancheva, and A. Mosharrof Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monoamines Med. Physiol. C.R. Acad. Bulg. Sci. 40 1987 85 87
43. E.L. Stone, M.N. Ismail, S.H. Lee, Y. Luu, K. Ramirez, S.M. Haslam, S.B. Ho, A. Dell, M. Fukuda, and J.D. Marth Glycosyltransferase function in core 2-type protein O glycosylation Mol. Cell Biol. 29 July (13) 2009 3770 3782
44. P. Tyrer, and D. Baldwin Generalised anxiety disorder Lancet 368 2006 2156 2166 (Pubitemid 44894560)
45. D. van Diermen, A. Marston, J. Bravo, M. Reist, P.A. Carrupt, and K. Hostettmann Monoamine oxidase inhibition by Rhodiola rosea L. roots J. Ethnopharmacol. 122 2009 397 401
46. F.A.C. Wiegant, S. Surinova, E. Ytsma, M. Langelaar-Makkinje, G. Wikman, and J.A. Post Plant adaptogens increase lifespan and stress resistance in C. elegans Biogerontology 10 1 2009 27 42 10.1007/s10522-008-9151-9
47. F.A.C. Wiegant, G. Limandjaja, S.A.H. de Poot, L.A. Bayda, O.N. Vorontsova, T.A. Zenina, M. Langelaar Makkinje, J.A. Post, and G. Wikman Plant adaptogens activate cellular adaptive mechanisms by causing mild damage L. Lukyanova, N. Takeda, P.K. Singal, Adaptation Biology and Medicine: Health Potentials vol. 5 2008 Narosa Publishers New Delhi 319 332
48. Y. Zhang, Y. Yao, H. Wang, Y. Guo, H. Zhang, and L. Chen Effects of salidroside on glioma formation and growth inhibition together with improvement of tumor microenvironment Chin. J. Cancer Res. 25 October (5) 2013 520 526