Extracellular mitochondrial DNA is generated by fibroblasts and predicts death in idiopathic pulmonary fibrosis

American Journal of Respiratory and Critical Care Medicine

Volumn 196, Issue 12, 2017, Pages 1571-1581

  Ryu, Changwan ^a   Sun, Huanxing ^a   Gulati, Mridu ^a   Herazo Maya, Jose D ^a   Chen, Yonglin ^d   Osafo Addo, Awo ^a   Brandsdorfer, Caitlin ^a   Winkler, Julia ^a   Blaul, Christina ^a   Faunce, Jaden ^a   Pan, Hongyi ^a   Woolard, Tony ^a   Tzouvelekis, Argyrios ^a   Antin Ozerkis, Danielle E ^a   Puchalski, Jonathan T ^a   Slade, Martin ^a   Gonzalez, Anjelica L ^d   Bogenhagen, Daniel F ^e   Kirillov, Varvara ^f   Feghali Bostwick, Carol ^g   Gibson, Kevin ^h   Lindell, Kathleen ^h   Herzog, Raimund I ^b   Dela Cruz, Charles S ^a   Mehal, Wajahat ^c   Kaminski, Naftali ^a   Herzog, Erica L ^a   Trujillo, Glenda ^e,f   more..

^a Department of Medicine   (United States)

^b Section of Endocrinology and Metabolism Department of Internal Medicine   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d YALE UNIVERSITY   (United States)

^e Department of Pharmacology ^*  (United States)

^f STONY BROOK UNIVERSITY   (United States)

^g MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^h UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Biomarkers; Interstitial lung disease; Mechanotransduction; Mitochondria

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; MITOCHONDRIAL DNA; TRANSFORMING GROWTH FACTOR BETA1;

AGED; ALL CAUSE MORTALITY; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DISEASE COURSE; EVENT FREE SURVIVAL; FEMALE; FIBROBLAST; FIBROSING ALVEOLITIS; HUMAN; HUMAN CELL; HYDROGEL; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; MECHANOTRANSDUCTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; DISEASE FREE SURVIVAL; METABOLISM; MORTALITY;

AGED; DISEASE-FREE SURVIVAL; DNA, MITOCHONDRIAL; FEMALE; FIBROBLASTS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; MALE;

EID: 85033548205     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201612-2480OC     Document Type: Article

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