Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans

American Journal of Human Genetics

Volumn 101, Issue 5, 2017, Pages 752-767

  Crawford, Jacob E ^a,h   Amaru, Ricardo ^b   Song, Jihyun ^c   Julian, Colleen G ^d   Racimo, Fernando ^a,e   Cheng, Jade Yu ^a,e   Guo, Xiuqing ^f   Yao, Jie ^f   Ambale Venkatesh, Bharath ^g   Lima, João A ^g   Rotter, Jerome I ^f   Stehlik, Josef ^c   Moore, Lorna G ^d   Prchal, Josef T ^c   Nielsen, Rasmus ^a,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSIDAD MAYOR DE SAN ANDRÉS   (Bolivia)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f HARBOR UCLA MEDICAL CENTER   (United States)

^g JOHNS HOPKINS UNIVERSITY   (United States)

^h VERILY LIFE SCIENCES   (United States)

Author keywords

adaptation; Andean; Aymara; high altitude; hypoxia; natural selection

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; TRANSCRIPTION FACTOR TBX5;

ADULT; AGED; ALTITUDE ACCLIMATIZATION; ANDEAN AMERIND PEOPLE; ARTICLE; BRINP3 GENE; CARDIOVASCULAR FUNCTION; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE; GENE MAPPING; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; HYPOXIA; MALE; NATURAL SELECTION; NOS2 GENE; PHENOTYPIC VARIATION; POLYCYTHEMIA; PRIORITY JOURNAL; TBX5 GENE; WHOLE GENOME SEQUENCING; ADAPTATION; ALTITUDE; ALTITUDE DISEASE; CARDIOVASCULAR SYSTEM; GENETIC SELECTION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HEART FAILURE; MIDDLE AGED; PATHOPHYSIOLOGY; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY;

ADAPTATION, PHYSIOLOGICAL; AGED; AGED, 80 AND OVER; ALTITUDE; ALTITUDE SICKNESS; CARDIOVASCULAR SYSTEM; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HEART FAILURE; HUMANS; HYPOXIA; MALE; MIDDLE AGED; POLYCYTHEMIA; POLYMORPHISM, SINGLE NUCLEOTIDE; SELECTION, GENETIC;

EID: 85033583648     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2017.09.023     Document Type: Article

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